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1. Correction to: Effects of early extubation followed by noninvasive ventilation versus standard extubation on the duration of invasive mechanical ventilation in hypoxemic non-hypercapnic patients: a systematic review and individual patient data meta-analysis of randomized controlled trials (Critical Care, (2021), 25, 1, (189), 10.1186/s13054-021-03595-5)

Author

Paolo Navalesi, Gianmaria Cammarota, Miguel Ferrer, F. Moretto, Dipesh Mistry, Federico Longhini, Francesco Barone-Adesi, Alessandro Pecere, Gavin D. Perkins, Michele Carron, Rosanna Vaschetto, R. Pletsch-Assuncao, F Della Corte, and Haibo Qiu

Subjects
Mechanical ventilation, business.industry, RC86-88.9, medicine.medical_treatment, Medical emergencies. Critical care. Intensive care. First aid, Patient data, Critical Care and Intensive Care Medicine, law.invention, Randomized controlled trial, law, Meta-analysis, Anesthesia, Medicine, Noninvasive ventilation, Duration (project management), business
Published
2021

2. Predictors of intubation in COVID-19 patients treated with out-of-ICU continuous positive airway pressure

Author

Paolo Navalesi, Carlo Olivieri, F. Della Corte, Fabrizio Racca, Davide Colombo, Lorenza Scotti, Gianmaria Cammarota, Francesco Barone-Adesi, Rosanna Vaschetto, Carlo Maestrone, N. De Vita, and Claudio Pissaia

Subjects
Male, SARS, Severe acute respiratory syndrome, medicine.medical_treatment, HFNC, High flow nasal cannula, chemistry.chemical_compound, 0302 clinical medicine, FiO2, Fraction of inspired oxygen, Fraction of inspired oxygen, Medicine, Intubation, 030212 general & internal medicine, Continuous positive airway pressure, continuous positive pressure ventilation, CPAP, Continuous positive airway pressure, COVID-19, Coronavirus disease 2019, SpO2, Peripheral oxygen saturation, Continuous Positive Airway Pressure, Area under the curve, respiratory system, ICU, Intensive care unit, Intensive Care Units, medicine.anatomical_structure, Anesthesia, Original Article, PaO2, Arterial oxygen partial pressure, therapeutics, circulatory and respiratory physiology, Pulmonary and Respiratory Medicine, NIPPV, Noninvasive positive pressure ventilation, Respiratory rate, Continuous positive pressure ventilation, COVID-19, Predictors of intubation, SARS-CoV-2, 03 medical and health sciences, Lactate dehydrogenase, White blood cell, ARDS, Acute respiratory distress syndrome, Intubation, Intratracheal, Humans, LDH, Lactate dehydrogenase, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, CCI, Charlson Comorbidity Index, business.industry, CI, Confidence interval, MERS, Middle East respiratory syndrome, RR, Respiratory rate, ABG, Arterial blood gas analysis, ARF, Acute respiratory failure, respiratory tract diseases, Oxygen, 030228 respiratory system, Respiratory failure, chemistry, business
Abstract

Background As delayed intubation may worsen the outcome of coronavirus disease 2019 (COVID-19) patients treated with continuous positive airway pressure (CPAP), we sought to determine COVID-specific early predictors of CPAP failure. Methods In this observational retrospective multicentre study, we included all COVID-19 patients treated with out-of-ICU CPAP, candidates for intubation in case of CPAP failure. From these patients, we collected demographic and clinical data. Results A total of 397 COVID-19 patients were treated with CPAP for respiratory failure, with the therapeutic goal of providing intubation in case of CPAP failure. Univariable analysis showed that, age, lactate dehydrogenase (LDH) and white cell counts were all significantly lower in patients with successful CPAP treatment compared to those failing it and undergoing subsequent intubation. The percentage changes between baseline and CPAP application in the ratio of partial pressure arterial oxygen (PaO2) and fraction of inspired oxygen (FiO2), PaO2, respiratory rate and ROX index were higher in patients experiencing successful CPAP compared to those failing it. FiO2 and male gender were also significantly associated with intubation. Multivariable analysis adjusting for age, gender, Charlson comorbidity index, percentage change in PaO2/FiO2 or PaO2 and FiO2 separately, lactate, white blood cell count, LDH and C-reactive protein levels led to an area under the curve of 0.818 and confirmed that age, LDH and percentage increase in PaO2/FiO2 are predictors of intubation. Conclusions In COVID-19 patients requiring CPAP, age, LDH and percentage change in PaO2/FiO2 after starting CPAP are predictors of intubation.

Published
2020

3. ESICM LIVES 2016: part one

Author

L. Bos, L. Schouten, L. van Vught, M. Wiewel, D. Ong, O. Cremer, A. Artigas, I. Martin-Loeches, A. Hoogendijk, T. van der Poll, J. Horn, N. Juffermans, M. Schultz, N. de Prost, T. Pham, G. Carteaux, A. Mekontso Dessap, C. Brun-Buisson, E. Fan, G. Bellani, J. Laffey, A. Mercat, L. Brochard, B. Maitre, LUNG SAFE investigators and the ESICM study group, P. A. Howells, D. R. Thickett, C. Knox, D. P. Park, F. Gao, O. Tucker, T. Whitehouse, D. F. McAuley, G. D. Perkins, LUNG SAFE Investigators and the ESICM Trials Group, L. Pisani, J. P. Roozeman, F. D. Simonis, A. Giangregorio, L. R. Schouten, S. M. Van der Hoeven, A. Serpa Neto, E. Festic, A. M. Dondorp, S. Grasso, L. D. Bos, M. J. Schultz, M. Koster-Brouwer, D. Verboom, B. Scicluna, K. van de Groep, J. Frencken, M. Bonten, J. I. Ko, K. S. Kim, G. J. Suh, W. Y. Kwon, K. Kim, J. H. Shin, O. T. Ranzani, E. Prina, R. Menendez, A. Ceccato, R. Mendez, C. Cilloniz, A. Gabarrus, M. Ferrer, A. Torres, A. Urbano, L. A. Zhang, D. Swigon, F. Pike, R. S. Parker, G. Clermont, C. Scheer, S. O. Kuhn, A. Modler, M. Vollmer, C. Fuchs, K. Hahnenkamp, S. Rehberg, M. Gründling, A. Taggu, N. Darang, N. Öveges, I. László, K. Tánczos, M. Németh, G. Lebák, B. Tudor, D. Érces, J. Kaszaki, W. Huber, D. Trásy, Z. Molnár, G. Ferrara, V. S. Kanoore Edul, H. S. Canales, E. Martins, C. Canullán, G. Murias, M. O. Pozo, J. F. Caminos Eguillor, M. G. Buscetti, C. Ince, A. Dubin, H. D. Aya, A. Rhodes, N. Fletcher, R. M. Grounds, M. Cecconi, M. Jacquet-Lagrèze, M. Riche, R. Schweizer, P. Portran, W. Fornier, M. Lilot, J. Neidecker, J. L. Fellahi, A. Escoresca-Ortega, A. Gutiérrez-Pizarraya, L. Charris-Castro, Y. Corcia-Palomo, E. Fernandez-Delgado, J. Garnacho-Montero, C. Roger, L. Muller, L. Elotmani, J. Lipman, J. Y. Lefrant, J. A. Roberts, R. Muñoz-Bermúdez, M. Samper, C. Climent, F. Vasco, V. Sara, S. Luque, N. Campillo, S. Grau Cerrato, J. R. Masclans, F. Alvarez-Lerma, S. Carvalho Brugger, G. Jimenez Jimenez, M. Miralbés Torner, J. Trujillano Cabello, B. Balsera Garrido, X. Nuvials Casals, F. Barcenilla Gaite, M. Vallverdú Vidal, M. Palomar Martínez, V. Gusarov, D. Shilkin, M. Dementienko, E. Nesterova, N. Lashenkova, A. Kuzovlev, M. Zamyatin, A. Demoule, S. Carreira, S. Lavault, O. Palancca, E. Morawiec, J. Mayaux, I. Arnulf, T. Similowski, B. S. Rasmussen, R. G. Maltesen, M. Hanifa, S. Pedersen, S. R. Kristensen, R. Wimmer, M. Panigada, G. Li Bassi, T. Kolobow, A. Zanella, M. Cressoni, L. Berra, V. Parrini, H. Kandil, G. Salati, S. Livigni, A. Amatu, A. Andreotti, F. Tagliaferri, G. Moise, G. Mercurio, A. Costa, A. Vezzani, S. Lindau, J. Babel, M. Cavana, D. Consonni, A. Pesenti, L. Gattinoni, for the GRAVITY-VAP TRIAL NETWORK, P. Mansouri, F. Zand, L. Zahed, F. Dehghanrad, M. Bahrani, M. Ghorbani, B. Cambiaghi, O. Moerer, T. Mauri, N. Kunze-Szikszay, C. Ritter, M. Quintel, L. M. Vilander, M. A. Kaunisto, S. T. Vaara, V. Pettilä, FINNAKI Study Group, J. L. G. Haitsma Mulier, S. Rozemeijer, A. M. E. Spoelstra-de Man, P. E. Elbers, P. R. Tuinman, M. C. de Waard, H. M. Oudemans-van Straaten, A. M. A. Liberatore, R. B. Souza, A. M. C. R. P. F. Martins, J. C. F. Vieira, I. H. J. Koh, M. Galindo Martínez, R. Jiménez Sánchez, L. Martínez Gascón, M. D. Rodríguez Mulero, A. Ortín Freire, A. Ojados Muñoz, S. Rebollo Acebes, Á. Fernández Martínez, S. Moreno Aliaga, L. Herrera Para, J. Murcia Payá, F. Rodríguez Mulero, P. Guerci, Y. Ince, P. Heeman, B. Ergin, Z. Uz, M. Massey, R. Papatella, E. Bulent, F. Toraman, E. R. Longbottom, H. D. Torrance, H. C. Owen, C. J. Hinds, R. M. Pearse, M. J. O’Dywer, Z. Trogrlic, M. van der Jagt, H. Lingsma, H. H. Ponssen, J. F. Schoonderbeek, F. Schreiner, S. J. Verbrugge, S. Duran, T. van Achterberg, J. Bakker, D. A. M. P. J. Gommers, E. Ista, A. Krajčová, P. Waldauf, F. Duška, A. Shah, N. Roy, S. McKechnie, C. Doree, S. Fisher, S. J. Stanworth, J. F. Jensen, D. Overgaard, M. H. Bestle, D. F. Christensen, I. Egerod, The RAPIT Group, A. Pivkina, I. Zhivotneva, N. Pasko, A. Alklit, R. L. Hansen, H. Knudsen, L. B. Grode, The RAPIT group, M. Hravnak, L. Chen, A. Dubrawski, M. R. Pinsky, S. M. Parry, L. D. Knight, B. C. Connolly, C. E. Baldwin, Z. A. Puthucheary, L. Denehy, N. Hart, P. E. Morris, J. Mortimore, C. L. Granger, H. I. Jensen, R. Piers, B. Van den Bulcke, J. Malmgren, V. Metaxa, A. K. Reyners, M. Darmon, K. Rusinova, D. Talmor, A. P. Meert, L. Cancelliere, L. Zubek, P. Maia, A. Michalsen, J. Decruyenaere, E. Kompanje, S. Vanheule, E. Azoulay, S. Vansteelandt, D. Benoit, C. Ryan, D. Dawson, J. Ball, K. Noone, B. Aisling, S. Prudden, A. Ntantana, D. Matamis, S. Savvidou, M. Giannakou, M. Gouva, G. Nakos, V. Koulouras, J. Aron, G. Lumley, D. Milliken, K. Dhadwal, B. A. McGrath, S. J. Lynch, B. Bovento, G. Sharpe, E. Grainger, S. Pieri-Davies, S. Wallace, B. McGrath, M. Jung, J. Cho, H. Park, G. Suh, O. Kousha, J. Paddle, L. Gamrin Gripenberg, M. Sundström Rehal, J. Wernerman, O. Rooyackers, H. J. de Grooth, W. P. Choo, A. M. Spoelstra-de Man, E. L. Swart, L. Talan, G. Güven, N. D. Altıntas, M. Padar, G. Uusvel, L. Starkopf, J. Starkopf, A. Reintam Blaser, M. S. Kalaiselvan, A. S. Arunkumar, M. K. Renuka, R. L. Shivkumar, M. Volbeda, D. ten Kate, M. Hoekstra, J. M. van der Maaten, M. W. Nijsten, A. Komaromi, Å. Norberg, M. Smedberg, M. Mori, L. Pettersson, M. Theodorakopoulou, T. Christodoulopoulou, A. Diamantakis, F. Frantzeskaki, M. Kontogiorgi, E. Chrysanthopoulou, M. Lygnos, C. Diakaki, A. Armaganidis, K. Gundogan, E. Dogan, R. Coskun, S. Muhtaroglu, M. Sungur, T. Ziegler, M. Guven, A. Kleyman, W. Khaliq, D. Andreas, M. Singer, R. Meierhans, R. Schuepbach, I. De Brito-Ashurst, G. Sabetian, R. Nikandish, F. Hagar, M. Masjedi, B. Maghsudi, A. Vazin, E. Asadpour, K. C. Kao, L. C. Chiu, C. Y. Hung, C. H. Chang, S. H. Li, H. C. Hu, S. El Maraghi, M. Ali, D. Rageb, M. Helmy, J. Marin-Corral, C. Vilà, A. Vàzquez, I. Martín-Loeches, E. Díaz, J. C. Yébenes, A. Rodriguez, F. Álvarez-Lerma, H1N1 SEMICYUC/GETGAG Working Group, N. Varga, A. Cortina-Gutiérrez, L. Dono, M. Martínez-Martínez, C. Maldonado, E. Papiol, M. Pérez-Carrasco, R. Ferrer, K. Nweze, B. Morton, I. Welters, M. Houard, B. Voisin, G. Ledoux, S. Six, E. Jaillette, S. Nseir, S. Romdhani, R. Bouneb, D. Loghmari, N. Ben Aicha, J. Ayachi, K. Meddeb, I. Chouchène, A. Khedher, M. Boussarsar, K. S. Chan, W. L. Yu, J. Nolla, L. Vidaur, J. Bonastre, B. Suberbiola, J. E. Guerrero, H1N1 SEMICYUC/GETGAG working group, N. Ramon Coll, G. Jiménez Jiménez, J. Codina Calero, M. García, M. C. de la Torre, E. Vendrell, E. Palomera, E. Güell, M. Serra-Prat, J. F. Bermejo-Martín, J. Almirall, E. Tomas, A. Escoval, F. Froe, M. H. Vitoria Pereira, N. Velez, E. Viegas, E. Filipe, C. Groves, M. Reay, A. Ballin, F. Facchin, G. Sartori, F. Zarantonello, E. Campello, C. M. Radu, S. Rossi, C. Ori, P. Simioni, N. Umei, I. Shingo, A. C. Santos, C. Candeias, I. Moniz, R. Marçal, Z. Costa e Silva, J. M. Ribeiro, J. F. Georger, J. P. Ponthus, M. Tchir, V. Amilien, M. Ayoub, E. Barsam, G. Martucci, G. Panarello, F. Tuzzolino, G. Capitanio, V. Ferrazza, T. Carollo, L. Giovanni, A. Arcadipane, M. López Sánchez, M. A. González-Gay, F. J. Llorca Díaz, M. I. Rubio López, E. Zogheib, L. Villeret, J. Nader, M. Bernasinski, P. Besserve, T. Caus, H. Dupont, P. Morimont, S. Habran, R. Hubert, T. Desaive, F. Blaffart, N. Janssen, J. Guiot, A. Pironet, P. Dauby, B. Lambermont, T. Pettenuzzo, G. Citton, C. Kirakli, O. Ediboglu, S. Ataman, M. Yarici, F. Tuksavul, S. Keating, A. Gibson, M. Gilles, M. Dunn, G. Price, N. Young, P. Remeta, P. Bishop, M. D. Fernández Zamora, J. Muñoz-Bono, E. Curiel-Balsera, E. Aguilar-Alonso, R. Hinojosa, A. Gordillo-Brenes, J. A. Arboleda-Sánchez, ARIAM-CARDIAC SURGERY PROJECT AUTHORS, I. Skorniakov, D. Vikulova, C. Whiteley, O. Shaikh, A. Jones, M. Ostermann, L. Forni, M. Scott, J. Sahatjian, W. Linde-Zwirble, D. Hansell, P. Laoveeravat, N. Srisawat, M. Kongwibulwut, S. Peerapornrattana, N. Suwachittanont, T. O. Wirotwan, P. Chatkaew, P. Saeyub, K. Latthaprecha, K. Tiranathanagul, S. Eiam-ong, J. A. Kellum, R. E. Berthelsen, A. Perner, A. E. K. Jensen, J. U. Jensen, D. J. Gebhard, J. Price, C. E. Kennedy, A. Akcan-Arikan, Y. R. Kang, M. N. Nakamae, K. Hamed, M. M. Khaled, R. Aly Soliman, M. Sherif Mokhtar, G. Seller-Pérez, D. Arias-Verdú, E. Llopar-Valdor, I. De-Diós-Chacón, G. Quesada-García, M. E. Herrera-Gutierrez, R. Hafes, G. Carroll, P. Doherty, C. Wright, I. G. Guerra Vera, M. Ralston, M. L. Gemmell, A. MacKay, E. Black, R. I. Docking, R. Appleton, M. R. Ralston, L. Gemmell, A. Mackay, J. G. Röttgering, P. W. G. Elbers, N. Mejeni, J. Nsiala, A. Kilembe, P. Akilimali, G. Thomas, A. E. Andersson, A. M. Fagerdahl, V. Knudsen, P-INFECT, A. Ben Cheikh, Y. Hamdaoui, A. Guiga, N. Fraj, N. Sma, I. Chouchene, N. Bouafia, A. Amirian, B. Ziaian, C. Fleischmann, D. O. Thomas-Rueddel, A. Schettler, D. Schwarzkopf, A. Stacke, K. Reinhart, A. Martins, P. Sousa, G. Snell, R. Matsa, T. T. S. Paary, A. M. Cavalheiro, L. L. Rocha, C. S. Vallone, A. Tonilo, M. D. S. Lobato, D. T. Malheiro, G. Sussumo, N. M. Lucino, V. D. Rosenthal, A. Sanaei Dashti, A. Yousefipour, J. R. Goodall, M. Williamson, E. Tant, N. Thomas, C. Balci, C. Gonen, E. Haftacı, H. Gurarda, E. Karaca, B. Paldusová, I. Zýková, D. Šímová, S. Houston, L. D’Antona, J. Lloyd, V. Garnelo-Rey, M. Sosic, V. Sotosek-Tokmazic, J. Kuharic, I. Antoncic, S. Dunatov, A. Sustic, C. T. Chong, M. Sim, T. Lyovarin, F. M. Acosta Díaz, S. Narbona Galdó, M. Muñoz Garach, O. Moreno Romero, A. M. Pérez Bailón, A. Carranza Pinel, M. Colmenero, A. Gritsan, A. Gazenkampf, E. Korchagin, N. Dovbish, R. M. Lee, M. P. P. Lim, B. C. L. Lim, J. J. See, R. Assis, F. Filipe, N. Lopes, L. Pessoa, T. Pereira, N. Catorze, M. S. Aydogan, C. Aldasoro, P. Marchio, A. Jorda, M. D. Mauricio, S. Guerra-Ojeda, M. Gimeno-Raga, M. Colque-Cano, A. Bertomeu-Artecero, M. Aldasoro, S. L. Valles, D. Tonon, T. Triglia, J. C. Martin, M. C. Alessi, N. Bruder, P. Garrigue, L. Velly, S. Spina, V. Scaravilli, C. Marzorati, E. Colombo, D. Savo, A. Vargiolu, G. Cavenaghi, G. Citerio, A. H. V. Andrade, P. Bulgarelli, J. A. P. Araujo, V. Gonzalez, V. A. Souza, C. Massant, C. A. C. Abreu Filho, R. A. Morbeck, L. E. Burgo, R. van Groenendael, L. T. van Eijk, G. P. Leijte, B. Koeneman, M. Kox, P. Pickkers, A. García-de la Torre, M. de la Torre-Prados, A. Fernández-Porcel, C. Rueda-Molina, P. Nuevo-Ortega, T. Tsvetanova-Spasova, E. Cámara-Sola, A. García-Alcántara, L. Salido-Díaz, X. Liao, T. Feng, J. Zhang, X. Cao, Q. Wu, Z. Xie, H. Li, Y. Kang, M. S. Winkler, A. Nierhaus, E. Mudersbach, A. Bauer, L. Robbe, C. Zahrte, E. Schwedhelm, S. Kluge, C. Zöllner, E. Mitsi, S. H. Pennington, J. Reine, A. D. Wright, R. Parker, I. D. Welters, J. D. Blakey, G. Rajam, E. W. Ades, D. M. Ferreira, D. Wang, A. Kadioglu, S. B. Gordon, R. Koch, J. Rahamat-Langedoen, J. Schloesser, M. de Jonge, J. Bringue, R. Guillamat-Prats, E. Torrents, M. L. Martinez, M. Camprubí-Rimblas, L. Blanch, S. Y. Park, Y. B. Park, D. K. Song, S. Shrestha, S. H. Park, Y. Koh, M. J. Park, C. W. Hong, O. Lesur, D. Coquerel, X. Sainsily, J. Cote, T. Söllradl, A. Murza, L. Dumont, R. Dumaine, M. Grandbois, P. Sarret, E. Marsault, D. Salvail, M. Auger-Messier, F. Chagnon, Apelin Group, M. P. Lauretta, E. Greco, A. Dyson, S. Preau, M. Ambler, A. Sigurta, S. Saeed, L. Topcu Sarıca, N. Zibandeh, D. Genc, F. Gul, T. Akkoc, E. Kombak, L. Cinel, I. Cinel, S. J. Pollen, N. Arulkumaran, G. Warnes, D. J. Pennington, K. Brohi, M. J. O’Dwyer, H. Y. Kim, S. Na, J. Kim, Y. F. Chang, A. Chao, P. Y. Shih, C. T. Lee, Y. C. Yeh, L. W. Chen, M. Adriaanse, W. Rietdijk, S. Funcke, S. Sauerlaender, B. Saugel, H. Pinnschmidt, D. A. Reuter, R. Nitzschke, S. Perbet, C. Biboulet, A. Lenoire, D. Bourdeaux, B. Pereira, B. Plaud, J. E. Bazin, V. Sautou, A. Mebazaa, J. M. Constantin, M. Legrand, Y. Boyko, P. Jennum, M. Nikolic, H. Oerding, R. Holst, P. Toft, H. K. Nedergaard, T. Haberlandt, S. Park, S. Kim, Y. J. Cho, Y. J. Lim, A. Chan, S. Tang, S. L. Nunes, S. Forsberg, H. Blomqvist, L. Berggren, M. Sörberg, T. Sarapohja, C. J. Wickerts, J. G. M. Hofhuis, L. Rose, B. Blackwood, E. Akerman, J. Mcgaughey, M. Fossum, H. Foss, E. Georgiou, H. J. Graff, M. Kalafati, R. Sperlinga, A. Schafer, A. G. Wojnicka, P. E. Spronk, F. Khalili, R. Afshari, H. Haddad Khodaei, S. Javadpour, P. Petramfar, S. Nasimi, H. Tabei, A. Gunther, J. O. Hansen, P. Sackey, H. Storm, J. Bernhardsson, Ø. Sundin, A. Bjärtå, A. Bienert, P. Smuszkiewicz, P. Wiczling, K. Przybylowski, A. Borsuk, I. Trojanowska, J. Matysiak, Z. Kokot, M. Paterska, E. Grzeskowiak, A. Messina, E. Bonicolini, D. Colombo, G. Moro, S. Romagnoli, A. R. De Gaudio, F. Della Corte, S. M. Romano, J. A. Silversides, E. Major, E. E. Mann, A. J. Ferguson, D. F. Mcauley, J. C. Marshall, J. A. Diaz-Rodriguez, R. Silva-Medina, E. Gomez-Sandoval, N. Gomez-Gonzalez, R. Soriano-Orozco, P. L. Gonzalez-Carrillo, M. Hernández-Flores, K. Pilarczyk, J. Lubarksi, D. Wendt, F. Dusse, J. Günter, B. Huschens, E. Demircioglu, H. Jakob, A. Palmaccio, A. M. Dell’Anna, D. L. Grieco, F. Torrini, C. Iaquaniello, F. Bongiovanni, M. Antonelli, L. Toscani, D. Antonakaki, D. Bastoni, M. Jozwiak, F. Depret, J. L. Teboul, J. Alphonsine, C. Lai, C. Richard, X. Monnet, G. Demeter, I. Kertmegi, A. Hasanin, A. Lotfy, A. El-adawy, H. Nassar, S. Mahmoud, A. Abougabal, A. Mukhtar, F. Quinty, S. Habchi, A. Luzi, E. Antok, G. Hernandez, B. Lara, L. Enberg, M. Ortega, P. Leon, C. Kripper, P. Aguilera, E. Kattan, M. Lehmann, S. Sakka, B. Bein, R. M. Schmid, J. Preti, J. Creteur, A. Herpain, J. Marc, F. Trojette, S. Bar, L. Kontar, D. Titeca, J. Richecoeur, B. Gelee, N. Verrier, R. Mercier, E. Lorne, J. Maizel, M. Slama, M. E. Abdelfattah, A. Eladawy, M. A. Ali Elsayed, A. Pedraza Montenegro, E. Monares Zepeda, J. Franco Granillo, J. S. Aguirre Sánchez, G. Camarena Alejo, A. Rugerio Cabrera, A. A. Tanaka Montoya, C. Lee, F. Hatib, M. Cannesson, P. Theerawit, T. Morasert, Y. Sutherasan, G. Zani, S. Mescolini, M. Diamanti, R. Righetti, A. Scaramuzza, M. Papetti, M. Terenzoni, C. Gecele, M. Fusari, K. A. Hakim, A. Chaari, M. Ismail, A. H. Elsaka, T. M. Mahmoud, K. Bousselmi, V. Kauts, W. F. Casey, S. D. Hutchings, D. Naumann, J. Wendon, S. Watts, E. Kirkman, Z. Jian, S. Buddi, J. Settels, P. Bertini, F. Guarracino, C. Trepte, P. Richter, S. A. Haas, V. Eichhorn, J. C. Kubitz, M. S. Soliman, W. I. Hamimy, A. Z. Fouad, A. M. Mukhtar, M. Charlton, L. Tonks, L. Mclelland, T. J. Coats, J. P. Thompson, M. R. Sims, D. Williams, D. Z. Roushdy, R. A. Soliman, R. A. Nahas, M. Y. Arafa, W. T. Hung, C. C. Chiang, W. C. Huang, K. C. Lin, S. C. Lin, C. C. Cheng, P. L. Kang, S. R. Wann, G. Y. Mar, C. P. Liu, M. Lopez Carranza, H. Sancho Fernandez, J. A. Sanchez Roman, F. Lucena, A. Campanario Garcia, A. Loza Vazquez, A. Lesmes Serrano, ARIAM-SEMICYUC Registry Investigators, L. Sayagues Moreira, R. Vidal-Perez, U. Anido Herranz, J. M. Garcia Acuna, C. Pena Gil, J. L. Garcia Allut, P. Rascado Sedes, C. Martin Lopez, E. Saborido Paz, C. Galban Rodriguez, J. R. Gonzalez-Juanatey, A. Vallejo-Baez, M. V. de la Torre-Prados, ARIAM Group, R. Marharaj, K. Gervasio, M. Bottiroli, M. Mondino, D. De Caria, A. Calini, E. Montrasio, F. Milazzo, M. P. Gagliardone, A. Vallejo-Báez, ARIAM group, U. Anido, M. Cheikh-Bouhlel, M. P. R. D. L. Dela Cruz, J. M. Bernardo, F. Galfo, A. Marino, C. C. Chao, P. Hou, C. C. Hung, C. H. Chiang, Y. J. Liou, S. M. Hung, Y. S. Lin, F. Y. Kuo, K. R. Chiou, C. J. Chen, L. S. Yan, C. Y. Liu, H. H. Wang, H. L. Chen, C. K. Ho, S. Grewal, S. Gopal, C. Corbett, A. Wilson, J. Capps, W. Ayoub, A. Lomas, S. Ghani, J. Moore, D. Atkinson, M. Sharman, W. Swinnen, J. Pauwels, K. Mignolet, E. Pannier, A. Koch, T. Sarens, W. Temmerman, A. M. Elmenshawy, A. M. Fayed, M. Elboriuny, E. Hamdy, E. Zakaria, A. C. Falk, A. Petosic, K. Olafsen, H. Wøien, H. Flaatten, K. Sunde, J. J. Cáceres Agra, J. L. Santana Cabrera, J. D. Martín Santana, L. Melián Alzola, H. Rodríguez Pérez, T. Castro Pires, H. Calderón, A. Pereira, S. Castro, C. Granja, I. Norkiene, I. Urbanaviciute, G. Kezyte, D. Ringaitiene, T. Jovaisa, G. Vogel, U. B. Johansson, A. Sandgren, C. Svensen, E. Joelsson-Alm, M. A. Leite, L. D. Murbach, E. F. Osaku, C. R. L. M. Costa, M. Pelenz, N. M. Neitzke, M. M. Moraes, J. L. Jaskowiak, M. M. M. Silva, R. S. Zaponi, L. R. L. Abentroth, S. M. Ogasawara, A. C. Jorge, P. A. D. Duarte, J. Barreto, S. T. Duarte, S. Taba, D. Miglioranza, D. P. Gund, C. F. Lordani, H. Vollmer, M. Gager, C. Waldmann, A. T. Mazzeo, R. Tesio, C. Filippini, M. E. Vallero, C. Giolitti, S. Caccia, M. Medugno, T. Tenaglia, R. Rosato, I. Mastromauro, L. Brazzi, P. P. Terragni, R. Urbino, V. Fanelli, V. M. Ranieri, L. Mascia, J. Ballantyne, L. Paton, P. Perez-Teran, O. Roca, J. C. Ruiz-Rodriguez, A. Zapatero, J. Serra, S. Bianzina, P. Cornara, G. Rodi, G. Tavazzi, M. Pozzi, G. A. Iotti, F. Mojoli, A. Braschi, A. Vishnu, D. Buche, R. Pande, D. L. J. Moolenaar, F. Bakhshi-Raiez, D. A. Dongelmans, N. F. de Keizer, D. W. de Lange, I. Fuentes Fernández, D. Martínez Baño, J. L. Buendía Moreno, R. Jara Rubio, J. Scott, D. Phelan, D. Morely, J. O’Flynn, P. Stapleton, M. Lynch, B. Marsh, E. Carton, C. O’Loughlin, K. C. Cheng, M. I. Sung, M. O. Elghonemi, M. H. Saleh, T. S. Meyhoff, M. Krag, P. B. Hjortrup, M. H. Møller, T. Öhman, T. Sigmundsson, E. Redondo, M. Hallbäck, F. Suarez-Sipmann, H. Björne, C. Hällsjö Sander, KARISMA, D. Chiumello, C. Chiurazzi, M. Brioni, I. Algieri, M. Guanziroli, G. Vergani, T. Tonetti, I. Tomic, A. Colombo, F. Crimella, E. Carlesso, V. Gasparovic, R. El-Sherif, M. Abd Al-Basser, A. Raafat, A. El-Sherif, L. R. A. Schouten, O. L. Cremer, D. S. Y. Ong, G. Amoruso, G. Cinnella, L. D. J. Bos, P. Schmidle, M. Findeisen, P. Hoppmann, J. Jaitner, F. Brettner, T. Lahmer, EXODUS-investigators, G. Rajagopalan, V. Bansal, R. Frank, R. Hinds, J. Levitt, United States Critical Illness and Injury Trials Group/LIPS-B investigators, S. Siddiqui, SICM NICER Group, J. P. Gilbert, K. Sim, C. H. Wang, I. J. Li, W. R. Tang, P. Persona, A. De Cassai, M. Franco, A. Goffi, B. Llorente Ruiz, J. Lujan Varas, R. Molina Montero, C. Pintado Delgado, O. Navarrete, M. Vazquez Mezquita, E. Alonso Peces, M. A. M. Nakamura, L. A. Hajjar, F. R. B. G. Galas, T. A. Ortiz, M. B. P. Amato, L. Bitker, N. Costes, D. Le Bars, F. Lavenne, D. Mojgan, J. C. Richard, D. Massari, M. Gotti, P. Cadringher, A. Zerman, M. Türkoğlu, G. Arık, F. Yıldırım, Z. Güllü, I. Kara, N. Boyacı, B. Basarık Aydoğan, Ü. Gaygısız, K. Gönderen, G. Aygencel, M. Aydoğdu, Z. Ülger, G. Gürsel, J. Riera, C. Maldonado Toral, C. Mazo, M. Martínez, J. Baldirà, L. Lagunes, A. Roman, M. Deu, J. Rello, D. J. Levine, R. M. Mohus, Å. Askim, J. Paulsen, A. Mehl, A. T. Dewan, J. K. Damås, E. Solligård, B. O. Åsvold, Mid-Norway Sepsis Research Center, A. DeWan, O. Aktepe, A. Kara, H. Yeter, A. Topeli, M. Norrenberg, M. Devroey, H. Khader, J. C. Preiser, Z. Tang, C. Qiu, L. Tong, C. Cai, O. Apostolopoulou, J. Y. Moon, M. R. Park, I. S. Kwon, G. R. Chon, J. Y. Ahn, S. J. Kwon, Y. J. Chang, J. Y. Lee, S. Y. Yoon, J. W. Lee, The Korean Chungcheong Critical Care Research Group, M. Kostalas, J. Mckinlay, G. Kooner, G. Dudas, A. Horton, C. Kerr, N. Karanjia, B. Creagh-Brown, N. D. Altintas, S. Izdes, O. Keremoglu, A. Alkan, S. Neselioglu, O. Erel, N. Tardif, T. Gustafsson, K. N. MacEachern, M. Traille, I. Bromberg, S. E. Lapinsky, M. J. Moore, J. L. García-Garmendia, F. Villarrasa-Clemente, F. Maroto-Monserrat, O. Rufo-Tejeiro, V. Jorge-Amigo, M. Sánchez-Santamaría, C. Colón-Pallarés, A. Barrero-Almodóvar, S. Gallego-Lara, C. T. Anthon, R. B. Müller, N. Haase, K. Møller, J. Wetterslev, M. Nakanishi, A. Kuriyama, T. Fukuoka, M. A. Abd el Halim, M. H. Elsaid hafez, A. M. Moktar, H. M. Elazizy, K. Abdel Hakim, M. Elbahr, T. Mahmoud, E. Khalil, W. Casey, S. H. Zaky, A. Rizk, R. Ahmed, G. A. Ospina-Tascón, A. F. Garcia Marin, G. J. Echeverry, W. F. Bermudez, H. J. Madriñan-Navia, J. D. Valencia, E. Quiñonez, A. Marulanda, C. A. Arango-Dávila, A. Bruhn, D. De Backer, D. Orbegozo Cortes, F. Su, J. L. Vincent, L. Tullo, L. Mirabella, P. Di Molfetta, M. Dambrosio, C. Villavicencio Lujan, J. Leache irigoyen, M. Cartanya ferré, R. Carbonell García, M. Ahmed, M. El Ayashi, E. Ayman, M. Salem, S. Fathy, A. Zaghlol, M. F. Aguilar Arzapalo, Å. Valsø, T. Rustøen, I. Schou-Bredal, L. Skogstad, K. Tøien, C. Padilla, Y. Palmeiro, W. Egbaria, R. Kigli, B. Maertens, K. Blot, S. Blot, E. Santana-Santos, E. R. dos Santos, R. E. D. L. Ferretti-Rebustini, R. D. C. C. D. O. dos Santos, R. G. S. Verardino, L. A. Bortolotto, A. M. Doyle, I. Naldrett, J. Tillman, S. Price, P. Pearson, J. Greaves, D. Goodall, A. Berry, A. Richardson, G. O. Odundo, P. Omengo, P. Obonyo, N. M. Chanzu, R. Kleinpell, S. J. Sarris, P. Nedved, M. Heitschmidt, H. Ben-Ghezala, S. Snouda, S. Djobbi, N. K. J. Adhikari, D. Leasa, D. Fergusson, D. A. Mckim, J. Weblin, D. McWilliams, F. Doesburg, F. Cnossen, W. Dieperink, W. Bult, M. W. N. Nijsten, G. A. Galvez-Blanco, C. I. Olvera Guzman, J. Santos Stroud, R. Thomson, M. Llaurado-Serra, A. Lobo-Civico, M. Pi-Guerrero, I. Blanco-Sanchez, A. Piñol-Tena, C. Paños-Espinosa, Y. Alabart-Segura, B. Coloma-Gomez, A. Fernandez-Blanco, F. Braga-Dias, M. Treso-Geira, A. Valeiras-Valero, L. Martinez-Reyes, A. Sandiumenge, M. F. Jimenez-Herrera, CAPCRI Study, R. Prada, P. Juárez, R. Argandoña, J. J. Díaz, C. Sánchez Ramirez, P. Saavedra, S. Ruiz Santana, O. Obukhova, S. Kashiya, I. A. Kurmukov, A. M. Pronina, P. Simeone, L. Puybasset, G. Auzias, O. Coulon, B. Lesimple, G. Torkomian, A. Bartkowska-Sniatkowska, O. Szerkus, D. Siluk, J. Bartkowiak-Wieczorek, J. Rosada-Kurasinska, J. Warzybok, R. Kaliszan, C. Hernandez Caballero, S. Roberts, G. Isgro, D. Hall, G. Guillaume, O. Passouant, F. Dumas, W. Bougouin, B. Champigneulle, M. Arnaout, J. Chelly, J. D. Chiche, O. Varenne, J. P. Mira, E. Marijon, A. Cariou, M. Beerepoot, H. R. Touw, K. Parlevliet, C. Boer, P. W. Elbers, Á. J. Roldán Reina, Y. Corcia Palomo, R. Martín Bermúdez, L. Martín Villén, I. Palacios García, J. R. Naranjo Izurieta, J. B. Pérez Bernal, F. J. Jiménez Jiménez, Cardiac Arrest Group HUVR, F. Cota-Delgado, T. Kaneko, H. Tanaka, M. Kamikawa, R. Karashima, S. Iwashita, H. Irie, S. Kasaoka, O. Arola, R. Laitio, A. Saraste, J. Airaksinen, M. Pietilä, M. Hynninen, J. Wennervirta, M. Bäcklund, E. Ylikoski, P. Silvasti, E. Nukarinen, J. Grönlund, V. P. Harjola, J. Niiranen, K. Korpi, M. Varpula, R. O. Roine, T. Laitio, for the Xe-HYPOTHECA study group, S. Salah, B. G. Hassen, A. Mohamed Fehmi, Y. C. Hsu, J. Barea-Mendoza, C. García-Fuentes, M. Castillo-Jaramillo, H. Dominguez-Aguado, R. Viejo-Moreno, L. Terceros-Almanza, S. Bermejo Aznárez, C. Mudarra-Reche, W. Xu, M. Chico-Fernández, J. C. Montejo-González, K. Crewdson, M. Thomas, M. Merghani, L. Fenner, P. Morgan, D. Lockey, E. J. van Lieshout, B. Oomen, J. M. Binnekade, R. J. de Haan, N. P. Juffermans, M. B. Vroom, R. Algarte, L. Martínez, B. Sánchez, I. Romero, F. Martínez, S. Quintana, J. Trenado, O. Sheikh, D. Pogson, R. Clinton, F. Riccio, A. Arthur, L. Young, A. Sinclair, D. Markopoulou, K. Venetsanou, L. Filippou, E. Salla, S. Stratouli, I. Alamanos, A. H. Guirgis, R. Gutiérrez Rodriguez, M. J. Furones Lorente, I. Macias Guarasa, A. Ukere, S. Meisner, G. Greiwe, B. Opitz, D. Benten, B. Nashan, L. Fischer, C. J. C. Trepte, C. R. Behem, B. Ana, A. Vazir, D. Gibson, M. R. Hadavi, M. Riahi alam, M. R. Sasani, N. Parenti, F. Agrusta, C. Palazzi, B. Pifferi, R. Sganzerla, F. Tagliazucchi, A. Luciani, M. Möller, J. Müller-Engelmann, G. Montag, P. Adams, C. Lange, J. Neuzner, R. Gradaus, K. H. Wodack, F. Thürk, A. D. Waldmann, M. F. Grässler, S. Nishimoto, S. H. Böhm, E. Kaniusas, C. J. Trepte, M. Wallin, F. Suarez Sipman, A. Oldner, L. Colinas, R. Vicho, M. Serna, R. Cuena, A. Canabal, ECOCRITIC group, M. Etman, M. El Bahr, A. El Sakka, A. Arali, O. Bond, P. De Santis, E. Iesu, F. Franchi, S. Scolletta, F. S. Taccone, Z. Marutyan, L. Hamidova, A. Shakotko, V. Movsisyan, I. Uysupova, A. Evdokimov, S. Petrikov, F. J. Redondo Calvo, N. Bejarano, V. Baladron, R. Villazala, J. Redondo, D. Padilla, P. Villarejo, C. Gomez-Gonzalez, S. Mas-Font, A. Puppo-Moreno, M. Herrera-Gutierrez, M. Garcia-Garcia, S. Aldunate-Calvo, NEFROCON Investigators, E. P. Plata-Menchaca, X. L. Pérez-Fernández, M. Estruch, A. Betbese-Roig, P. Cárdenas Campos, M. Rojas Lora, N. D. Toapanta Gaibor, R. S. Contreras Medina, V. D. Gumucio Sanguino, E. J. Casanova, J. Sabater Riera, SIRAKI group, K. Kritmetapak, S. Peerapornratana, P. Kittiskulnam, T. Dissayabutra, P. Susantithapong, K. Praditpornsilpa, K. Tungsanga, S. Eiam-Ong, T. Winkelmann, T. Busch, J. Meixensberger, S. Bercker, E. M. Flores Cabeza, M. Sánchez Sánchez, N. Cáceres Giménez, C. Gutierrez Melón, E. Herrero de Lucas, P. Millán Estañ, M. Hernández Bernal, A. Garcia de Lorenzo y Mateos, P. A. C. Specht, M. Balik, M. Zakharchenko, F. Los, H. Brodska, C. de Tymowski, P. Augustin, M. Desmard, P. Montravers, S. N. Stapel, R. de Boer, H. M. Oudemans, A. Hollinger, T. Schweingruber, F. Jockers, M. Dickenmann, M. Siegemund, Clinical Intensive Care Research Basel, N. Runciman, L. Alban, C. Turrini, T. Sasso, T. Langer, P. Taccone, C. Marenghi, G. Grasselli, P. Wibart, T. Reginault, M. Garcia, B. Barbrel, A. Benard, C. Bader, F. Vargas, H. N. Bui, G. Hilbert, J. M. Serrano Simón, P. Carmona Sánchez, F. Ruiz Ferrón, M. García de Acilu, J. Marin, V. Antonia, L. Ruano, M. Monica, G. Hong, D. H. Kim, Y. S. Kim, J. S. Park, Y. K. Jee, Z. Yu xiang, W. Jia-xing, W. Xiao dan, N. Wen long, W. Yu, Z. Yan, X. Cheng, T. Kobayashi, Y. Onodera, R. Akimoto, A. Sugiura, H. Suzuki, M. Iwabuchi, M. Nakane, K. Kawamae, P. Carmona Sanchez, M. D. Bautista Rodriguez, M. Rodriguez Delgado, V. Martínez de Pinillos Sánchez, A. Mula Gómez, P. Beuret, C. Fortes, M. Lauer, M. Reboul, J. C. Chakarian, X. Fabre, B. Philippon-Jouve, S. Devillez, M. Clerc, N. Rittayamai, M. Sklar, M. Dres, M. Rauseo, C. Campbell, B. West, D. E. Tullis, M. Okada, N. Ahmad, M. Wood, A. Glossop, J. Higuera Lucas, A. Blandino Ortiz, D. Cabestrero Alonso, R. De Pablo Sánchez, L. Rey González, R. Costa, G. Spinazzola, A. Pizza, G. Ferrone, M. Rossi, G. Conti, H. Ribeiro, J. Alves, M. Sousa, P. Reis, C. S. Socolovsky, R. P. Cauley, J. E. Frankel, A. L. Beam, K. O. Olaniran, F. K. Gibbons, K. B. Christopher, J. Pennington, P. Zolfaghari, H. S. King, H. H. Y. Kong, H. P. Shum, W. W. Yan, C. Kaymak, N. Okumus, A. Sari, B. Erdogdu, S. Aksun, H. Basar, A. Ozcan, N. Ozcan, D. Oztuna, J. A. Malmgren, S. Lundin, K. Torén, M. Eckerström, A. Wallin, A. C. Waldenström, for the Section on Ethics of the ESICM, F. C. Riccio, A. C. P. Antonio, A. F. Leivas, F. Kenji, E. James, S. Jonnada, C. S. Gerrard, N. Jones, J. D. Salciccioli, D. C. Marshall, M. Komorowski, A. Hartley, M. C. Sykes, R. Goodson, J. Shalhoub, J. R. Fernández Villanueva, R. Fernández Garda, A. M. López Lago, E. Rodríguez Ruiz, R. Hernández Vaquero, C. Galbán Rodríguez, E. Varo Pérez, C. Hilasque, I. Oliva, G. Sirgo, M. C. Martin, M. Olona, M. C. Gilavert, M. Bodí, C. Ebm, G. Aggarwal, S. Huddart, N. Quiney, S. M. Fernandes, J. Santos Silva, J. Gouveia, D. Silva, R. Marques, H. Bento, A. Alvarez, Z. Costa Silva, D. Díaz Diaz, M. Villanova Martínez, E. Palencia Herrejon, A. Martinez de la Gandara, G. Gonzalo, M. A. Lopez, P. Ruíz de Gopegui Miguelena, C. I. Bernal Matilla, P. Sánchez Chueca, M. D. C. Rodríguez Longares, R. Ramos Abril, A. L. Ruíz Aguilar, R. Garrido López de Murillas, R. Fernández Fernández, P. Morales Laborías, M. A. Díaz Castellanos, M. E. Morales Laborías, J. Park, S. Woo, T. West, E. Powell, A. Rimmer, C. Orford, J. Williams, P. Ruiz de Gopegui Miguelena, R. S. Bourne, R. Shulman, M. Tomlin, G. H. Mills, M. Borthwick, W. Berry, D. García Huertas, F. Manzano, F. Villagrán-Ramírez, A. Ruiz-Perea, C. Rodríguez-Mejías, F. Santiago-Ruiz, M. Colmenero-Ruiz, C. König, B. Matt, A. Kortgen, C. S. Hartog, A. Wong, C. Balan, G. Barker, S. Tachaboon, J. Paratz, G. Kayambu, R. Boots, R. Vlasenko, E. Gromova, S. Loginov, M. Kiselevskiy, Y. Dolgikova, K. B. Tang, C. M. Chau, K. N. Lam, E. Gil, G. Y. Suh, C. M. Park, C. R. Chung, C. H. Lai, Y. J. Cheng, V. Colella, N. Zarrillo, M. D’Amico, F. Forfori, B. Pezza, T. Laddomada, V. Beltramelli, M. L. Pizzaballa, A. Doronzio, B. Balicco, D. Kiers, W. van der Heijden, J. Gerretsen, Q. de Mast, S. el Messaoudi, G. Rongen, M. Gomes, N. P. Riksen, Y. Kashiwagi, K. Hayashi, Y. Inagaki, S. Fujita, A. Blet, M. Sadoune, J. Lemarié, N. Bihry, R. Bern, E. Polidano, R. Merval, J. M. Launay, B. Lévy, J. L. Samuel, J. Hartmann, S. Harm, and V. Weber

Subjects
LUNG SAFE investigators and the ESICM study group, medicine.medical_specialty, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], KARISMA, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], 030204 cardiovascular system & hematology, ARIAM Group, Critical Care and Intensive Care Medicine, Meeting Abstracts, Vascular occlusion, GRAVITY-VAP TRIAL NETWORK, 03 medical and health sciences, 0302 clinical medicine, H1N1 SEMICYUC/GETGAG working group, Xe-HYPOTHECA study group, Clinical Intensive Care Research Basel, Healthy volunteers, Journal Article, United States Critical Illness and Injury Trials Group/LIPS-B investigators, Medicine, ARIAM-CARDIAC SURGERY PROJECT AUTHORS, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), RAPIT group, FINNAKI Study Group, Cardiac Arrest Group HUVR, business.industry, Mid-Norway Sepsis Research Center, NEFROCON Investigators, lcsh:Medical emergencies. Critical care. Intensive care. First aid, SIRAKI group, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], 030208 emergency & critical care medicine, lcsh:RC86-88.9, SICM NICER Group, LUNG SAFE Investigators and the ESICM Trials Group, ARIAM-SEMICYUC Registry Investigators, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], CAPCRI Study, Apelin Group, Section on Ethics of the ESICM, Anesthesia, EXODUS-investigators, Infrared thermal imaging, Radiology, medicine.symptom, Korean Chungcheong Critical Care Research Group, ECOCRITIC group, business, P-INFECT
Abstract

Contains fulltext : 172380.pdf (Publisher’s version ) (Open Access)

Published
2016

4. High-dose rocuronium for rapid-sequence induction and reversal with sugammadex in two myasthenic patients

Author

P. Casarotti, C. Mendola, Gianmaria Cammarota, and F. Della Corte

Subjects
medicine.medical_specialty, medicine.drug_class, business.industry, medicine.medical_treatment, Perforation (oil well), Muscle relaxant, General Medicine, Rapid sequence induction, medicine.disease, Neuromuscular monitoring, Sugammadex, Surgery, Anesthesiology and Pain Medicine, Anesthesia, medicine, Upper gastrointestinal bleeding, Rocuronium, Elective surgery, business, medicine.drug
Abstract

The anesthetic management of patients affected by myasthenia gravis is usually challenging in elective surgery and even more so in emergency procedures. The difficulties involved are several-fold, ranging from the choice of an appropriate muscle relaxant (i.e. one that enables safe and rapid airway management) to neuromuscular monitoring and normal muscular recovery. Additionally, optimizing patient conditions - either pharmacologically or with plasmapheresis - before intervention is well beyond the realm of possibility. We discuss the anesthetic management of two myasthenic patients undergoing emergency surgery (for sigmoid perforation and upper gastrointestinal bleeding respectively). In both cases, we opted for rapid-sequence induction with high-dose rocuronium to prevent inhalation of gastric contents. We also report on the implication of neuromuscular monitoring. We found that the rocuronium-sugammadex combination was a useful and effective option in the emergency setting.

Published
2014

5. Non-invasive ventilation after surgery in amyotrophic lateral sclerosis

Author

Letizia Mazzini, C. A. Castioni, F. Della Corte, Carlo Olivieri, S. Livigni, Enrica Bersano, and Roberto Cantello

Subjects
medicine.medical_specialty, business.industry, Remifentanil, General Medicine, Perioperative, medicine.disease, Surgery, Discontinuation, Transplantation, Neurology, Respiratory failure, Anesthesia, medicine, Breathing, Neurology (clinical), Amyotrophic lateral sclerosis, Propofol, business, medicine.drug
Abstract

Background Surgery in patients affected by amyotrophic lateral sclerosis (ALS) presents a particular anesthetic challenge because of the risk of post-operative pulmonary complications. Aims of the study We report on the use of non-invasive ventilation (NIV) to prevent post-operative pulmonary complications (PPCs) in nine patients affected by ALS enrolled in a phase-1 clinical trial with stem cell transplantation. Methods All patients were treated with autologous mesenchymal stem cells implanted into the spinal cord with a surgical procedure. Anesthesia was induced with propofol and maintained with remifentanil and sevoflurane. No muscle relaxant was used. After awakening and regain of spontaneous breathing, patients were tracheally extubated. Non-invasive ventilation through nasal mask was delivered and non-invasive positive pressure ventilation and continuous positive pressure ventilation were started. Results The average time on NIV after surgery was 3 h and 12 min. All patients regained stable spontaneous breathing after NIV discontinuation and had no episodes of respiratory failure until the following day. Conclusions Our case series suggest that the use of NIV after surgery can be a safe strategy to prevent PPCs in patients affected by ALS. The perioperative procedure we chose for these patients appeared safe even in patients with advanced functional stage of the disease.

Published
2013

6. Thoracic epidural analgesia in post-thoracotomy patients: comparison of three different concentrations of levobupivacaine and sufentanil

Author

C. Mendola, Daniela Ferrante, F. Della Corte, E. Oldani, Gianmaria Cammarota, G. Cecci, and Rosanna Vaschetto

Subjects
Adult, Male, medicine.medical_specialty, Sufentanil, Nausea, medicine.drug_class, Sedation, medicine.medical_treatment, Analgesic, Drug Administration Schedule, Double-Blind Method, medicine, Humans, Prospective Studies, Thoracotomy, Anesthetics, Local, Aged, Levobupivacaine, Pain Measurement, Aged, 80 and over, Pain, Postoperative, business.industry, Local anesthetic, Pruritus, Middle Aged, Bupivacaine, Surgery, Analgesia, Epidural, Analgesics, Opioid, Anesthesiology and Pain Medicine, Anesthesia, Postoperative Nausea and Vomiting, Vomiting, Female, Hypotension, medicine.symptom, business, medicine.drug
Abstract

Background Relative effects of dosage, volume and concentration of local anaesthetics used for postoperative thoracic epidural analgesia are still under debate. In this randomized, prospective, double-blinded study, we evaluated the incidence of side-effects such as changes in arterial pressure, postoperative nausea, vomiting, and pruritus in patients admitted for thoracic surgery during continuous thoracic epidural infusion using levobupivacaine and sufentanil mixture in three different volumes. Methods We studied 150 patients who underwent thoracotomy with a thoracic epidural catheter placed between T4 and T7. The patients were randomized into three groups which received 10 mg h−1 of levobupivacaine at three different concentrations (0.5%, 0.25%, and 0.15%), in combination with sufentanil at 2.6 μg h−1. Haemodynamic effects, pruritus, nausea, vomiting, sensory and motor block, pain score, additional analgesic requirement, sedation, and patient satisfaction were registered immediately after the surgical operation and on the first, second, and third postoperative days. Results We did not detect any differences in the incidence of side-effects such as changes in arterial pressure, and also postoperative nausea, vomiting, and pruritus. The three groups were also similar with regard to patient characteristics, sensory and motor block, pain score, analgesic rescue dose, sedation, and patient satisfaction. Conclusions The same dose of a mixture of levobupivacaine and sufentanil administered in three different volumes and concentrations during continuous thoracic epidural infusion for thoracotomy provided an equal incidence of adverse haemodynamic effects, nausea, vomiting, or pruritus.

Published
2009

7. Simulation of a Hospital Disaster Plan: A Virtual, Live Exercise

Author

Jeffrey M. Franc-Law, Michael J. Bullard, and F. Della Corte

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Disaster Planning, Physical examination, Emergency Nursing, Simulated patient, User-Computer Interface, Information system, Hospital Planning, Humans, Medicine, Computer Simulation, medicine.diagnostic_test, business.industry, Emergency department, medicine.disease, Laboratory results, Triage, Databases as Topic, Emergency medicine, Emergency Medicine, Female, Medical emergency, Disaster plan, Emergency Service, Hospital, business, Patient database
Abstract

Introduction:Currently, there is no widely available method to evaluate an emergency department disaster plan. Creation of a standardized patient data- base and the use of a virtual, live exercise may lead to a standardized and reproducible method that can be used to evaluate a disaster plan.Purpose:A virtual, live exercise was designed with the primary objective of evaluating a hospital's emergency department disaster plan. Education and training of participants was a secondary goal.Methods:A database (disastermed.ca) of histories, physical examination findings, and laboratory results for 136 simulated patients was created using information derived from actual patient encounters.The patient database was used to perform a virtual, live exercise using a training version of the emergency department's information system software.Results:Several solutions to increase patient flow were demonstrated during the exercise. Conducting the exercise helped identify several faults in the hospital disaster plan, including outlining the important rate-limiting step. In addition, a significant degree of under-triage was demonstrated. Estimates of multiple markers of patient flow were identified and compared to Canadian guidelines. Most participants reported that the exercise was a valuable learning experience.Conclusions:A virtual, live exercise using the disastermed.ca patient database was an inexpensive method to evaluate the emergency department disaster plan. This included discovery of new approaches to managing patients, delineating the rate-limiting steps, and evaluating triage accuracy. Use of the patient timestamps has potential as a standardized international benchmark of hospital disaster plan efficacy. Participant satisfaction was high.

Published
2008

8. Psychological aspects of pain

Author

E. Torre, P. Brustia, P. Zeppegno, D. Moniaci, F. Della Corte, A. Renghi, and Luca Gramaglia

Subjects
Aging, medicine.medical_specialty, Health (social science), media_common.quotation_subject, Alternative medicine, Psychological intervention, Pain, Ischemia, Perception, medicine, Humans, Aged, media_common, Peripheral Vascular Diseases, Depression, business.industry, Extremities, Critical limb ischemia, Feeling, Physical therapy, Pain catastrophizing, Psychological aspects, Geriatrics and Gerontology, medicine.symptom, business, Gerontology
Abstract

The patients affected by critical limb ischemia (CLI) are patients generally considered difficult cases, destined to repeated approach to the sanitary structures. They are patients affected by many pathologies since years, that they know to be potentially lethal often have already faced many interventions, with partial and not long-lasting benefits, they go from one specialist to another and sometimes they entrust themselves to alternative medicine. Physicians have to take in charge not the pathology but to take in charge the patient. For the control of the pain it turns out essential, near the block of the perception of the pain, to act with psychological participation, in order to interfere with the perception of the pain and the meant one of the pain, modify the feelings associated to the pain, modify the behavior induced by pain.

Published
2007

9. Worsening of chronic pain: The treatment

Author

A. Fassiola, Luca Gramaglia, Piero Brustia, F. Della Corte, and Alessandra Renghi

Subjects
Male, Aging, medicine.medical_specialty, Health (social science), Ischemia, Pain, Multidisciplinary team, Amputation, Surgical, Analgesic therapy, medicine, Humans, Aged, Aged, 80 and over, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Chronic pain, Extremities, medicine.disease, Limb ischemia, Peripheral, Phantom Limb, Chronic Disease, Physical therapy, Female, Geriatrics and Gerontology, business, Gerontology
Abstract

Chronic pain is a symptom that inevitably goes along with a condition of critical ischemia of the lower limbs, termed also as "obstructive peripheral arteriopathy". This sometimes displays worsening, provoking difficult physical and psychological behaviors of the patients. The complexity of this kind of patients results in difficulties in their clinical management. A multidisciplinary team, namely the close and coordinated collaboration of various kinds of professionists, could give better results, than an individual approach, thanks to strategies of re-equilibrating the systemic homeostasis of the given patient.

Published
2007

11. Authors' response to a letter from Dr. Esquinas

Author

S. Livigni, C. A. Castioni, Carlo Olivieri, Enrica Bersano, Letizia Mazzini, F. Della Corte, and Roberto Cantello

Subjects
Lung Diseases, Male, Noninvasive Ventilation, Neurology, business.industry, MEDLINE, Medicine, Library science, Humans, Female, Neurology (clinical), General Medicine, business
Published
2014

12. Complications of Irrigations Solutions during Transurethral Resection of the Prostate in Spinal Anesthesia

Author

F. Della Corte, Ervin Kocjancic, Bruno Frea, A. Gratarola, Paolo Gontero, and C. Biamino

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Spinal anesthesia, Medicine, General Medicine, business, Surgery, Transurethral resection of the prostate
Abstract

Perspective study in order to estimate the incidence of TURP-Syndrome, in spinal anesthesia (SA) with volemic expansion with sodium chloride solution 0.9 % vs 3%. Materials and Methods Two groups (gr) of patients (pt) A (n=20) and B (n=20) in SA have received like respective 500 ml of NaCl 0.9% and 250 ml. of NaCl 3%. The bladder was irrigated with a solution containing 1.5% glycine (1). We estimated: weight of prostate adenoma and weight of removed tessue, Sodium (Na) preop - intraop - postop. and after 24 hours, Ammonium (NH4+) pre - postop, volumes (V) of dropped solutions, V of dropped glycine (gl), operation time, core body temperature intraop and postop, mental state intra and postop., osmolarity. Results We found no significant difference in weight of adenoma and removed tessue. We have not observed any differences in the V of infusive solutions in the periop. We have not observed any difference in the values of Na preop. and postop, in those of NH4+ preop and postop, in operation time and in the V of gl. During procedure 5 pz. (S group) showed: visual disturbances, mental confusion (TURP-Syndrome) and hypertention (2). No pz. have any Na and NH4+ intraop.values altered. Time of TURP appeared bigger in non symptomatic patients (69 mn gr S. vs 48.43 gr.A and 47.26 gr. B). The V of instilled gl. has appeared meaningfully more elevated in gr. S (21.4 / vs 12 in gr.A and 12.31 in gr. B). The Na and NH4+ postop., Na after 24 hours and core body temperature have turned out statistically omogenee in all pt. In the 5 symptomatic pt the osmolarity values entered in normality ranges and they did not show differences between the groups considered. Conclusions We have not noticed any differences in using of the NaCl solution 0.9% versus NaCl 3% like volemic prefilling; the symptomatic patients have endured one longer procedure and greater amount of irrigating solution; their values of Na and NH4+ were in the limits of the normality; for this reasons perhaps the cause of symptoms in our patients would be searched in direct toxicity of glycine as inhibitory neurotrasmitter in CNS.

Published
2005

13. Overtriage and undertriage in a prehospital system over 7 years

Author

Antonio Messina, Federico Lorenzo Barra, Davide Colombo, F. Della Corte, Luca Carenzo, and T Fontana

Subjects
medicine.medical_specialty, education.field_of_study, business.industry, Poster Presentation, Emergency medicine, Population, medicine, Critical Care and Intensive Care Medicine, education, business, Emergency medical system
Abstract

The Novara 118 emergency medical system (EMS) dispatch center manages medical emergency calls coming from a region that spreads out over 1,400 km2 and includes 88 towns and a population of 385,000 people; inhabitant density is 275 inhabitants/km2.

Published
2013

14. Virtual reality and live scenario simulation: options for training medical students in mass casualty incident triage

Author

Federico Lorenzo Barra, G Gugliotta, P.L. Ingrassia, Luca Ragazzoni, Luca Carenzo, Davide Colombo, and F. Della Corte

Subjects
Emergency management, business.industry, Mass Casualty, Scenario simulation, Virtual reality, Critical Care and Intensive Care Medicine, medicine.disease, Triage, Health personnel, Mass-casualty incident, Nursing, Poster Presentation, Medicine, Medical emergency, business
Abstract

Multicasualty triage is the process of establishing the priority of care among casualties in disaster management. Recent mass casualty incidents (MCI) revealed that health personnel are unfamiliar with the triage protocols. The objective of this study is to compare the relative impact of two simulation-based methods for training medical students in mass casualty triage using the Simple Triage and Rapid Treatment (START) algorithm.

Published
2012

15. European comprehensive training course on prehospital advanced trauma life support in adults

Author

Rui Araújo, P Driscoll, Wolfgang Dick, M. Lipp, F. Della Corte, Giuseppe Nardi, P Oakley, R Girbes, A E Hernando Lorenzo, and Marc Sabbe

Subjects
Adult, business.industry, Training course, medicine.disease, Advanced trauma life support, Europe, Emergency Medical Technicians, Nursing, Emergency Medicine, medicine, Humans, Curriculum, Medical emergency, business
Published
2002

16. Medical Emergency Response in Toxicological Mass Casualty

Author

P.L. Ingrassia, Luca Ragazzoni, and F. Della Corte

Subjects
Red Crescent, Mass-casualty incident, Human health, Terrorism, medicine, Mass Casualty, Business, Medical emergency, Natural disaster, medicine.disease, Personal protective equipment
Abstract

Emergencies and disasters can occur anywhere in the world, affecting human health and lives and the infrastructure built to support them. Chemical releases arising from technological incidents, natural disasters, and conflict and terrorism are common [1]. The International Federation of Red Cross and Red Crescent Societies has estimated that between 1998 and 2007, there were nearly 3,200 technological disasters with approximately 100,000 people killed and nearly 2 million people affected. Unfortunately, the threat of major events involving chemicals is predicted to increase worldwide for three main reasons. First, the chemical industry is rapidly growing, and the number of chemicals available in the market is increasing [2]. Second, chemical incidents may have an impact beyond their original location, in some cases crossing national borders. Third, there is concern regarding the deliberate use of chemicals for terrorist purposes [3].

Published
2011

18. Forms for registration of CPR efforts and outcome, respectively for out-of-hospital and in-hospital cardiac arrest

Author

R. Juchems, R. Schröder, J. Bahr, S. Holmberg, P. Lewi, F. Della Corte, Wolfgang Dick, M. von Planta, P Calle, H.J. Hennes, D. Zideman, E. Edgren, K. Linko, K. Steinbereithner, L. Wiklund, W. Buylaert, L. Bossaert, D. Chamberlain, H.K. Lindner, T.J. Tamsma, P Martens, A. Mullie, P.Y. Gueugniaud, H. W. Gervais, B. Eberle, G. Pelosi, F. Cavaliere, J.P. Jantzen, A.R. Aitkenhead, R. van Hoeyweghen, E. Pfenninger, W. Mauritz, L. Come, J. Schüttler, J. Crul, J.C. Otteni, Herman Delooz, H. Tunstall-Pedoe, D. Kettler, P. Baskett, and G. Kroesen

Subjects
Out of hospital, business.industry, Emergency Medicine, Medicine, Medical emergency, Emergency Nursing, Cardiology and Cardiovascular Medicine, business, Hospital ward, medicine.disease, Outcome (game theory), Out of hospital cardiac arrest
Published
1992

19. Neurogenic pulmonary edema: a presenting symptom in multiple sclerosis

Author

Domenico Schiavino, F. Della Corte, Enzo Ricci, Cesare Colosimo, and N Gentiloni

Subjects
Bradycardia, medicine.medical_specialty, Multiple Sclerosis, Neurology, Adolescent, pulmonary, Pulmonary Edema, Lesion, medicine, Paralysis, Humans, Respiratory function, business.industry, General Neuroscience, Multiple sclerosis, Settore MED/09 - MEDICINA INTERNA, medicine.disease, Magnetic Resonance Imaging, Radiography, Anesthesia, Heart failure, Etiology, Prednisone, Female, Neurology (clinical), medicine.symptom, business
Abstract

Altered cardiovascular and respiratory function is uncommonly encountered in multiple sclerosis, though it may appear late in the course of the disease [4]. Episodes of acute ventilatory failure due to autonomic and/or voluntary respiratory function paralysis have already been described. These episodes are often accompanied by a focal neurological deficit which expresses lesion at the level of the medulla [6]. A demyelinating bulbar lesion leading to altered cardiovascular function is likewise infrequent but when it happens, bradycardia, postural hypotension [2], or acute pulmonary edema without heart failure may occur [1]. We present a case of non cardiogenic acute pulmonary edema which had neither a toxic insult nor an infective agent as etiology, but appeared as the initial manifestation of a multifocal demyelinating syndrome.

Published
1992

21. Accuracy of computer simulation to predict patient flow during mass-casualty incidents

Author

Micheal J. Bullard, Jeffrey M. Franc-Law, and F. Della Corte

Subjects
Poison control, Physical examination, Disaster Planning, Emergency Nursing, computer.software_genre, Simulated patient, Disasters, User-Computer Interface, medicine, Humans, Mass Casualty Incidents, Computer Simulation, medicine.diagnostic_test, business.industry, Human factors and ergonomics, Emergency department, medicine.disease, Triage, Simulation software, Mass-casualty incident, Emergency Medicine, Medical emergency, business, Emergency Service, Hospital, computer
Abstract

Introduction:Although most hospitals have an emergency department disas- ter plan, most never have been implemented in a true disaster or been tested objectively. Computer simulation may be a useful tool to predict emergency department patient flow during a disaster.Purpose:The aim of this study was to compare the accuracy of a computer simulation in predicting emergency department patient flow during a masscasualty incident with that of a real-time, virtual, live exercise.Methods:History, physical examination findings, and laboratory results for 136 simulated patients were extracted from the disastermed.ca patient database as used as input into a computer simulation designed to represent the emergency department at the University of Alberta Hospital.The computer simulation was developed using a commercially available simulation software platform (2005, SimProcess, CACI Products, San Diego CA). Patient flow parameters were compared to a previous virtual, live exercise using the same data set.Results:Although results between the computer simulation and the live exercise appear similar, they differ statistically with respect to many patient benchmarks. There was a marked difference between the triage codes assigned during the live exercise and those from the patient database; however, this alone did not account for the differences between the patient groups. It is likely that novel approaches to patient care developed by the live exercise group, which are difficult to model by computer software, contributed to differences between the groups. Computer simulation was useful, however, in predicting how small changes to emergency department structure, such as adding staff or patient care areas, can influence patient flow.Conclusions:Computer simulation is helpful in defining the effects of changes to a hospital disaster plan. However, it cannot fully replace participant exercises. Rather, computer simulation and live exercises are complementary, and both may be useful for disaster plan evaluation.

Published
2008

22. THE MINI-SIGH TEST: A NEW HAEMODYNAMIC TEST OF FLUID RESPONSIVENESS IN ICU PATIENTS UNDERGOING PRESSURE SUPPORT VENTILATION

Author

Eleonora Bonicolini, A. R. De Gaudio, Federico Longhini, G De Mattei, F. Della Corte, Antonio Messina, Paolo Navalesi, Davide Colombo, and Stefano Romagnoli

Subjects
Insufflation, business.industry, Hemodynamics, Pressure support ventilation, Stroke volume, Critical Care and Intensive Care Medicine, Pulse pressure, Preload, medicine.anatomical_structure, Ventricle, Anesthesia, medicine, Oral Presentation, business, Tidal volume
Abstract

Dynamic predictors of fluid responsiveness (FR) perform poorly in ICU patients receiving partial ventilatory assistance. Because these modes of partial support are increasingly used, FR dynamic indexes are applicable only in a few ICU patients [1]. To overcome these limitations, novel approaches for testing FR in ICU have been proposed, such as the passive leg raising and the end-expiratory occlusion. These tests, however, may not always be applicable [2]. During controlled mechanical ventilation, Pulse Pressure (PP) and left ventricle stroke volume are coupled; their variations are due to the reduction of right ventricle stroke volume consequent to ventilator insufflation and are either proportional to the tidal volume and closely related to preload dependence.

Published
2015

23. Application of new educational methodologies in disaster medicine

Author

F. La Mura, F. Della Corte, and A. Gratarola

Subjects
medicine.medical_specialty, education.field_of_study, Knowledge management, business.industry, Population, Public relations, Body of knowledge, Occupational medicine, Virtual patient, Epidemiology, medicine, media_common.cataloged_instance, European union, Architecture, business, education, Disaster medicine, media_common
Abstract

Commonly, Disaster Medicine educational issues are often related to the Emergency Medicine domain, even though in Europe there is no clear definition about these two subjects. Yet, following the extraordinary succession of natural and technological disasters in Europe during the past several years (e.g. Chernobyl, flooding, forest fires), the governments belonging to the European Union are putting increasing pressure on national entities (ministries, universities, hospitals, local governments, etc.) to develop official plans, protocols, and guidelines that can be implemented in case the regular ‘pathways’ fail at any level. The study of disaster situations is included in the core curriculum of many schools at the undergraduate and post-graduate level (ranging from Architecture to Computer Science to Economics), and the possibility of short-, medium-, and long-term chain-reaction effects involving the environment and affected population are being examined. At least in Europe, the body of knowledge belonging to the study of Medicine, despite being very rich and formally exhaustive, is mostly oriented to the ideal situation of doctor and patient, rather than to the occurrence of any type of system failure causing a massive number of casualties and the need to provide treatment, even in hostile environments and over time. Two core subjects, Epidemiology and Occupational Medicine, offer students the possibility to think in terms of hundreds to millions of patients.

Published
2006

24. Introduction to Trauma Care and Improving Performance

Author

Carlo Olivieri, Gian Luca Vignazia, and F. Della Corte

Subjects
Burden of disease, medicine.medical_specialty, Traumatic injury, business.industry, Emergency medicine, medicine, Chest injury, Trauma care, business, Spinal injury, World health
Abstract

Traumatic injury and trauma deaths have been worldwide considered a major health problem [1]. The World Health Organization estimates that 16 000 people die everyday from trauma injuries, and for every person who dies, several thousands more are injured, many of them with permanent sequelae. Injury accounts for 16% of the global burden of disease [2].

Published
2006

25. Trauma Scoring Systems

Author

Gian Luca Vignazia, M. Cavaglia, and F. Della Corte

Subjects
Pulmonary contusion, medicine.medical_specialty, Receiver operating characteristic, business.industry, Emergency medicine, Psychological intervention, Medicine, Injury Severity Score, business, medicine.disease, Triage, Thoracic trauma, Trauma scoring
Abstract

During the last 20 years many trauma-scoring indexes have been developed and their applicability seems to be important mainly because they could allow [1]: comparisons of the efficacy of different therapeutic interventions and outcome quick triage during the pre-hospital phases as well as priority treatments.

Published
2002

26. New setting of neurally adjusted ventilatory assist during mask noninvasive ventilation

Author

Rosanna Vaschetto, Chun Pan, F. Della Corte, Jianfeng Xie, Paolo Navalesi, Gianmaria Cammarota, Federico Longhini, Haibo Qiu, Y Yian, and Ling Liu

Subjects
medicine.medical_specialty, Visual analogue scale, business.industry, Pressure support ventilation, Critical Care and Intensive Care Medicine, Diaphragm (structural system), Internal medicine, Poster Presentation, medicine, Cardiology, Neurally adjusted ventilatory assist, Arterial blood, Noninvasive ventilation, In patient, Intensive care medicine, business
Abstract

Noninvasive ventilation through a mask is commonly applied in pressure support ventilation (nPSV). Recent studies showed that noninvasive neurally adjusted ventilatory assist (nNAVA) improves patient-ventilator interaction and synchrony. More recently we described a new setting for nNAVA (nNAVA15) able to reduce the peak of electrical activity of the diaphragm (EAdipeak) and dyspnea (assessed by a visual analogue scale, VASd), compared with both nPSV and nNAVA, in patients undergoing NIV through a helmet, by improving the rate pressurization. We therefore designed a physiological study to evaluate and compare the effects of nNAVA15 with nPSV and nNAVA on VASd, EAdipeak, pressurization rate and arterial blood gases (ABGs).

Published
2014

27. A new setting to improve noninvasive neurally adjusted ventilatory assist by helmet

Author

Gianmaria Cammarota, Carlo Olivieri, Raffaella Perucca, Federico Longhini, Rosanna Vaschetto, F. Della Corte, Antonio Messina, Davide Colombo, and Paolo Navalesi

Subjects
medicine.medical_specialty, business.industry, Visual analogue scale, Pressure support ventilation, Critical Care and Intensive Care Medicine, Diaphragm (structural system), Internal medicine, Poster Presentation, Emergency medicine, Neurally adjusted ventilatory assist, Cardiology, Medicine, Arterial blood, In patient, Acute respiratory failure, business, human activities
Abstract

Noninvasive neurally adjusted ventilatory assist by helmet (hNAVA) was shown to improve, compared with pressure support ventilation by helmet (hPSV), patient-ventilator interaction and synchrony in patients with acute respiratory failure without affecting peak electrical activity of the diaphragm (EAdipeak) [1]. Recently, a new helmet is available, which improves pressurization during hPSV. We propose a new setting of hNAVA (hNAVA15) to achieve further improvement. We compare hPSV, hNAVA and hNAVA15, all delivered using the new helmet, with respect to patient's dyspnea, assessed by a visual analogue scale (VASd), arterial blood gases (ABGs), EAdipeak, rate of ventilator pressurization and triggering performance.

Published
2014

28. Cerebral Blood Flow and Metabolism in Neurotrauma

Author

Anselmo Caricato, F. La Mura, and F. Della Corte

Subjects
medicine.medical_specialty, Neurological injury, Severe head injury, business.industry, fungi, Head injury, food and beverages, Metabolism, Primary lesion, medicine.disease, Cerebral blood flow, Internal medicine, Cardiology, Medicine, Cerebral perfusion pressure, business, Pathological
Abstract

Primary neurological injury due to any kind of insult (traumatic, ischaemic, hypoxic, metabolic) can be followed by a chain of pathological events, that can worsen or perpetuate the primary lesion within minutes, hours or days. This group of derangements is traditionally defined as secondary damage, and its principal determinant, regardless of the producing cause, is ischaemia-anoxia.

Published
2001

29. Core curriculum in Emergency Medicine

Author

H. Askitopoulou, J. Jakubaszko, Raed Arafat, F. Della Corte, and Marc Sabbe

Subjects
medicine.medical_specialty, Anesthesiology and Pain Medicine, business.industry, Family medicine, Emergency medicine, Medicine, business, Core curriculum
Published
2008

30. Cerebral Blood Flow and Metabolism in Severe Head Injury

Author

F. Della Corte, F. Pappalardo, and Anselmo Caricato

Subjects
Severe head injury, business.industry, fungi, Head injury, food and beverages, Metabolism, Primary lesion, medicine.disease, Neurologic injury, Cerebral blood flow, Anesthesia, Medicine, Cerebral perfusion pressure, business, Pathological
Abstract

Primary neurologic injury due to any kind of insult (traumatic, ischemic, hypoxic, metabolic) can be followed by a chain of pathological events, that can worsen or perpetuate the primary lesion within minutes, hours or days. This group of derangements is traditionally defined as secondary damage, and its principal determinant, regardless of the producing cause, is ischemia-anoxia.

Published
1998

34. Quantitative cerebral blood flow and metabolism determination in the first 48 hours after severe head injury with a new dynamic SPECT device

Author

A. Barelli, A. Giordano, Paolo Campioni, G. Galli, F. Della Corte, Mariano Alberto Pennisi, and Anselmo Caricato

Subjects
Adult, Male, medicine.medical_specialty, Neurology, Time Factors, Adolescent, cerebral blood flow, Hemodynamics, Head trauma, Central nervous system disease, Settore MED/41 - ANESTESIOLOGIA, medicine, Humans, Tomography, Neuroradiology, Intracranial pressure, Aged, Tomography, Emission-Computed, Single-Photon, business.industry, imaging, Metabolism, Middle Aged, head injury, SPECT, medicine.disease, nervous system, Cerebral blood flow, Anesthesia, Brain Injuries, Cerebrovascular Circulation, cardiovascular system, Surgery, Female, Emission-Computed, Neurology (clinical), business, Single-Photon, circulatory and respiratory physiology
Abstract

To determine cerebral blood flow (CBF) and metabolism in the acute phase after severe head injury by a new dynamic SPECT device using 133Xenon and to evaluate a possible role of CBF and metabolism in the determination of prognosis.Prospective study.General intensive care unit in a universitary teaching hospital.23 severely head injured patients having CT scan and CBF determination, intracranial pressure (ICP) and jugular bulb oxygen saturation monitoring in the first 48 hours.CBF varied from 18.0 to 60.0 ml/100 g/min. No correlation was found between early CBF and severity of trauma evaluated with the Glasgow Coma Score (GCS) (F = 2.151, p = 0.142) and between CBF and prognosis at 6 months evaluated with Glasgow outcome score (GOS) (F = 0.491, p = 0.622: rs = 0.251, p = 0.246). CMRO2 was depressed in relation to the severity of injury, specifically ranging from 0.9 +/- 0.5 ml/100 g/min in patients with GCS 3 to 1.7 +/- 0.8 ml/100 g/min in patients with GCS 6-7. In no patient with CMRO2 less than 0.8 ml/100 g/min was a good outcome observed. A significant correlation was found between GCS and GOS (rs = 0.699, p = 0.0002), between CMRO2 and GOS (F = 4.303, p = 0.031; rs = 0.525, p = 0.013) and between AJDO2 and GOS (F = 3.602, p = 0.046; rs = 0.491, p = 0.017). Fronto-occipital ratio (F/O) of CBF distribution was significantly lower than normal values (chi 2 = 18.658, p = 0.001) but did not correlate either with prognosis (chi 2 = 1.626, p = 0.443) or with severity (chi 2 = 1.913, p = 0.384).CBF in the first 48 hours after trauma varies within a large range of values and is not correlated with severity and prognosis. Clinical evaluation with GCS and CMRO2 are much more reliable indicators of severity of head trauma and have a significant role in the determination of prognosis. F/O ration is significantly altered from normal values confirming "post-traumatic hypofrontalism" but does not correlate with severity and prognosis.

Published
1997

35. Fluid responsiveness in pressure support ventilation: role of asynchrony

Author

M De Lucia, Antonio Messina, Gianmaria Cammarota, F. Della Corte, Davide Colombo, and Paolo Navalesi

Subjects
medicine.medical_specialty, business.industry, Fluid responsiveness, Hemodynamics, Pressure support ventilation, Critical Care and Intensive Care Medicine, Asynchrony (computer programming), Pulse pressure, Internal medicine, Emergency medicine, Poster Presentation, Cardiology, medicine, In patient, Potential source, business
Abstract

Pulse pressure variation (PPV) is a dynamic indicator of fluid responsiveness, which is known to have a low sensibility and specificity in patients ventilated in pressure support (PS) [1]. We aim to investigate patient-ventilator asynchrony as a potential source of hemodynamic interference in PS.

Published
2013

36. Pathophysiology and Monitoring of Cerebral Edema

Author

F. Della Corte, Ornella Piazza, A. Clemente, and Manuela Pennisi

Subjects
Pathology, medicine.medical_specialty, Cerebral blood flow, Brain edema, business.industry, Secondary Lesion, medicine, Cerebral perfusion pressure, medicine.disease, business, Pathophysiology, Microcirculation, Cerebral edema
Abstract

After primary neurologic damage due to a traumatic, ischemic, hypoxic or metabolic event, a secondary lesion may arise, worsening it and becoming a vicious circle. Locally, the initial energetic breakdown or the tissue mechanical disruption set off a number of biochemical chain reactions leading to a derangement of molecular structures and liberating toxic mediators. Globally, these reactions are responsible for brain edema and disorders of microcirculation (1).

Published
1996

37. Efficacy of a Disaster Medicine Course for Undergraduates

Author

F. Della Corte, Marco Tengattini, Federico Lorenzo Barra, P.L. Ingrassia, Luca Ragazzoni, and F. Barra

Subjects
Medical education, business.industry, Emergency Medicine, Medicine, business, Disaster medicine, Course (navigation)
Published
2011

38. How to Reduce the Ischemic Brain Damage Secondary to Severe Head Injury?

Author

Paolo Pola, Giulio Maira, P. Amante, Carmelo Anile, A. Dal Lago, F. Della Corte, Annunziato Mangiola, P. Palma, and A. Rinaldi

Subjects
medicine.medical_specialty, Severe head injury, business.industry, medicine.medical_treatment, Glasgow Outcome Scale, Head injury, Ischemia, Brain damage, medicine.disease, Internal medicine, medicine, Cardiology, Decompressive craniectomy, Cerebral perfusion pressure, medicine.symptom, business, Cause of death
Abstract

Head injury represents the cause of injury deaths in 50–70% of cases and is the main cause of death in the group under 20 years of age. Brain sequelae are often so severe as to hinder a satisfactory social reintegration. Prevention and control of the extension of the secondary cerebral lesions are important. Ischaemia has been recognized as the common final pathway in post-traumatic brain damage and seems to be mainly due to acute intracranial hypertension and decreased cerebral perfusion pressure (CPP) [3].

Published
1993

39. Biomechanical Regulation of Cerebral Blood Flow

Author

A. Rinaldi, Giulio Maira, F. Della Corte, P. Palma, P. Amante, A. Ferraresi, R. Calimici, Annunziato Mangiola, and Carmelo Anile

Subjects
medicine.medical_specialty, Hydraulic control, Cardiac cycle, business.industry, Dura mater, medicine.anatomical_structure, Cerebral blood volume, Cerebral blood flow, Internal medicine, Circulatory system, medicine, Cardiology, Pulsatile blood flow, Cerebral perfusion pressure, business
Abstract

It is generally accepted that myogenic, metabolic and neurogenic regulation mechanisms exist for the cerebral blood flow (CBF). Recently, a hydraulic control acting at the predural level has been suggested by Chopp et al. [2] These mechanisms, however, do not take into consideration the problem represented by the peculiar feature of the brain (an incompressible organ) within the skull and dura mater (a rigid box and a stiff envelope), perfused by a pulsatile blood flow through a vascular tree with elastic walls. On the basis of this consideration we think that the progressive CBF reduction up to cerebral circulatory arrest following severe intracranial hypertension is probably due to an unbalance between cerebral blood volume variations during each cardiac cycle and the compensatory systems, primarily the venous vascular bed.

Published
1993

40. Do brainstem auditory evoked potentials detect the actual cessation of cerebral functions in brain dead patients?

Author

A. Barelli, Claudio Sandroni, F. Della Corte, R. Calimici, S. I. Magalini, and Rodolfo Proietti

Subjects
Brain dead, Adult, Male, Resuscitation, Brain Death, Electrodiagnosis, medicine.diagnostic_test, Adolescent, business.industry, Middle Aged, Critical Care and Intensive Care Medicine, Auditory brainstem response, Anesthesia, medicine, Evoked Potentials, Auditory, Humans, Female, Brainstem, business, Aged, Brain Stem
Published
1990

41. 759 Does saline hypertonic solution reduce the risk of Turp syndrome?

Author

M. Genta, A. Gratarola, C. Biamino, F. Della Corte, Paolo Gontero, Bruno Frea, and Davide Colombo

Subjects
medicine.medical_specialty, business.industry, Urology, medicine.medical_treatment, Anesthesia, TURP syndrome, medicine, Tonicity, business, Saline, Surgery
Published
2004

42. Cerebral blood flow II

Author

K. A. Jensen, T. Vandekerckhove, A. León, L Balestra, R. Priern, M. Nolla, Juan Sahuquillo, M. Freundlich, M. Clavel, Mariano Alberto Pennisi, R. Diaz, C. Triginer, A. Robles, Jan Poelaert, R. Schultheiß, M. Baguena, J. Robusté, R. Monforte, C. De Deyne, L. Bünemann, A. Giordano, Georg E. Cold, L. L. Sánchez-Masa, Anselmo Caricato, L Patrignani, C. Torres, H. Hansen, A. Garnacho, C. Cedzich, Maria A. Poca, Francis Colardyn, K. Therkelsen, A. Ayuso, and F. Della Corte

Subjects
medicine.medical_specialty, Cerebral circulation, Cerebral blood flow, business.industry, Anesthesiology, Pain medicine, Anesthesia, medicine, Cerebral perfusion pressure, Critical Care and Intensive Care Medicine, business
Published
1992

46. An Experimental Model of 'Brain Tamponade'. Preliminary Observations on ICP Dynamics, Carotid Blood Flow Velocitometry and EEG Activity

Author

C. Anile, A. Dal Lago, A. Rinaldi, F. Della Corte, M. Visocchi, R. Calimici, Giulio Maira, R. Roselli, S. Bradariolo, A. Ferraresi, and M. Sericchio

Subjects
Pathology, medicine.medical_specialty, business.industry, Hemodynamics, Blood flow, medicine.disease, Brain ischemia, Blood pressure, Cerebral blood flow, medicine, Tamponade, Cerebral perfusion pressure, business, Intracranial pressure
Abstract

Brain tamponade (BT) represents a condition of cerebral blood flow (CBF) arrest due to a progressive or often sudden increase in intracranial pressure (ICP) up to values close to the corresponding systemic arterial pressure values. This situation, peculiar to an anatomical configuration characterized by the presence of an incompressible organ within a rigid envelope, as the brain substance within the skull, can induce as its final step a diffuse or compartmental brain ischemia. Considering the scarce metabolic autonomy of the CNS, this could produce irreversible damages. Implicated in this process are the direct relationships between cerebral blood volume changes and vascular impedances. To investigate the hemodynamic mechanisms underlying BT we have carried out an experimental study in the rabbit because its cerebral blood supply is analogous to the human (Meyer et al. 1986).

Published
1989

47. Injury of the vertebral artery after closed head trauma

Author

F. Pappalardo, F. Della Corte, Ornella Piazza, A Pennisi Mariano, Anselmo Caricato, Massimo Rollo, DELLA CORTE, F, Caricato, A, PENNISI MARIANO, A, Pappalardo, F, Piazza, Ornella, and Rollo, M.

Subjects
Adult, Male, medicine.medical_specialty, Vertebral artery, Poison control, Dissection (medical), Wounds, Nonpenetrating, Lesion, Neck Injuries, medicine.artery, Injury prevention, Settore MED/41 - ANESTESIOLOGIA, Basilar artery, Medicine, Nonpenetrating, Craniocerebral Trauma, Humans, Vertebral Artery, medicine.diagnostic_test, business.industry, medicine.disease, Surgery, Wounds, Emergency Medicine, medicine.symptom, business, Ligation, Cerebral angiography
Abstract

Two case reports characterized by the complete occlusion of the basilar artery, secondary to dissection of the vertebral artery after closed head trauma are described. These lesions, often clinically silent in the beginning, were able to cause severe neurologic impairment, even after minor head trauma in healthy individuals without predisposing structural disorders. Early detection, based upon the knowledge of the modality of the trauma and upon a correct diagnostic approach, is mandatory to reduce secondary injury. The authors suggest an extensive use of cerebral angiography or angio-magnetic resonance in all cases where clinical conditions are more severe than the computed tomography scan, particularly if the trauma produced a cervical injury with a movement of flexo-extension of the neck. Therapeutic management is discussed. Anti-coagulants, thrombolytic agents or surgical ligation of the vessel has been proposed to prevent the extension of the lesion and to improve the outcome. Language: en

48. Comparison of two disaster drills' management performed by trained and not-trained students: key times evaluation

Author

P.L. Ingrassia, Luca Carenzo, Marco Tengattini, Federico Lorenzo Barra, F. Della Corte, Federico Prato, and Davide Colombo

Subjects
medicine.medical_specialty, Medical education, business.industry, Alternative medicine, Evacuation strategy, Critical Care and Intensive Care Medicine, nobody, Poster Presentation, Emergency medicine, Key (cryptography), medicine, Objective evaluation, business, Disaster medicine
Abstract

The aim of this report is to compare two disaster exercises' management of students with different backgrounds. To our knowledge nobody has ever compared two exercises, probably because of the difficulty in their evaluation. We implemented a tool for an objective evaluation [1] and we used it for this purpose.

49. Ischaemic myelopathy associated with cocaine: Clinical, neurophysiological, and neuroradiological features

Author

Paolo Profice, Antonio Oliviero, P. Tonali, V. Di Lazzaro, F. Della Corte, Tommaso Tartaglione, Domenico Restuccia, M. Valeriani, Manuela Pennisi, Cesare Colosimo, and Raffaele Nardone

Subjects
Adult, Male, medicine.medical_specialty, Anterior spinal artery, Short Report, Ischemia, Infarction, Central nervous system disease, Cocaine-Related Disorders, Myelopathy, Internal medicine, medicine.artery, medicine, Humans, Vascular disease, business.industry, medicine.disease, Spinal cord, Magnetic Resonance Imaging, Surgery, Psychiatry and Mental health, medicine.anatomical_structure, Spinal Cord, Cardiology, Neurology (clinical), business, Complication
Abstract

Two patients with spinal infarction and one patient with the previously unreported complication of spinal transient ischaemic attack associated with cocaine misuse are reported. Spinal MRI documented an infarction in the territory of the anterior spinal artery in the first two patients and was completely normal in the patient with a transient ischaemic attack. Motor evoked potentials were abnormal in all three patients.

50. IGM-ENRICHED POLYCLONAL IMMUNOGLOBULINS IN AN EXPERIMENTAL MODEL OF GRAM NEGATIVE PNEUMONIA DEVELOPING SEPTIC SHOCK

Author

Annalisa Chiocchetti, Francesca Mercalli, Paolo Navalesi, F. Della Corte, Umberto Dianzani, A Pagni, Teresa Esposito, Renzo Boldorini, Rosanna Vaschetto, and Nausicaa Clemente

Subjects
Mechanical ventilation, biology, Septic shock, business.industry, medicine.medical_treatment, Standard treatment, Critical Care and Intensive Care Medicine, medicine.disease, Intensive care unit, law.invention, Clinical trial, Pneumonia, law, Polyclonal antibodies, Poster Presentation, Immunology, medicine, biology.protein, Antibody, business
Abstract

Severe pneumonia is a major challenge in the Intensive Care Unit, as it is characterized by high morbidity and mortality. A high rate of patients with pneumonia, in particular ventilator-associated poneumonia, develops septic shock. Although some interesting results have been reported in uncontrolled studies where IgM-enriched human intravenous immunoglobulins were added to the standard treatment of septic shock, a well-conducted clinical trial is missing[1]. Also, physiopathological data supporting such a trial are presently insufficient.

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