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Fake news is inaccurate information that is intentionally disseminated for a specific purpose. If allowed to spread, fake news can harm the political and social spheres, so several studies are conducted to detect fake news. This study uses a deep learning method with several architectures such as CNN, Bidirectional LSTM, and ResNet, combined with pre-trained word embedding, trained using four different datasets. Each data goes through a data augmentation process using the back-translation method to reduce data imbalances between classes. The results showed that the Bidirectional LSTM architecture outperformed CNN and ResNet on all tested datasets.

This research is a design of a display cabinet cooling system with integrated energy from PLN electricity and solar power. This equipment is used for displaying marine fish and other fresh sea food in restaurants or cafes in support of Balinese culinary specialties, namely grilled fish and seafood which are very well known and can be a very extraordinary carrying capacity for Bali tourism. This cooling system is designed to be able to maintain the temperature of the cooling room (cabin) up to -5 oC. This is in accordance with the standards for storing fresh sea fish and sea food in a temperature range of -2oC to 2oC, where fish and sea food are still in a very fresh condition for an average of 1 week. Other standards to maintain product freshness also require room humidity between RH 90% – RH 95%. Furthermore, data collection on system performance is carried out using the commissioning test method to determine the initial performance achievement of the tool so that its shortcomings can be evaluated which will be developed and corrected in further research. From the research, it is found that the temperature achievement is very good, the solar and PLN integration system with the Automatic Transfer Switch (ATS) control system has also worked well where the switch occurs when the battery charging condition is below 30% or below 10V. However, something that has not been achieved is the humidity in this system, the average relative humidity (RH) is 50% so that the final condition of the product becomes dry on the surface of the fish. This relatively low humidity is due to the fact that it still relies on the humidity increase system by opening the cooler cabin door. In the next development, the right humidifier system will be designed for this display cabinet system.

Utilization of solar energy in Indonesia has begun to bloom. This is due to the fact that Indonesia is located at the equator where the sun is exposed all year round and is a very environmentally friendly energy. Based on this, solar energy is used as an option to meet electricity needs by using a photovoltaic (PV) system. The use of a photovoltaic system as a power provider to operate a pool water pump at a villa in Bali is an example of the application of a photovoltaic system. In this study, A Seri and Parallel photovoltaic arrays were used with a panel system that was integrated with PLN electricity. The angle of inclination and direction of placement chosen in this study is 15° with facing north, which refers to research that, has been done previously. PV designs and a series of control panels that can be accessed via the internet will be described as well. The aim in this research is investigate how photovoltaic design used as a solar power plant which applied to the module can be runing the pool water pump in the villa or tourist accommodation.

Keberhasilan pencegahan komplikasi Diabetes Melitus dapat dicapai salah satunya melalui kepatuhan dalam terapi farmakologi yaitu penggunaan Obat Hipoglikemik Oral. Keberhasilan suatu pengobatan pada pasien DM memerlukan kemampuan dan keyakinan yang tinggi pada diri sendiri atau yang disebut dengan Self efficacy. Tujuan penelitian ini adalah untuk mengetahui hubungan Self efficacy dengan kepatuhan minum obat hipoglikemik oral pada penderita diabetes melitus tipe II. Desain penelitian yang digunakan adalah deskriptif korelasional dengan rancangan cross sectional. Teknik sampling digunakan consecutive sampling dengan jumlah sampel sebanyak 60 orang penderita DM tipe II. Hasil penelitian didapatkan yaitu 25 orang (41,7%) memiliki Self efficacy dalam kategori tinggi dan 31 orang (51,7%) memiliki kepatuhan minum obat hipoglikemik oral dalam kategori tinggi. Hasil uji Rank Spearman dengan α = 0,05 didapatkan angka p value = 0,000 dan koefisien korelasi (r) = 0,936 yang berarti ada hubungan antara Self efficacy dengan kepatuhan minum obat hipoglikemik oral dengan kekuatan hubungan kuat dan berarah positif. Self efficacy akan berpengaruh terhadap kemampuan menyesuaikan diri, memahami dan mengenal masalah yang dihadapi dan memotivasi dirinya untuk suatu perubahan perilaku salah satunya kepatuhan berobat.

BACKGROUND: Lack of knowledge and inappropriate attitude toward pain management have been recognized as major obstacles to the application of pain management by health workers. Most of the nurses carry out pain management when performing invasive actions on children is not good. AIM: The purpose of this study was to analyze the relationship between the level of knowledge and the behavior of nurses in pain management in children during invasive procedures. METHODS: This study used an analytic observational design with a cross-sectional engineering design with a total population of 30 nurses and a total sample of 30 nurses at RSI A. Yani Surabaya and used a total sampling technique. The independent variable in this study is the level of knowledge, while the dependent variable is the behavior of nurses when performing invasive actions on children. Data were analyzed using the Fisher Exact Test for significance α = 0.05. The data collection instrument used a questionnaire and observation sheet. RESULTS: The results showed that 23 respondents who have sufficient knowledge with 18 respondents having positive behavior and 5 respondents being negative. While 4 respondents who have good knowledge with positive behavior 3 respondents and 1 respondent behaves negatively. respondents who have less knowledge, there are 3 respondents with negative behavior. p = 0.033 (p < 0.05) then there is a knowledge relationship with the behavior of nurses on pain management in children during invasive procedures. CONCLUSION: The level of knowledge of nurses about pain management in children during invasive procedures obtained a enough level of knowledge. The nurse’s behavior level toward pain management in children during invasive procedures is positive. The results of the analysis using statistical tests showed that there was a relationship between the knowledge and behavior of nurses about pain management in children during invasive procedures.

BACKGROUND: The role of neurotrophic factors (brain-derived neurotrophic factors and glial cell line-derived neurotrophic factors) and early electrical stimulation (EES) in the injured nerve has found promising in several studies. However, there is still limited knowledge about the effect of EES in the distal part of the nerve to sustain this level of expression of growth factors. AIM: We aim to evaluate the effects of EES in in neural regeneration by measuring the expression of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in animal model. METHODS: The research was conducted starting from April to May 2021 using male Wistar rats. Using general anesthesia, the sciatic nerve was cut. The intervention group was treated with EES in the distal stump, right after nerve resection (20 Hz, 1–2 mA, 2–5 s), while the control group received no treatment after nerve resection. A reoperation on day 3 was performed in both groups to measure BDNF and GDNF expression level of the distal nerve tissue by ELISA as well as histopathological examination of sprouting axons of the injured proximal nerve. RESULTS: A total of 32 samples were included in the study. A statistically significant levels of GDNF is found higher in the EES group (n = 16) than the control group (n = 16) (35. 71 pg/100 mg, confidence interval (CI) 95% 23.93, 47.48, p < 0.05). The number of sprouting axons is found lower in the EES group (p < 0.05). The BDNF level is similar between the two groups, however not significant. After a subgroup analysis, it was found that the greater the level of GDNF, the fewer the axon sprouts in both groups (fewer axon group 58.35 [n = 22, CI 95% 45.14, 71.55] vs. more axon group 47.14 [n = 10, CI 95% 35.33, 58.95]), p < 0.05. CONCLUSION: The EES proves its benefit in accelerating the axonal regeneration by increasing the expression GDNF in the distal nerve stumps in the electrical excited degenerated sciatic nerve in the rat model.

The Sunda Strait tsunami disaster in 2018 claimed the lives of more than 430 people and caused various damage to infrastructure in coastal areas. This disaster also had an impact on the education sector. Schools located in disaster-prone areas are vulnerable to building damage that causes casualties and psychological problems for students. The west coast of Pandeglang Regency is a tsunami-prone area and is home to hundreds of elementary and high school schools in the area. The aim of this study is to analyze of the structural framework for schools affected by the sunda strait tsunami. The research locus was determined by purposive sampling in three locations: MTs Masyariqul Anwar in Labuan, SDN Mekarjaya 3 in Panimbang, and SDN Tamanjaya 2 in Sumur. This research data analysis uses qualitative data analysis techniques by Miles, Huberman and Saldana (2014). This research used disaster school survey form issued by National Disaster Management Agency (BNPB) which regulated in Head of BNPB Regulation No. 4 of 2012 on Implementation Guidelines of Disaster Safe Schools. The research finding that MTs Masyariqul Anwar, SDN Mekarjaya 3, and SDN Tamanjaya 2 can be concluded that MTs Masyariqul Anwar and SDN Tamanjaya 2 have a good level of school security with some notes that need to be improved. Meanwhile, SDN Mekarjaya 3 has a sufficient level of school security with several factors that are so inadequate that they must be repaired and improved immediately.

Bank merupakan lembaga keuangan yang dituntut untuk dapat menghasilkan profitabilitas agar dapat menjalankan fungsi dan perannya. Penilaian profitabilitas menggunakan Return on Asset (ROA). Bilamana ROA suatu bank semakin tinggi, maka semakin besar kemampuan bank dalam menghasilkan keuntungan. Penelitian ini bertujuan untuk menganalisis pengaruh NIM (Net Interest Margin), LDR (Loan to Deposit Ratio), NPL (Non Performing Loan), dan BOPO (Biaya Operasional Pendapatan Operasional) terhadap ROA pada bank umum swasta nasional devisa (BUSN Devisa) di Indonesia. Penelitian dilakukan pada semua BUSN Devisa se-Indonesia terdaftar di OJK 2015-2019. Sampel sebanyak 135 melalui purposive sampling pada kategori BUSN Devisa di Indonesia yang menunjukkan ROA yang positif periode 2015-2019. Penelitian ini menggunakan observasi non partisipan dan regresi linier berganda. Hasil menunjukkan secara parsial NIM berpengaruh positif signifikan terhadap ROA dan BOPO secara parsial berpengaruh negatif signifikan terhadap ROA. Sedangkan LDR dan NPL secara parsial tidak berpengaruh signifikan terhadap ROA pada BUSN Devisa di Indonesia. Kata kunci : NIM, LDR, NPL, BOPO, ROA

Background: The COVID-19 pandemic has had a wide impact on both pregnant women and their babies. Necrotizing enterocolitis (NEC) is a gastrointestinal emergency in neonates with high morbidity and mortality. Objective: This study aims to investigate the incidence of NEC in preterm infants born to mothers with confirmed COVID-19. Methods: This observational study was conducted in neonatal intensive care unit at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from May 2020 to April 2021. All preterm infants born to mothers with positive COVID-19 based on swab examination were included as study participants. PCR swab examination was performed within 48 hours after birth. The diagnosis of COVID-19 was defined as positive if the swab test result could detect the SARS-CoV-2 virus. The diagnosis of NEC was established by clinical symptoms and confirmed by abdominal radiography. Results: Out of 45 preterm infants included in this study, 6 infants experienced NEC. Factors that were significantly associated with the incidence of NEC included asphyxia and intubated mother. Positive PCR results from the infants alone did not significantly increase the risk of NEC. The combination of asphyxia and intubated mother (Odds Ratio [OR]=10.000, 95% Confidence Interval [CI]=1.056-94.677, P=0.020) and the combination of positive PCR result, asphyxia, and intubated mother (OR=2.438, 95% CI=1.673-3.551, P=0.007) were found to be significantly associated with the incidence of NEC Conclusion: Significant factors associated with the incidence of NEC in preterm infants born to mothers with COVID-19 included asphyxia and intubated mothers prior to delivery. A positive PCR result alone did not significantly increase the risk of NEC.

This research was conducted because of the discrepancy between the theory of cash turnover, receivables turnover and profitability with the existing conditions in food and beverage companies on the IDX in 2016-2020. The purpose of this study was to determine the effect of partially and simultaneously cash turnover, accounts receivable turnover on profitability. The independent variables in this study are cash turnover and receivables turnover, the dependent variable in this study is profitability as measured by Return On Assets (ROA). The results show that there is a positive and significant effect between cash turnover on company profitability, then there is no effect There is a significant relationship between accounts receivable turnover on profitability and there is a positive and significant effect between cash turnover and accounts receivable turnover simultaneously on the company's profitability.

Patients with sleep apnea (sleep apnea) are increasing, almost more than 80% of people with this disorder are undiagnosed. Symptoms of sleep apnea are stopping breathing for more than 10 seconds. The purpose of this study was to design an apnea monitor device in order to detect symptoms of sleep apnea. The contribution in this study is a monitoring system or remote monitoring so that other people can monitor the patient's condition even though they are not accompanying him. In order to facilitate the process of monitoring and diagnosing patients, a Apnea Monitor Based on Bluetooth with Signal Display in Android with a delivery system via a bluetooth network that displays respiratory signals on Android so that patients can be treated quickly when breathing stops (apnea) . The design of this device uses a piezoelectric sensor to detect breathing which is placed on the patient's abdomen. The sensor output in the form of voltage is then conditioned on the PSA circuit. Using the ESP32 microcontroller as a signal processing which is formed by the PSA circuit and processed into a signal and respiration value. The respiration signal and value are then sent to the android device using the Bluetooth network. When a respiratory arrest is detected for more than 10 seconds, the device will turn on the indicator and buzzeer on the device and also send a warning to the Android or Roboremo application in the form of a notification "Apnea!" and a beep sound as a reminder when there is apnea in the patient so that the user can immediately take action on the patient. The test in this study there are 5 respondents who have been tested on this module by comparing the respiration rate per minute with the Patient Monitor, and the test results in this study obtained the measurement and calculation results, the lowest error value was 1.58% and the highest error value was 2.9%, the module can also transmit data well and without data loss with a distance of 10 meters in the room and 5 meters in different rooms. This module can be implemented in the patient monitoring process so that it can reduce sufferers of sleep apnea disorders. the module can also transmit data well and without data loss with a distance of 10 meters in the room and 5 meters in different rooms. This module can be implemented in the patient monitoring process so that it can reduce sufferers of sleep apnea disorders. the module can also transmit data well and without data loss with a distance of 10 meters in the room and 5 meters in different rooms. This module can be implemented in the patient monitoring process so that it can reduce sufferers of sleep apnea disorders.

During the past one and a half year, we all have faced the COVID-19 pandemic. In national defense perspective, COVID-19 Pandemic could be viewed as a non-military threat to national defense. The COVID-19 pandemic is a wake-up call that improves our awareness on the necessity to be fully independent and self-sufficient in health sector. So far, we have been complacent with the ease of importing raw materials for medicines and medical devices. Thus, the advent of the COVID-19 pandemic has made us aware to reduce Indonesia’s high dependence on import of health and medicine goods. Despite of the losses and prolonged sadness brought by the COVID-19 pandemic, there are also positive impacts for this nation as the result of the COVID-19 pandemic. One of the impacts on the National Health System is the strengthening and involvement of all levels of society and the apparatus in dealing with COVID-19 pandemic, which can be seen in the prevention, detection, and orderly response to COVID-19. Adjustment of public health service capacity is also carried out very swiftly to respond the pandemic situation. Another indicator is seen in the financing of medical and healthcare sector that was able to rapidly finding sources of funding for a very sharp increase in public health needs. Meanwhile, Human Resources capacity development appears to be very prominent as seen from the rapid improvement of training and research in medical and healthcare competences. No less important is the pharmaceuticals and medical devices sectors that are more determined to improve their independence and self-sufficiency in terms of drugs and vaccines raw materials. Independent raw materials provision for drugs and vaccines has an important value in the national economy and strengthening national security in the public health sector.

Floods are among the most frequently occurring natural hazards in Malawi, often with public health implications. This mixed methods study assessed the capacity for and implementation status of the disaster risk management (DRM) strategy for the health sector in Malawi, using flooding in the Nsanje District as a case. Data were collected using desk review and a workshop methodology involving key officials from government ministries, national and international development partners, and the academia. The results show that Malawi had recently strengthened its DRM institutional frameworks, with a pronounced policy shift from reactive to proactive management of disasters. Health sector personnel and structures were key contributors in the design and implementation of DRM activities at all levels. Development partners played a significant role in strengthening DRM coordination and implementation capacity. Lack of funding and the limited availability, and often fragmented nature, of vulnerability and risk assessment data were identified as key challenges. Limited human resource capacity and inadequate planning processes at district level impeded full implementation of DRM policies. These findings call for community-level interventions for improved coordination, planning, and human resource capacity to strengthen community disaster resilience and improve public health. The approach used in this study can serve as a model framework for other districts in Malawi, as well as in other low- and middle-income countries in the context of Sendai Framework implementation.

One source of learning in universities is a digital library. In the era of industry 4.0, most universities have implemented digital libraries in supporting the learning process. However, the reality shows that digital library management is still ineffective. Therefore, the implementation of digital libraries needs to be evaluated for determining the digital library effectiveness used as learning resources in supporting the learning process in universities. Many evaluation tools are used to evaluate the effectiveness of digital libraries but have not provided accurate recommendation results to support decision-making. This research presents an innovation in the form of an evaluation tool that can be used to evaluate the digital library effectiveness in universities. That evaluation tool is called the Alkin - WP -based digital library evaluation software. This software is a desktop platform that contains aspects of measuring the digital library effectiveness by referring to the components of the Alkin evaluation model and the WP ( Weighted Product ) method. This research aimed to show the effectiveness level of the utilization of Alkin - WP -based digital library evaluation software. This research method was R & D (Research & Development) which refers to the ten development stages of the Borg and Gall model. In this research, development was focused only on a few stages, included: usage trials, final product revision, dissemination, and implementation. The subjects involved in assessing the implementation/utilization of the Alkin-WP -based digital library evaluation software were 35 people, in the usage trials were six people, in product revision were three people, and at the stage of dissemination were 15 people. The tools used to collect data were questionnaires and interview guidelines. The data analysis technique used was descriptive quantitative. The effectiveness level of utilizing the Alkin-WP -based digital library evaluation software was 88.34%. It showed that the evaluation software had effective. The impact of this research results on the scientific field of educational evaluation is being able to show the existence of a new evaluation tool based on educational evaluation and artificial intelligence. That evaluation tool can easier for library heads to make policies for revamping digital library services based on accurate recommendations. Doi: 10.28991/esj-2021-01308 Full Text: PDF

Introduction: Diabetes mellitus (DM) is a metabolic disease that can cause complications in the form of damage to male reproductive organs, such as decreased sperm motility and cell count, impaired spermatogenesis, and erectile dysfunction. A measurement that can be done to detect male reproductive disorders is to measure the thickness of the seminiferous tubule epithelium. Herbal medicines can be used to support treating diabetes. Studies have claimed that African bitter leaf helps in treating DM and its complications. Purpose: This study aims to determine the effect of African bitter leaf extract on epithelium thickness of seminiferous tubules in rats with DM. Method: True Experimental with Post-Test Only Control Group Design using Rattus norvegicus. Rats were divided into five groups, with six rats in each group. Rats were administered with a single dose of alloxan 150 mg/kg BW/IP. Group K is diabetic rats given glibenclamide 0,63 mg/kg BW. Group P0 are diabetic rats given CMC 0,1% 0,7 ml. Group P1 are diabetic rats given African bitter leaf extract 100 mg/kg BW. Group P2 are diabetic rats given African bitter leaf extract 200 mg/kg BW. Group P3 are diabetic rats given African bitter leaf extract 400 mg/kg BW. Treatments were given with oral gavage for 14 days. Rats were dissected, and their testis was made as histological slides. Results are statistically tested with ANOVA. Results: The average epithelium thickness from group K are 79,61 μm, group P0 are 59,96 μm, group P1 are 71,87 μm, group P2 are 67,31 μm, group P3 are 63,95 μm showed significant result (p=0,000). Conclusions: African bitter leaf extract affects epithelium thickness of seminiferous tubules, with group K, shows the best result, followed by group P1.

The preparation of physical infrastructure carried out by the government is indeed worthy of being appreciated. However, developing ten tourist destinations as "New Bali"; to foster the economy can be a failure if it only touches the financial and physical capital side but does not look at social capital. This research was conducted to answer how social capital could attract more tourists as the central pillar of the tourism industry. The concept of social capital derives from questioning upon two traditional perspectives dominating the festivity of intellectual discussion on the matter of understanding and explaining human behavior; rationalists andstructuralists. The social capital framework maintains that a comprehensive understanding of human behavior requires multi-dimensional approaches, social capital theory, which integrates considerations of both an individuals rational decision making and the social, relational, and structural aspects of that decision making.The research was conducted using a qualitative approach. There were several focus groupdiscussions held in four main areas in Bali, between a period of October 2019, in line with several significant events in Bali, including Bali Readers and Writers Festival and Nusa Dua iesta. Interviews and Observations were used to describe qualitatively, how could social capital attract more tourists to visit Bali and stands as main pillars for the tourism industry in Bali. Four main dimensions of social capital were found during the research, including social network support, personal relationships, civic engagement, and trust (cooperative norms). Althoughseveral challenges and new upcoming cases came from stakeholders; support, residents had put their best efforts to keep and maintain the sustainability of social capital to support the tourism industry in their mainland. These four dimensions could be identified and replicated in other islands, that purposively developed as new priority destinations of state government.

Researches on the implementation of information technology in Balinese culture and Hindu religion are still relatively rare, because Balinese culture is often perceived as “old fashioned” compared to information technology as something modern. In Hinduism, Yadnya ceremony is a religious ceremony when Hindus expressed gratitude to God, to fellow humans, to the resi, (priest/teacher), to the ancestors, and to Bhuta Kala. The implementation of Yadnya is usually accompanied with bebantenan (offerings) or upakara. Nowadays there are many Hindus, especially the younger generation who do not understand about bebantenan and Yadnya ceremony themselves. This is because information about bebantenan and Yadnya ceremony is relatively difficult to obtain. This paper proposes a multimedia based E-Upakara system or Bebantenan Information System that is a part of E-UpacaraYadnya System. Tree data structure is used to model the informations about data contained in bebantenan, and to illustrare the relations between bebantenan and Yadnya. The system can provide information related to the Yadnya ceremony such as the time the ceremony is held, the ceremony procedures, the bebantenan used during the ceremony, procedures of making bebantenan, videos, and pictures of banten.

The use of natural asphalt is an alternative to meet the high demand for oil asphalt. Asbuton is natural asphalt from Buton Island, Indonesia. However, the use of Asbuton is not as easy as oil asphalt because the asphalt it contains is hard. The asphalt-concrete mixture must go through a rejuvenation process for several days before being compacted. This study aims to determine the performance of asphalt-concrete mixture using Asbuton if it is compacted immediately after mixing, without giving time for the rejuvenation process. Compaction is done when the mixture is hot and after the mixture is cold. Compaction of the asphalt-concrete mixture in hot temperature (150ºC), based on mechanical characteristics (stability, flow, and Marshall Quotient), has better performance than that compacted in cold temperature (30ºC). However, compaction in both hot and cold temperatures, based on their volumetric characteristics, does not meet the requirements for use as road pavements. The performance of the asphalt mixture can be improved by giving time in the process of softening the asphalt content in Asbuton

This paper shows a technical study and analysis of the fatigue damage assessment of bus structural steel under service loading. Two bus prototypes (passenger-loaded and empty) are used in the experimental measurement for a typical city road. A deterministic analysis is performed for fatigue damage assessment and the remaining strength. These parameters are used for the construction of fatigue design curves, which can predict the designed fatigue life to failure. Results show a promising prediction that can be used for best practice in future design. To complete the investigation, this work also examined the different perspectives of system failure on the basis of the probability of fatigue life in the form of a distribution function. All results are satisfactory from the analysis perspective. However, design improvement should be addressed to achieve the target life.

Acute Lymphoblastic Leukemia (ALL) increases annually and the incidence is mostly found in children. Its high failure rate is due to infection in the induction phase of chemotherapy. One of the strategies is laboratory testing to determine prognostic factors or predictors that can help clinicians determine therapy and outcomes in ALL. Research related to Procalcitonin (PCT), Erythrocyte Sedimentation Rate (ESR), and Red-cell Distribution Width (RDW) test in ALL children with poor outcomes has never been performed at Dr. Soetomo Hospital, Surabaya. This study aimed to determine the correlation of some infection parameters (PCT, ESR, and RDW) with outcomes in ALL. This was a cross-sectional study in the Pediatric Ward of the Dr. Soetomo Hospital in the period of June-August 2019. A total of 34 ALL patients after the induction phase of chemotherapy according to ALL-2018 protocol were included in this research. Procalcitonin, ESR, and RDW were determined using an ELFA method, photometrical capillary stopped-flow kinetic method, and flow cytometry method. The age of the study subjects ranged from 3 months to 16 years old, 32 patients (94.1%) were categorized as ALL-L1, 23 patients (67.6%) used protocol of high-risk group stratification. The study subjects were divided into 10 patients with poor outcomes and 24 patients with a good outcome. Procalcitonin was (2.66±13.15), ESR was (22.65±19.18), and RDW was (14.97±2.727). There was a significant correlation between PCT and outcomes.

To evaluate the effect of Ipomea batatas tuber extract (IBTE) on blood lipid profile and atherogenic index in plasma (AIP) of dyslipidemia rats. First, IBTE was extracted by methanol. Fat-rich diets was given for 30 days to induce dyslipidemia in rats. Then, IBTE was given to dyslipidemia rats for 21 days. Lipid profiles in the form of total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), high lipoprotein-cholesterol (HDL-C) and AIP in rats were measured and analyzed. The results showed that administration of IBTE 150, 300 and 600mg/kg BW was able to improve the blood lipid profile of dyslipidemia rats, where there was a decrease in levels of TC, TG and LDL-C, and an increase in HDL-C levels. In line with this, the AIP value has also decreased. The conclusion was IBTE have affect to improve the blood lipid profile of dyslipidemia rats and the AIP.

Corona Virus Disease (COVID-19) pandemic is an actual threat currently experienced throughout the world, including Indonesia. COVID-19 pandemic response must be seriously carried out due to its threats against the national defense system. At the forefront of COVID-19 pandemic response is human resources that play important role as national defense system components which capability need to be managed and developed in a continuous manner. Against the background, this research aims to analyze defense sector human resource capacity management and development in COVID-19 pandemic response in Indonesia. This research employed descriptive qualitative method using primary and secondary data. The results showed that the capability-based approach emphasizes "what we need to do" in dealing with the increasingly complex threats, and defense sector human resources capacity development and management are carried out through selection and knowledge development processes to influence attitudes and encourage behavior changes. The results further showed that as a defense sector component, The Indonesian Armed Forces (TNI) personnel possesses the required readiness and capabilities to carry out their tasks with 3,426 medical and non-medical qualification personnel who have been directly involved at the forefront role of COVID-19 pandemic response.

The metal-supported solid oxide fuel cell (MS-SOFC) is of current research interest in the clean energy field due to its high performance, quick start-up, thermal cycle stability, and lower raw material cost compared to the conventional cermet-based SOFC. To efficiently operate a MS-SOFC using complex hydrocarbon and logistic fuels, it is required to introduce an internal reforming catalyst within the anode metal scaffold. This review article discusses some examples of the performance of MS-SOFCs under hydrocarbon and logistic fuels with and without an additional reforming catalyst. We also discuss the performance improvement of conventional cermet-based SOFCs by adding reforming catalysts via the infiltration method. This information can be directly applied to future MS-SOFC applications. Furthermore, this review article proposes possible novel methods such as direct precursor infiltration, catalyst-anode premixing, and atomic layer deposition methods to introduce the reforming catalyst into a MS-SOFC for improving its initial electrochemical performance and long-term stability under hydrocarbon and logistics fuel.

Companies and other business entities must disclose or report the company's social activities included in the sustainability report. However, the level of sustainability report reporting in Indonesia is still low. The purpose of this study was to determine the effect of profitability, company activity, and industry type on the disclosure of sustainability report. This research was conducted at the LQ45 company on the Indonesia Stock Exchange for the period 2017-2019 by accessing the official website ww.idx.co.id. The population in this study amounted to 45 companies. Sampling using purposive sampling technique. The sample in this study were 16 companies with 48 observational data. The analysis technique used in this study was multiple linear regression analysis. Based on the research results, it was found that profitability had a negative effect on the disclosure of sustainability reports. Company activities have a positive effect on sustainability report disclosure. Industry type has no effect on sustainability report disclosure. Keywords: Profitability; Company Activities; Industry Type; Sustainability Report.

Taxes are an important source of funding for the Indonesian economy. Tax Avoidance is a company's effort to minimize the company's tax burden by looking for gaps in a country's tax weaknesses, so the scheme is legal. This study aims to obtain empirical evidence of the correlation of managerial ownership, the proportion of independent commissioners, and the audit committee on tax avoidance. The theory used is the Agency Theory. The research was carried out on mining entities that are on the IDX in the period 2017-2019, with a population of 43 entities. The number of samples obtained are 11 companies with purposive sampling method. Data collection is done by non-participant observation. The data analysis technique applied is multiple linear regression. The findings indicate that the proportion of independent commissioners has a negative effect on tax avoidance. However, managerial ownership and audit committee have no effect on tax avoidance. Keywords: Managerial Ownership; The Proportion of Independent Comissioners; Audit Committee.

Background Serious mental illnesses (SMI) such as schizophrenia and bipolar disorder first develop between ages 14 and 25. Once diagnosed, young peoples’ health can deteriorate, and it is therefore vital to detect this early to prevent severe outcomes including hospitalisations and deaths by suicide. The main study aim is to describe and discuss observational studies that examine signs of deterioration in young patients with SMI. Methods A systematic review guided by the published protocol was conducted. Cumulative Index to Nursing and allied Health Literature (CINAHL), MEDLINE, Embase, PsycINFO, Health Management Information Consortium (HMIC) and Web of Science were searched against pre-defined criteria until 1 March 2021. Observational studies were extracted according to design, country, participant, indicator, outcome and main finding categories. Quality was assessed independently using the Newcastle Ottawa Scale (NOS). Results Of the 15,788 publications identified, 5 studies were included and subjected to narrative synthesis. Two indicators of mental health deterioration were identified: cognitive functioning (decline, worsening and poor school/academic performance) and expressed emotion status. Indicators revealed mixed views on predicting deterioration. Worsening cognitive functioning and expressed emotion status significantly predicted medication non-adherence and relapse respectively. However, a decline in cognitive functioning (poor academic performance) was not found to significantly correlate to deaths by suicide. Study quality was mostly poor and associations between indicators and varied outcomes were weak. The heterogeneous nature of the data made comparisons difficult and did not allow for further statistical analysis. Conclusion To our knowledge, this is the first review of observational studies to identify indicators of deterioration in young patients with SMI. Worsening cognitive functioning and expressed emotion status could indicate non-adherence and relapse in young patients with SMI but larger sample sizes in good quality studies are needed. The dearth of observational studies means further research is required to ascertain other indicators of deterioration before serious outcomes occur. Funding This work was supported by the National Institute for Health Research (NIHR) Imperial Patient Safety Translational Research Centre via an NIHR programme grant. The authors are also grateful for support from the NIHR under the Applied Health Research programme for North West London and the NIHR Imperial Biomedical Research Centre. The views expressed in this publication are those of the authors and not necessarily those of the National Health Service (NHS), the NIHR or the Department of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Trial registration This systematic review has been registered on PROSPERO (registration number: CRD42017075755).

Background Ames test is used worldwide for detecting the bacterial mutagenicity of chemicals. In silico analyses of bacterial mutagenicity have recently gained acceptance by regulatory agencies; however, current in silico models for prediction remain to be improved. The Japan Pharmaceutical Manufacturers Association (JPMA) organized a task force in 2017 in which eight Japanese pharmaceutical companies had participated. The purpose of this task force was to disclose a piece of pharmaceutical companies’ proprietary Ames test data. Results Ames test data for 99 chemicals of various chemical classes were collected for disclosure in this study. These chemicals are related to the manufacturing process of pharmaceutical drugs, including reagents, synthetic intermediates, and drug substances. The structure-activity (mutagenicity) relationships are discussed in relation to structural alerts for each chemical class. In addition, in silico analyses of these chemicals were conducted using a knowledge-based model of Derek Nexus (Derek) and a statistics-based model (GT1_BMUT module) of CASE Ultra. To calculate the effectiveness of these models, 89 chemicals for Derek and 54 chemicals for CASE Ultra were selected; major exclusions were the salt form of four chemicals that were tested both in the salt and free forms for both models, and 35 chemicals called “known” positives or negatives for CASE Ultra. For Derek, the sensitivity, specificity, and accuracy were 65% (15/23), 71% (47/66), and 70% (62/89), respectively. The sensitivity, specificity, and accuracy were 50% (6/12), 60% (25/42), and 57% (31/54) for CASE Ultra, respectively. The ratio of overall disagreement between the CASE Ultra “known” positives/negatives and the actual test results was 11% (4/35). In this study, 19 out of 28 mutagens (68%) were detected with TA100 and/or TA98, and 9 out of 28 mutagens (32%) were detected with either TA1535, TA1537, WP2uvrA, or their combination. Conclusion The Ames test data presented here will help avoid duplicated Ames testing in some cases, support duplicate testing in other cases, improve in silico models, and enhance our understanding of the mechanisms of mutagenesis.

Background Painful diabetic neuropathy is one of the most common complications of type 2 diabetes mellitus, with approximately 30–50% of people will experience diabetic neuropathy. Chronic hyperglycemia will cause an inflammatory process that will trigger an immune response included leukotrienes. Leukotriene B4 is associated with hemoglobin glycation levels. This study aimed to determine high serum leukotriene B4 levels and other factors as a risk factor for painful diabetic neuropathy in type 2 diabetes mellitus patient. Results Forty-two subjects with 22 cases (median age 56.5 ± 4.9 years) and 20 controls (median age 56.5 ± 5.2 years) group were collected. In bivariate analysis, significant factor for high risk PDN was high leukotriene B4 serum level (OR 5.10; 95% CI 1.34–19.4, p 0.014). Meanwhile, insignificant factors were anti-diabetic drugs (OR 2.139; 0.62–7.37; p = 0.226), and duration of diabetes mellitus (OR 2.282; 0.56–9.25; p = 0.315). Independent risk factor was serum leukotriene B4 levels (OR 5.10; 95% CI 1.336–19.470; p = 0.017). Conclusions In this study, high leukotriene B4 serum levels increase the risk of painful diabetic neuropathy among type 2 diabetes mellitus. The leukotriene B4 may consider as a potential biomarker for early detection in high risk for PDN and early treatment.

Acute myocardial infarction, commonly referred to as a heart attack, is the most common cause of sudden death where a monitoring tool is needed that is equipped with a system that can notify doctors to take immediate action. The purpose of this study was to design a heart attack detection device through indicators of vital human signs. The contribution of this research is that the system works in real-time, has more parameters, uses wireless, and is equipped with a system to detect indications of a heart attack. In order for wireless monitoring to be carried out in real-time and supported by a detection system, this design uses a radio frequency module as data transmission and uses a warning system that is used for detection. Respiration rate was measured using the piezoelectric sensor, and body temperature was measured using the DS18B20 temperature sensor. Processing of sensor data is done with ESP32, which is displayed wirelessly by the HC-12 module on the PC. If an indication of a heart attack is detected in the parameter value, the tool will activate a notification on the PC. In every indication of a heart attack, it was found that this design can provide notification properly. The results showed that the largest respiratory error value was 4%, and the largest body temperature error value was 0.55%. The results of this study can be implemented in patients who have been diagnosed with heart attack disease so that it can facilitate monitoring the patient's condition.

Saat krisis kesehatan Covid-19 merebak tingkat ketidakpastian di masyarakat semakin tinggi. Pemerintah memiliki tanggungjawab untuk mengurangi ketidakpastian dengan memberikan pesan yang tepat kepada publik terdampak. Di Indonesia, Kementerian Kesehatan (Kemenkes) dan satuan gugus tugas Covid-19 (Satgas Covid-19) menjadi dua instansi yang secara aktif memberikan informasi terkait Covid-19. Penelitian ini bertujuan untuk menjelaskan secara deskriptif pesan yang disampaikan oleh kedua instansi terkait dengan Covid-19 melalui metode konten analisis. Hasil penelitian menemukan bahwa baik Kemenkes maupun Satgas Covid-19 memberikan penekanan pada pesan terkait upaya yang dilakukan pemerintah untuk menangani penyebaran Covid-19, perkembangan angka kasus, dan anjuran adopsi protokol kesehatan. Namun, kedua instansi tidak memberi porsi yang cukup terhadap pesan yang menjelaskan situasi krisis yang sedang dan ekspresi simpati kepada publik. Padahal penjelasan terkait situasi dapat mendorong publik untuk mengadopsi anjuran pemerintah, sementara ekspresi simpati diperlukan dalam situasi krisis untuk memberi rasa aman di tengah ketidakpastian.

BACKGROUND: Coronavirus is a health problem that is happened worldwide and impacted on many sectors. However, there is no research that provides information on health professional survivors from coronavirus disease 2019 (COVID-19) experience in self-management. AIM: The purpose of this study is to explore self-management experience among health professional survivors from COVID-19 in West Nusa Tenggara, Indonesia. METHODS: Purposive sampling, one-on-one, in-depth with semi-structural interviews was conducted to collect the data in this study. Data saturation was achieved after interviewing twelve health professional survivors from COVID-19 in West Nusa Tenggara, Indonesia. Narratives were analyzed by Colaizzi’s (1978) seven-step method. RESULTS: Four emergent themes were identified in this study including self-awareness (preventing transmission, improving immunity system, dietary adjustment and accessing appropriate treatment), social relationship (negative feeling and social support), stress management (sharing experience each other’s, reducing negative emotional, and self-introspection), focus on learning (looking for information from survival COVID-19, looking for information from YouTube and looking for information from google search). CONCLUSION: The experience among health professionals in self-management while struggling to recover quickly from COVID-19 can be used as valuable information for Indonesian society.

Background: Diabetic Peripheral Neuropathy (DPN) is a microvascular complication that commonly occurs in people with diabetes mellitus. Geriatrics with type 2 diabetes mellitus is one of the populations most vulnerable to this complication. An epidemiological study states that geriatrics has a 32% greater risk of developing this complication compared to other age groups. There have not been many studies conducted to evaluate the risk factors that influence this DPN complication, so it needs to be done an individual evaluation for the elderly population. Objective: This study aims to explore the risk factors that influence the incidence of DPN in elderly patients with type 2 diabetes mellitus. Methods: A case-control study design was carried out on 70 geriatrics with type 2 diabetes mellitus. The outcome determined was the incidence of DPN to track the cause of DPN exposure retrospectively. Influential risk factors are determined by the Odds Ratio (OR) with a 95% confidence interval (CI). All statistical analyzes were two-tailed, and p-values

This article offers examples of how modeling can motivate health equity inquiry and research. This article also considers how equity fits into cost-effectiveness frameworks, how economic modeling can broaden the range of options for improving health equity, and how information other than results of cost-effectiveness analyses can inform health technology assessment.

In the pandemic covid-19 this many of them small or large affected by the start of her ways merchandise not up to the decline in turnover will also affect the company even, to employees so increasing the number increased unemployment. Because it certainly makes the psychological society in dealing with economics disturbed. See the situation and conditions like that in an activity KKN 2021 this year we took the theme gave motivation and opportunity entrepreneurial by trade angkringan people who are affected by the pandemic covid-19. The motivation was by the provision of the understanding that in scavenge some easy do not have to work as an employee, with it could also. by tradeIn relation to stay up late as business opportunities we provide cover wagons angkringan complete with furniture with system rent 10.000/day.We were hoping with this motivation as well as business opportunities were very minimal capital this can be solutions to the impact of the pandemic covid-19.

The COVID-19 pandemic is a national disaster so the need for arrangements to support the handling of COVID-19 continues to be pursued. The real sector is expected to be able to survive and not terminate employment. The multiplier effect due to the covid pandemic requires government assistance as a policyholder. Taxes are a source of state finance, now changing to a second function, namely the regular function. Government Regulation No. 23, 44, 86, 110 and 143 regarding tax incentives for taxpayers affected by the coronavirus pandemic 19. Of the total 68,101 taxpayers at the Directorate General of Taxes in Bali, only 16,624 take advantage of tax incentives, so it must be investigated why taxpayers do not make optimal use of incentives that should be used to stimulate economic growth. The methodology used in this study is a descriptive interpretative qualitative method. The results of the study found that incentives used by taxpayers have stimulated economic growth, but there are taxpayers who do not take advantage of incentives due to the complexity of procedures and some do not receive information about incentives so that in the future the Directorate General of Taxes needs to simplify procedures and wider socialization.