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1. Immunodeficiency in Down's syndrome

Author

Lorraine J. Beard, G.T. Mai, A. Ferrante, D. M. Roberton, C. Pearson, R. K. S. Loh, V. Vuddhakul, David H.B. Goh, S.C. Harth, Y.H. Thong, and B. Rowan-Kelly

Subjects
S syndrome, business.industry, medicine, medicine.disease, business, Virology, Immunodeficiency
Published
1991
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2. Alterations in Function and Subpopulations of Peripheral Blood Mononuclear Leukocytes in Children with Portal Hypertension Leukocyte Subtypes and Function in Portal Hypertension

Author

David H.B. Goh, Antonio Ferrante, Lorraine J. Beard, and Geoffrey P. Davidson

Subjects
Adult, Cytotoxicity, Immunologic, Adolescent, T-Lymphocytes, Immunology, Peripheral blood mononuclear cell, Monocytes, Hypertension, Portal, Leukocyte function, Humans, Immunology and Allergy, Medicine, Child, B-Lymphocytes, Life span, business.industry, General Medicine, medicine.disease, Peripheral blood, Killer Cells, Natural, Phenotype, Child, Preschool, Splenomegaly, Leukocytes, Mononuclear, Portal hypertension, business
Abstract

Children with advanced portal hypertension usually have splenomegaly (often associated with hypersplenism) which may lead to a decreased life span of circulating blood leukocytes. In a group of 6 children (age range 4–15 years; mean age 8.5 years) with portal hypertension, we examined peripheral blood mononuclear leukocytes for possible changes in their proportions, numbers and function. Compared to normal subjects, children with portal hypertension had a marked reduction in the percentages and absolute numbers of T lymphocytes (CD3+), T ‘helper/inducer’ (CD4+) and T ‘suppressor/cytotoxic’ (CD8+) cells. However, the percentages of B lymphocytes (FMC1+), natural killer cells (Leu 11+) and monocytes (morphological) were increased, and the absolute numbers of B cells were significantly increased in these patients. Lymphocyte responsiveness to phytohemagglutinin, pokeweed mitogen and concanavalin A were depressed in the patients, while the natural killer cell cytotoxicity was slightly increased. Thus, children with portal hypertension show changes in the relative proportions and absolute numbers of peripheral blood mononuclear blood leukocyte subpopulations as well as changes in mononuclear leukocyte function.

Published
1989
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3. Books Received at the Editorial Office

Author

Herman Meurs, Carola Fabbri, Jan G.R. de Monchy, Ian Kimber, Klaus P. Hammann, Takao Morito, R. Rubocki, Kathleen E. Harris, David H.B. Goh, Giuliano Motta, Reiji Kasukawa, Antonio Miadonna, A. Halstensen, D. Muirhead, M. Froldi, R. Djurup, C.O. Solberg, Jørgen Henrichsen, Hiroshi Yasueda, R. Mäntyjärvi, J.Y. Cesbron, K. Louhelainen, William J. Houlihan, M. Wasik, Henk F. Kauffman, Guy J.W.J. Zigterman, Mark L. Lee, Yasuo Yui, A. Capron, Tomoe Nishimaki, A. Næss, M. Jansze, Adiet Timmermans, B.A. Baldo, Klaas de Vries, Karin Prellner, P. Gullstrand, Harm Snippe, P.A. Botham, Alberto Tedeschi, F. Milgrom, Antonio Ferrante, Carlo Zanussi, Roy Patterson, Maurizio Lorini, Poul Christensen, Hiroshi Yoshida, Morio Masaki, Frances Mocatta, Kyoichi Kano, Massimo Agosti, Antonio Marini, Stuart T. Walsh, S.A. Ford, C.G.M. Magnusson, Karsten Offenbartl, T. Virtanen, E. Leggieri, S.G.O. Johansson, Takao Shida, Mita H, Jan M.N. Willers, Hanns C. Hopf, Gerard H. Koëter, N.J. Rattray, and Hideo Nakarai

Subjects
Gerontology, business.industry, Immunology, Immunology and Allergy, Library science, Medicine, General Medicine, business
Published
1986
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