1. Clinical Significance of Interleukin-6 in the Diagnosis of Sepsis and Discriminating Sepsis Induced by Gram-negative Bacteria
- Author
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Xian-jun Wang, Wen-xia Shao, Dao-jun Yu, and Wei-ying Zhang
- Subjects
Calcitonin ,Male ,0301 basic medicine ,Microbiology (medical) ,China ,medicine.medical_specialty ,Gram-negative bacteria ,Adolescent ,medicine.drug_class ,Calcitonin Gene-Related Peptide ,Antibiotics ,Gastroenterology ,Procalcitonin ,Diagnosis, Differential ,Sepsis ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Internal medicine ,Gram-Negative Bacteria ,medicine ,Humans ,Clinical significance ,Child ,Interleukin 6 ,Gram-Positive Bacterial Infections ,biology ,Interleukin-6 ,business.industry ,Area under the curve ,Infant ,Interleukin ,biology.organism_classification ,medicine.disease ,Anti-Bacterial Agents ,C-Reactive Protein ,030104 developmental biology ,Infectious Diseases ,ROC Curve ,Area Under Curve ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,biology.protein ,Female ,Gram-Negative Bacterial Infections ,business ,Biomarkers - Abstract
Background To discuss the clinical significance of interleukin (IL)-6 in the differential diagnosis of sepsis and its capability of differentiating the sepsis induced by Gram-negative bacteria from that induced by Gram-positive bacteria. Methods A total of 379 children with sepsis were involved in this study to form the case group, and their C-reactive protein (CRP), procalcitonin (PCT) and IL-6 levels before antibiotics and after recovery were checked. Receiver operating characteristic curve was applied to evaluate the significance of CRP, PCT and IL-6 in the differential diagnosis of sepsis and their capability of differentiating the sepsis induced by Gram-negative bacteria from that induced by Gram-positive bacteria. Results When these 3 indicators were applied to the differential diagnosis of sepsis, the area under the curve (AUC) of IL-6, PCT and CRP was 0.881, 0.877 and 0.754, respectively. The combination of IL-6 and PCT presented highest diagnostic efficiency. CRP, PCT and IL-6 levels in children with sepsis induced by Gram-negative bacteria were significantly higher than those in children with sepsis induced by Gram-positive bacteria. Conclusions CRP, IL-6 and PCT are applicable to the differential diagnosis of sepsis and differentiating the sepsis induced by Gram-negative bacteria from Gram-positive bacteria. Appropriate combinations of these indicators are capable of increasing differential diagnosis efficiency. These indicators can be used as markers of antibiotics usage, but whether they can be used as markers to withdraw antibiotics is still needed to be observed.
- Published
- 2018