1. Association Between Vitamin A Intake and Disease Severity in Early-Onset Heterotopic Ossification of the Posterior Longitudinal Ligament of the Spine
- Author
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Satoshi Kato, Ryo Takagi, Tsutomu Endo, Kei Ando, Kazuyoshi Kobayashi, Kazufumi Okada, Masahiko Takahata, Shiro Imagama, Masahiro Kanayama, Takashi Kaito, Yoshiharu Kawaguchi, Hiroaki Sakai, Shiro Ikegawa, Yuichiro Hisada, Yoshinao Koike, Norimasa Iwasaki, and Itaru Oda
- Subjects
medicine.medical_specialty ,severe obesity ,030209 endocrinology & metabolism ,Gastroenterology ,vitamin B6 ,vitamin A ,Vitamin A intake ,03 medical and health sciences ,0302 clinical medicine ,Disease severity ,Internal medicine ,medicine ,Posterior longitudinal ligament ,Orthopedics and Sports Medicine ,dietary habits ,030304 developmental biology ,Early onset ,early-onset OPLL ,0303 health sciences ,Ossification ,business.industry ,medicine.disease ,Spine (zoology) ,heterotopic ossification ,Surgery ,Heterotopic ossification ,Neurology (clinical) ,medicine.symptom ,Vitamin b6 ,business - Abstract
Study Design: A sex- and age-matched case-control study and a cross-sectional study. Objective: In our previous study, patients with early-onset (Methods: In Study 1, the simple brief-type self-administered diet history questionnaire (BDHQ) was used to compare nutrient intake levels of early-onset OPLL patients (n = 13) with those of sex- and age-matched non-OPLL controls (n = 39) or with those of common OPLL (onset age ≥ 50 years, n = 62). In Study 2, serological validation was conducted for thoracic OPLL patients (n = 77) and non-OPLL controls (n = 101) in a nationwide multicenter study in Japan. Results: The BDHQ showed that the early-onset OPLL patients had significantly lower intakes of vitamins A and B6 than non-OPLL controls. These results were validated by lower serum vitamins A and B6 levels in the early-onset thoracic OPLL patients. The severity of OPLL negatively correlated with serum vitamin A levels in male early-onset OPLL patients. The multiple regression analysis revealed that the severity of thoracic OPLL had an association with onset age and serum vitamin A level. Conclusions: Vitamin A deficiency resulting from unbalanced dietary habits is associated with exacerbation of male early-onset OPLL.
- Published
- 2022