43 results on '"D'Amore M."'
Search Results
2. Factors Associated With Real-Life Functioning in Persons With Schizophrenia in a 4-Year Follow-up Study of the Italian Network for Research on Psychoses
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Mucci, A., Galderisi, S., Gibertoni, D., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Blasi, G., Brasso, C., Bucci, P., Carpiniello, B., Cuomo, A., Dell'Osso, L., Giordano, G. M., Marchesi, C., Monteleone, P., Niolu, C., Oldani, L., Pettorruso, M., Pompili, M., Roncone, R., Rossi, R., Tenconi, E., Vita, A., Zeppegno, P., Maj, M., Piegari, G., Aiello, C., Brando, F., Giuliani, L., Palumbo, D., Coccia, C., Papalino, M., Calia, V., Romano, R., Barlati, S., Deste, G., Valsecchi, P., Pinna, F., Lai, A., Lostia di Santa Sofia, S., Salvina Signorelli, M., Fusar Poli, L., Surace, T., Martinotti, G., Montemitro, C., Fraticelli, S., Altamura, M., Angelini, E., Elia, A., Calcagno, P., Belvederi Murri, M., Cattedra, S., Pacitti, F., Talevi, D., Socci, V., Giusti, L., Salza, A., Mammarella, S., de Bartolomeis, A., Favaro, A., Collantoni, E., Meneguzzo, P., Tonna, M., Ossola, P., Gerra, M. L., Gramaglia, C., Binda, V., Gambaro, E., Carmassi, C., Carpita, B., Cremone, I. M., Corrivetti, G., Cascino, G., Del Buono, G., Brugnoli, R., Comparelli, A., Corigliano, V., Buzzanca, A., Gerardi, N., Frascarelli, M., Fagiolini, A., Goracci, A., Bolognesi, S., Siracusano, A., Di Lorenzo, G., Ribolsi, M., Montemagni, C., Riccardi, C., Del Favero, E., Mucci, A., Galderisi, S., Gibertoni, D., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Blasi, G., Brasso, C., Bucci, P., Carpiniello, B., Cuomo, A., Dell'Osso, L., Giordano, G. M., Marchesi, C., Monteleone, P., Niolu, C., Oldani, L., Pettorruso, M., Pompili, M., Roncone, R., Rossi, R., Tenconi, E., Vita, A., Zeppegno, P., Maj, M., Mucci A., Galderisi S., Gibertoni D., Rossi A., Rocca P., Bertolino A., Aguglia E., Amore M., Bellomo A., Biondi M., Blasi G., Brasso C., Bucci P., Carpiniello B., Cuomo A., Dell'Osso L., Giordano G.M., Marchesi C., Monteleone P., Niolu C., Oldani L., Pettorruso M., Pompili M., Roncone R., Rossi R., Tenconi E., Vita A., Zeppegno P., and Maj M.
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Adult ,Hospitals, Psychiatric ,Male ,Mental Health Services ,Social Cognition ,Apathy ,Psychological intervention ,Relapse prevention ,schizophrenia ,functioning ,psychopatology ,Structural equation modeling ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,Cognitive Dysfunction ,Female ,Follow-Up Studies ,Independent Living ,Italy ,Middle Aged ,Psychotic Disorders ,Schizophrenia ,Functional Status ,Original Investigation ,business.industry ,Mental health ,Hospitals ,Cognitive training ,030227 psychiatry ,Psychiatry and Mental health ,Settore MED/25 ,schizophrenia, real-life functioning, SEM ,Psychiatric ,Work Skills ,business ,Psychosocial ,030217 neurology & neurosurgery ,Psychopathology ,Clinical psychology - Abstract
Importance: The goal of schizophrenia treatment has shifted from symptom reduction and relapse prevention to functional recovery; however, recovery rates remain low. Prospective identification of variables associated with real-life functioning domains is essential for personalized and integrated treatment programs. Objective: To assess whether baseline illness-related variables, personal resources, and context-related factors are associated with work skills, interpersonal relationships, and everyday life skills at 4-year follow-up. Design, Setting, and Participants: This multicenter prospective cohort study was conducted across 24 Italian university psychiatric clinics or mental health departments in which 921 patients enrolled in a cross-sectional study were contacted after 4 years for reassessment. Recruitment of community-dwelling, clinically stable persons with schizophrenia was conducted from March 2016 to December 2017, and data were analyzed from January to May 2020. Main Outcomes and Measures: Psychopathology, social and nonsocial cognition, functional capacity, personal resources, and context-related factors were assessed, with real-life functioning as the main outcome. Structural equation modeling, multiple regression analyses, and latent change score modeling were used to identify variables that were associated with real-life functioning domains at follow-up and with changes from baseline in these domains. Results: In total, 618 participants (427 male [69.1%]; mean [SD] age, 45.1 [10.5] years) were included. Five baseline variables were directly associated with real-life functioning at follow-up: neurocognition with everyday life (β, 0.274; 95% CI, 0.207-0.341; P
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- 2021
3. Lightweight aggregates from waste materials: reappraisal of expansion behavior and prediction schemes for bloating
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Dondi, M., Cappelletti, P., D'Amore, M., de Gennaro, R., Graziano, S.F., Langella, A., Raimondo, M., and Zanelli, C.
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Concrete -- Analysis -- Mechanical properties ,Aggregates (Building materials) -- Analysis -- Mechanical properties ,Building materials -- Analysis -- Mechanical properties ,Business ,Construction and materials industries - Abstract
ABSTRACT There is a growing concern on lightweight aggregates (LWA) for recycling of waste materials: this manufacturing technology is considered a flexible tool to make it possible the conversion of [...]
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- 2016
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4. How to improve the physical health of people with severe mental illness? A multicentric randomized controlled trial on the efficacy of a lifestyle group intervention
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Luciano, M, Sampogna, G, Amore, M, Andriola, I, Calcagno, P, Carmassi, C, Del Vecchio, V, Dell'Osso, L, Di Lorenzo, G, Gelao, B, Giallonardo, V, Rossi, A, Rossi, R, Siracusano, A, Fiorillo, A, Lifestyle working group, Bianciardi, E, Niolu, C, Luciano, M., Sampogna, G., Amore, M., Andriola, I., Calcagno, P., Carmassi, C., Del Vecchio, V., Dell'Osso, L., Di Lorenzo, G., Gelao, B., Giallonardo, V., Rossi, A., Rossi, R., Siracusano, A., and Fiorillo, A.
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lifestyle ,medicine.medical_specialty ,Bipolar Disorder ,Severe Mental Disorders ,HOMA-IR index ,Comorbidity ,law.invention ,BMI ,Randomized controlled trial ,law ,Humans ,Medicine ,Homa index ,Framingham risk score ,RCT ,severe mental disorders ,waist circumference ,Life Style ,Mental Disorders ,Psychotic Disorders ,Schizophrenia ,Framingham Risk Score ,business.industry ,Physical health ,medicine.disease ,Mental illness ,Psychiatry and Mental health ,severe mental disorder ,Settore MED/25 ,Physical therapy ,Group intervention ,business ,Research Article - Abstract
Background People with severe mental illnesses (SMI) have a mortality rate two times higher compared to the general population, with a decade of years of life lost. In this randomized controlled trial (RCT), we assessed in a sample of people with bipolar disorder, major depressive disorder, and schizophrenia spectrum disorder, the efficacy of an innovative psychosocial group intervention compared to a brief psychoeducational group intervention on patients’ body mass index (BMI), body weight, waist circumference, Framingham and HOMA-IR indexes. Methods This is a multicentric RCT with blinded outcome assessments carried out in six Italian university centers. After recruitment patients were randomized to receive a 6-month psychosocial intervention to improve patients’ physical health or a brief psychoeducational intervention. All recruited patients were assessed with standardized assessment instruments at baseline and after 6 months. Anthropometric parameters and blood samples have also been collected. Results Four-hundred and two patients with a diagnosis of bipolar disorder (43.3%), schizophrenia or other psychotic disorder (29.9%), or major depression (26.9%) were randomly allocated to the experimental (N = 206) or the control group (N = 195). After 6 months, patients from the experimental group reported a significant reduction in BMI (odds ratio [OR]: 1.93, 95% confidence intervals [CI]: 1.31–2.84; p p p Conclusions The experimental group intervention was effective in improving the physical health in SMI patients. Further studies are needed to evaluate the feasibility of this intervention in real-world settings.
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- 2021
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5. Prevalence of antipsychotic-induced extrapyramidal symptoms and their association with neurocognition and social cognition in outpatients with schizophrenia in the 'real-life'
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Monteleone, P., Cascino, G., Monteleone, A. M., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Collantoni, E., Corrivetti, G., Cuomo, A., Bellomo, A., D'Ambrosio, E., Dell'Osso, L., Frascarelli, M., Giordano, G. M., Giuliani, L., Marchesi, C., Montemagni, C., Oldani, L., Pinna, F., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Galderisi, S., Maj, M., Del Buono, G., Marciello, F., Di Palo, P., Sangiuliano, M., Di Gioia, C., Barlati, S., Deste, G., Turrina, C., Carpiniello, B., Marras, L., Muscas, M., Bucci, P., Piegari, G., Brando, F., Aiello, C., Poli, L. F., Saitta, G., Surace, T., Altamura, M., Malerba, S., Padalino, F., Calcagno, P., Murri, M. B., Escelsior, A., Giusti, L., Bianchini, V., Salza, A., Pacitti, F., Socci, V., Lucaselli, A., De Bartolomeis, A., Gramaglia, C., Feggi, A., Jona, A., Favaro, A., Tenconi, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Cremone, I. M., Carpita, B., Biondi, M., Di Fabio, F., Accinni, T., Brugnoli, R., Comparelli, A., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Ribolsi, M., Niolu, C., Brasso, C., Riccardi, C., Del Favero, E., Monteleone, P., Cascino, G., Monteleone, A. M., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Collantoni, E., Corrivetti, G., Cuomo, A., Bellomo, A., D'Ambrosio, E., Dell'Osso, L., Frascarelli, M., Giordano, G. M., Giuliani, L., Marchesi, C., Montemagni, C., Oldani, L., Pinna, F., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Galderisi, S., and Maj, M.
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Adult ,Male ,Social Cognition ,Extrapyramidal symptoms ,Chlorpromazine ,medicine.medical_treatment ,Antipsychotic ,03 medical and health sciences ,0302 clinical medicine ,Cognition ,Basal Ganglia Diseases ,Social cognition ,Prevalence ,Medicine ,Antipsychotics ,Humans ,Extrapyramidal symptom ,Neurocognition ,Biological Psychiatry ,Pharmacology ,business.industry ,Parkinsonism ,Middle Aged ,medicine.disease ,Risperidone ,030227 psychiatry ,Settore MED/25 ,Schizophrenia ,Female ,Schizophrenic Psychology ,medicine.symptom ,business ,Neurocognitive ,Antipsychotic Agents ,Psychopathology ,Clinical psychology - Abstract
First generation antipsychotics (FGAs) are more likely to induce extrapyramidal side-effects (EPS) than second generation antipsychotics (SGAs), and EPS have been shown associated to cognitive deficits in schizophrenia. So far, no study has explored the relationships between EPS and social cognition (SC) in people with schizophrenia. Therefore, we assessed the prevalence of EPS in a large sample of drug-treated community-dwelling persons with schizophrenia and explored their relationships with patients' neurocognitive and SC abilities. 875 patients underwent EPS, psychopathological, neurocognitive and SC assessments by means of standardized measures. Relationships between EPS, psychopathology and neurocognitive and SC measures were investigated by correlation tests. Moreover, a partial correlation network was computed by means of a network analysis. 256 patients were treated with FGAs alone or in combination with SGA and 619 with SGAs. EPS were significantly more frequent in FGA-treated group than in the SGA-treated one. Patients with EPS disclosed a more severe psychopathology and were more impaired in neurocognitive and SC measures compared to those without EPS. Disorganization, expressive deficit, and duration of illness were significantly associated to both neurocognitive and SC measures while EPS were associated to neurocognitive measures only. The network analysis showed that parkinsonism was the sole EPS directly connected to both psychopathological and neurocognitive indices whereas no direct connection emerged between EPS and SC measures. Present findings confirm that EPS are still present in the era of SGAs and contribute, together with other clinical variables, to the neurocognitive but not to the SC impairment of patients with schizophrenia.
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- 2021
6. The impact of clinical and social factors on the physical health of people with severe mental illness: Results from an Italian multicentre study
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Luciano, M, Sampogna, G, Del Vecchio, V, Giallonardo, V, Palummo, C, Andriola, I, Amore, M, Rossi, R, Carmassi, C, Siracusano, A, Fiorillo, A, De Rosa, C, Giannelli, L, Malangone, C, Pocai, B, Zinno, F, Sangiuliano, M, Di Gioia, C, Calcagno, P, Serafini, G, Pacitti, F, Rossi, A, Pedrinelli, V, Cordone, A, Di Lorenzo, G, Niolu, C, Luciano, M., Sampogna, G., Del Vecchio, V., Giallonardo, V., Palummo, C., Andriola, I., Amore, M., Rossi, R., Carmassi, C., Siracusano, A., and Fiorillo, A.
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medicine.medical_specialty ,Social Stigma ,Social Factor ,Comorbidity ,HOMA index ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Humans ,Medicine ,Bipolar disorder ,Social Factors ,Psychiatry ,Biological Psychiatry ,Hospitalizations ,Depressive Disorder ,Depressive Disorder, Major ,business.industry ,Mental Disorders ,Major ,medicine.disease ,Mental illness ,030227 psychiatry ,Hospitalization ,Mental disorder ,Stigma ,Psychiatry and Mental health ,Settore MED/25 ,Italy ,Schizophrenia ,Quality of Life ,Anxiety ,Framingham risk score ,medicine.symptom ,business ,Mental disorders ,Quality of life ,Psychosocial ,030217 neurology & neurosurgery ,Human ,Psychopathology - Abstract
Our manuscript aims to: 1) assess physical health in a sample of patients with severe mental disorders; and 2) identify the psychopathological and psychosocial characteristics associated with an increased likelihood of having a poor physical health. The study, funded by the Italian Ministry of Education, has been carried out in psychiatric outpatient units of six Italian University sites. All recruited patients have been assessed through standardized assessment instruments. Moreover, anthropometric parameters have been obtained at recruitment and a blood samples have been collected to assess cardiometabolic parameters. Four-hundred and two patients with a primary diagnosis of bipolar disorder (43.3%), schizophrenia or other psychotic disorder (29.9%), or major depression (26.9%) were recruited. Internalized stigma, psychosocial functioning, quality of life, psychiatric hospitalizations, depressive/anxiety and manic symptoms and cognition were those domains more strongly associated with poor metabolic parameters, including high body mass index, HOMA and Framingham indexes and waist circumference. There were no statistically significant differences among the three diagnostic groups. Our findings highlight the importance of perceived stigma and quality of life on patients’ physical health. This should be taken into account when developing plans for reducing the mortality rate in patients with severe mental disorders.
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- 2021
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7. Magnetic shielding of apertures loaded by resistive coating
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D'Amore, M., De Santis, V., and Feliziani, M.
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Finite element method -- Usage ,Impedance (Electricity) -- Measurement ,Magnetic shielding -- Analysis ,Power lines -- Design and construction ,Business ,Electronics ,Electronics and electrical industries - Published
- 2010
8. Fast transient analysis of next-generation interconnects based on carbon nanotubes
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D'Amore, M., Sarto, M.S., and Tamburrano, A.
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Delay lines -- Analysis ,Interconnected electric utility systems -- Design and construction ,International interconnected electric utility systems -- Design and construction ,Nanotubes -- Electric properties ,Nanotubes -- Usage ,Power lines -- Design and construction ,Complementary metal oxide semiconductors -- Usage ,Business ,Computers ,Electronics ,Electronics and electrical industries - Published
- 2010
9. Progress review of electromagnetic compatibility analysis technologies for packages, printed circuit boards, and novel interconnects
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Er-Ping Li, Xing-Chang Wei, Cangellaris, A.C., En-Xiao Liu, Yao-Jiang Zhang, D'Amore, M., Joungho Kim, and Sudo, T.
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Electromagnetic compatibility -- Analysis ,Integrated circuits -- Design and construction ,Semiconductor chips -- Design and construction ,Circuit printing -- Innovations ,Printed circuits -- Innovations ,Mobile communication systems -- Analysis ,Wireless communication systems -- Analysis ,Standard IC ,Printed circuit board ,Wireless technology ,Business ,Computers ,Electronics ,Electronics and electrical industries - Published
- 2010
10. The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study
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Vita, A., Barlati, S., Deste, G., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Carpiniello, B., Collantoni, E., Cuomo, A., D'Ambrosio, E., dell' Osso, L., di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Zeppegno, P., Nibbio, G., Galderisi, S., Maj, M., Ceraso, A., Galluzzo, A., Lisoni, J., Di Palo, P., Papalino, M., Romano, R., Pinna, F., Lai, A., di Santa Sofia, S. L., Bucci, P., Piegari, G., Brando, F., Giuliani, L., Signorelli, M. S., Poli, L. F., Martinotti, G., Pettorruso, M., Montemitro, C., Altamura, M., Malerba, S., Padalino, F., Amerio, A., Cal-Cagno, P., Zampogna, D., Giusti, L., Salza, A., Mammarella, S., Pacitti, F., Socci, V., Talevi, D., Gramaglia, C., Feggi, A., Jona, A., Favaro, A., Tenconi, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Gesi, C., Carpita, B., Corrivetti, G., Cascino, G., del Buono, G., Di Fabio, F., Buzzanca, A., Girardi, N., Brugnoli, R., Comparelli, A., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Niolu, C., Ribolsi, M., Brasso, C., Riccardi, C., Del Favero, E., Vita, A., Barlati, S., Deste, G., Rocca, P., Rossi, A., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Carpiniello, B., Collantoni, E., Cuomo, A., D'Ambrosio, E., dell' Osso, L., di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Zeppegno, P., Nibbio, G., Galderisi, S., Maj, M., Ceraso, A., Galluzzo, A., Lisoni, J., Di Palo, P., Papalino, M., Romano, R., Pinna, F., Lai, A., di Santa Sofia, S. L., Bucci, P., Piegari, G., Brando, F., Giuliani, L., Signorelli, M. S., Poli, L. F., Martinotti, G., Pettorruso, M., Montemitro, C., Altamura, M., Malerba, S., Padalino, F., Amerio, A., Cal-Cagno, P., Zampogna, D., Giusti, L., Salza, A., Mammarella, S., Pacitti, F., Socci, V., Talevi, D., Gramaglia, C., Feggi, A., Jona, A., Favaro, A., Tenconi, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Gesi, C., Carpita, B., Corrivetti, G., Cascino, G., del Buono, G., Di Fabio, F., Buzzanca, A., Girardi, N., Brugnoli, R., Comparelli, A., Corigliano, V., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Niolu, C., Ribolsi, M., Brasso, C., Riccardi, C., and Del Favero, E.
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schizophrenia ,autism spectrum disorders ,cognition ,psychosocial functioning ,social cognition ,Adult ,Male ,Social Cognition ,Interpersonal Relation ,autism spectrum disorders, cognition, psychosocial functioning, schizophrenia, social cognition ,Disease ,Autism spectrum disorders ,Cognition ,Psychosocial functioning ,Schizophrenia ,Social cognition ,Psychotic Disorder ,behavioral disciplines and activities ,03 medical and health sciences ,Interpersonal relationship ,0302 clinical medicine ,mental disorders ,Medicine ,Humans ,Interpersonal Relations ,Autism spectrum disorder ,Autistic Disorder ,business.industry ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Multicenter study ,Settore MED/25 ,Italy ,Psychotic Disorders ,Autism ,Female ,Verbal memory ,business ,030217 neurology & neurosurgery ,Research Article ,Clinical psychology ,Human - Abstract
Background Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic disorder but their relationships with cognitive aspects and functional outcomes of the disease remain to be addressed in large samples of individuals. Aims To investigate the clinical, cognitive, and functional correlates of ASD symptoms in a large sample of people diagnosed with schizophrenia. Methods The severity of ASD symptoms was measured with the PANSS Autism Severity Scale (PAUSS) in 921 individuals recruited for the Italian Network for Research on Psychoses multicenter study. Based on the PAUSS scores, three groups of subjects were compared on a wide array of cognitive and functional measures. Results Subjects with more severe ASD symptoms showed a poorer performance in the processing speed (p = 0.010), attention (p = 0.011), verbal memory (p = 0.035), and social cognition (p = 0.001) domains, and an overall lower global cognitive composite score (p = 0.010). Subjects with more severe ASD symptoms also showed poorer functional capacity (p = 0.004), real-world interpersonal relationships (p p Conclusions These findings strengthen the notion that ASD symptoms may have a relevant impact on different aspects of the disease, crucial to the life of people with schizophrenia. Prominent ASD symptoms may characterize a specific subpopulation of individuals with SSD.
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- 2020
11. Studying the Composition and Mineralogy of the Hermean Surface with the Mercury Radiometer and Thermal Infrared Spectrometer (MERTIS) for the BepiColombo Mission: An Update
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Hiesinger, H, Helbert, J, Alemanno, G, Bauch, KE, D’Amore, M, Maturilli, A, Morlok, A, Reitze, MP, Stangarone, C, Stojic, AN, Varatharajan, I, Weber, I, Arnold, G, Banaszkiewicz, M, Bauch, K, Benkhoff, J, Bischoff, A, Blecka, M, Bowles, N, Calcutt, S, Colangeli, L, Erard, S, Fonti, S, Greenhagen, BT, Groussain, O, Hirsch, H, Jahn, J, Killen, R, Knollenberg, J, Kührt, E, Lorenz, E, Mann, I, Mall, U, Moroz, L, Peter, G, Rataj, M, Robinson, M, Skrbek, W, Spohn, T, Sprague, A, Stöffler, D, Stojic, A, Taylor, F, Venus, H, Warrell, J, and Walter, I
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Spectral signature ,Radiometer ,Spectrometer ,Spacecraft ,business.industry ,BepiColombo ,MERTIS instrument ,Mineralogy ,Astronomy and Astrophysics ,Mercury ,Space weathering ,law.invention ,Orbiter ,Planetary science ,Space and Planetary Science ,Planet ,law ,Environmental science ,business ,Spectroscopy - Abstract
Launched onboard the BepiColombo Mercury Planetary Orbiter (MPO) in October 2018, the Mercury Radiometer and Thermal Infrared Spectrometer (MERTIS) is on its way to planet Mercury. MERTIS consists of a push-broom IR-spectrometer (TIS) and a radiometer (TIR), which operate in the wavelength regions of 7-14 μm and 7-40 μm, respectively. This wavelength region is characterized by several diagnostic spectral signatures: the Christiansen feature (CF), Reststrahlen bands (RB), and the Transparency feature (TF), which will allow us to identify and map rock-forming silicates, sulfides as well as other minerals. Thus, the instrument is particularly well-suited to study the mineralogy and composition of the hermean surface at a spatial resolution of about 500 m globally and better than 500 m for approximately 5-10% of the surface. The instrument is fully functional onboard the BepiColombo spacecraft and exceeds all requirements (e.g., mass, power, performance). To prepare for the science phase at Mercury, the team developed an innovative operations plan to maximize the scientific output while at the same time saving spacecraft resources (e.g., data downlink). The upcoming fly-bys will be excellent opportunities to further test and adapt our software and operational procedures. In summary, the team is undertaking action at multiple levels, including performing a comprehensive suite of spectroscopic measurements in our laboratories on relevant analog materials, performing extensive spectral modeling, examining space weathering effects, and modeling the thermal behavior of the hermean surface.
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- 2020
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12. Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition
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Bucci, P., Galderisi, S., Mucci, A., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Andriola, I., Bellomo, A., Biondi, M., Cuomo, A., Dell'Osso, L., Favaro, A., Gambi, F., Giordano, G. M., Girardi, P., Marchesi, C., Monteleone, P., Montemagni, C., Niolu, C., Oldani, L., Pacitti, F., Pinna, F., Roncone, R., Vita, A., Zeppegno, P., Maj, M., Patriarca, Sara, Pietrafesa, Daria, Aiello, Carmen, Longo, Luisa, Barone, Marina, Romano, Raffaella, Atti, Anna Rita, Barlati, Stefano, Deste, Giacomo, Valsecchi, Paolo, Carpiniello, Bernardo, Tusconi, Massimo, Puddu, Laura, Signorelli, Maria Salvina, Cannavò, Dario, Minutolo, Giuseppe, Corbo, Mariangela, Montemitro, Chiara, Baroni, Gaia, Altamura, Mario, La Montagna, Maddalena, Carnevale, Raffaella, Murri, Martino Belvederi, Calcagno, Pietro, Bugliani, Michele, Pizziconi, Giulia, Logozzo, Francesca, Rossi, Rodolfo, Giusti, Laura, Salza, Anna, Malavolta, Maurizio, Orsenigo, Giulia, Grassi, Silvia, De Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Gambaro, Eleonora, Tenconi, Elena, Ferronato, Luisa, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Carmassi, Claudia, Cremone, Ivan Mirko, Carpita, Barbara, Buzzanca, Antonio, Girardi, Nicoletta, Frascarelli, Marianna, Del Casale, Antonio, Comparelli, Anna, Corigliano, Valentina, Siracusano, Alberto, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Del Buono, Gianfranco, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Mancini, Irene, Bava, Irene, Cardillo, Simona, Bucci P., Galderisi S., Mucci A., Rossi A., Rocca P., Bertolino A., Aguglia E., Amore M., Andriola I., Bellomo A., Biondi M., Cuomo A., dell'Osso L., Favaro A., Gambi F., Giordano G.M., Girardi P., Marchesi C., Monteleone P., Montemagni C., Niolu C., Oldani L., Pacitti F., Pinna F., Roncone R., Vita A., Zeppegno P., Maj M., Patriarca S., Pietrafesa D., Aiello C., Longo L., Barone M., Romano R., Atti A.R., Barlati S., Deste G., Valsecchi P., Carpiniello B., Tusconi M., Puddu L., Signorelli M.S., Cannavo D., Minutolo G., Corbo M., Montemitro C., Baroni G., Altamura M., La Montagna M., Carnevale R., Murri M.B., Calcagno P., Bugliani M., Pizziconi G., Logozzo F., Rossi R., Giusti L., Salza A., Malavolta M., Orsenigo G., Grassi S., De Bartolomeis A., Gramaglia C., Gattoni E., Gambaro E., Tenconi E., Ferronato L., Collantoni E., Tonna M., Ossola P., Gerra M.L., Carmassi C., Cremone I.M., Carpita B., Buzzanca A., Girardi N., Frascarelli M., Del Casale A., Comparelli A., Corigliano V., Siracusano A., Di Lorenzo G., Ribolsi M., Corrivetti G., Bartoli L., Del Buono G., Fagiolini A., Bolognesi S., Goracci A., Mancini I., Bava I., Cardillo S., Bucci, P., Galderisi, S., Mucci, A., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Andriola, I., Bellomo, A., Biondi, Maria, Cuomo, Anna, Dell'Osso, L., Favaro, A., Gambi, F., Giordano, G. M., Girardi, P., Marchesi, C., Monteleone, P., Montemagni, C., Niolu, C., Oldani, L., Pacitti, F., Pinna, F., Roncone, R., DE VITA, Anna, Zeppegno, P., Maj, M., Patriarca, Sara, Pietrafesa, Daria, Aiello, Carmen, Longo, Luisa, Barone, Marina, Romano, Raffaella, Atti, Anna Rita, Barlati, Stefano, Deste, Giacomo, Valsecchi, Paolo, Carpiniello, Bernardo, Tusconi, Massimo, Puddu, Laura, Signorelli, Maria Salvina, Cannavò, Dario, Minutolo, Giuseppe, Corbo, Mariangela, Montemitro, Chiara, Baroni, Gaia, Altamura, Mario, La Montagna, Maddalena, Carnevale, Raffaella, Murri, Martino Belvederi, Calcagno, Pietro, Bugliani, Michele, Pizziconi, Giulia, Logozzo, Francesca, Rossi, Rodolfo, Giusti, Laura, Salza, Anna, Malavolta, Maurizio, Orsenigo, Giulia, Grassi, Silvia, De Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Gambaro, Eleonora, Tenconi, Elena, Ferronato, Luisa, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Carmassi, Claudia, Cremone, Ivan Mirko, Carpita, Barbara, Buzzanca, Antonio, Girardi, Nicoletta, Frascarelli, Marianna, Del Casale, Antonio, Comparelli, Anna, Corigliano, Valentina, Siracusano, Alberto, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Del Buono, Gianfranco, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Mancini, Irene, Bava, Irene, Cardillo, Simona, Biondi, M., Cuomo, A., Vita, A., and Casale, Antonio
- Subjects
Male ,avolition ,Severity of Illness Index ,cognitive functioning ,0302 clinical medicine ,Cognition ,Academic Performance ,Medicine ,Psychopathology ,Depression ,primary negative symptoms ,Middle Aged ,Psychiatric Status Rating Scale ,avolition, cognitive functioning, poor emotion expression, premorbid adjustment, primary negative symptoms ,poor emotion expression ,premorbid adjustment ,Psychiatry and Mental Health ,Memory, Short-Term ,Schizophrenia ,Female ,Schizophrenic Psychology ,medicine.symptom ,Psychosocial ,Social Adjustment ,Clinical psychology ,Human ,Adult ,primary negative symptom ,03 medical and health sciences ,Cognition Disorder ,Memory ,Social cognition ,Humans ,Cognitive Dysfunction ,Cognitive skill ,Social Behavior ,Aged ,Cognition Disorders ,Motivation ,Psychiatric Status Rating Scales ,Settore MED/25 - Psichiatria ,Avolition ,business.industry ,medicine.disease ,030227 psychiatry ,Short-Term ,business ,Neurocognitive ,030217 neurology & neurosurgery - Abstract
Objective The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. Method Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored. Results We found an impairment of academic and social PA in patients (P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives (P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real-life functioning (P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real-life functioning impairment (P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition (P ≤ 0.000001). Conclusion Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs.
- Published
- 2018
13. Digital transmission performance of carrier channels on distribution power line networks
- Author
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D'Amore, M. and Sarto, M.S.
- Subjects
Power lines -- Carrier transmission ,Digital communications -- Research ,Broadband transmission -- Research ,Business ,Computers ,Electronics ,Electronics and electrical industries - Abstract
The analysis of the transmitting features of wire-to-ground and wire-to-wire carrier channels on power distribution networks is performed both in the frequency- and in the time-domain. A new formulation of the lossy ground return parameters is considered, which applies in a wide frequency-range and in case of poorly conductive soil. The sensitivity of the frequency-spectra and longitudinal profiles of the transmitted voltages to the distribution system configuration, load termination and ground resistivity is investigated. The eye-diagram approach is used in order to ascertain the transmission quality of carrier channels on tree- and mesh-type networks, in case of high capacity digital signals.
- Published
- 1997
14. Electromagnetic field radiated from broadband signal transmission on power line carrier channels
- Author
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D'Amore, M. and Sarto, M.
- Subjects
Power lines -- Carrier transmission ,Electromagnetic fields -- Measurement ,Electromagnetic radiation -- Measurement ,Electromagnetic interference -- Measurement ,Wave equation -- Numerical solutions ,Spread spectrum communications -- Research ,Broadband transmission -- Research ,Business ,Computers ,Electronics ,Electronics and electrical industries - Abstract
A rigorous procedure is presented for the evaluation of the rectangular components of the electromagnetic field radiated by excited carrier channels on multiconductor overhead power lines above a lossy ground. The proposed full wave approach, based on the use of Hertz potentials, allows to carry out the high-frequency analysis of a spread spectrum transmission system. Field sources are the current traveling along the line, which are evaluated by means of an accurate line simulation model including the ground return parameters, obtained by removing the Carson quasi-static hypotheses. The frequency-spectra and the lateral profiles of the field components radiated from wire-to-ground and wire-to-wire channels on a three-conductor distribution line are computed in a frequency-range up to 20 MHz.
- Published
- 1997
15. A new formulation of lossy ground return parameters for transient analysis of multiconductor dissipative lines
- Author
-
D'Amore, M., Sarto, M.S., and Pettersson, Per
- Subjects
Transients (Electricity) -- Research ,Electric power transmission -- Research ,Business ,Computers ,Electronics ,Electronics and electrical industries - Abstract
A new prediction model of the ground distributed parameters for the transient analysis of multiconductor lines is proposed, which applies in a wide frequency range and/or high ground resistivity. The obtained formulation, basing on a rigorous procedure, is simple to handle for implementation in a computer code. The comparison between the developed approach and the Carson model is carried out in order to define analytically the differences concerning the expressions of the line parameters. Both the models are applied to the computation of the transient voltages of a power line excited by a current source or an EMP-plane wave.
- Published
- 1997
16. A new efficient procedure for the transient analysis of dissipative power networks with nonlinear loads
- Author
-
D'Amore, M. and Sarto, M.S.
- Subjects
Electric power systems -- Models ,Electric power system stability -- Analysis ,Transients (Electricity) -- Models ,Business ,Computers ,Electronics ,Electronics and electrical industries - Abstract
A new procedure, based on a combined frequency- and time-domain approach, is presented for the transient analysis of dissipative power networks with nonlinear loads described by monotone characteristics. Special care is paid to the solution of the network transient equations in case the line-sections are closed on protective devices such as varistors. Networks excited by transient internal sources or external electromagnetic fields are analysed. A simple procedure is implemented to include the simulation of coupling phenomena in the Electromagnetic Transient Program (EMTP). Applications are carried out to predict transient voltages and currents in medium-voltage power networks.
- Published
- 1996
17. Telecommunication systems on power distribution networks: high frequency performances of carrier channels
- Author
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Cortina, R., Pioltini, G., Celozzi, S., and D'Amore, M.
- Subjects
Telecommunication systems -- Innovations ,Power lines -- Research ,Electric power distribution -- Research ,Business ,Computers ,Electronics ,Electronics and electrical industries - Abstract
In the framework of a project aimed at the design and installation of a new extensive Distribution Automation System in the ENEL S.p.A. (Italian National Electricity Company) distribution network, this paper presents the investigations carried out to check the feasibility of a line carrier system on the primary (medium voltage 10-30 kV) network. In particular, this paper reports the experimental investigations conducted in the laboratory on various network components, to assess their behavior in the 20-100 kHz frequency range, and some signal transmission tests on real networks. Analytical procedures to predict the high frequency signal propagation in the network, set up for this purpose, are also described. The results of their applications to various network configurations are used as a guide for the optimal design of the power carrier communication system.
- Published
- 1994
18. The management of acute venous thromboembolism in clinical practice - study rationale and protocol of the European PREFER in VTE Registry
- Author
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Agnelli, G., Gitt, A. K., Bauersachs, R., Fronk, E. -M., Laeis, P., Mismetti, P., Monreal, M., Willich, S. N., Wolf, W. -P., Cohen, A. T., Brodmann, M., Rief, P., Eischer, L., Stoshikj, S., Hirschl, M., Weinmann, S., Marschang, P., Abbadie, F., Achkar, A., Addala, A., Adnet, F., Alexandra, J. -F., Aquilanti, S., Belhassane, A., Benaroya, A., Berremili, T., Grenot, M. C., Birr, V., Holtea, D., Bonnin, C., Bosler, F., Durand, M. -G. B., Brisot, D., Brousse, C., De La Fuente, T., Cayman, R., Cazaubon, M., Champion, O., Chanut, M., Chevalet, P., Connault, J., Durant, C., Constans, J., Cordeanu, M., Couturaud, F., Lacut, K., De Dedker, L., Decoulx, E., Derrien, B., Diamand, J. -M., Diard, A., Douadi, Y., Dupas, S., Remond, S. S. M., Sevestre, M. -A., Edhery, S., Falvo, N., Taralunga, C. F., Ferrari, E., Gaillard, C., Garrigues, D., Gillet, J. L., Giordana, P., Grange, C., Vital-Durand, D., Grare, F., Henni, A. H., Heuser, S., Schmidt, J., Hidden-Henic, V., Hottin, D., Imbert, B., Pernod, G., Jakob, D., Jacquinandi, V., Jurus, C., Lacoste, A., Laroche, J. -P., Martin, M., Mazollier, C., Mersel, T., Miserey, G., Nedey, C., Nou, M., Quere, I., Ouvry, P., Peuch, B., Pichot, O., Poulain, V., Ray, P., Rifai, A., Roy, P. -M., Saby, J. -C., Simon, F., Simonot-Lalandec, E., Stephan, D., Tissot, A., Vodoungnon, H., Adamczyk, A., Schnabl, S., Ahmad, W. A., Weber, H., Axthelm, C., Bergmann, K., Beschorner, U., Knittel, M., Binias, K. -H., Pasligh, M., Boral, M., Friederike, G., Bratsch, H., Brauer, G., Burghard, S., Demann, C., Rennebaum, C., Demmig, A., Eberlein, U., Enger, F., Eschenburg, J., Forkmann, L., Frank, J., Freischmidt, H., Gassauer, M., Fritsche, I., Kubicek-Hofmann, C., Goebels, M. -C., Guggenbichler, S., Hartel, D., Hartmann, K., Heilberger, P., Heinsius, A., Held, M., Schnupp, S., Herman, G., Herold, J., Hertrich, F., Hommel, H., Hutte, G., Kalka, C., Jungandreas, K., Ramthor, M., Karcher, J., Werner, N., Karl-Wollweber, S., Keilhau, D. -A., Kittel, K., Knolinski, T., Kohler, C., Werth, S., Kopplin, U., Korner, I., Wittig, K., Kroger, K., Moysidis, T., Kroschel, U., Leschke, M., zur Nieden, T., Lubbert, G., Lutz, A., Wucherpfennig, P., Marencke, G. -H., Mortensen, K., Reppel, M., Nelles, H., Nestler, K., Neumeister, A., Schlosser, A., Oettler, W., Ott, I., Otto, A., Pertermann, A., Pfister, R., Pindur, L., Pourhassan, S., Predel, D., Pudollek, T., Reimer, D., Richter, C., Rieker, E., Rothenbucher, G., Rothhagen, B., Rudolff, S., Stucker, M., Schafer, A., Sonnenschein, K., Schafnitzl, W., Schellong, S., Voigts, B., Schiller, M., Schmeink, T., Schneider, H., Schon, N., Schulze, M., Sechtem, U., Sedl, S., Werno, H. S., Stachowitz, J., Thieme, M., Tiefenbacher, C., Tsantilas, D., Vieth, P., vom Dahl, J., Grun-Himmelmann, K., von Bilderling, P., von Maltik, T., Weinrich, K., Weyer, M., Koln, E. K., Wirtz, P., Wittig, I., Zierock, P., Ageno, W., Caprioli, M., Rancan, E., Guercini, F., Mommi, V., Amitrano, M., Cannavacciuolo, F., Amore, M., D'Antoni, S., Angelini, E., Forgia, S. L., Antignani, P. L., Calandra, G., Arone, A., Perticone, F., Sciacqua, A., Asaro, G., Bellisi, M., Attanzio, M. T., Pinto, A., Attinasi, V., Cillari, E., Sorvillo, S., Balbarini, A., Santini, C., Violo, C., Banfi, E., Lodigiani, C., Barcellona, D., Delpin, S., Marongiu, S., Barillari, G., Pasca, S, Bartolini, C., Verdecchia, P., Bartone, M., Mancuso, G., Bellanuova, I., Felis, S., Bellizzi, A., Masotti, L., Bianchi, M., Carugati, A., Bianchini, G., Guarnera, G., Boari, B., Gallerani, M., Pasin, M., Bortoluzzi, C., Parisi, R., Brucoli, C., Palasciano, G., Camporese, G., Tonello, C., Canafoglia, L., Rupoli, S., Cancellieri, E., Paoletti, O., Testa, S., Carlizza, A., Carnovali, M., Sada, S., Samaden, A., Casarsa, C., Mearelli, F., Pivetti, G., Catalini, R., Zingaretti, O., Vascolare, M., Cavazza, S., Cosmi, B., Cenci, C., Prisco, D., Silvestri, E., Ceresa, F., Patane, F., Ciampa, A., Siniscalchi, V., Ciarambino, T., De Bartolomeo, G., Clemente, M., Conti, F., Paiella, L., D'Avino, M., D'Alessandro, A., Placentino, M., Sollazzo, V., D'Angelo, A., Vigano, S., De Campora, P., Sangiuolo, R., De Franciscis, S., Serra, R., De Gaudenzi, E., De Santis, F., Piccinni, G. C., De Tommaso, I. D., Di Francesco, L., Vincentelli, G. M., Di Maggio, R., Saccullo, G., Siragusa, S., Di Micco, P., Fontanella, A., Di Michele, D., Di Minno, G., Tufano, A., Di Nisio, M., Porreca, E., Donadio, F., Imberti, D., Enea, I., Fabbian, F., Manfredini, R., Pala, M., Falanga, A., Milesi, V., Fiore, V., Franco, E., Giudice, G., Frausini, G., Rovinelli, M., Fuorlo, M., Landolfi, R., Morretti, T., Gamberini, S., Salmi, R., Ghirarduzzi, A., Veropalumbo, M. R., Ghizzi, M., Pepe, C., Gianniello, F., Martinelli, I., Iosub, D. I., Piovella, F., Iozzi, E., Talerico, A., Regina, M. L., Orlandini, F., Marconi, L., Palla, A., Marcucci, R., Poli, D., Margheriti, R., Sala, G., Marra, A., Marrocco, F., Montagna, E. S., Silvestris, F., Vallarelli, S., Mos, L., Rossetto, V., Mugno, F., Di Salvo, M., Nitti, C., Pennacchioni, M., Salvi, A., Olivieri, O., Tosi, F., Zorzi, F., Onesta, M., Pagliara, V., Villalta, S., Paolucci, G., Severino, S., Pierri, F., Russo, V., Pizzini, A. M., Quintavalla, R., Rubino, P., Ria, L., Schenone, A., Strafino, C., Tropeano, P., Vetrano, A., Zanatta, N., Cansino, M. D. A., Gutierrez, J. A., de las Revillas, F. A., Fernandez, C. A., Mijares, N. C., Blanco-Molina, M. A., Garcia, M. A., Seijo, D. J., Blazquez, R. A., Lopez-Saez, J. -B., Rodrigo, E. A., Blanch, J. V., Arxe, A. A., Dalmau, F. G. -B., Quincoces, A. B., Loizaga, A. G., Perez, J. L. B., Diaz, P. B., Loaiza, A. Q., Castellote, M. C., Alcantara, I. C., Padierna, M. L., Exposito, M. C., Mas, A. C., Castro, F. C., Sanz, R. C., de Saracho, J. O., de la Fuente, E. C., de Ancos Aracil, C., Ruiz, J. R., de Daborenea Gonzalez, M. D., Iglesias, A. F., de la Fuente Aguado, J., Gonzalez, L. G., del Carmen Fernandez-Capitan, M., Hernandez, A. L., del Toro Cervera, J., Rus, G. P., Bregel, J. L. D., Fernandez, F. D., Teresa Elias Hernandez, Palomares, L. J., Bataler, R. F., Rodriguez, J. A. N., Garcia, J. M. G., Porras, J. R. G., Garcia, M. G., Lopez, E. H., Lazaro, A. R., Jaras, M. J., Castro, D. J., Madridejos, R. J. -R., Navas, J. M. P., Lecumberri, R., Martinez, N., Castellanos, G. T. L., Espinosa, L. M., Jimenez, L. L., Cobo, O. M., Saiz, C. M., Pizarro, Y. R., Yglesias, P. J. M., Martin del Pozo, M., Melibovsky, L., Altarriba, E. S., Bosch, M. M., Secades, R. M., Lujan, J. M. M., Mestre, A. R., Moral, P. M., Parra, J. A. T., Flores, A. M., Munoz-Torrero, J. F. S., Rodriguez, F. J. M., Fernandez, M. J. N., Sibajas, E. O., de Sedas, M. V., Caballero, P. P., del Campo, I. P. M., Sanchez, J. P., Gallego, A. R., Alvarez, I. V., Beltran, E. M. R., Fuentes, D. S., Schilling, V. R., Alvarez, J. S., Lopez, G. T., Caralt, J. M. S., Miranda, R. T., de Antonio, E. U., Banyai, M., Frank, U., Gian Reto Jorg, Jeanneret, C., Staub, D., Ackroyd, S., Agarwal, G., Mearns, B., Alikhan, R., Allameddine, A., Al-Refaie, F., Arden, C., Austin, A., Bakhai, A., Barton, T., Ewad, H., Body, R., Thachil, J., Chacko, J., Chandra, D., Charters, F., Church, A., Mcgrane, F., Clements, J., Clifford, P., Cox, D., Crouch, M., Crowther, M., Davies, E., Davies, M., Dimitri, S., Drebes, A., Franklin, S., George, J., Irvine, N., Gerofke, H., Gibbs, C., Goh, T., Gupta, S., Holmes, J., Jackson-Voyzey, E., Jones, N., Kallat, A., Kerr, P., Kesteven, P., Lench, T., Lester, W., Lowe, G., Lewis, M., Mccormack, T., Mccoye, A., Moriarty, A., Morris, W., Myers, B., Narayanan, M., Oo, N., Reed, M., Rose, P., Saja, K., Sivakumaran, M., Sohal, M., Solomons, G., Sultanzadeh, S. J., Venton, T., Wakeling, J., Walby, C., Waldron, M., Watt, S., Willcock, W., Agnelli, G., Gitt, A. K., Bauersachs, R., Fronk, E. -M., Laeis, P., Mismetti, P., Monreal, M., Willich, S. N., Wolf, W. -P., Cohen, A. T., Brodmann, M., Rief, P., Eischer, L., Stoshikj, S., Hirschl, M., Weinmann, S., Marschang, P., Abbadie, F., Achkar, A., Addala, A., Adnet, F., Alexandra, J. -F., Aquilanti, S., Belhassane, A., Benaroya, A., Berremili, T., Grenot, M. C., Birr, V., Holtea, D., Bonnin, C., Bosler, F., Durand, M. -G. B., Brisot, D., Brousse, C., De La Fuente, T., Cayman, R., Cazaubon, M., Champion, O., Chanut, M., Chevalet, P., Connault, J., Durant, C., Constans, J., Cordeanu, M., Couturaud, F., Lacut, K., De Dedker, L., Decoulx, E., Derrien, B., Diamand, J. -M., Diard, A., Douadi, Y., Dupas, S., Remond, S. S. M., Sevestre, M. -A., Edhery, S., Falvo, N., Taralunga, C. F., Ferrari, E., Gaillard, C., Garrigues, D., Gillet, J. L., Giordana, P., Grange, C., Vital-Durand, D., Grare, F., Henni, A. H., Heuser, S., Schmidt, J., Hidden-Henic, V., Hottin, D., Imbert, B., Pernod, G., Jakob, D., Jacquinandi, V., Jurus, C., Lacoste, A., Laroche, J. -P., Martin, M., Mazollier, C., Mersel, T., Miserey, G., Nedey, C., Nou, M., Quere, I., Ouvry, P., Peuch, B., Pichot, O., Poulain, V., Ray, P., Rifai, A., Roy, P. -M., Saby, J. -C., Simon, F., Simonot-Lalandec, E., Stephan, D., Tissot, A., Vodoungnon, H., Adamczyk, A., Schnabl, S., Ahmad, W. A., Weber, H., Axthelm, C., Bergmann, K., Beschorner, U., Knittel, M., Binias, K. -H., Pasligh, M., Boral, M., Friederike, G., Bratsch, H., Brauer, G., Burghard, S., Demann, C., Rennebaum, C., Demmig, A., Eberlein, U., Enger, F., Eschenburg, J., Forkmann, L., Frank, J., Freischmidt, H., Gassauer, M., Fritsche, I., Kubicek-Hofmann, C., Goebels, M. -C., Guggenbichler, S., Hartel, D., Hartmann, K., Heilberger, P., Heinsius, A., Held, M., Schnupp, S., Herman, G., Herold, J., Hertrich, F., Hommel, H., Hutte, G., Kalka, C., Jungandreas, K., Ramthor, M., Karcher, J., Werner, N., Karl-Wollweber, S., Keilhau, D. -A., Kittel, K., Knolinski, T., Kohler, C., Werth, S., Kopplin, U., Korner, I., Wittig, K., Kroger, K., Moysidis, T., Kroschel, U., Leschke, M., zur Nieden, T., Lubbert, G., Lutz, A., Wucherpfennig, P., Marencke, G. -H., Mortensen, K., Reppel, M., Nelles, H., Nestler, K., Neumeister, A., Schlosser, A., Oettler, W., Ott, I., Otto, A., Pertermann, A., Pfister, R., Pindur, L., Pourhassan, S., Predel, D., Pudollek, T., Reimer, D., Richter, C., Rieker, E., Rothenbucher, G., Rothhagen, B., Rudolff, S., Stucker, M., Schafer, A., Sonnenschein, K., Schafnitzl, W., Schellong, S., Voigts, B., Schiller, M., Schmeink, T., Schneider, H., Schon, N., Schulze, M., Sechtem, U., Sedl, S., Werno, H. S., Stachowitz, J., Thieme, M., Tiefenbacher, C., Tsantilas, D., Vieth, P., vom Dahl, J., Grun-Himmelmann, K., von Bilderling, P., von Maltik, T., Weinrich, K., Weyer, M., Koln, E. K., Wirtz, P., Wittig, I., Zierock, P., Ageno, W., Caprioli, M., Rancan, E., Guercini, F., Mommi, V., Amitrano, M., Cannavacciuolo, F., Amore, M., D'Antoni, S., Angelini, E., Forgia, S. L., Antignani, P. L., Calandra, G., Arone, A., Perticone, F., Sciacqua, A., Asaro, G., Bellisi, M., Attanzio, M. T., Pinto, A., Attinasi, V., Cillari, E., Sorvillo, S., Balbarini, A., Santini, C., Violo, C., Banfi, E., Lodigiani, C., Barcellona, D., Delpin, S., Marongiu, S., Barillari, G., Pasca, S., Bartolini, C., Verdecchia, P., Bartone, M., Mancuso, G., Bellanuova, I., Felis, S., Bellizzi, A., Masotti, L., Bianchi, M., Carugati, A., Bianchini, G., Guarnera, G., Boari, B., Gallerani, M., Pasin, M., Bortoluzzi, C., Parisi, R., Brucoli, C., Palasciano, G., Camporese, G., Tonello, C., Canafoglia, L., Rupoli, S., Cancellieri, E., Paoletti, O., Testa, S., Carlizza, A., Carnovali, M., Sada, S., Samaden, A., Casarsa, C., Mearelli, F., Pivetti, G., Catalini, R., Zingaretti, O., Vascolare, M., Cavazza, S., Cosmi, B., Cenci, C., Prisco, D., Silvestri, E., Ceresa, F., Patane, F., Ciampa, A., Siniscalchi, V., Ciarambino, T., De Bartolomeo, G., Clemente, M., Conti, F., Paiella, L., D'Avino, M., D'Alessandro, A., Placentino, M., Sollazzo, V., D'Angelo, A., Vigano, S., De Campora, P., Sangiuolo, R., De Franciscis, S., Serra, R., De Gaudenzi, E., De Santis, F., Piccinni, G. C., De Tommaso, I. D., Di Francesco, L., Vincentelli, G. M., Di Maggio, R., Saccullo, G., Siragusa, S., Di Micco, P., Fontanella, A., Di Michele, D., Di Minno, G., Tufano, A., Di Nisio, M., Porreca, E., Donadio, F., Imberti, D., Enea, I., Fabbian, F., Manfredini, R., Pala, M., Falanga, A., Milesi, V., Fiore, V., Franco, E., Giudice, G., Frausini, G., Rovinelli, M., Fuorlo, M., Landolfi, R., Morretti, T., Gamberini, S., Salmi, R., Ghirarduzzi, A., Veropalumbo, M. R., Ghizzi, M., Pepe, C., Gianniello, F., Martinelli, I., Iosub, D. I., Piovella, F., Iozzi, E., Talerico, A., Regina, M. L., Orlandini, F., Marconi, L., Palla, A., Marcucci, R., Poli, D., Margheriti, R., Sala, G., Marra, A., Marrocco, F., Montagna, E. S., Silvestris, F., Vallarelli, S., Mos, L., Rossetto, V., Mugno, F., Di Salvo, M., Nitti, C., Pennacchioni, M., Salvi, A., Olivieri, O., Tosi, F., Zorzi, F., Onesta, M., Pagliara, V., Villalta, S., Paolucci, G., Severino, S., Pierri, F., Russo, V., Pizzini, A. M., Quintavalla, R., Rubino, P., Ria, L., Schenone, A., Strafino, C., Tropeano, P., Vetrano, A., Zanatta, N., Cansino, M. D. A., Gutierrez, J. A., de las Revillas, F. A., Fernandez, C. A., Mijares, N. C., Blanco-Molina, M. A., Garcia, M. A., Seijo, D. J., Blazquez, R. A., Lopez-Saez, J. -B., Rodrigo, E. A., Blanch, J. V., Arxe, A. A., Dalmau, F. G. -B., Quincoces, A. B., Loizaga, A. G., Perez, J. L. B., Diaz, P. B., Loaiza, A. Q., Castellote, M. C., Alcantara, I. C., Padierna, M. L., Exposito, M. C., Mas, A. C., Castro, F. C., Sanz, R. C., de Saracho, J. O., de la Fuente, E. C., de Ancos Aracil, C., Ruiz, J. R., de Daborenea Gonzalez, M. D., Iglesias, A. F., de la Fuente Aguado, J., Gonzalez, L. G., del Carmen Fernandez-Capitan, M., Hernandez, A. L., del Toro Cervera, J., Rus, G. P., Bregel, J. L. D., Fernandez, F. D., Teresa Elias, Hernandez, Palomares, L. J., Bataler, R. F., Rodriguez, J. A. N., Garcia, J. M. G., Porras, J. R. G., Garcia, M. G., Lopez, E. H., Lazaro, A. R., Jaras, M. J., Castro, D. J., Madridejos, R. J. -R., Navas, J. M. P., Lecumberri, R., Martinez, N., Castellanos, G. T. L., Espinosa, L. M., Jimenez, L. L., Cobo, O. M., Saiz, C. M., Pizarro, Y. R., Yglesias, P. J. M., Martin del Pozo, M., Melibovsky, L., Altarriba, E. S., Bosch, M. M., Secades, R. M., Lujan, J. M. M., Mestre, A. R., Moral, P. M., Parra, J. A. T., Flores, A. M., Munoz-Torrero, J. F. S., Rodriguez, F. J. M., Fernandez, M. J. N., Sibajas, E. O., de Sedas, M. V., Caballero, P. P., del Campo, I. P. M., Sanchez, J. P., Gallego, A. R., Alvarez, I. V., Beltran, E. M. R., Fuentes, D. S., Schilling, V. R., Alvarez, J. S., Lopez, G. T., Caralt, J. M. S., Miranda, R. T., de Antonio, E. U., Banyai, M., Frank, U., Gian Reto, Jorg, Jeanneret, C., Staub, D., Ackroyd, S., Agarwal, G., Mearns, B., Alikhan, R., Allameddine, A., Al-Refaie, F., Arden, C., Austin, A., Bakhai, A., Barton, T., Ewad, H., Body, R., Thachil, J., Chacko, J., Chandra, D., Charters, F., Church, A., Mcgrane, F., Clements, J., Clifford, P., Cox, D., Crouch, M., Crowther, M., Davies, E., Davies, M., Dimitri, S., Drebes, A., Franklin, S., George, J., Irvine, N., Gerofke, H., Gibbs, C., Goh, T., Gupta, S., Holmes, J., Jackson-Voyzey, E., Jones, N., Kallat, A., Kerr, P., Kesteven, P., Lench, T., Lester, W., Lowe, G., Lewis, M., Mccormack, T., Mccoye, A., Moriarty, A., Morris, W., Myers, B., Narayanan, M., Oo, N., Reed, M., Rose, P., Saja, K., Sivakumaran, M., Sohal, M., Solomons, G., Sultanzadeh, S. J., Venton, T., Wakeling, J., Walby, C., Waldron, M., Watt, S., Willcock, W., Zafar, A., Agnelli, G, Gitt, A, Bauersachs, R, Fronk, E, Laeis, P, Mismetti, P, Monreal, M, Willich, S, Wolf, W, Cohen, A, Brodmann, M, Rief, P, Eischer, L, Stoshikj, S, Hirschl, M, Weinmann, S, Marschang, P, Abbadie, F, Achkar, A, Addala, A, Adnet, F, Alexandra, J, Aquilanti, S, Belhassane, A, Benaroya, A, Berremili, T, Grenot, M, Birr, V, Holtea, D, Bonnin, C, Bosler, F, Durand, M, Brisot, D, Brousse, C, De La Fuente, T, Cayman, R, Cazaubon, M, Champion, O, Chanut, M, Chevalet, P, Connault, J, Durant, C, Constans, J, Cordeanu, M, Couturaud, F, Lacut, K, De Dedker, L, Decoulx, E, Derrien, B, Diamand, J, Diard, A, Douadi, Y, Dupas, S, Remond, S, Sevestre, M, Edhery, S, Falvo, N, Taralunga, C, Ferrari, E, Gaillard, C, Garrigues, D, Gillet, J, Giordana, P, Grange, C, Vital-Durand, D, Grare, F, Henni, A, Heuser, S, Schmidt, J, Hidden-Henic, V, Hottin, D, Imbert, B, Pernod, G, Jakob, D, Jacquinandi, V, Jurus, C, Lacoste, A, Laroche, J, Martin, M, Mazollier, C, Mersel, T, Miserey, G, Nedey, C, Nou, M, Quere, I, Ouvry, P, Peuch, B, Pichot, O, Poulain, V, Ray, P, Rifai, A, Roy, P, Saby, J, Simon, F, Simonot-Lalandec, E, Stephan, D, Tissot, A, Vodoungnon, H, Adamczyk, A, Schnabl, S, Ahmad, W, Weber, H, Axthelm, C, Bergmann, K, Beschorner, U, Knittel, M, Binias, K, Pasligh, M, Boral, M, Friederike, G, Bratsch, H, Brauer, G, Burghard, S, Demann, C, Rennebaum, C, Demmig, A, Eberlein, U, Enger, F, Eschenburg, J, Forkmann, L, Frank, J, Freischmidt, H, Gassauer, M, Fritsche, I, Kubicek-Hofmann, C, Goebels, M, Guggenbichler, S, Hartel, D, Hartmann, K, Heilberger, P, Heinsius, A, Held, M, Schnupp, S, Herman, G, Herold, J, Hertrich, F, Hommel, H, Hutte, G, Kalka, C, Jungandreas, K, Ramthor, M, Karcher, J, Werner, N, Karl-Wollweber, S, Keilhau, D, Kittel, K, Knolinski, T, Kohler, C, Werth, S, Kopplin, U, Korner, I, Wittig, K, Kroger, K, Moysidis, T, Kroschel, U, Leschke, M, zur Nieden, T, Lubbert, G, Lutz, A, Wucherpfennig, P, Marencke, G, Mortensen, K, Reppel, M, Nelles, H, Nestler, K, Neumeister, A, Schlosser, A, Oettler, W, Ott, I, Otto, A, Pertermann, A, Pfister, R, Pindur, L, Pourhassan, S, Predel, D, Pudollek, T, Reimer, D, Richter, C, Rieker, E, Rothenbucher, G, Rothhagen, B, Rudolff, S, Stucker, M, Schafer, A, Sonnenschein, K, Schafnitzl, W, Schellong, S, Voigts, B, Schiller, M, Schmeink, T, Schneider, H, Schon, N, Schulze, M, Sechtem, U, Sedl, S, Werno, H, Stachowitz, J, Thieme, M, Tiefenbacher, C, Tsantilas, D, Vieth, P, vom Dahl, J, Grun-Himmelmann, K, von Bilderling, P, von Maltik, T, Weinrich, K, Weyer, M, Koln, E, Wirtz, P, Wittig, I, Zierock, P, Ageno, W, Caprioli, M, Rancan, E, Guercini, F, Mommi, V, Amitrano, M, Cannavacciuolo, F, Amore, M, D'Antoni, S, Angelini, E, Forgia, S, Antignani, P, Calandra, G, Arone, A, Perticone, F, Sciacqua, A, Asaro, G, Bellisi, M, Attanzio, M, Pinto, A, Attinasi, V, Cillari, E, Sorvillo, S, Balbarini, A, Santini, C, Violo, C, Banfi, E, Lodigiani, C, Barcellona, D, Delpin, S, Marongiu, S, Barillari, G, Pasca, S, Bartolini, C, Verdecchia, P, Bartone, M, Mancuso, G, Bellanuova, I, Felis, S, Bellizzi, A, Masotti, L, Bianchi, M, Carugati, A, Bianchini, G, Guarnera, G, Boari, B, Gallerani, M, Pasin, M, Bortoluzzi, C, Parisi, R, Brucoli, C, Palasciano, G, Camporese, G, Tonello, C, Canafoglia, L, Rupoli, S, Cancellieri, E, Paoletti, O, Testa, S, Carlizza, A, Carnovali, M, Sada, S, Samaden, A, Casarsa, C, Mearelli, F, Pivetti, G, Catalini, R, Zingaretti, O, Vascolare, M, Cavazza, S, Cosmi, B, Cenci, C, Prisco, D, Silvestri, E, Ceresa, F, Patane, F, Ciampa, A, Siniscalchi, V, Ciarambino, T, De Bartolomeo, G, Clemente, M, Conti, F, Paiella, L, D'Avino, M, D'Alessandro, A, Placentino, M, Sollazzo, V, D'Angelo, A, Vigano, S, De Campora, P, Sangiuolo, R, De Franciscis, S, Serra, R, De Gaudenzi, E, De Santis, F, Piccinni, G, De Tommaso, I, Di Francesco, L, Vincentelli, G, Di Maggio, R, Saccullo, G, Siragusa, S, Di Micco, P, Fontanella, A, Di Michele, D, Di Minno, G, Tufano, A, Di Nisio, M, Porreca, E, Donadio, F, Imberti, D, Enea, I, Fabbian, F, Manfredini, R, Pala, M, Falanga, A, Milesi, V, Fiore, V, Franco, E, Giudice, G, Frausini, G, Rovinelli, M, Fuorlo, M, Landolfi, R, Morretti, T, Gamberini, S, Salmi, R, Ghirarduzzi, A, Veropalumbo, M, Ghizzi, M, Pepe, C, Gianniello, F, Martinelli, I, Iosub, D, Piovella, F, Iozzi, E, Talerico, A, Regina, M, Orlandini, F, Marconi, L, Palla, A, Marcucci, R, Poli, D, Margheriti, R, Sala, G, Marra, A, Marrocco, F, Montagna, E, Silvestris, F, Vallarelli, S, Mos, L, Rossetto, V, Mugno, F, Di Salvo, M, Nitti, C, Pennacchioni, M, Salvi, A, Olivieri, O, Tosi, F, Zorzi, F, Onesta, M, Pagliara, V, Villalta, S, Paolucci, G, Severino, S, Pierri, F, Russo, V, Pizzini, A, Quintavalla, R, Rubino, P, Ria, L, Schenone, A, Strafino, C, Tropeano, P, Vetrano, A, Zanatta, N, Cansino, M, Gutierrez, J, de las Revillas, F, Fernandez, C, Mijares, N, Blanco-Molina, M, Garcia, M, Seijo, D, Blazquez, R, Lopez-Saez, J, Rodrigo, E, Blanch, J, Arxe, A, Dalmau, F, Quincoces, A, Loizaga, A, Perez, J, Diaz, P, Loaiza, A, Castellote, M, Alcantara, I, Padierna, M, Exposito, M, Mas, A, Castro, F, Sanz, R, de Saracho, J, de la Fuente, E, de Ancos Aracil, C, Ruiz, J, de Daborenea Gonzalez, M, Iglesias, A, de la Fuente Aguado, J, Gonzalez, L, del Carmen Fernandez-Capitan, M, Hernandez, A, del Toro Cervera, J, Rus, G, Bregel, J, Fernandez, F, Teresa Elias, H, Palomares, L, Bataler, R, Rodriguez, J, Garcia, J, Porras, J, Lopez, E, Lazaro, A, Jaras, M, Castro, D, Madridejos, R, Navas, J, Lecumberri, R, Martinez, N, Castellanos, G, Espinosa, L, Jimenez, L, Cobo, O, Saiz, C, Pizarro, Y, Yglesias, P, Martin del Pozo, M, Melibovsky, L, Altarriba, E, Bosch, M, Secades, R, Lujan, J, Mestre, A, Moral, P, Parra, J, Flores, A, Munoz-Torrero, J, Rodriguez, F, Fernandez, M, Sibajas, E, de Sedas, M, Caballero, P, del Campo, I, Sanchez, J, Gallego, A, Alvarez, I, Beltran, E, Fuentes, D, Schilling, V, Alvarez, J, Lopez, G, Caralt, J, Miranda, R, de Antonio, E, Banyai, M, Frank, U, Gian Reto, J, Jeanneret, C, Staub, D, Ackroyd, S, Agarwal, G, Mearns, B, Alikhan, R, Allameddine, A, Al-Refaie, F, Arden, C, Austin, A, Bakhai, A, Barton, T, Ewad, H, Body, R, Thachil, J, Chacko, J, Chandra, D, Charters, F, Church, A, Mcgrane, F, Clements, J, Clifford, P, Cox, D, Crouch, M, Crowther, M, Davies, E, Davies, M, Dimitri, S, Drebes, A, Franklin, S, George, J, Irvine, N, Gerofke, H, Gibbs, C, Goh, T, Gupta, S, Holmes, J, Jackson-Voyzey, E, Jones, N, Kallat, A, Kerr, P, Kesteven, P, Lench, T, Lester, W, Lowe, G, Lewis, M, Mccormack, T, Mccoye, A, Moriarty, A, Morris, W, Myers, B, Narayanan, M, Oo, N, Reed, M, Rose, P, Saja, K, Sivakumaran, M, Sohal, M, Solomons, G, Sultanzadeh, S, Venton, T, Wakeling, J, Walby, C, Waldron, M, Watt, S, Willcock, W, and Zafar, A
- Subjects
Drug Utilization ,Pediatrics ,medicine.medical_specialty ,Novel Oral Anticoagulants ,Registry ,Deep vein ,Alternative medicine ,Anticoagulation ,Patient satisfaction ,Quality of life ,Health care ,medicine ,Anticoagulation, Novel Oral Anticoagulants, Prevention, Registry, Venous Thromboembolism, Vitamin K antagonists ,cardiovascular diseases ,business.industry ,Prevention ,Venous Thromboembolism ,Vitamin K antagonists ,Hematology ,Novel Oral Anticoagulant ,medicine.disease ,equipment and supplies ,Pulmonary embolism ,medicine.anatomical_structure ,Emergency medicine ,Original Clinical Investigation ,Observational study ,business - Abstract
Background: Venous thromboembolism (VTE) is a major health problem, with over one million events every year in Europe. However, there is a paucity of data on the current management in real life, including factors influencing treatment pathways, patient satisfaction, quality of life (QoL), and utilization of health care resources and the corresponding costs. The PREFER in VTE registry has been designed to address this and to understand medical care and needs as well as potential gaps for improvement. Methods/design: The PREFER in VTE registry was a prospective, observational, multicenter study conducted in seven European countries including Austria, France Germany, Italy, Spain, Switzerland, and the UK to assess the characteristics and the management of patients with VTE, the use of health care resources, and to provide data to estimate the costs for 12 months treatment following a first-time and/or recurrent VTE diagnosed in hospitals or specialized or primary care centers. In addition, existing anticoagulant treatment patterns, patient pathways, clinical outcomes, treatment satisfaction, and health related QoL were documented. The centers were chosen to reflect the care environment in which patients with VTE are managed in each of the participating countries. Patients were eligible to be enrolled into the registry if they were at least 18 years old, had a symptomatic, objectively confirmed first time or recurrent acute VTE defined as either distal or proximal deep vein thrombosis, pulmonary embolism or both. After the baseline visit at the time of the acute VTE event, further follow-up documentations occurred at 1, 3, 6 and 12 months. Follow-up data was collected by either routinely scheduled visits or by telephone calls. Results: Overall, 381 centers participated, which enrolled 3,545 patients during an observational period of 1 year. Conclusion: The PREFER in VTE registry will provide valuable insights into the characteristics of patients with VTE and their acute and mid-term management, as well as into drug utilization and the use of health care resources in acute first-time and/or recurrent VTE across Europe in clinical practice. Trial registration: Registered in DRKS register, ID number: DRKS00004795
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- 2015
19. The influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophrenia
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Galderisi, S, Rossi, A, Rocca, P, Bertolino, A, Mucci, A, Bucci, P, Rucci, P, Gibertoni, D, Aguglia, E, Amore, M, Bellomo, A, Biondi, M, Brugnoli, R, Dell'Osso, L, De Ronchi, D, Di Emidio, G, Di Giannantonio, M, Fagiolini, A, Marchesi, C, Monteleone, P, Oldani, L, Pinna, G, S, Pinna, F, Roncone, R, Sacchetti, E, Santonastaso, P, Siracusano, A, Vita, A, Zeppegno, P, Maj, M, Chieffi, M, De Simone, S, De Riso, F, Giugliano, R, Piegari, G, Vignapiano, A, Caforio, G, Mancini, M, Colagiorgio, L, Porcelli, S, Salfi, R, Bianchini, O, Galluzzo, A, Barlati, S, Carpiniello, B, Fatteri, F, Di Santa Sofia, S, Cannavò, D, Minutolo, G, Signorelli, M, Martinotti, G, Di Iorio, G, Acciavatti, T, Pallanti, S, Faravelli, C, Altamura, M, Stella, E, Marasco, D, Calcagno, P, Respino, M, Marozzi, V, Riccardi, I, Collazzoni, A, Stratta, P, Giusti, L, Ussorio, D, Delauretis, I, Serati, M, Caldiroli, A, Palazzo, C, Iasevoli, Fz, Gramaglia, C, Gili, S, Gattoni, E, Tenconi, E, Giannunzio, V, Monaco, F, De Panfilis, C, Camerlengo, A, Ossola, P, Landi, P, Rutigliano, G, Pergentini, I, Mauri, M, Di Fabio, F, Torti, C, Buzzanca, A, Comparelli, A, De Carolis, A, Corigliano, V, DI LORENZO, G, Niolu, C, Troisi, A, Corrivetti, Aa, G, Pinto, Diasco, Aa, F, Goracci, A, Bolognesi, S, Borghini, E, Montemagni, C, Frieri, T, Birindelli, N, Galderisi, S., Rossi, A., Rocca, P., Bertolino, A., Mucci, A., Bucci, P., Rucci, P., Gibertoni, D., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Brugnoli, R., Dell'Osso, L., De Ronchi, D., Di Emidio, G., Di Giannantonio, M., Fagiolini, A., Marchesi, C., Monteleone, P., Oldani, L., Pinna, F., Roncone, R., Sacchetti, E., Santonastaso, P., Siracusano, A., Vita, A., Zeppegno, P., Maj, M., Chieffi, M., De Simone, S., De Riso, F., Giugliano, R., Piegari, G., Vignapiano, A., Caforio, G., Mancini, M., Colagiorgio, L., Porcelli, S., Salfi, R., Bianchini, O., Galluzzo, A., Barlati, S., Carpiniello, B., Fatteri, F., Di Santa Sofia, S. L., Cannavo, D., Minutolo, G., Signorelli, M., Martinotti, G., Di Iorio, G., Acciavatti, T., Pallanti, S., Faravelli, C., Altamura, M., Stella, E., Marasco, D., Calcagno, P., Respino, M., Marozzi, V., Riccardi, I., Collazzoni, A., Stratta, P., Giusti, L., Ussorio, D., Delauretis, I., Serati, M., Caldiroli, A., Palazzo, C., Iasevoli, F., Gramaglia, C., Gili, S., Gattoni, E., Tenconi, E., Giannunzio, V., Monaco, F., De Panfilis, C., Camerlengo, A., Ossola, P., Landi, P., Rutigliano, G., Pergentini, I., Mauri, M., Di Fabio, F., Torti, C., Buzzanca, A., Comparelli, A., De Carolis, A., Corigliano, V., Di Lorenzo, G., Niolu, C., Troisi, A., Corrivetti, G., Pinto, G., Diasco, F., Goracci, A., Bolognesi, S., Borghini, E., Montemagni, C., Frieri, T., Birindelli, N., Galderisi, Silvana, Rossi, Alessandro, Rocca, Paola, Bertolino, Alessandro, Mucci, Armida, Bucci, Paola, Rucci, Paola, Gibertoni, Dino, Aguglia, Eugenio, Amore, Mario, Bellomo, Antonello, Biondi, Massimo, Brugnoli, Roberto, Dell'Osso, Liliana, De Ronchi, Diana, Di Emidio, Gabriella, Di Giannantonio, Massimo, Fagiolini, Andrea, Marchesi, Carlo, Monteleone, Palmiero, Oldani, Lucio, Pinna, Federica, Roncone, Rita, Sacchetti, Emilio, Santonastaso, Paolo, Siracusano, Alberto, Vita, Antonio, Zeppegno, Patrizia, Maj, Mario, Chieffi, Marcello, De Simone, Stefania, De Riso, Francesco, Giugliano, Rosa, Piegari, Giuseppe, Vignapiano, Annarita, Caforio, Grazia, Mancini, Marina, Colagiorgio, Lucia, Porcelli, Stefano, Salfi, Raffaele, Bianchini, Oriana, Galluzzo, Alessandro, Barlati, Stefano, Carpiniello, Bernardo, Fatteri, Francesca, Di Santa Sofia, Silvia Lostia, Cannavò, Dario, Minutolo, Giuseppe, Signorelli, Maria, Martinotti, Giovanni, Di Iorio, Giuseppe, Acciavatti, Tiziano, Pallanti, Stefano, Faravelli, Carlo, Altamura, Mario, Stella, Eleonora, Marasco, Daniele, Calcagno, Pietro, Respino, Matteo, Marozzi, Valentina, Riccardi, Ilaria, Collazzoni, Alberto, Stratta, Paolo, Giusti, Laura, Ussorio, Donatella, Delauretis, Ida, Serati, Marta, Caldiroli, Alice, Palazzo, Carlotta, Iasevoli, Felice, Gramaglia, Carla, Gili, Sabrina, Gattoni, Eleonora, Tenconi, Elena, Giannunzio, Valeria, Monaco, Francesco, De Panfilis, Chiara, Camerlengo, Annalisa, Ossola, Paolo, Landi, Paola, Rutigliano, Grazia, Pergentini, Irene, Mauri, Mauro, Di Fabio, Fabio, Torti, Chiara, Buzzanca, Antonino, Comparelli, Anna, De Carolis, Antonella, Corigliano, Valentina, Di Lorenzo, Giorgio, Niolu, Cinzia, Troisi, Alfonso, Corrivetti, Giulio, Pinto, Gaetano, Diasco, Ferdinando, Goracci, Arianna, Bolognesi, Simone, Borghini, Elisa, Montemagni, Cristiana, Frieri, Tiziana, and Birindelli, Nadia
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medicine.medical_specialty ,media_common.quotation_subject ,neurocognition ,positive symptoms ,Context (language use) ,avolition ,Personal resource ,Social cognition ,Avolition ,Disorganization ,Engagement with mental health services ,Internalized stigma ,Neurocognition ,Personal resources ,Positive symptoms ,Real-life functioning ,Resilience ,Schizophrenia ,Psychiatry and Mental Health ,Psychiatric Mental Health ,medicine ,real-life functioning ,personal resources ,Psychiatry ,resilience ,Settore MED/25 - Psichiatria ,media_common ,business.industry ,Schizophrenia, avolition, disorganization, engagement with mental health services, internalized stigma, neurocognition, personal resources, positive symptoms, real-life functioning, resilience ,disorganization ,internalized stigma ,engagement with mental health services ,Social environment ,Research Reports ,medicine.disease ,Mental health ,Psychiatry and Mental health ,Psychological resilience ,Pshychiatric Mental Health ,medicine.symptom ,business ,Positive symptom ,Independent living ,Engagement with mental health service - Abstract
In people suffering from schizophrenia, major areas of everyday life are impaired, including independent living, productive activities and social relationships. Enhanced understanding of factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes. The goal of the present study was to identify predictors of real-life functioning in people with schizophrenia, and to assess their relative contribution. Based on previous literature and clinical experience, several factors were selected and grouped into three categories: illness-related variables, personal resources and context-related factors. Some of these variables were never investigated before in relationship with real-life functioning. In 921 patients with schizophrenia living in the community, we found that variables relevant to the disease, personal resources and social context explain 53.8% of real-life functioning variance in a structural equation model. Neurocognition exhibited the strongest, though indirect, association with real-life functioning. Positive symptoms and disorganization, as well as avolition, proved to have significant direct and indirect effects, while depression had no significant association and poor emotional expression was only indirectly and weakly related to real-life functioning. Availability of a disability pension and access to social and family incentives also showed a significant direct association with functioning. Social cognition, functional capacity, resilience, internalized stigma and engagement with mental health services served as mediators. The observed complex associations among investigated predictors, mediators and real-life functioning strongly suggest that integrated and personalized programs should be provided as standard treatment to people with schizophrenia. In people suffering from schizophrenia, major areas of everyday life are impaired, including independent living, productive activities and social relationships. Enhanced understanding of factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes. The goal of the present study was to identify predictors of real-life functioning in people with schizophrenia, and to assess their relative contribution. Based on previous literature and clinical experience, several factors were selected and grouped into three categories: illness-related variables, personal resources and context-related factors. Some of these variables were never investigated before in relationship with real-life functioning. In 921 patients with schizophrenia living in the community, we found that variables relevant to the disease, personal resources and social context explain 53.8% of real-life functioning variance in a structural equation model. Neurocognition exhibited the strongest, though indirect, association with real-life functioning. Positive symptoms and disorganization, as well as avolition, proved to have significant direct and indirect effects, while depression had no significant association and poor emotional expression was only indirectly and weakly related to real-life functioning. Availability of a disability pension and access to social and family incentives also showed a significant direct association with functioning. Social cognition, functional capacity, resilience, internalized stigma and engagement with mental health services served as mediators. The observed complex associations among investigated predictors, mediators and real-life functioning strongly suggest that integrated and personalized programs should be provided as standard treatment to people with schizophrenia.
- Published
- 2014
20. The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry
- Author
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Cohen, At, Gitt, Ak, Bauersachs, R, Fronk, Em, Laeis, P, Mismetti, P, Monreal, M, Willich, Sn, Bramlage, P, Agnelli, G, Brodmann, M, Rief, P, Eischer, L, Stoshikj, S, Hirschl, M, Weinmann, S, Peter Marschang, P, Abbadie, F, Achkar, A, Addala, A, Reynaldo, P, Adnet, F, Alexandra, Jf, Aquilanti, S, Belhassane, A, Benaroya, B, Berremili, T, Grenot, Mc, Birr, V, Holtea, D, Bonnin, C, Bosler, F, Bresin Durand MG, Brisot, D, Brousse, C, De La Fuente, T, Cayman, C, Cazaubon, M, Champion, O, Chanut, M, Chevalet, P, Connault, J, Durant, C, Constans, J, Cordeanu, M, Couturaud, F, Lacut, K, De Dedker, L, Piloquet, Fx, Decoulx, E, Derrien, B, Diamand, Jm, Diard, A, Douadi, Y, Dupas, S, Modeliar Remond SS, Sevestre, Ma, Edhery, S, Falvo, N, Farcas Taralunga, C, Ferrari, E, Gaillard, C, Garrigues, D, Gillet, Jl, Giordana, P, Grange, C, Vital-Durand, D, Grare, F, Hadj Henni, A, Heuser, S, Schmidt, J, Hidden-Henic, V, Hottin, D, Imbert, B, Pernod, G, Jakob, D, Jacquinandi, V, Jurus, C, Lacoste, A, Laroche, Jp, Martin, M, Mazollier, C, Mersel, T, Miserey, G, Nedey, C, Nou, M, Quere, I, Ouvry, P, Peuch, B, Pichot, O, Poulain, V, Ray, P, Rifai, A, Roy, Pm, Saby, Jc, Simon, F, Simonot-Lalandec, E, Stephan, D, Tissot, A, Vodoungnon, H, Adamczyk, A, Schnabl, S, Al Ahmad, W, Weber, H, Axthelm, C, Axthelm, P, Bergmann, K, Beschorner, U, Knittel, M, Binias, Kh, Pasligh, M, Boral, M, Girke, F, Bratsch, H, Brauer, G, Burghard, S, Demann, C, Rennebaum, C, Emter, E, Demmig, A, Eberlein, U, Enger, F, Eschenburg, J, Eschenburg, Ju, Forkmann, L, Frank, J, Freischmidt, H, Gassauer, M, Fritsche, I, Kubicek–hofmann, C, Goebels, Mc, Guggenbichler, S, Härtel, D, Hartmann, K, Heilberger, P, Heinsius, A, Held, M, Schnupp, S, Herman, G, Herold, J, Hertrich, F, Hommel, H, Hütte, G, Kalka, C, Jungandreas, K, Ramthor, M, Karcher, J, Werner, N, Karl-Wollweber, S, Keilhau, Da, Kittel, K, Knolinski, T, Köhler, C, Werth, S, Kopplin, U, Körner, I, Wittig, K, Dres, P, Kröger, K, Moysidis, T, Kroschel, U, Leschke, M, zur Nieden, T, Lübbert, G, Lutz, A, Wucherpfennig, P, Marencke, Gh, Mortensen, K, Reppel, M, Nelles, H, Nestler, K, Neumeister, A, Schlosser, A, Oettler, W, Ott, I, Otto, A, Pertermann, A, Pfister, R, Pindur, P, Pourhassan, S, Predel, D, Pudollek, T, Reimer, D, Richter, R, Eberhad Rieker, E, Rothenbücher, G, Rothhagen, B, Rudolff, S, Stücker, M, Schäfer, A, Sonnenschein, K, Schafnitzl, W, Schellong, S, Voigts, B, Schiller, M, Schmeink, T, Schmeink, P, Schneider, H, Schön, N, Schulze, M, Sechtem, U, Sedl, S, Werno, Hs, Stachowitz, J, Thieme, M, Tiefenbacher, C, Tsantilas, D, Vieth, P, vom Dahl, J, Grün-Himmelmann, K, von Bilderling, P, von Maltik, T, Weinrich, K, Weyer, M, Wirtz, P, Wittig, I, Zierock, P, Ageno, W, Caprioli, C, Rancan, E, Guercini, F, Mommi, V, Amitrano, M, Cannavacciuolo, F, Amore, M, D'Antoni, S, Angelini, E, La Forgia, S, Antignani, Pl, Calandra, G, Arone, A, Perticone, F, Sciacqua, A, Asaro, G, Bellisi, M, Attanzio, Mt, Pinto, A, Attinasi, V, Cillari, E, Sorvillo, S, Balbarini, A, Santini, C, Violo, C, Banfi, E, Lodigiani, C, Barcellona, D, Delpin, S, Marongiu, S, Barillari, G, Pasca, S, Bartolini, C, Verdecchia, P, Bartone, M, Mancuso, G, Bellanuova, I, Felis, S, Bellizzi, A, Masotti, L, Bianchi, M, Carugati, A, Bianchini, G, Guarnera, G, Boari, B, Gallerani, M, Pasin, M, Bortoluzzi, C, Parisi, R, Brucoli, C, Palasciano, G, Camporese, G, Tonello, C, Canafoglia, L, Rupoli, S, Cancellieri, E, Paoletti, O, Testa, S, Carlizza, A, Carnovali, M, Sada, S, Samaden, A, Casarsa, C, Mearelli, F, Pivetti, G, Catalini, R, Zingaretti, O, Cavazza, S, Cosmi, B, Cenci, C, Prisco, D, Silvestri, E, Ceresa, F, Patanè, F, Ciampa, A, Siniscalchi, V, Ciarambino, T, De Bartolomeo, G, Clemente, M, Conti, F, Paiella, L, D’Avino, M, D'Alessandro, A, Placentino, M, Sollazzo, V, D'Angelo, A, Viganò, S, De Campora, P, Sangiuolo, R, De Franciscis, S, Serra, R, De Gaudenzi, E, De Santis, F, Piccinni, Gc, De Tommaso, I, Di Francesco, L, Vincentelli, Gm, Di Maggio, R, Saccullo, G, Siragusa, S, Di Micco, P, Fontanella, A, Di Michele, D, Di Minno, G, Tufano, A, Di Nisio, M, Porreca, E, Donadio, F, Imberti, D, Enea, I, Fabbian, F, Manfredini, R, Pala, P, Falanga, A, Milesi, V, Fiore, V, Signorelli, Ss, Franco, E, Giudice, G, Frausini, G, Rovinelli, M, Fuorlo, M, Landolfi, R, Morretti, T, Gamberini, S, Salmi, R, Ghirarduzzi, A, Ghizzi, G, Pepe, C, Gianniello, F, Martinelli, I, Iosub, Di, Piovella, F, Iozzi, E, Talerico, A, La Regina, M, Orlandini, F, Marconi, L, Palla, A, Marcucci, R, Poli, D, Margheriti, R, Sala, G, Marra, A, Marrocco, F, Montagna, Es, Silvestris, F, Vallarelli, S, Mos, L, Rossetto, V, Mugno, F, Di Salvo, M, Nitti, C, Pennacchioni, M, Salvi, A, Olivieri, O, Tosi, F, Zorzi, F, Onesta, M, Pagliara, V, Villalta, S, Paolucci, G, Severino, S, Pierri, F, Russo, V, Pizzini, Am, Quintavalla, R, Rubino, P, Ria, L, Schenone, A, Strafino, C, Tropeano, P, Vetrano, V, Zanatta, N, Adarraga Cansino MD, Gutierrez, Ja, de las Revillas FA, Amado Fernández, C, Calvo Mijares, N, Blanco-Molina, Ma, Garcia, Ma, Joya Seijo, D, Aranda Blazquez, R, López-Sáez, Jb, Arellano Rodrigo, E, Villalta Blanch, J, Armengou Arxe, A, García-Bragado Dalmau, F, Ballaz Quincoces, A, García Loizaga, A, Beato Pérez JL, Bedate Díaz, P, Quezada Loaiza, A, Castellote, Mc, Cañas Alcántara, I, Lluís Padierna, M, Carrasco Expósito, M, Millón Caño JA, Carrasco Mas, A, Cereto Castro, F, Castrodeza Sanz, R, Ortiz de Saracho, J, Cisneros de la Fuente, E, de Ancos Aracil, C, Ruiz, J, de Daborenea González MD, Fernández Iglesias, A, de la Fuente Aguado, J, González, Lg, del Carmen Fernández-Capitán, M, Lorenzo Hernández, A, del Toro Cervera, J, Pérez Rus, G, Delgado Bregel JL, Díez Fernández, F, Santalla Valle EA, Elias Hernández, T, Jara Palomares, L, Ferri Bataler, R, Nieto Rodríguez JA, García García JM, Villanueva Montes MA, González Porras JR, Guil García, M, San Román Terán CM, Hernando López, E, Roncero Lázaro, A, Jaras, Mj, Jiménez Castro, D, Jiménez-Rodríguez Madridejos, R, Pedrajas Navas JM, Lecumberri, R, Martínez, N, López Castellanos GT, Manzano Espinosa, L, López Jiménez, L, Madridano Cobo, O, Mainez Saiz, C, Romero Pizarro, Y, Marchena Yglesias PJ, Martín del Pozo, M, Melibovsky, L, Altarriba, Es, Monreal Bosch, M, Monte Secades, R, Mora Luján JM, Riera Mestre, A, Moral Moral, P, Todolí Parra JA, Moreno Flores, A, Sánchez Muñoz-Torrero JF, Muñoz Rodríguez FJ, Núñez Fernández MJ, Oncala Sibajas, E, Vaquero de Sedas, M, Parra Caballero, P, Pons Martín del Campo, I, Portillo Sánchez, J, Rivera Gallego, A, Villaverde Álvarez, I, Rodríguez Beltrán EM, Sánchez Fuentes, D, Roldán Schilling, V, Sánchez Álvarez, J, López, Gt, Suriñach Caralt JM, Tirado Miranda, R, Usandizaga de Antonio, E, Banyai, M, Frank, U, Jörg, Gr, Jeanneret, C, Staub, D, Ackroyd, A, Agarwal, G, Mearns, B, Alikhan, R, Allameddine, A, Al-Refaie, F, Arden, C, Austin, A, Bakhai, A, Barton, T, Ewad, H, Body, R, Thachil, J, Chacko, J, Chandra, D, Charters, F, Church, A, Mcgrane, F, Clements, J, Clifford, P, Cox, D, Crouch, M, Crowther, M, Davies, E, Davies, M, Dimitri, S, Drebes, A, Franklin, S, George, J, Irvine, N, Gerofke, H, Gibbs, C, Goh, T, Gupta, S, Holmes, J, Jackson-Voyzey, E, Jones, N, Kallat, A, Kerr, P, Kesteven, P, Lench, T, Lester, W, Lowe, G, Lewis, M, Mccormack, T, Mccoye, A, Moriarty, A, Morris, W, Narayanan, M, Oo, N, Reed, M, Rose, P, Saja, K, Sivakumaran, M, Sohal, M, Solomons, G, Sultanzadeh, Sj, Venton, T, Wakeling, J, Walby, C, Waldron, M, Watt, S, Willcock, W, and Zafar, A.
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Male ,Time Factors ,Databases, Factual ,Administration, Oral ,Disease ,Comorbidity ,030204 cardiovascular system & hematology ,registry ,Direct oral anticoagulants ,0302 clinical medicine ,Recurrence ,Risk Factors ,Epidemiology ,030212 general & internal medicine ,Prospective Studies ,Registries ,anticoagulation ,LS4_7 ,Venous Thrombosis ,Hematology ,Venous Thromboembolism ,Vitamin K antagonist ,Middle Aged ,Thrombosis ,Pulmonary embolism ,Europe ,vitamin K antagonists ,Treatment Outcome ,Administration ,Female ,Coagulation and Fibrinolysis ,Venous thromboembolism ,Oral ,Adult ,medicine.medical_specialty ,Registry ,medicine.drug_class ,Socio-culturale ,Hemorrhage ,direct oral anticoagulants ,Venous thromboembolism, anticoagulation, direct oral anticoagulants, registry, vitamin K antagonists ,Anticoagulation ,Vitamin K antagonists ,Aged ,Anticoagulants ,Humans ,Pulmonary Embolism ,03 medical and health sciences ,Databases ,Disease registry ,Internal medicine ,medicine ,cardiovascular diseases ,Intensive care medicine ,Factual ,business.industry ,medicine.disease ,equipment and supplies ,Clinical trial ,business - Abstract
SummaryVenous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0% were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5%). The diagnosis was deep-vein thrombosis (DVT) in 59.5% and pulmonary embolism (PE) in 40.5%. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5%), hypertension (42.3%) and dyslipidaemia (21.1%). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2%), almost half received a vitamin K antagonist (48.7%) and nearly a quarter received a DOAC (24.5%). Almost a quarter of all presentations were for recurrent VTE, with >80% of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes.
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- 2016
21. A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial
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Ruggeri, Mirella, Bonetto, Chiara, Lasalvia, Antonio, Girolamo, De, G, Fioritti, A, Rucci, P, Santonastaso, P, Neri, G, Pileggi, F, Ghigi, D, Miceli, M, Scarone, S, Cocchi, A, Torresani, S, Faravelli, C, Zimmermann, Christa, Meneghelli, A, Cremonese, C, Scocco, P, Leuci, E, Mazzi, F, Gennarelli, M, Brambilla, P, Bissoli, S, Bertani, Me, Tosato, Sarah, DE SANTI, Katia, Poli, Sara, Cristofalo, Doriana, Tansella, Michele, Get, Up, Group, Ruggeri, M, Mirella, Me, Bonetto, C, Cristofalo, D, De Santi, K, Lasalvia, A, Lunardi, S, Negretto, V, Poli, S, Tosato, S, Zamboni, Mg, Ballarin, M, Bocchio, Chiavetto, L, Scasselatti, C, Zanardini, R, Bellani, Marcella, Bertoldo, A, Marinelli, Veronica, Perlini, Cinzia, Rambaldelli, Gianluca, Bertani, M, Lazzarotto, L, Bardella, S, Gardellin, F, Lamonaca, D, Lunardon, M, Magnabosco, R, Martucci, M, Nicolau, S, Nifosì, F, Pavanati, M, Rossi, M, Piazza, C, Piccione, G, Sala, A, Sale, A, Stefan, B, Zotos, S, Balbo, M, Boggian, I, Ceccato, E, Dall'Agnola, R, Girotto, B, Goss, Claudia, Leoni, R, Mai, A, Pasqualini, A, Roccato, S, Rossi, A, Strizzolo, S, Urbani, A, Ald, F, Bianchi, B, Cappellari, P, Conti, R, Battisti, De, Lazzarin, E, Merlin, S, Migliorini, G, Pozzan, T, Sarto, L, Visonà, S, Brazzoli, A, Campi, A, Carmagnani, R, Giambelli, S, Gianella, A, Lunardi, L, Madaghiele, D, Maestrelli, P, Paiola, L, Posteri, E, Viola, L, Zamberlan, V, Zenari, M, Zanoni, M, Bonadonna, G, Bonomo, M, Veronese, A, Anderle, P, Angelozz, A, Amalric, I, Baron, G, Candeago, Eb, Castelli, F, Chieco, M, Costanzo, Di, E, Derossi, M, Doriguzzi, M, Galvano, O, Lattanz, M, Lezzi, R, Marcato, M, Marcolin, A, Marini, F, Matranga, M, Scalabrin, D, Zucchetto, M, Zadro, F, Austoni, G, Bianco, M, Bordino, F, Dario, F, Risio, De, A, Gatto, A, Granà, S, Favero, E, Franceschin, A, Friederici, S, Marangon, V, Pascolo, M, Ramon, L, Zambolin, S, Riolo, R, Buffon, A, Bortolo, Di, Fortin, S, Matarrese, F, Mogni, S, Codemo, N, Russi, A, Silvestro, A, Turella, E, Viel, P, Dominoni, A, Andreose, L, Boemio, M, Bressan, L, Cabbia, A, Canesso, E, Cian, R, Dal, Piccol, Dalla, C, Pasqua, Mm, Prisco, Di, Mantellato, L, Luison, M, Morgante, S, Santi, M, Sacillotto, M, Scabbio, M, Sponga, P, Sguotto, Ml, Stach, F, Vettorato, Mg, Martinello, G, Dassiè, F, Marino, S, Cibiniel, L, Masetto, I, Cabianca, O, Valente, A, Caberlotto, L, Passoni, A, Flumian, P, Daniel, L, Gion, M, Stanziale, S, Alborino, F, Bortolozzo, V, Bacelle, L, Bicciato, L, Basso, D, Navaglia, F, Manoni, F, Ercolin, M, Giubilini, F, Imbesi, M, Semrov, E, Giovanni, Cs, Taro, E, Ceno, V, Ovest, P, Anelli, S, Amore, M, Bigi, L, Britta, W, Anna, Gb, Bonatti, U, Borziani, M, Crosato, I, Galluccio, R, Galeotti, M, Gozzi, M, Greco, V, Guagnini, E, Pagani, S, Maccherozzi, M, Marchi, F, Melato, E, Mazzucchi, E, Marzullo, F, Pellegrini, P, Petrolini, N, Volta, P, Bonara, F, Brusamonti, E, Croci, R, Flamia, I, Fontana, F, Losi, R, Marchioro, R, Raffaini, L, Ruju, L, Saginario, A, Tondelli, Mg, Marrama, D, Bernardelli, L, Bonacini, F, Florindo, A, Merli, M, Nappo, P, Sola, L, Tondelli, O, Tonna, M, Torre, Mt, Tosatti, M, Venturelli, G, Zampolla, D, Bernardi, A, Cavalli, C, Cigala, L, Ciraudo, C, Bari, Di, Ferri, L, Gombi, F, Leurini, S, Mandatelli, E, Maccaferri, S, Oroboncoide, M, Pisa, B, Ricci, C, Poggi, E, Zurlini, C, Malpeli, M, Colla, R, Teodori, E, Vecchia, L, D'Andrea, R, Trenti, T, Paolini, P, Carpeggiani, P, Gagliostro, M, Pratelli, M, Lazzaro, S, Antonelli, A, Battistini, L, Bellini, F, Bonini, E, Capelli, Cb, Didomizio, C, Drei, C, Fucci, G, Gualandi, A, Grazia, Mr, Losi, Am, Mazzoni, Fm, Marangoni, D, Monna, G, Morselli, M, Oggioni, A, Oprandi, S, Paganelli, W, Passerini, M, Piscitelli, M, Reggiani, G, Rossi, G, Salvatori, F, Trasforini, S, Uslenghi, C, Veggetti, S, Bartolucci, G, Baruffa, R, Bertelli, R, Borghi, L, Ciavarella, P, Paltrinieri, E, Rizzardi, F, Serra, P, Suzzi, D, Carlo, U, Arienti, P, Aureli, F, Avanzi, R, Callegari, V, Corsino, A, Host, P, Michetti, R, Rizzo, F, Simoncelli, P, Soldati, E, Succi, E, Bertozzi, M, Canetti, E, Cavicchioli, L, Ceccarelli, E, Cenni, S, Marzola, G, Gallina, V, Leoni, C, Olivieri, A, Piccolo, E, Ravagli, S, Russo, R, Tedeschini, D, Verenini, M, Abram, W, Granata, V, Curcio, A, Guerra, G, Granini, S, Natali, L, Montanari, E, Pasi, F, Ventura, U, Valenti, S, Francesca, M, Farneti, R, Ravagli, P, Floris, R, Maroncelli, O, Volpones, G, Casali, D, Bencini, A, Cellini, M, Biase, De, Barbara, L, Charles, L, Pratesi, C, Tanini, A, Loparrino, R, Ulivelli, C, Cussoto, C, Dei, N, Fumanti, E, Pantani, M, Zeloni, G, Bellini, R, Cellesi, R, Dorigo, N, Gullì, P, Ialeggio, L, Pisanu, M, Rinaldi, G, Konze, A, Modignani, L, Frova, M, Monzani, E, Zanobio, A, Malagoli, M, Pagani, R, Barbera, S, Morganti, C, Amadè, Es, Brambilla, V, Montanari, A, Caterina, G, Lopez, C, Marocchi, A, Moletta, A, Sberna, M, Cascio, Mt, Manzone, Ml, Barbara, B, Mari, L, Razzini, E, Bianchi, Y, Pellizzer, Mr, Verdecchia, A, Sferrazza, Mg, Pismataro, R, D'Eril, Gv, Barassi, A, Pacciolla, R, Faraci, G, Rosmini, B, Carpi, F, Soelva, M, Anderlan, M, Francesco, De, M, Duregger, E, Vettori, C, Doimo, S, Kompatscher, E, Forer, M, Kerschbaumer, H, Gampe, A, Nicoletti, M, Acerbi, C, Aquilino, D, Azzali, S, Bensi, L, Cappellari, D, Casana, E, Campagnola, N, Dal, Corso, Di, E, Micco, E, Gobbi, E, Mairaghi, L, Malak, S, Mesiano, L, Paterlini, F, Perini, M, Puliti, Em, Rispoli, R, Rizzo, E, Sergenti, C, Soave, M, Alpi, A, Bislenghi, L, Bolis, T, Colnaghi, F, Fascendini, S, Grignani, S, Patelli, G, Casale, S, Zimmermann, C, Deledda, G, Goss, C, Mazzi, Maria Angela, Rimondini, Michela, Scassellati, C, Bonvicini, C, Longo, S, Ventriglia, M, Squitti, R, Frisoni, G, Pievani, M, Balestrieri, M, Perlini, C, Marinelli, V, Bellani, M, Rambaldelli, G, Atzori, M, Beltramello, A, Alessandrini, F, Pizzini, Francesca, Zoccatelli, G, Politi, P, Emanuele, E, Brondino, N, Martino, G, Bergami, A, Zarbo, R, Riva, Ma, Fumagalli, F, Molteni, R, Calabrese, F, Guidotti, G, Luoni, A, Macchi, F, Artioli, S, Baldetti, M, Bizzocchi, M, Bolzon, D, Bonello, E, Cacciari, G, Carraresi, C, Caselli, G, Furlato, K, Garlassi, S, Gavarini, A, Macchetti, F, Marteddu, V, Plebiscita, G, Totaro, S, Bebbington, P, Birchwood, M, Dazzan, P, Kuipers, E, Thornicroft, G, Pariante, C, Lawrie, S, Soares, J. C., Ruggeri, M., Bonetto, C., Lasalvia, A., De Girolamo, G., Bertani, M., Rucci, P., Santonastaso, P., Neri, G., Pileggi, F., Ghigi, D., Miceli, M., Scarone, S., Cocchi, A., Torresani, S., Faravelli, C., Zimmermann, C., Meneghelli, A., Cremonese, C., Scocco, P., Leuci, E., Mazzi, F., Gennarelli, Massimo, Brambilla, P., Bissoli, S., Lazzarotto, L., Bardella, S., Gardellin, F., Lamonaca, D., Lunardon, M., Magnabosco, R., Martucci, M., Nicolau, S., Nifosì, F., Bertani, M. E., Tosato, S., De Santi, K., Poli, S., Cristofalo, D., Tansella, Michele, Lunardi, S., Negretto, V., Zamboni, M. G., Ballarin, M., Chiavetto, Luisella Bocchio, Scasselatti, C., Zanardini, R., Bellani, M., Bertoldo, A., Marinelli, Valentina, Perlini, C., Rambaldelli, G., Pasqualini, A., Pavanati, M., Rossi, M., Piazza, C., Piccione, G., Sala, A., Roccato, S., Rossi-, A., Sale, A., Stefan, B., Strizzolo, S., Zotos, S., Balbo, M., Boggian, I., Ceccato, E., Dall’Agnola, R., Girotto, B., Leoni, R., Mai, A., Urbani, Alessandro, Ald, F., Bianchi, Benedetta, Cappellari, P., Conti, R., De Battisti, L., Lazzarin, E., Merlin, S., Migliorini, G., Pozzan, T., Sarto, L., Visonà, S., Brazzoli, A., Campi, A., Carmagnani, R., Giambelli, S., Gianella, A., Lunardi-, L., Madaghiele, D., Maestrelli, P., Paiola, L., Posteri, E., Viola, L., Zamberlan, V., Zenari, M., Zanoni, M., Bonadonna, G., Bonomo, M., Veronese, A., Anderle, P., Angelozz, A., Amalric, I., Baron, G., Candeago, E. B., Castelli, F., Chieco, M., Di Costanzo, E., Derossi, M., Doriguzzi, M., Galvano, O., Lattanz, M., Lezzi, R., Marcato, M., Marcolin, A., Marini, F., Matranga, M., Scalabrin, D., Zucchetto, M., Zadro, F., Austoni, G., Bianco, M., Bordino, F., Dario, F., DE RISIO, Alfredo, Gatto, A., Granà, S., Favero, E., Franceschin, A., Friederici, S., Marangon, V., Pascolo, M., Ramon, L., Zambolin, S., Riolo, R., Buffon, A., Di Bortolo, E., Fortin, S., Matarrese, F., Mogni, S., Codemo, N., Russi, A., Silvestro, Antonina, Turella, E., Viel, P., Dominoni, A., Andreose, L., Boemio, M., Bressan, L., Cabbia, A., Canesso, E., Cian, R., Dal Piccol, C., Dalla Pasqua, M. M., Di Prisco, A., Mantellato, L., Luison, M., Morgante, S., Santi, M., Sacillotto, M., Scabbio, M., Sponga, P., Sguotto, M. L., Stach, F., Vettorato, M. G., Martinello, G., Dassiè, F., DI MARINO, Simone, Cibiniel, L., Masetto, I., Cabianca, O., Valente, MADDALENA AGNESE, Caberlotto, L., Passoni, A., Flumian, P., Daniel, L., Gion, M., Stanziale, S., Alborino, F., Bortolozzo, V., Bacelle, L., Bicciato, L., Basso, D., Navaglia, F., Manoni, F., Ercolin, M., Giubilini, F., Imbesi, M., Semrov, E., Giovanni, C. S., Taro e Ceno, V., Ovest, P., Anelli, S., Amore, M., Bigi, L., Britta, W., Anna, G. B., Bonatti, U., Borziani, M., Crosato, I., Galluccio, R., Galeotti, M., Gozzi, M., Greco, V., Guagnini, E., Pagani, S., Maccherozzi, M., Marchi, F., Melato, E., Mazzucchi, E., Marzullo, F., Pellegrini, Pietro Carlo, Petrolini, N., Volta, P., Bonara, F., Brusamonti, E., Croci, R., Flamia, I., Fontana, F., Losi, R., Marchioro, R., Raffaini, L., Ruju, L., Saginario, A., Tondelli, M. G., Marrama, D., Bernardelli, L., Bonacini, F., Florindo, A., Merli, M., Nappo, P., Sola, L., Tondelli-, O., Tonna, M., Torre, M. T., Tosatti, M., Venturelli, G., Zampolla, D., Bernardi, A., Cavalli, Chiara, Cigala, L., Ciraudo, C., Di Bari, A., Ferri, L., Gombi, F., Leurini, S., Mandatelli, E., Maccaferri, S., Oroboncoide, M., Pisa, B., Ricci, Carmine, Poggi, E., Zurlini, C., Malpeli, M., Colla, R., Teodori, E., Vecchia, L., D’Andrea, R., Trenti, T., Paolini, P., Carpeggiani, P., Gagliostro, M., Pratelli, M., Lazzaro, S., Antonelli, A., Battistini, Luca, Bellini, Fiorella, Bonini, E., Capelli, C. B., Didomizio, C., Drei, C., Fucci, G., Gualandi, A., Grazia, M. R., Losi-, A. M., Mazzoni, F. M., Marangoni, D., Monna, G., Morselli, M., Oggioni, A., Oprandi, S., Paganelli, W., Passerini, M., Piscitelli, M., Reggiani, G., Rossi-, G., Salvatori, Franco, Trasforini, S., Uslenghi, C., Veggetti, S., Bartolucci, Giuliana, Baruffa, R., Bertelli, R., Borghi, L., Ciavarella, P., Paltrinieri, E., Rizzardi, F., Serra, P., Suzzi, D., Carlo, U., Arienti, P., Aureli, F., Avanzi, R., Callegari, V., Corsino, A., Host, P., Michetti, R., Rizzo, F., Simoncelli, P., Soldati, E., Succi, E., Bertozzi, M., Canetti, E., Cavicchioli, L., Ceccarelli, E., Cenni, S., Marzola, G., Gallina, V., Leoni, C., Olivieri, A., Piccolo, Elisa, Ravagli, S., Russo, R., Tedeschini, D., Verenini, M., Abram, W., Granata, V., Curcio, A., Guerra, G., Granini, S., Natali, L., Montanari, Eleonora, Pasi, F., Ventura, U., Valenti, S., Francesca, M., Farneti, R., Ravagli-, P., Floris, R., Maroncelli, O., Volpones, G., Casali, D., Bencini, A., Cellini, M., De Biase, L., Barbara, L., Charles, L., Pratesi, C., Tanini, A., Loparrino, R., Ulivelli, C., Cussoto, C., Dei, N., Fumanti, E., Pantani, M., Zeloni, G., Bellini-, R., Cellesi, R., Dorigo, N., Gullì, P., Ialeggio, L., Pisanu, M., Rinaldi, G., Konze, A., Modignani, L., Frova, M., Monzani, E., Amadè, E. S., Zanobio, A., Malagoli, M., Pagani-, R., Barbera, S., Morganti, C., Brambilla-, V., Montanari-, A., Caterina, G., LOPEZ CORTES, Carlo, Marocchi, A., Moletta, A., Sberna, M., Cascio, M. T., Manzone, M. L., Barbara-, B., Mari, L., Razzini, E., Bianchi-, Y., Pellizzer, M. R., Verdecchia, A., Sferrazza, M. G., Pismataro, R., D’Eril, G. V., Barassi, A., Pacciolla, R., Faraci, G., Rosmini, B., Carpi, F., Soelva, M., Anderlan, M., De Francesco, M., Duregger, E., Vettori, C., Doimo, S., Kompatscher, E., Forer, M., Kerschbaumer, H., Gampe, A., Nicoletti, M., Acerbi, C., Aquilino, D., Azzali, S., Bensi, L., Cappellari-, D., Casana, E., Campagnola, N., Dal Corso, E., Di Micco, E., Gobbi, E., Mairaghi, L., Malak, S., Mesiano, L., Paterlini, F., Perini, Matteo, Puliti, E. M., Rispoli, R., Rizzo-, E., Sergenti, C., Soave, M., Alpi, A., Bislenghi, L., Bolis, T., Colnaghi, F., Fascendini, S., Grignani, S., Patelli, G., Casale, S., Deledda, G., Goss, C., Mazzi-, M., Rimondini, M., Scassellati, C., Bonvicini, C., Longo, Salvatore, Bocchio Chiavetto, L., Ventriglia, M., Squitti, R., Frisoni, G., Pievani, M., Balestrieri, M., Atzori, M., Beltramello, A., Alessandrini, F., Pizzini, F., Zoccatelli, G., Politi, P., Emanuele, E., Brondino, N., Martino, G., Bergami, A., Zarbo, R., Riva, M. A., Fumagalli, F., Molteni, R., Calabrese, F., Guidotti, Giovanni, Luoni, Alessia, Macchi, F., Artioli, S., Baldetti, M., Bizzocchi, M., Bolzon, D., Bonello, E., Cacciari, G., Carraresi, C., Caselli, G., Furlato, K., Garlassi, S., Gavarini, A., Macchetti, F., Marteddu, V., Plebiscita, G., Totaro, S., Bebbington, P., Birchwood, M., Dazzan, P., Kuipers, E., Thornicroft, G., Pariante, C., Lawrie, S., Soares, J. C., Mirella Ruggeri, Chiara Bonetto, Antonio Lasalvia, Giovanni De Girolamo, Angelo Fioritti, Paola Rucci, Paolo Santonastaso, Giovanni Neri, Francesca Pileggi, Daniela Ghigi, Maurizio Miceli, Silvio Scarone, Angelo Cocchi, Stefano Torresani, Carlo Faravelli, Christa Zimmermann, Anna Meneghelli, Carla Cremonese, Paolo Scocco, Emanuela Leuci, Fausto Mazzi, Massimo Gennarelli, Paolo Brambilla, Sarah Bissoli, Maria Elena Bertani, Sarah Tosato, Katia De Santi, Sara Poli, Doriana Cristofalo, Michele Tansella, and and THE GET UP GROUP
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Research design ,Time Factors ,early psychosis, psychosocial interventions, cluster randomized triales ,medicine.medical_treatment ,Psychological intervention ,Medicine (miscellaneous) ,Assertive community treatment ,Severity of Illness Index ,law.invention ,Study Protocol ,Randomized controlled trial ,law ,Recurrence ,Early psychosi ,Cluster Analysis ,Pharmacology (medical) ,lcsh:R5-920 ,Family Relation ,Community Mental Health Service ,First-episode psychosis ,Community Mental Health Center ,Community Mental Health Services ,Cognitive behavioral therapy ,Treatment Outcome ,Cognitive Therapy ,Italy ,Research Design ,First-episode psychosisEarly psychosisCognitive behavioral therapyPsychosocial interventionAssertive community treatment ,Family Relations ,lcsh:Medicine (General) ,Psychosocial ,Human ,pragmatic trial ,Early psychosis ,Family intervention ,Psychosocial intervention ,Community Mental Health Centers ,Humans ,Patient Selection ,Psychotic Disorders ,Sample Size ,Case Management ,Cognitive Behavioral Therapy ,medicine.medical_specialty ,psychosocial interventions ,Time Factor ,cluster randomized triales ,Psychotic Disorder ,First-episode psychosi ,medicine ,Psychiatry ,Cluster Analysi ,business.industry ,Mental health ,Cognitive therapy ,business - Abstract
Background Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in ‘real-world’ services. Methods/Design The Psychosis early Intervention and Assessment of Needs and Outcome (PIANO) trial is part of a larger research program (Genetics, Endophenotypes and Treatment: Understanding early Psychosis - GET UP) which aims to compare, at 9 months, the effectiveness of a multi-component psychosocial intervention versus treatment as usual (TAU) in a large epidemiologically based cohort of patients with FEP and their family members recruited from all public community mental health centers (CMHCs) located in two entire regions of Italy (Veneto and Emilia Romagna), and in the cities of Florence, Milan and Bolzano. The GET UP PIANO trial has a pragmatic cluster randomized controlled design. The randomized units (clusters) are the CMHCs, and the units of observation are the centers’ patients and their family members. Patients in the experimental group will receive TAU plus: 1) cognitive behavioral therapy sessions, 2) psycho-educational sessions for family members, and 3) case management. Patient enrolment will take place over a 1-year period. Several psychopathological, psychological, functioning, and service use variables will be assessed at baseline and follow-up. The primary outcomes are: 1) change from baseline to follow-up in positive and negative symptoms’ severity and subjective appraisal; 2) relapse occurrences between baseline and follow-up, that is, episodes resulting in admission and/or any case-note records of re-emergence of positive psychotic symptoms. The expected number of recruited patients is about 400, and that of relatives about 300. Owing to the implementation of the intervention at the CMHC level, the blinding of patients, clinicians, and raters is not possible, but every effort will be made to preserve the independency of the raters. We expect that this study will generate evidence on the best treatments for FEP, and will identify barriers that may hinder its feasibility in ‘real-world’ clinical settings, patient/family conditions that may render this intervention ineffective or inappropriate, and clinical, psychological, environmental, and service organization predictors of treatment effectiveness, compliance, and service satisfaction. Trial registration ClinicalTrials.gov Identifier NCT01436331
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- 2012
22. Image Enhancement in the Compressed Domain
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J.S. McElvain, M. Amore, Sanjit K. Mitra, Marco Carli, Amore M, Mitra SK, Carli M, McElvain JS, Amore, M, Mitra, Sk, Carli, Marco, and Mcelvain, Js
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Image coding ,business.industry ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Data_CODINGANDINFORMATIONTHEORY ,Sharpening ,Image enhancement ,Dct coefficient ,Jpeg compression ,Discrete cosine transform ,Computer vision ,Artificial intelligence ,business ,Quantization (image processing) ,Transform coding ,Mathematics - Abstract
In this paper a new image enhancement method in the transform domain is proposed. The technique is based on sharpening the magnitude of the DCT coefficients and has been integrated into the JPEG compression process to improve the visual quality of the image before it is decompressed.
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- 2007
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23. Subthreshold mania as predictor of depression during interferon treatment in HCV+ patients without current or lifetime psychiatric disorders
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Luca Maggi, Enrico Beverini, Mario Amore, Mario Maj, Maurizia Rossana Brunetto, Liliana Dell'Osso, Vincenzo Scarallo, Giuseppe Ferrari, Alessia Baldini, Stefano Pini, Elena Manca, Quirico Semeraro, Ferruccio Bonino, Paola Rucci, Alessandro Del Debbio, Marina Carlini, Dell'Osso, L, Pini, S, Maggi, L, Rucci, P, DEL DEBBIO, A, Carlini, M, Baldini, A, Ferrari, G, Manca, E, Beverini, E, Amore, M, Scarallo, V, Semeraro, Q, Brunetto, M, Bonino, F, Maj, Mario, Dell'Osso L., Pini S., Maggi L., Rucci P., Del Debbio A., Carlini M., Baldini A., Ferrari G., Manca E., Beverini E., Amore M., Scarallo V., Semeraro Q., Brunetto M., Bonino F., and Maj M.
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Adult ,Male ,medicine.medical_specialty ,Bipolar Disorder ,Injections, Subcutaneous ,Statistics as Topic ,Alpha interferon ,Administration, Oral ,Pilot Projects ,Interferon alpha-2 ,Irritability ,Antiviral Agents ,Pharmacotherapy ,INTERFERON THERAPY ,Risk Factors ,Ribavirin ,medicine ,Humans ,Psychiatry ,Interferon alfa ,Depression (differential diagnoses) ,Aged ,Depressive Disorder, Major ,business.industry ,Interferon-alpha ,Hepatitis C, Chronic ,Middle Aged ,Recombinant Proteins ,Diagnostic and Statistical Manual of Mental Disorders ,Psychiatry and Mental health ,Clinical Psychology ,psychiatric disorders ,Anxiety ,Drug Therapy, Combination ,Female ,Viral disease ,medicine.symptom ,business ,Mania ,medicine.drug - Abstract
Background Depression is considered the most frequent interferon (IFN)-α-induced psychiatric disorder. However, other neuropsychiatric side effects of IFN treatment, such as irritability, anxiety, and manic episodes, are reported as well. We analyzed the impact of lifetime manic–hypomanic symptoms and anxiety on the development of depression in hepatitis-C-virus-infected subjects treated with two different types of IFN-α. Methods At baseline, subjects received thorough diagnostic assessment to exclude lifetime or current psychiatric symptoms. During treatment, subjects were administered interviewer-based and self-report instruments. Results Six (12%) of 49 individuals with a negative history of psychiatric disorders developed major depression during treatment with IFN. The onset of depression was significantly associated with the presence of lifetime subthreshold manic–hypomanic symptoms. Subjects exceeding manic threshold were more likely to develop depression than those below threshold (33.3% vs. 7.5%, P =.033). Conclusions Our data suggest that individuals treated with IFN with no past history of psychiatric disorders are more likely to develop depression if they experienced subthreshold manic–hypomanic symptoms in their lifetime. These findings derive from an exploratory study and may have important implications for the prevention of IFN-induced depression if replicated in larger studies.
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- 2007
24. Assessing response, remission and treatment resistance in patients with Obsessive-Compulsive Disorder with and without Tic Disorders: Results from a multicenter study
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Roberta Necci, Donatella Marazziti, Sylvia Rigardetto, Andrea Aguglia, Nicolaja Girone, Mauro Porta, Giuseppe Mania, Dario Conti, Domenico Servello, Bernardo Dell'Osso, Domenico De Berardis, Orsola Gambini, Umberto Albert, Mario Amore, Sara De Michele, Beatrice Benatti, Rita Cafaro, Andrea Amerio, Caterina Viganò, Benedetta De Martini, Federico Mucci, Roberta Balestrino, Roberta Galentino, Antonio Tundo, Stefano Pallanti, Alberto Priori, Matteo Briguglio, Giacomo Grassi, Davide Prestia, Benatti, B., Girone, N., Conti, D., Cafaro, R., Vigano, C., Briguglio, M., Marazziti, D., Mucci, F., Gambini, O., De Martini, B., Tundo, A., Necci, R., De Berardis, D., Galentino, R., De Michele, S., Balestrino, R., Albert, U., Rigardetto, S., Mania, G., Grassi, G., Pallanti, S., Amerio, A., Aguglia, A., Prestia, D., Amore, M., Priori, A., Servello, D., Porta, M., and Dell'Osso, B.
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Pediatrics ,medicine.medical_specialty ,Tic disorder ,Obsessive-Compulsive Disorder ,Psychopharmacology ,Remission ,Obsessive compulsive disorder ,Response ,Treatment resistance ,Comorbidity ,Obsessive–compulsive disorder ,Obsessive compulsive ,mental disorders ,medicine ,psychopharmacology ,remission ,response ,tic disorder ,treatment resistance ,Humans ,In patient ,business.industry ,medicine.disease ,Psychiatry and Mental health ,Multicenter study ,Tic Disorders ,Quality of Life ,Tics ,Neurology (clinical) ,business - Abstract
BackgroundHighlighting the relationship between obsessive–compulsive disorder (OCD) and tic disorder (TD), two highly disabling, comorbid, and difficult-to-treat conditions, Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) acknowledged a new “tic-related” specifier for OCD, ie, obsessive–compulsive tic-related disorder (OCTD). As patients with OCTD may frequently show poor treatment response, the aim of this multicenter study was to investigate rates and clinical correlates of response, remission, and treatment resistance in a large multicenter sample of OCD patients with versus without tics.MethodsA sample of 398 patients with a DSM-5 diagnosis of OCD with and without comorbid TD was assessed from 10 different psychiatric departments across Italy. For the purpose of the study, treatment response profiles in the whole sample were analyzed comparing the rates of response, remission, and treatment-resistance as well as related clinical features. Multivariate logistic regressions were performed to identify possible factors associated with treatment response.ResultsThe remission group was associated with later ages of onset of TD and OCD. Moreover, significantly higher rates of psychiatric comorbidities, TD, and lifetime suicidal ideation and attempts emerged in the treatment-resistant group, with larger degrees of perceived worsened quality of life and family involvement.ConclusionsAlthough remission was associated with later ages of OCD and TD onset, specific clinical factors, such as early onset and presence of psychiatric comorbidities and concomitant TD, predicted a worse treatment response with a significant impairment in quality of life for both patients and their caregivers, suggesting a worse profile of treatment response for patients with OCTD.
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- 2022
25. Factors associated with lifetime suicide attempts in bipolar disorder: results from an Italian nationwide study
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Andrea Fagiolini, Guido Di Sciascio, Giuseppe Maina, Claudia Palumbo, Maurizio Pompili, Massimiliano Buoli, Pasquale De Fazio, Andrea de Bartolomeis, Giorgio Di Lorenzo, Gabriele Sani, Luca Steardo, Mario Amore, Alberto Siracusano, Alfonso Tortorella, Bruno Mario Cesana, A. Carlo Altamura, Mario Altamura, Bernardo Dell'Osso, Gabriele Di Salvo, Marco Di Nicola, Emi Bondi, Antonello Bellomo, Emilio Sacchetti, Umberto Albert, Andrea Fiorillo, Simone Bolognesi, Alessandro Bertolino, Buoli, M., Cesana, B. M., Bolognesi, S., Fagiolini, A., Albert, U., Di Salvo, G., Maina, G., de Bartolomeis, A., Pompili, M., Palumbo, C., Bondi, E., Steardo, L., De Fazio, P., Amore, M., Altamura, M., Bellomo, A., Bertolino, A., Di Nicola, M., Di Sciascio, G., Fiorillo, A., Sacchetti, E., Sani, G., Siracusano, A., Di Lorenzo, G., Tortorella, A., Altamura, A. C., and Dell'Osso, B.
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Male ,Bipolar Disorder ,Settore MED/25 - PSCHIATRIA ,medicine.medical_treatment ,Suicidal attempts ,Suicide, Attempted ,Bipolar Disorder (BD) ,Clinical features ,Outcome ,Logistic regression ,Suicidal Ideation ,Risk Factors ,Female patient ,medicine ,Psychoeducation ,Humans ,Pharmacology (medical) ,Bipolar disorder ,Biological Psychiatry ,Attempted ,Univariate analysis ,business.industry ,General Medicine ,Odds ratio ,medicine.disease ,Suicide ,Psychiatry and Mental health ,Italy ,Psychotic Disorders ,Settore MED/25 ,Clinical feature ,Suicidal behavior ,Female ,business ,Attribution ,Demography - Abstract
The purpose of the present study was to detect demographic and clinical factors associated with lifetime suicide attempts in Bipolar Disorder (BD). A total of 1673 bipolar patients from different psychiatric departments were compared according to the lifetime presence of suicide attempts on demographic/clinical variables. Owing to the large number of variables statistically related to the dependent variable (presence of suicide attempts) at the univariate analyses, preliminary multiple logistic regression analyses were realized. A final multivariable logistic regression was then performed, considering the presence of lifetime suicide attempts as the dependent variable and statistically significant demographic/clinical characteristics as independent variables. The final multivariable logistic regression analysis showed that an earlier age at first contact with psychiatric services (odds ratio [OR] = 0.97, p p p p p p
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- 2021
26. Which factors delay treatment in bipolar disorder? A nationwide study focussed on duration of untreated illness
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Alfonso Tortorella, Alfredo Carlo Altamura, Alberto Siracusano, Andrea Fiorillo, Bernardo Dell'Osso, A. de Bartolomeis, Paola Rocca, Luca Steardo, Alessandro Bertolino, Emilio Sacchetti, Emi Bondi, G. Di Lorenzo, Umberto Albert, Maurizio Pompili, Gabriele Sani, M. Di Nicola, G. Di Sciascio, Giuseppe Maina, Andrea Fagiolini, Massimiliano Buoli, Bruno Mario Cesana, Antonello Bellomo, Mario Amore, Buoli, M., Cesana, B. M., Fagiolini, A., Albert, U., Maina, G., de Bartolomeis, A., Pompili, M., Bondi, E., Steardo, L., Amore, M., Bellomo, A., Bertolino, A., Di Nicola, M., Di Sciascio, G., Fiorillo, A., Rocca, P., Sacchetti, E., Sani, G., Siracusano, A., Di Lorenzo, G., Tortorella, A., Altamura, A. C., and Dell'Osso, B.
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medicine.medical_specialty ,Bipolar Disorder ,clinical features ,Suicide, Attempted ,Suicidal Ideation ,Correlation ,03 medical and health sciences ,duration of untreated illness (DUI) ,0302 clinical medicine ,Internal medicine ,Medicine ,Humans ,In patient ,Bipolar disorder ,Biological Psychiatry ,Attempted ,First episode ,Depressive Disorder ,Depressive Disorder, Major ,business.industry ,Major ,bipolar disorder (BD) ,outcome ,medicine.disease ,030227 psychiatry ,clinical feature ,Substance abuse ,Suicide ,Psychiatry and Mental health ,Settore MED/25 ,Psychotic Disorders ,Psychiatric diagnosis ,Major depressive disorder ,Pshychiatric Mental Health ,business ,030217 neurology & neurosurgery - Abstract
AIM The aim of the present study was to detect factors associated with duration of untreated illness (DUI) in bipolar disorder (BD). METHOD A total of 1575 patients were selected for the purposes of the study. Correlation analyses were performed to analyse the relation between DUI and quantitative variables. The length of DUI was compared between groups defined by qualitative variables through one-way analyses of variance or Kruskal-Wallis's tests according to the distribution of the variable. Linear multivariable regressions were used to find the most parsimonious set of variables independently associated with DUI: to this aim, qualitative variables were inserted with the numeric code of their classes by assuming a proportional effect moving from one class to another. RESULTS An inverse significant correlation between length of DUI and time between visits in euthymic patients was observed (r = -.52, P
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- 2021
27. Tolerability and efficacy of vortioxetine versus SSRIs in elderly with major depression. Study protocol of the VESPA study: a pragmatic, multicentre, open-label, parallel-group, superiority, randomized trial
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Mario Amore, Barbara D'Avanzo, Angelo Barbato, Davide Papola, Elisa Zanini, Armando D'Agostino, Pasquale De Fazio, Simone Cavallotti, Lorenzo Tarsitani, Luigi Grassi, Andrea Aguglia, Michela Nosè, Rosangela Caruso, Giulia Turrini, Giovanni Ostuzzi, Francesco Amaddeo, Massimo Biondi, Mirella Ruggeri, Cristina Crocamo, Igor Monti, Maria Chiara Alessi, Chiara Di Natale, Giuseppe Carrà, Chiara Gastaldon, Corrado Barbui, Giovanni Martinotti, Paola Bortolaso, Eugenio Aguglia, Laura Giusti, Marianna Purgato, Rita Roncone, Camilla Callegari, Mauro Tettamanti, Alessandro Rodolico, Francesco Bartoli, Ostuzzi, G, Gastaldon, C, Barbato, A, D'Avanzo, B, Tettamanti, M, Monti, I, Aguglia, A, Aguglia, E, Alessi, M, Amore, M, Bartoli, F, Biondi, M, Bortolaso, P, Callegari, C, Carrà, G, Caruso, R, Cavallotti, S, Crocamo, C, D'Agostino, A, De Fazio, P, Di Natale, C, Giusti, L, Grassi, L, Martinotti, G, Nose, M, Papola, D, Purgato, M, Rodolico, A, Roncone, R, Tarsitani, L, Turrini, G, Zanini, E, Amaddeo, F, Ruggeri, M, and Barbui, C
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medicine.medical_specialty ,Medicine (miscellaneous) ,Antidepressant ,Equivalence Trials as Topic ,Antidepressants ,Depression ,Elderly ,Pragmatic trial ,Randomized clinical trial ,Vortioxetine ,NO ,law.invention ,Study Protocol ,03 medical and health sciences ,Antidepressants, Depression, Elderly, Pragmatic trial, Randomized clinical trial, Equivalence Trials as Topic, Vortioxetine, Serotonin Uptake Inhibitors ,0302 clinical medicine ,Randomized controlled trial ,Quality of life ,Rating scale ,law ,Pragmatic Clinical Trials as Topic ,medicine ,Humans ,Multicenter Studies as Topic ,Pharmacology (medical) ,030212 general & internal medicine ,Depression (differential diagnoses) ,Aged ,Depressive Disorder, Major ,Depressive Disorder ,lcsh:R5-920 ,business.industry ,Major ,Guideline ,Italy ,Serotonin Uptake Inhibitors ,Tolerability ,Good clinical practice ,Physical therapy ,lcsh:Medicine (General) ,business ,Selective Serotonin Reuptake Inhibitors ,030217 neurology & neurosurgery - Abstract
Introduction Depression is a highly prevalent condition in the elderly, with a vast impact on quality of life, life expectancy, and medical outcomes. Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed agents in this condition and, although generally safe, tolerability issues cannot be overlooked. Vortioxetine is an antidepressant with a novel mechanism of action. Based on studies to date, it may have a promising tolerability profile in the elderly, as it does not adversely affect psychomotor or cognitive performance and does not alter cardiovascular and endocrine parameters. The present study aims to assess the tolerability profile of vortioxetine in comparison with the SSRIs considered as a single group in elderly participants with depression. The rate of participants withdrawing from treatment due to adverse events after 6 months of follow up will be the primary outcome. Methods and analysis This is a pragmatic, multicentre, open-label, parallel-group, superiority, randomized trial funded by the Italian Medicines Agency (AIFA - Agenzia Italiana del Farmaco). Thirteen Italian Community Psychiatric Services will consecutively enrol elderly participants suffering from an episode of major depression over a period of 12 months. Participants will be assessed at baseline and after 1, 3 and 6 months of follow up. At each time point, the following validated rating scales will be administered: Montgomery–Åsberg Depression Rating Scale (MADRS), Antidepressant Side-Effect Checklist (ASEC), EuroQual 5 Dimensions (EQ-5D), Short Blessed Test (SBT), and Charlson Age-Comorbidity Index (CACI). Outcome assessors and the statistician will be masked to treatment allocation. A total of 358 participants (179 in each group) will be enrolled. Ethics and dissemination This study will fully adhere to the ICH E6 Guideline for Good Clinical Practice. Participants’ data will be managed and safeguarded according to the European Data Protection Regulation 2016/679. An external Ethical Advisory Board will help guarantee high ethical standards. Trial registration Clinicaltrials.gov: NCT03779789, Registered on 19 December 2018. Submitted on 19 December. EudraCT number: 2018–001444-66. Trial status Protocol version 1.5; 09/06/2018. Recruitment started In February 2019 and it is ongoing. It is expected to end approximately on 30 September 2021.
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- 2020
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28. A Specific Inflammatory Profile Underlying Suicide Risk? Systematic Review of the Main Literature Findings
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Mario Amore, Valentina Maria Parisi, Andrea Amerio, Maurizio Pompili, Gianluca Serafini, Gaia Sampogna, Andrea Fiorillo, Andrea Aguglia, Serafini, G., Parisi, V. M., Aguglia, A., Amerio, A., Sampogna, G., Fiorillo, A., Pompili, M., and Amore, M.
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Risk ,Inflammatory cytokine ,inflammatory cytokines ,Health, Toxicology and Mutagenesis ,lcsh:Medicine ,Suicide, Attempted ,suicidal behavior ,Review ,Suicidal Ideation ,Proinflammatory cytokine ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Mediator ,Immune system ,immune pathways ,immunological differences ,major depressive disorder ,medicine ,Humans ,Immunological difference ,Suicidal ideation ,Inflammation ,Depressive Disorder, Major ,business.industry ,lcsh:R ,Public Health, Environmental and Occupational Health ,Interleukin ,medicine.disease ,030227 psychiatry ,Vascular endothelial growth factor ,Suicide ,chemistry ,Immunology ,Cytokines ,Major depressive disorder ,Tumor necrosis factor alpha ,medicine.symptom ,business ,Immune pathway ,030217 neurology & neurosurgery - Abstract
Consistent evidence indicates the association between inflammatory markers and suicidal behavior. The burden related to immunological differences have been widely documented in both major affective disorders and suicidal behavior. Importantly, abnormally elevated pro-inflammatory cytokines levels have been reported to correlate with suicidal behavior but whether and to what extent specific inflammatory cytokines abnormalities may contribute to our understanding of the complex pathophysiology of suicide is unknown. The present manuscript aimed to systematically review the current literature about the role of pro-inflammatory cytokines in suicidal behavior. Most studies showed a link between abnormally higher interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β1, vascular endothelial growth factor (VEGF), kynurenic acid (KYN), and lower IL-2, IL-4, and interferon (IFN)-γ levels in specific brain regions and suicidal behavior. Unfortunately, most studies are not able to exclude the exact contribution of major depressive disorder (MDD) as a mediator/moderator of the link between inflammatory cytokines abnormalities and suicidal behavior. The association between suicidal patients (both suicide attempters or those with suicidal ideation) and the altered immune system was documented by most studies, but this does not reflect the existence of a specific causal link. Additional studies are needed to clarify the immune pathways underlying suicidal behavior.
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- 2020
29. Schizophrenia and 'unmet needs': From diagnosis to care in Italy
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Paolo Girardi, Andrea Fagiolini, Bernardo Carpiniello, Mario Amore, Silvana Galderisi, Eugenio Aguglia, Antonio Vita, Armida Mucci, Marco A. Riva, Galderisi, S., Riva, M. A., Girardi, P., Amore, M., Carpiniello, B., Aguglia, E., Fagiolini, A., Mucci, A., and Vita, A.
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Adult ,Mental Health Services ,medicine.medical_specialty ,Consensus ,Delphi consensus ,early diagnosis ,schizophrenia ,treatment gaps ,Health Services Accessibility ,Humans ,Italy ,Patient Care Team ,Psychiatry ,Quality of Life ,Schizophrenia ,Best practice ,Schizophrenia (object-oriented programming) ,Delphi method ,Psychological intervention ,Intervention (counseling) ,medicine ,Social isolation ,Delphi consensu ,business.industry ,medicine.disease ,Comorbidity ,Psychiatry and Mental health ,early diagnosi ,Family medicine ,Settore BIO/14 - Farmacologia ,medicine.symptom ,business ,Psychosocial ,Research Article - Abstract
Background. Schizophrenia is a leading cause of disability. People living with schizophrenia (PLWS) present unemployment, social isolation, excess mortality and morbidity, and poor quality of life. Early recognition and appropriate treatment reduce the risk of chronicity and comorbidity. Personalization and integration of pharmacological and psychosocial interventions, as well as accurate identification and management of psychiatric and somatic comorbidities, can significantly improve mental and physical health of PLWS, promoting recovery. Methods. A three-step Delphi approach was used to explore consensus on the essential components of early recognition and intervention, personalization, and integration of care to improve schizophrenia outcome, and on barriers and challenges to close treatment gaps. The consensus involved 8 Italian experts of schizophrenia, 100 psychiatrists from academic and nonacademic settings, including representatives of Italian Society of Psychiatry, and 65 trainees in psychiatry. Results. A strong consensus (from mostly agree to totally agree) emerged on the importance of early diagnosis (97%), standardized assessments (91%), correct management of somatic and psychiatric comorbidities (99%), and personalization and integration of care (94%). Lack of time, human resources, and training were identified as the main barriers and challenges to the translation of knowledge into clinical practice. Conclusions. The results of this Delphi study demonstrated a strong consensus on main components of schizophrenia care, as well as on unmet needs to promote best practice and gaps between knowledge and clinical practice. The involvement of a large group of professionals and trainees in this in-depth consensus process might contribute to raise awareness and stimulate innovative strategies to improve the outcome of PLWS.
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- 2020
30. Suicidal ideation and suicidal attempts in patients with obsessive-compulsive tic-related disorder vs obsessive-compulsive disorder: Results of a multicenter Italian study
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Alberto Priori, Federico Mucci, Stefano Pallanti, Matteo Briguglio, Silvia Ferrari, Domenico Servello, Liliana Dell'Osso, Sara De Michele, Beatrice Benatti, Roberta Necci, Benedetta Demartini, Giuseppe Maina, Sylvia Rigardetto, Roberta Galentino, Domenico De Berardis, M. Bosi, Giacomo Grassi, Anna Colombo, Mario Amore, Caterina Viganò, Orsola Gambini, Andrea Amerio, Donatella Marazziti, Bernardo Dell'Osso, Umberto Albert, Benedetta Grancini, Antonio Tundo, Nicolaja Girone, Mauro Porta, Benatti, B., Ferrari, S., Grancini, B., Girone, N., Briguglio, M., Marazziti, D., Mucci, F., Dell'Osso, L., Gambini, O., Demartini, B., Tundo, A., Necci, R., De Berardis, D., Galentino, R., De Michele, S., Albert, U., Rigardetto, S., Maina, G., Grassi, G., Pallanti, S., Amerio, A., Amore, M., Priori, A., Servello, D., Vigano, C., Bosi, M., Colombo, A., Porta, M., and Dell'Osso, B.
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Adult ,Male ,medicine.medical_specialty ,Tic disorder ,Obsessive-Compulsive Disorder ,Adolescent ,suicidality ,Suicide, Attempted ,Obsessive-compulsive disorder ,tic disorder ,Female ,Humans ,Italy ,Middle Aged ,Sex Factors ,Tic Disorders ,Tics ,Young Adult ,Suicidal Ideation ,behavioral disciplines and activities ,03 medical and health sciences ,0302 clinical medicine ,mental disorders ,Epidemiology ,medicine ,In patient ,Family history ,Psychiatry ,Prospective cohort study ,Suicidal ideation ,Attempted ,Suicide attempt ,business.industry ,medicine.disease ,humanities ,030227 psychiatry ,Psychiatry and Mental health ,Suicide ,Related disorder ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
BackgroundObsessive-compulsive disorder (OCD) and tic disorder (TD) represent highly disabling, chronic and often comorbid psychiatric conditions. While recent studies showed a high risk of suicide for patients with OCD, little is known about those patients with comorbid TD (OCTD). Aim of this study was to characterize suicidal behaviors among patients with OCD and OCTD.MethodsThree hundred and thirteen outpatients with OCD (n = 157) and OCTD (n = 156) were recruited from nine different psychiatric Italian departments and assessed using an ad-hoc developed questionnaire investigating, among other domains, suicide attempt (SA) and ideation (SI). The sample was divided into four subgroups: OCD with SA (OCD-SA), OCD without SA (OCD-noSA), OCTD with SA (OCTD-SA), and OCTD without SA (OCTD-noSA).ResultsNo differences between groups were found in terms of SI, while SA rates were significantly higher in patients with OCTD compared to patients with OCD. OCTD-SA group showed a significant male prevalence and higher unemployment rates compared to OCD-SA and OCD-noSA sample. Both OCTD-groups showed an earlier age of psychiatric comorbidity onset (other than TD) compared to the OCD-SA sample. Moreover, patients with OCTD-SA showed higher rates of other psychiatric comorbidities and positive psychiatric family history compared to the OCD-SA group and to the OCD-noSA groups. OCTD-SA and OCD-SA samples showed higher rates of antipsychotics therapies and treatment resistance compared to OCD-noSA groups.ConclusionsPatients with OCTD vs with OCD showed a significantly higher rate of SA with no differences in SI. In particular, OCTD-SA group showed different unfavorable epidemiological and clinical features which need to be confirmed in future prospective studies.
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- 2020
31. Instrumental assessment of balance and gait in depression: A systematic review
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Stamatula Zanetidou, Alice Coni, Lorenzo Chiari, Carlo Tacconi, Francesca Neviani, Mario Amore, Erika Nerozzi, Martino Belvederi Murri, Klea D Bertakis, Matteo Respino, Andrea Escelsior, Marco Bertolotti, Federico Triolo, Belvederi Murri M., Triolo F., Coni A., Tacconi C., Nerozzi E., Escelsior A., Respino M., Neviani F., Bertolotti M., Bertakis K., Chiari L., Zanetidou S., and Amore M.
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medicine.medical_specialty ,Poison control ,Postural stability ,Physical exercise ,NO ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Medicine ,Humans ,Longitudinal Studies ,Gait ,Exercise ,Postural Balance ,Biological Psychiatry ,Depression (differential diagnoses) ,Balance (ability) ,Psychomotor learning ,Agitation ,Depressive Disorder ,Psychomotor retardation ,business.industry ,Depression ,Slowing ,Antidepressive Agents ,030227 psychiatry ,Case-Control Studies ,Cross-Sectional Studies ,Psychiatry and Mental health ,Mood ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Psychomotor symptoms of depression are understudied despite having a severe impact on patient outcomes. This review aims to summarize the evidence on motor features of depression assessed with instrumental procedures, and examine age-related differences. We included studies investigating posture, balance and gait ascertained with instrumental measurements among individuals with depressive symptoms or disorders. Studies on subjects with specific physical illnesses were excluded. Methodological quality was assessed with the Newcastle - Ottawa Scale (NOS) and PRISMA guidelines were followed. 33 studies (13 case-control, five cross-sectional, nine longitudinal and six intervention) with overall low-medium quality were included. Different instruments were employed to assess posture (e.g. digital cameras), balance (balance, stepping platform) or gait (e.g. Six-Minute-Walking Test, instrumented walkways). Results suggest that depression in adults is associated with significant impairments of posture, balance and gait. Motor abnormalities among depressed older adults may depend on the interplay of physical diseases, cognitive impairment and mood. Very few intervention studies measured motor symptoms as outcome. Available evidence suggests, however, that antidepressant drugs and physical exercise may be beneficial for motor abnormalities. Despite the lack of high-quality studies, instrumental assessments confirm the presence and importance of motor abnormalities in depression, with potential age-related differences in their pathophysiology.
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- 2020
32. Physical Exercise for Late-Life Depression: Effects on Heart Rate Variability
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Chiara Mussi, Marco Menchetti, George S. Alexopoulos, Graziano Ceresini, Aderville Cabassi, Ferdinando Tripi, Luigi Bagnoli, Alessandro Piras, Paola Rucci, Mario Amore, Martino Belvederi Murri, Giulio Toni, Giuliano Ermini, Roberto Senaldi, Stamatula Zanetidou, Massimo F Piepoli, Salvatore Squatrito, Donato Zocchi, Toni, G, Belvederi Murri, M, Piepoli, M, Zanetidou, S, Cabassi, A, Squatrito, Salvatore, Bagnoli, L, Piras, Alessandro, Mussi, C, Senaldi, R, Menchetti, Marco, Zocchi, Donato, Ermini, Giuliano, Ceresini, G, Tripi, F, Rucci, Paola, Alexopoulos, G, and Amore, M.
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Male ,medicine.medical_specialty ,Physical exercise ,elderly ,NO ,Late Onset Disorders ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Heart Rate ,law ,Sertraline ,Internal medicine ,Heart rate ,medicine ,Humans ,Heart rate variability ,Single-Blind Method ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,Depressive Disorder, Major ,antidepressant ,exercise ,business.industry ,autonomic nervous system ,heart rate variability ,antidepressants ,major depression ,Geriatrics and Gerontology ,Psychiatry and Mental Health ,Late life depression ,Antidepressive Agents ,Exercise Therapy ,030227 psychiatry ,Psychiatry and Mental health ,Autonomic nervous system ,Physical therapy ,Cardiology ,Female ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Objectives Late-life major depression is associated with increased cardiovascular risk and impaired autonomic control of the heart, as evident from reduced heart rate variability (HRV). Moreover, antidepressant drug therapy also might be associated with further reductions of HRV. In the SEEDS study, we investigated whether sertraline associated with physical exercise protocols led to improvements of HRV, compared with antidepressant drug therapy alone. Design Single-blind randomized controlled trial. Setting Psychiatric consultation-liaison program for primary care. Participants Patients aged 65–85 years with major depression, recruited from primary care. Interventions Sertraline plus structured, tailored group physical exercise (S + EX) versus sertraline alone (S) for 24 weeks. Measurements HRV indices (RR, percentage of NN intervals greater than 50 msec [pNN50], square root of the mean squared differences of successive NN intervals [RMSSD], standard deviation of heart rate [SDHR], standard deviation of the NN interval [SDNN], high-frequency band [HF], low-frequency band [LF], and their ratio [LF/HF]) were measured at baseline, week 12, and week 24. Psychiatric and medical assessments. Results Participants displayed significant improvements of most HRV indices over time, irrespective of the group assignment (pNN50, RMSSD, SDHR, SDNN, HF, LF, and LF/HF). Moreover, patients in the S + EX group displayed greater increases of different HRV indices(RR, pNN50, RMSSD, SDHR, SDNN, HF, and LF) compared with those in the S group. Conclusions The combination of structured physical exercise and sertraline might exert positive effects on the autonomic control of the heart among older patients with major depression.
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- 2016
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33. Attitudes of Italian Psychiatrists Toward the Evaluation of Physical Comorbidities and Sexual Dysfunction in Patients With Schizophrenia. Implications for Clinical Practice
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Emmanuele A. Jannini, Andrea Fagiolini, Palmiero Monteleone, Mario Amore, Giuseppe Maina, Massimo Clerici, Alberto Siracusano, Antonio Vita, Alessandro Rossi, Aderville Cabassi, Paolo Girardi, Monteleone, P, Amore, M, Cabassi, A, Clerici, M, Fagiolini, A, Girardi, P, Jannini, E, Maina, G, Rossi, A, Vita, A, and Siracusano, A
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physical comorbiditie ,medicine.medical_specialty ,prolactin ,lcsh:RC435-571 ,medicine.medical_treatment ,Settore MED/13 - Endocrinologia ,03 medical and health sciences ,0302 clinical medicine ,physical comorbidities ,antipsychotic ,cardiometabolic risk ,psychometric test ,schizophrenia ,sexual dysfunction ,survey ,lcsh:Psychiatry ,Health care ,mental disorders ,medicine ,In patient ,Antipsychotic ,Psychiatry ,Settore MED/25 - Psichiatria ,Original Research ,Cardiometabolic risk ,business.industry ,medicine.disease ,Mental illness ,030227 psychiatry ,Clinical Practice ,Psychiatry and Mental health ,Sexual dysfunction ,Schizophrenia ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Treatment guidelines for patients with schizophrenia recommend evaluating their risk of physical comorbidities, especially since these patients are known to have decreased life expectancy due to comorbidities. Therefore, to the authors’ knowledge, this is the first national survey conducted to investigate how Italian psychiatrists deal with the risk of physical comorbidities and sexual dysfunction in patients with schizophrenia. A sample of 750 psychiatrists completed an ad hoc online survey investigating their decision making about performing blood tests, clinical and instrumental examinations, and scheduling follow-up appointments in relation to the different phases of the illness and possible pharmacological side effects. Compared to patients in therapeutic continuation, those diagnosed for the first time and those who received a therapeutic change were visited more frequently (every 15 to 17 days vs. every 40 days, respectively), and were more regularly prescribed blood tests and instrumental examinations (every 4.2 to 4.4 months vs. every 9 months, respectively). There was a high interest in the surveillance of cardiometabolic risk. In 54% of patients, prolactin testing was not requested before starting an antipsychotic. In terms of specialist referrals, only 5% of surveyed psychiatrists “never” sought for additional counseling. There was little attention given to sexual functioning assessment based on the survey results about patients' daily life and with regard to deciding to prescribe additional examinations. In fact, only up to 3% of psychiatrists reported assessing sexual functioning using specific psychometric tests. In summary, Italian psychiatrists describes themselves as careful healthcare providers for the physical illnesses of patients with schizophrenia but with several shortcomings. For instance, clinical attention toward patients’ sexual and reproductive healthcare needs remains a challenge. Psychiatrists should take the lead for the integrated education, assessment, and care of medical needs of their patients with mental illness. Based on the results of this survey, the authors also believe that a future challenge for the management of patients with mental illness will be the classification of patients based on their risk of comorbidities, to help ensure optimal healthcare provision for those at greater risk of other illnesses.
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- 2019
34. Predictors of recurrence in a sample of 508 outpatients with major depressive disorder
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André F. Carvalho, Maurizio Pompili, Andrea Fiorillo, Andrea Aguglia, Xenia Gonda, Gianluca Serafini, Francesca Santi, Mario Amore, Serafini, G., Santi, F., Gonda, X., Aguglia, A., Fiorillo, A., Pompili, M., Carvalho, A. F., and Amore, M.
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Duration of untreated illness ,Male ,Pediatrics ,medicine.medical_specialty ,Younger age ,Current age ,Multivariate analysis ,age at first treatment ,duration of untreated illness ,first lifetime illness episode ,major depressive disorder ,mdd single/recurrent episode ,melancholic features ,depressive disorder, major ,humans ,male ,middle aged ,outpatients ,recurrence ,risk factors ,socioeconomic factors ,Age at first treatment ,First lifetime illness episode ,Major depressive disorder ,MDD single/recurrent episode ,Melancholic features ,Detailed data ,Duration of untreated illne ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Risk Factors ,Outpatients ,medicine ,Humans ,Biological Psychiatry ,Depressive Disorder, Major ,business.industry ,Medical record ,Middle Aged ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Socioeconomic Factors ,Single episode ,business ,030217 neurology & neurosurgery ,Cohort study - Abstract
Objective Specific predictors of relapse/recurrence in major depressive disorder (MDD) have been identified but evidence across studies are inconsistent. This study aimed to identify the most relevant socio-demographic/clinical predictors of MDD recurrence in a sample of 508 outpatients. Methods This naturalistic cohort study included 508 currently euthymic MDD patients (mean age = 54.1 ± 16.2) of which 53.9% had a single and 46.1% recurrent depressive episodes. A detailed data collection was performed and illness histories were retraced through clinical files and lifetime computerized medical records. Results Compared to patients with single episode, MDD patients with recurrent episodes significantly differ regarding current age, gender, working status, positive history of psychiatric disorders in family, first-lifetime illness episode characteristics, first-episode and current psychotic symptoms, current melancholic features and seasonality, age at first treatment, duration of untreated illness, and comorbid cardiovascular/endocrinological conditions. However, after multivariate analyses controlling for current age, gender, educational level, working status differences, psychiatric conditions in family, and age of illness episode, recurrence was associated with older age (p ≤ .001), younger age at first treatment (p ≤ .005), being treated with previous psychoactive treatments (p .001), and longer duration of untreated illness (p .001). Conclusions The variables associated with MDD recurrence identified in the current study may aid in the stratification of patients who could benefit from more intensive maintenance treatments for MDD. However, clinicians should rapidly identify cases that are not likely to recur in order to avoid unnecessary treatments which are commonly considered as the standard of care.
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- 2018
35. TNF blocker drugs modulate human TNF-α-converting enzyme pro-domain shedding induced by autoantibodies
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Vincenzo Mitolo, Dario Domenico Lofrumento, Margherita Sisto, S. Caprio, Sabrina Lisi, Massimo D'Amore, Sisto, M, Lisi, S, Lofrumento, Dario Domenico, Caprio, S, Mitolo, V, and D'Amore, M.
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musculoskeletal diseases ,Immunology ,ADAM17 Protein ,Pharmacology ,Antibodies, Monoclonal, Humanized ,Autoantigens ,Receptors, Tumor Necrosis Factor ,Salivary Glands ,Autoimmune Diseases ,Etanercept ,Immune system ,Autoimmune disease ,RNA, Small Cytoplasmic ,Adalimumab ,Humans ,Immunology and Allergy ,Medicine ,Protein Precursors ,Cells, Cultured ,Shedding ,Autoantibodies ,TACE ,biology ,Tumor Necrosis Factor-alpha ,business.industry ,Autoantibody ,Antibodies, Monoclonal ,Epithelial Cells ,Hematology ,medicine.disease ,Autoantibodie ,Protein Structure, Tertiary ,ADAM Proteins ,Sjogren's Syndrome ,Ribonucleoproteins ,Immunoglobulin G ,Monoclonal ,biology.protein ,Tumor necrosis factor alpha ,Antibody ,business ,Protein Processing, Post-Translational ,medicine.drug - Abstract
Novel biologic therapies targeted against specific components of the immune system, including blockade of TNF-α have revolutionized therapeutic approaches to inflammatory conditions and systemic inhibitors of TNF-α have been approved for the treatment of a wide variety of autoimmune diseases. No studies aimed to elucidate the effects of anti-TNF-α blockers on tumour necrosis factor-α convertase (TACE) expression and activation have yet been published. TACE is the principal protease involved in the activation of pro-TNF-α and is a target for anti-TNF-α therapy. Here we focused on regulation of TACE expression in human salivary gland epithelial cells (SGEC) treated by anti-Ro/SSA autoantibodies (autoAbs), characterizing primary Sjögren's syndrome and on the effect of anti-Ro/SSA autoAbs on TACE pro-domain shedding and activation. To test the hypothesis that anti-TNF-α blocker drugs affect TACE expression, we used Adalimumab and Etanercept to block TNF-α and evaluate the effects of these biological agents on post-translational regulation of TACE. Anti-Ro/SSA autoAbs determines TACE pro-domain shedding suggesting that TACE activity is necessary for the release of TNF-α observed in anti-Ro/SSA autoAbs-stimulated cells. The comparative efficacy analysis of the regulation of TACE activity by Adalimumab and Etanercept revealed that Adalimumab appear to be significantly more efficacious than Etanercept in preventing TACE activation caused by anti-Ro/SSA autoAbs. It is intriguing to consider that regulation of TACE may participate in the pathogenic role of autoantibodies and the modulation of TACE expression by TNF-α antagonists might contribute to the beneficial effect of these drugs in inflammatory and autoimmune diseases.
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- 2010
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36. Psychological status at the menopausal transition: an Italian epidemiological study
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Mario Amore, A. Palareti, Pietro Di Donato, Domenico De Aloysio, Alessandro Papalini, Annalisa Berti, Giuseppe Ferrari, Carla Chirico, Amore M., Di Donato P., Papalini A., Berti A., Palareti A., Ferrari G., Chirico C., and De Aloysio D.
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MENOPAUSE ,medicine.medical_specialty ,General Biochemistry, Genetics and Molecular Biology ,Surveys and Questionnaires ,Epidemiology ,medicine ,Humans ,Psychology ,Registries ,Psychiatry ,Depression (differential diagnoses) ,PSYCHOSOCIAL ,business.industry ,Mental Disorders ,Public health ,Obstetrics and Gynecology ,Middle Aged ,medicine.disease ,Menopause ,Cross-Sectional Studies ,EPIDEMIOLOGICAL ,Italy ,Anxiety ,Female ,Rural area ,medicine.symptom ,business ,Psychosocial ,Social status - Abstract
Objectives: To provide epidemiological data about psychological symptoms derived from a large Italian non-clinical sample, and to investigate the correlation with psychosocial factors. Methods: The study design was a cross-sectional postal survey of a sample of menopausal women recruited from the General Registry Office in Ferrara’s province. Four thousands and seventy-three women were sent a questionnaire designed on the basis of the Women Health Questionnaire (WHQ). Together with the WHQ, women were asked to fill out a personal file to define social status, cultural level, family’s characteristics, recent menstrual cycles, gynaecological history and operations, drug’s assumption, life events in the last year and lifetime depression. Results: Factor analysis resulted in eight clusters of symptoms. Among psychiatric symptoms, three different clusters were identified: depressive symptoms, depressed mood with anxiety symptoms, and anxiety. The cluster “depressive symptoms” was more evident in the postmenopausal period with respect to the premenopausal one. Conclusion: The cluster “depressive symptoms” is significantly different in the premenopausal group with respect to the postmenopausal group , with greater levels of symptomatology in the postmenopausal group . On the contrary, the factor “depressed mood with anxiety symptoms” is present to the same extent in the pre-, peri- and postmenopausal groups. Prior depression is the most predictive variable of subsequent depression in postmenopausal women. Factors related to more pronounced depressive symptoms are number of life events, postmenopausal status, place of residence in rural areas and lower cultural level.
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- 2004
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37. An integrated infrastructure for distributed waste water quality monitoring and decision support
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Annalisa Agresta, Bruno Lanza, G. Di Francia, M. Salvato, Luca Capezzuto, Angelo Leopardi, F. Formisano, M. Panico, Grazia Fattoruso, B. Kumar, S. De Vito, Antonio Buonanno, C. Di Cristo, P. Delli Veneri, F. Ambrosino, Carlo Tebano, F. Scognamiglio, M. Amore, De Vito, S., Fattoruso, G., Buonanno, A., Lanza, B., Capezzuto, L., Tebano, C., Salvato, M., Agresta, A., Ambrosino, F., Formisano, F., Delli Veneri, P., Di Francia, G., Leopardi, A., Di Cristo, C., Banik, B. K., Panico, M., Scognamiglio, F., and Amore, M.
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Data stream ,Decision support system ,Engineering ,decision support ,Situation awareness ,business.industry ,Transport network ,waste water management ,computer.software_genre ,Data modeling ,Risk analysis (engineering) ,Scalability ,Data mining ,Water cycle management ,business ,computer ,sensor network ,Risk management - Abstract
Waste water management plant protection is a major concern for water cycle management entities. The rapid identification and possible localization of anomalous or even malicious waste liquids immissions may allow for undertaking pollution risk mitigation actions (e.g. using of ancillary basins) and reduce maintainance costs. Pervasive monitoring of the transport network is hence needed although economic and technical issues prevent its implementation. The SIMONA project is aimed to design, deploy and test an integrated, intelligent, pervasive monitoring infrastructure based on a network of low cost/low mainteinance quali-quantitative multisensor nodes. A scalable data processing facility permit the ingestion and the processing of the data stream while a set of models provide for quali-quantitative forecasting increasing the manager situational awareness about the smart infrastructure. All the information is made available via a GIS based Web HCI.
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- 2015
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38. Relationships of local lithium concentrations in drinking water to regional suicide rates in Italy
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Maurizio Pompili, Annamaria Lima, Mario Amore, Andrea Fiorillo, Paolo Valera, Monica Vichi, Domenico Cicchella, Ross J. Baldessarini, Enrico Dinelli, Roger Pycha, Stefano Albanese, Benedetto De Vivo, Paolo Girardi, Pompili, Maurizio, Vichi, Monica, Dinelli, Enrico, Pycha, Roger, Valera, Paolo, Albanese, Stefano, Lima, Annamaria, De Vivo, Benedetto, Cicchella, Domenico, Fiorillo, Andrea, Amore, Mario, Girardi, Paolo, Baldessarini, Ross J., DE VIVO, Benedetto, Pompili, M., Vichi, M., Dinelli, E., Pycha, R., Valera, P., Albanese, S., Lima, A., De Vivo, B., Cicchella, D., Fiorillo, A., Amore, M., Girardi, P., and Baldessarini, R.J.
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Male ,medicine.medical_specialty ,Injury control ,affective disorders ,Accident prevention ,Poison control ,chemistry.chemical_element ,biological psychiatry ,psychiatry and mental health ,Suicide rates ,Risk Assessment ,Suicide prevention ,Animal science ,lithium ,mood stabilizers ,quality of life ,suicide ,Biological Psychiatry ,Psychiatry and Mental Health ,Humans ,Medicine ,Sex Distribution ,Psychiatry ,affective disorder ,Mood Disorders ,business.industry ,Drinking Water ,Italy ,chemistry ,mood stabilizer ,Multivariate Analysis ,Linear Models ,Female ,Lithium ,business - Abstract
Objectives. Higher natural concentrations of lithium in drinking water may be associated with lower local rates of suicide. Methods. Lithium concentrations in drinking water were assayed by mass spectrometry at 145 sites in Italy, and compared with reported local suicide rates for men and women between 1980 and 2011. Results. Lithium concentrations in drinking water averaged 5.28 [CI: 4.08–6.48] μg/L (0.761 [0.588–0.934] μEq/L) and ranged from 0.110 to 60.8 μg/L (1.58 to 8.76 μEq/L). Lithium concentrations and local suicide rates were not significantly inversely related, except in 1980–1989, particularly among women. Conclusions. A proposed association between trace lithium concentrations in drinking water and risk of suicide was only partially supported, and mechanisms for potential clinical effects of trace levels of lithium are unknown.
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- 2015
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39. Physical exercise for late-life major depression
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M, Belvederi Murri, M, Amore, M, Menchetti, G, Toni, F, Neviani, M, Cerri, M B L, Rocchi, D, Zocchi, L, Bagnoli, E, Tam, A, Buffa, S, Ferrara, M, Neri, G S, Alexopoulos, S, Zanetidou, Maria Lidia, Gerra, Belvederi Murri, M., Amore, M., Menchetti, M., Toni, G., Neviani, F., Cerri, M., Rocchi, M.B.L., Zocchi, D., Bagnoli, L., Tam, E., Buffa, A., Ferrara, S., Neri, M., Alexopoulos, G.S., Zanetidou, S., DIP. DI FISIOLOGIA UMANA E GENERALE, DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE, Facolta' di SCIENZE MOTORIE, Da definire, AREA MIN. 06 - Scienze mediche, and AREA MIN. 05 - Scienze biologiche
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Male ,45% of participants in the sertraline group ,Psychological intervention ,exercise, depression, higher-intensity exercise, sertraline, antidepressant therapy ,law.invention ,0302 clinical medicine ,Randomized controlled trial ,law ,Sertraline ,80 and over ,Depression (differential diagnoses) ,Aged, 80 and over ,Remission Induction ,Combined Modality Therapy ,Antidepressive Agents ,Exercise Therapy ,Treatment Outcome ,Psychiatry and Mental Health ,depression ,Antidepressive Agent ,Female ,Psychology ,Human ,medicine.drug ,medicine.medical_specialty ,Influential Publications ,Physical exercise ,non-progressive exercise plus sertraline (S+NPE) and sertraline alone. The primary outcome was remission (a score of ⩽10 on the Hamilton Rating Scale for Depression). Results: A total of 121 patients were included. At study end ,Medication Adherence ,NO ,03 medical and health sciences ,lower-intensity ,Internal medicine ,Background: Interventions including physical exercise may help improve the outcomes of late-life major depression ,medicine ,Humans ,Aerobic exercise ,higher-intensity exercise ,Exercise physiology ,Aged ,Depressive Disorder, Major ,Exercise ,65+years%29+with+major+depression+were+randomised+to+24+weeks+of+higher-intensity%2C+progressive+aerobic+exercise+plus+sertraline+%28S%2BPAE%29%2C+lower-intensity%2C+non-progressive+exercise+plus+sertraline+%28S%2BNPE%29+and+sertraline+alone%2E+The+primary+outcome+was+remission+%28a+score+of+⩽10+on+the+Hamilton+Rating+Scale+for+Depression%29%2E+Results%3A+A+total+of+121+patients+were+included%2E+At+study+end%2C+45%25+of+participants+in+the+sertraline+group%2C+73%25+of+those+in+the+S%2BNPE+group+and+81%25+of+those+in+the+S%2BPAE+group+achieved+remission+%28P+=+0%2E001%29%2E+A+shorter+time+to+remission+was+observed+in+the+S%2BPAE+group+than+in+the+sertraline-only+group%2E+Conclusions%3A+Physical+exercise+may+be+a+safe+and+effective+augmentation+to+antidepressant+therapy+in+late-life+major+depression%22">Background: Interventions including physical exercise may help improve the outcomes of late-life major depression, but few studies are available. Aims: To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression. Method: Primary care patients (>65 years) with major depression were randomised to 24 weeks of higher-intensity, progressive aerobic exercise plus sertraline (S+PAE), lower-intensity, non-progressive exercise plus sertraline (S+NPE) and sertraline alone. The primary outcome was remission (a score of ⩽10 on the Hamilton Rating Scale for Depression). Results: A total of 121 patients were included. At study end, 45% of participants in the sertraline group, 73% of those in the S+NPE group and 81% of those in the S+PAE group achieved remission (P = 0.001). A shorter time to remission was observed in the S+PAE group than in the sertraline-only group. Conclusions: Physical exercise may be a safe and effective augmentation to antidepressant therapy in late-life major depression ,Psychiatry ,Depressive Disorder ,progressive aerobic exercise plus sertraline (S+PAE) ,business.industry ,antidepressant therapy ,Major ,Hamilton Rating Scale for Depression ,73% of those in the S+NPE group and 81% of those in the S+PAE group achieved remission (P = 0.001). A shorter time to remission was observed in the S+PAE group than in the sertraline-only group. Conclusions: Physical exercise may be a safe and effective augmentation to antidepressant therapy in late-life major depression ,030227 psychiatry ,but few studies are available. Aims: To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression. Method: Primary care patients (> ,business ,65 years) with major depression were randomised to 24 weeks of higher-intensity ,030217 neurology & neurosurgery - Abstract
none 14 BACKGROUND: Interventions including physical exercise may help improve the outcomes of late-life major depression, but few studies are available. AIMS: To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression. METHOD: Primary care patients (465 years) with major depression were randomised to 24 weeks of higher-intensity, progressive aerobic exercise plus sertraline (S+PAE), lower-intensity, non-progressive exercise plus sertraline (S+NPE) and sertraline alone. The primary outcome was remission (a score of ≤10 on the Hamilton Rating Scale for Depression). RESULTS: A total of 121 patients were included. At study end, 45% of participants in the sertraline group, 73% of those in the S+NPE group and 81% of those in the S+PAE group achieved remission (P = 0.001). A shorter time to remission was observed in the S+PAE group than in the sertraline-only group. CONCLUSIONS: Physical exercise may be a safe and effective augmentation to antidepressant therapy in late-life major depression. Belvederi Murri, M.; Amore, M.; Menchetti, M.; Toni, G.; Neviani, F.; Cerri, M.; Rocchi, M.B.L.; Zocchi, D.; Bagnoli, L.; Tam, E.; Buffa, A.; Ferrara, S.; Neri, M.; Alexopoulos, G.S.; Zanetidou, S. Belvederi Murri, M.; Amore, M.; Menchetti, M.; Toni, G.; Neviani, F.; Cerri, M.; Rocchi, M.B.L.; Zocchi, D.; Bagnoli, L.; Tam, E.; Buffa, A.; Ferrara, S.; Neri, M.; Alexopoulos, G.S.; Zanetidou, S.
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- 2015
40. Comparison of CE and HPLC for therapeutic drug monitoring of the antiepileptic drug topiramate
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Roberto Mandrioli, Laura Mercolini, Maria Augusta Raggi, Ernst Kenndler, Nadia Ghedini, Mario Amore, Mandrioli R., Mercolini L., Ghedini N., Amore M., Kenndler E., and Raggi M.A.
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Topiramate ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Antiepileptic drug ,General Medicine ,THERAPEUTIC DRUG MONITORING ,Pharmacology ,TOPIRAMATE ,ANTICONVULSANT ,Psychiatry and Mental health ,Sodium channel blocker ,Anticonvulsant ,Therapeutic drug monitoring ,HPLC AND EC METHODS ,Medicine ,Pharmacology (medical) ,SODIUM CHANNEL BLOCKER ,business ,medicine.drug - Abstract
Topiramate (2,3:4,5-bis-O −(1-methylethylidene)-D-fructopyranose sulfamate) is one of the most recent anticonvulsant agents introduced in the market. It seems to act as a sodium channel blocker and a chloride channel activator, but its exact mechanism of action is still unclear. While it is generally considered safer than other, older drugs (such as carbamazepine, valproate or barbiturates), its use can still cause severe side effects: during chronic treatment, patients can suffer from vision loss (glaucoma, myopia), osteoporosis, hyperthermia and nephrolithiasis. In order to achieve optimal therapeutic efficacy and to reduce the incidence of side and toxic effects, therapeutic drug monitoring (TDM) of patients undergoing treatment with topiramate is clearly advisable. Two original methods were developed and compared for the TDM of topiramate: one based on HPLC with fluorescence detection and one based on capillary electrophoresis (CE) with indirect UV detection. Topiramate does not possess significant chromophores, thus it has extremely low UV-visible absorbance and no spontaneous fluorescence. In order to achieve sufficient sensitivity, the analyte was derivatised with dansyl chloride before HPLC analysis, while indirect UV detection was implemented for CE, using sulfamethoxazole as the absorbance probe. Both analytical methods were fully validated. HPLC-F is somewhat more complicated and time-consuming, due to the derivatisation procedure, but has also better precision and extraction yields. It has also the advantage of allowing the determination of other low-absorbing antiepileptics, such as gabapentin and vigabatrin. The CE method, on the other hand, has the advantage of requiring much lower volumes of sample and of expensive and polluting solvents. The methods have demonstrated to be suitable for the monitoring of patients undergoing therapy with topiramate. They can be used alternatively, according to the needs of the analysis and other considerations, such the potential for interference of other co-administered drugs.
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- 2011
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41. Some issues in modelling bubbling and circulating fluidized-bed coal combustors
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Piero Salatino, Matteo D'Amore, Riccardo Chirone, Umberto Arena, M. Miccio, Arena, Umberto, Chirone, R., D'Amore, M., Miccio, M., Salatino, P., U., Arena, R., Chirone, M., Damore, M., Miccio, and Salatino, Piero
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Petroleum engineering ,business.industry ,General Chemical Engineering ,chemistry.chemical_element ,Coal combustion products ,Combustion ,Modelling ,Fluidized bed ,Coal ,chemistry ,Fluidized bed combustion ,Char ,Comminution ,Diffusion (business) ,Process engineering ,business ,Carbon - Abstract
Fundamental aspects of coal combustion in the two types of atmospheric fluidized combustors, i.e. those based on bubbling and on circulating technologies, have been studied in order to determine those variables which play a dominant role in the reactor performance. The analysis is based on two relatively simple models, which take into account carbon surface reaction, intraparticle and external diffusion as well as phenomena of comminution of coal and its char. Performances of the two types of fluidized-bed combustors are discussed with reference to coal combustion only, without taking into consideration the emission issues. Sensitivities of main output variables to changes in fuel properties, design and operating variables are evaluated.
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- 1995
42. Carbon attrition in the fluidized combustion of a metallurgical coke
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Riccardo Chirone, L. Massimilla, Matteo D'Amore, Umberto Arena, Arena, Umberto, Chirone, R, D'Amore, M, and Massimilla, L.
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business.industry ,General Chemical Engineering ,Metallurgy ,Fossil fuel ,technology, industry, and agriculture ,General Physics and Astronomy ,Energy Engineering and Power Technology ,chemistry.chemical_element ,General Chemistry ,Coke ,Combustion ,complex mixtures ,respiratory tract diseases ,Fuel Technology ,chemistry ,otorhinolaryngologic diseases ,Combustor ,Environmental science ,Coal ,Fluidized bed combustion ,business ,Energy source ,Carbon - Abstract
The multiplication of carbon particles inside the bed of a fluidised coal combustor can be related to fragmentation and attrition. Attrition generates finer carbon which is rapidly elutriated from the bed. Previous work on attrition was carried out on a non-swelling coal. The present paper reports an extension of this work to a metallurgical coke during fluidised bed combustion. In comparison with the coal, metallurgical coal is not subject to fragmentation and is less reactive. This enabled attrition to be examined separately and at higher bed carbon content for a given fluidising velocity and excess air.
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- 1984
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43. Rationale for BepiColombo Studies of Mercury’s Surface and Composition
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Rita Schulz, Emma J. Bunce, Matteo Massironi, Romolo Politi, Adrian Martindale, Francesco Quarati, Anna Milillo, Ryuku Hyodo, David L. Pegg, Gabriele Cremonese, Alan Owens, Peter Wurz, C. C. Malliband, Claudia Stangarone, Alice Lucchetti, M. Cristina De Sanctis, Valentina Galluzzi, John Wright, Julia Martikainen, Gianrico Filacchione, Mario D'Amore, Indhu Varatharajan, Hauke Hussmann, A. Doressoundiram, L. Guzzetta, Harald Hiesinger, Larry R. Nittler, David A. Rothery, Antti Penttilä, Lorenza Giacomini, Thomas Cornet, Andreas Morlok, Bernard Charlier, Manuel Grande, Tomas Kohout, Vladislav Tretiyakov, I. G. Mitrofanov, Alessandro Maturilli, Océane Barraud, Cristina Re, G. Alemanno, Sebastien Besse, Rosario Brunetto, Cristian Carli, Daniel Heyner, Maxim Litvak, Iris Weber, Paul K. Byrne, Joern Helbert, Alexey Malakhov, Maxim Mokrousov, Olivier Namur, Maurizio Pajola, Paolo Mancinelli, Fabrizio Capaccioni, Timo Väisänen, Aleksandra N. Stojic, A. S. Kozyrev, Maria Teresa Capria, Karri Muinonen, Luigi Ferranti, Francesca Zambon, J. S. Oliveira, A. B. Sanin, Nicolas Bott, Pasquale Palumbo, Geology and Geophysics, Department of Geosciences and Geography, Planetary-system research, Department of Physics, Particle Physics and Astrophysics, Observatoire de Paris, Université Paris sciences et lettres (PSL), Institut d'astrophysique spatiale (IAS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Rothery, D. A., Massironi, M., Alemanno, G., Barraud, O., Besse, S., Bott, N., Brunetto, R., Bunce, E., Byrne, P., Capaccioni, F., Capria, M. T., Carli, C., Charlier, B., Cornet, T., Cremonese, G., D'Amore, M., De Sanctis, M. C., Doressoundiram, A., Ferranti, L., Filacchione, G., Galluzzi, V., Giacomini, L., Grande, M., Guzzetta, L. G., Helbert, J., Heyner, D., Hiesinger, H., Hussmann, H., Hyodo, R., Kohout, T., Kozyrev, A., Litvak, M., Lucchetti, A., Malakhov, A., Malliband, C., Mancinelli, P., Martikainen, J., Martindale, A., Maturilli, A., Milillo, A., Mitrofanov, I., Mokrousov, M., Morlok, A., Muinonen, K., Namur, O., Owens, A., Nittler, L. R., Oliveira, J. S., Palumbo, P., Pajola, M., Pegg, D. L., Penttila, A., Politi, R., Quarati, F., Re, C., Sanin, A., Schulz, R., Stangarone, C., Stojic, A., Tretiyakov, V., Vaisanen, T., Varatharajan, I., Weber, I., Wright, J., Wurz, P., and Zambon, F.
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Volatiles ,SPECTROSCOPIC PROPERTIES ,010504 meteorology & atmospheric sciences ,BepiColombo ,X-RAY-FLUORESCENCE ,Volatile ,chemistry.chemical_element ,Planetare Labore ,Astronomy & Astrophysics ,Data rate ,01 natural sciences ,Space weathering ,114 Physical sciences ,Astrobiology ,Tectonism ,[SDU.STU.PL]Sciences of the Universe [physics]/Earth Sciences/Planetology ,Crust ,Mercury ,Volcanism ,EXPLOSIVE VOLCANISM ,Planet ,SILICATE FRACTIONATION ,0103 physical sciences ,METEOROID STREAM ,010303 astronomy & astrophysics ,CALORIS BASIN ,0105 earth and related environmental sciences ,Science & Technology ,Spacecraft ,business.industry ,520 Astronomy ,Planetengeodäsie ,WATER ICE ,Astronomy and Astrophysics ,REFLECTANCE SPECTRA ,620 Engineering ,NORTH POLAR-REGION ,115 Astronomy, Space science ,Mercury (element) ,Planetary science ,chemistry ,13. Climate action ,Space and Planetary Science ,Global distribution ,GLOBAL DISTRIBUTION ,Physical Sciences ,Water ice ,business - Abstract
BepiColombo has a larger and in many ways more capable suite of instruments relevant for determination of the topographic, physical, chemical and mineralogical properties of Mercury’s surface than the suite carried by NASA’s MESSENGER spacecraft. Moreover, BepiColombo’s data rate is substantially higher. This equips it to confirm, elaborate upon, and go beyond many of MESSENGER’s remarkable achievements. Furthermore, the geometry of BepiColombo’s orbital science campaign, beginning in 2026, will enable it to make uniformly resolved observations of both northern and southern hemispheres. This will offer more detailed and complete imaging and topographic mapping, element mapping with better sensitivity and improved spatial resolution, and totally new mineralogical mapping.We discuss MESSENGER data in the context of preparing for BepiColombo, and describe the contributions that we expect BepiColombo to make towards increased knowledge and understanding of Mercury’s surface and its composition. Much current work, including analysis of analogue materials, is directed towards better preparing ourselves to understand what BepiColombo might reveal. Some of MESSENGER’s more remarkable observations were obtained under unique or extreme conditions. BepiColombo should be able to confirm the validity of these observations and reveal the extent to which they are representative of the planet as a whole. It will also make new observations to clarify geological processes governing and reflecting crustal origin and evolution.We anticipate that the insights gained into Mercury’s geological history and its current space weathering environment will enable us to better understand the relationships of surface chemistry, morphologies and structures with the composition of crustal types, including the nature and mobility of volatile species. This will enable estimation of the composition of the mantle from which the crust was derived, and lead to tighter constraints on models for Mercury’s origin including the nature and original heliocentric distance of the material from which it formed.
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