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Summary A biphasic nursery outbreak of impetigoneonatorum and dermatitis exfoliativa neonatorum (Ritter's disease) is described. There were twelve cases of uncomplicated impetigo and ten cases of Ritter's disease. Of the ten infants with Ritter's disease,five died and five recovered. Only when therapy could be started with the earliest signs of illness was a fatal outcome prevented. The evidence suggests that a Staph. aureus hemolyticus was the causative organism. The epidemic was not finally controlled until all personnel with nasopharyngeal cultures positive for hemolytic Staph. aureus were rigidly excluded from the nurseries.

1. 1. A case of cardiac rupture through a calcified myocardial infarct, with the intermediate formation of a myocardial aneurysm, is reported. It is suggested that bacteremia resulting from a perinephric abscess, with localization of the inflammatory process in the myocardial aneurysm, brought about this unusual event. 2. 2. Coronary sclerosis is the most common cause of primary, massive, myocardial calcification; its etiologic relationship has been established in ten of fourteen cases reported in the literature and in our own.

1. Die durch die Verabreichung von 1,2–3,6 g Bleiacetat an wachsende Kaninchen innerhalb einer Versuchsdauer von 40–75 Tagen entstehende Knochenveranderung gleicht dem Bilde derakuten Osteoporose bzw. der sog. progressiven KnochenatrophieAskanazys. 2. Die im Verlauf der Erkrankung auftretende ortliche Fasermarkentwicklung ist als Begleiterscheinung der gesteigerten Abbauvorgange aufzufassen. 3. Die Ursache der Knochenveranderung ist die relativeBlutacidosis, die durch das Zusammenwirken der durch das Blei hervorgerufenen Nierenschadigung, der Nekrosen an den Einspritzungsstellen sowie des durch die Abnahme der Freslust eingetretenen Hungerzustandes bedingt ist, wobei aber der Bleiwirkung wohl die Hauptrolle zuzuschreiben ist.

Summary In a series of 1003 pairs of parabiosed rats, in which the right partner of each pair received 1000 rads total-body irradiation, the incidence of soft-part sarcomas at the anastomotic site was 8.7%. The incidence in other parts of the irradiated partner was 5.8%, and in the nonirradiated partner it was 0.3%. A combination of whole-body irradiation plus local factors of continuing trauma and scar formation is thought to account for the higher incidence of sarcomas in the anastomotic region. Systemic factors such as the endocrines may also play a secondary role.

A total-body dose of 1000 R X radiation to 1252 male and 1366 female NEDH rats protected by permanent parabiosis to an untreated partner yielded respective cancer incidences of 42.7 and 38.3% within mean life-spans slightly less than single controls. These incidences were significant at the 1% level of probability compared with lower rates in shielded partners as well as in over 600 control parabiont partners and 700 single controls in which both sexes were nearly equally represented. Significant cancer incidences were induced in skin and islet cells of males, soft supporting tissue, renal tubules, bone of males and females, and ovary. Parabiosis per se provided local conditions conducive to the development of sarcomas, possibly enhanced by radiation, in anastomosed tissue as well as systemic changes promoting the spontaneous development of lymphoma and leukemia in females and inhibiting that of mammary carcinoma in females and malignant pheochromocytoma in males. The effects in females were largely cance...

Ninety-five (7.6%) irradiated partners of 1244 parabiosed rats receiving 1000 R of whole-body irradiation developed renal tumors-10.3% of the males and 5.2% of the females. The commonest types of renal tumors were renal cell carcinomas, adenomas, and transitional cell carcinomas. As with irradiation carcinogenesis in general, renal tumors in irradiated rats appear earlier and with greater frequency than spontaneous tumors in nonirradiated rats. The nonneoplastic renal tubular epithelium of the irradiated tumor-bearing kidneys contained fewer mitoses than the renal tubular epithelium of their nonirradiated partners.

The fatal acute cardiac failure which sometimes intervenes during the course of exfoliative dermatitis due to arsphenamine is seldom anticipated clinically, and the microscopic appearance of the myocardium post mortem is even less expected. The cases of such myocardial changes following the onset of arsphenamine dermatitis comprise part of the general group of instances of a condition designated as acute interstitial, isolated or Fiedler's myocarditis. The more than 40 recorded cases making up this general group have in common the apparently spontaneous occurrence of progressive myocardial failure and diffuse interstitial inflammation involving a thickened left ventricular myocardium, according to postmortem observations. Fiedler in 1899 called attention to this peculiar nonspecific interstitial myocarditis, accounts of which first reached the American literature in 1929, with a review by Scott and Saphir. 1 They collected 30 cases and added 2 of their own but did not include Fiedler's cases because of their relative