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Our society has been facing a decentralizing effect on multiscale complexity in low-carbon transitions. The purpose of this work is to evaluate the roles of transaction rate, energy and carbon market regulation, energy consumption and energy capacity in single and one-way climate policy linked system in low carbon transition for distributed energy systems through agent-based simulation. A set of agent behavioral rules for the competition of high and low carbon energies mimics the domestic and exotic local dynamics of the energy production of distributed energy systems and the energy consumption of industrial firms under the impact of energy and carbon market fluctuation. Simulation results show that a single system cannot achieve low carbon transition, while a one-way climate policy linked system can realize low carbon transition. The results also show that the larger high and low energy capacity is, the system is less likely to achieve low carbon transition in the circumstance of the same transaction rate with the constant emission policy bias. Policy implications are drawn regarding the regulation of localized carbon markets in single and climate policy linked systems.

To better understand the economic crisis impact on industry economy in low carbon transition, the simplified macroeconomic system combined with a distributed industry-energy ecosystem, namely the economy-ecosystem, was established based on an agent-based modeling approach. A set of behavioral rules for each agent involved was formalized to study the competition between high and low carbon energy under the scheme of ecological life of industrial firms, and periodical economy crisis was emerged by adjusting asymmetric adjustment speed ratio of hiring to firing and default threshold that controls the ratio between total debt and total circulating currency. The impact of the economic crisis on the ecosystem in a distributed energy system and the interaction between the economy and ecosystem in low carbon transition under different conditions of the ecosystem were investigated. Simulation results show that high carbon energy is more resistant to economic crisis than low carbon energy. Moreover, low-carbon transition with economic recession state can be reached in economy-ecosystem. Various policy implications are also given to policymakers with different technical levels and economic status.

The aim of this study was to investigate the occurrence, correlated factors and prognosis of posttraumatic stress symptoms (PTSS) in patients with Cushing’s disease (CD). A total of 49 patients who were newly diagnosed with CD and underwent transsphenoidal surgery in our hospital from April 2015 to August 2017 were asked to participate in this study. Another group of 49 age and sex matched healthy control participants were also included for comparison. PTSS (measured with Impact of Event Scale-Revised, IES-R), depression/anxiety (measured with Hospital Anxiety and Depression scale, HADS) and quality of life (QoL; measured with 36-item short-form, SF-36) were evaluated at pre-surgery, 6 months post-surgery and 12 months post-surgery. The results showed that at preoperative stage, 15 (30.6%) CD patients developed PTSS, and they had higher 24 h UFC, and presented worse levels of depression, anxiety and QoL compared with patients without PTSS. Although most of them recovered postoperatively, there were still 5/15 (33.3%) patients persisted with PTSS for over a year. Additionally, one patient with recurred CD developed PTSS between 6 and 12 months postoperatively. Among the whole group of CD patients, the PTSS severity showed consistent improvement after surgery, which was in accordance with the progressing trends of depression, anxiety and psychological aspects of SF-36. However, compared with healthy individuals, CD patients in remission still performed worse in physical/mental health. In conclusion, patients with CD can develop PTSS, and they may persist for over a year even after successful surgery. Combined psychological intervention is advised for these patients.

The primary objective of this study was to investigate the incidence of PTSD at 3 months postoperatively in patients who were newly diagnosed with LGGs, and its association with 5-year survival. Moreover, QoL and other psychiatric disorders like depression and anxiety were also evaluated. From February 2011 to April 2013, patients who underwent low-grade glioma surgery at our hospital and come back for reexamination at 3-month follow-up were considered for this study. Interviews, HADS-A, HADS-D, and SF-36 scales were used for evaluating PTSD, anxiety, depression, and quality of life. Participants were asked to complete these assessments at 3 months after surgery. Followed-ups on survival status were made for 5 years. A total of 219 subjects comprising 83 women and 136 men with a mean age of 41.5 years were included in this study. At 3 months after surgery, 35 (16%) patients were diagnosed with PTSD. Younger age (OR = 2.23, [95% CI 1.02–4.84], P = 0.04) and frontal lobe involvement of tumor (OR = 2.57, [95% CI 1.06–6.23], P = 0.04) predicted PTSD. Patients with PTSD had higher anxiety and depression level, and had worse QoL in all eight dimensions of SF-36. Kaplan–Meier analyses demonstrated that diagnosis of PTSD was associated with shorter overall survival in LGG patients (Log-rank = 7.45, P = 0.01). After adjusting for other variables, PTSD remained associated with elevated 5-year overall mortality risk of LGG patients (HR = 2.98 [95% CI 1.10–8.05], P = 0.03). The results showed that newly diagnosed LGG patients suffering from PTSD at 3 months after surgery had lower rates of 5-year survival. In clinical practice, psychological evaluation is suggested for LGG patients and proper psychotherapy should be considered for those with PTSD.

The object of this study was to reveal the occurrence, risk factors and prognosis of posttraumatic stress disorder (PTSD) in patients with trigeminal neuralgia (TN). Adult patients who were diagnosed with TN were prospectively collected from our neuroscience center. Among the 103 patients recruited, thirty (29.1%) participants were identified as probable PTSD cases measured with PTSD Checklist for DSM-5 (PCL-5). Compared with patients without PTSD, patients with probable PTSD were more likely to be female, have severe pain intensity, be with severely interfered general activities, be with more intense depression and anxiety, and be more habitually using maladaptive coping strategies. Logistic regression analysis showed female sex, severe pain intensity, anxiety and depression predicted probable PTSD. In the 28 patients who were initially identified as probable PTSD and had 6-month follow-up data, 21 reported complete pain relief and 4 reported partial pain relief. Fifteen of the patients who experienced complete pain relief recovered from probable PTSD. Our work indicated that PTSD can develop among patients with TN. Complete pain relief through surgical treatments can help most patients with probable PTSD recover, however, psychological support is advised for those who are still obsessed by mental disorders even after pain relief.

To evaluate the perioperative safety and mid-term prognosis (≤12 months) of HydroSoft coils in treating ruptured aneurysms at the anterior circulation compared with bare platinum coils. Patients with aneurysmal subarachnoid hemorrhages admitted to our hospital between January 2009 and March 2012 were retrospectively analyzed. According to strict inclusion and exclusion criteria, cases were selected and classified into two groups: In group A, HydroSoft coils were used as the primary filling coils (≥40 % of total coil length); in group B, only bare platinum coils were used. Cases in both groups were all treated with stent-assistance. A comparison between the two groups was performed for periprocedural complications as well as immediate and mid-term outcomes. The stents used included Enterprise, Neuroform, and Solitaire. Fifty-six aneurysms were in group A patients, and 68 aneurysms were in group B patients. Compared with group B, group A did not have increased incidence of complications but had greater packing attenuation (44.5 ± 8.8–29.8 ± 9.1 %, t = 2.577, P = 0.014) and increased initial complete occlusion rates (63–44 %, χ 2 = 4.161, P = 0.041). Radiologic follow-up were performed in 46 patients from group A and 51 patients from group B. Complete occlusion rates at follow-up were significantly greater in group A than in group B (89.1–70.6 %, χ 2 = 5.08, P = 0.043); the difference in recanalization rates were statistically insignificant between the groups (6.5–5.9 %, P = 1.000). HydroSoft coils proved safe during the periprocedural period and provided greater initial complete occlusion rates, greater packing density, and better follow-up results compared with bare platinum coils.

It was the aim of this study to investigate Nup88 expression in normal colorectal mucosa, adenoma, adenocarcinoma and lymph node metastasis, as well as the relationship between Nup88 expression and clinicopathological features.Nup88 expression was examined by immunohistochemistry in 84 normal mucosa samples, 32 adenomas, 181 primary adenocarcinomas, and 18 lymph node metastases from colorectal tumour patients.Nup88 expression was observed in normal epithelial and tumour cells. The frequency of strong Nup88 expression was increased from normal mucosa or adenoma to primary tumour and lymph node metastasis (p0.0001). There was no significant difference in the expression between normal mucosa and adenoma (p = 0.41). The frequency of strong Nup88 expression was higher in ulcerated tumours (40%) than in polypoid/large fungating tumours (23%; p = 0.048). The frequency of strong Nup88 expression was significantly different among tumours with good (21%), moderate (42%) and poor differentiation (48%; p = 0.01). Nup88 expression was not related to the patients' gender, age, tumour location, size, histological type, invasive depth, lymph node status and Dukes stage (p0.05).Our results suggest that Nup88 may play a role during the development, aggressiveness and differentiation of colorectal tumours.

The poor clinical outcome of acute intracerebral hemorrhage (ICH) relates closely to the bleeding amount per unit of time and the hematoma position in the brain. Removal of an intracerebral hematoma in time can effectively improve clinical prognosis. Minimally invasive surgery (MIS) for the treatment of ICH is the main clinical method that is currently used, despite the lack of large-scale, clinical, multi-center, randomized controlled trials. This article comprehensively reviews the history and development of MIS for ICH and analyzes various roles of MIS in ICH treatment. General CT image-guided surgery with the local use of thrombolysis techniques is a major MIS method used in current ICH treatment.

To determine the safety and efficacy of endovascular therapy for the treatment of basilar artery dissection (BAD). Patients with BAD admitted to our hospital from June 2002 to December 2011 were retrospectively reviewed. Strict inclusion and exclusion criteria were made. At enrollment, patients’ manifestations were evaluated. The different devices and techniques used for each patient were recorded and further classified into two groups: the coiling-only group, in which lesions were treated only with coils; and the stented group, in which lesions were treated with only stents or by stent-assisted embolization. Shapes of BAD were described and classified into three types: dilation, pearl-and-string sign, and stenosis. Presentations of BAD were classified as ruptured or unruptured. Digital subtraction angiography results obtained immediately after intervention and at follow-up were evaluated and classified into two groups: stable/improved or recanalized/worsened. Clinical outcome was evaluated by modified Rankin Scale score. A total of 29 patients were included, and 28 of them were followed up clinically and angiographically. No significant difference of recurrence rate existed between ruptured and unruptured BAD. The coiling-only group demonstrated a significantly higher recurrence rate than the stent-assisted group. In the 22 instances of BAD presenting with dilated shapes, stented cases had better radiological outcome than unstented cases, and initial packing of completely/near completely occluded cases had better radiological follow-up results. Endovascular therapy proved safe and effective. Stent placement and initial complete occlusion were favorable factors for follow-up stable/improved outcome.

Adaptive variable structure controller was proposed to increase the robustness and decrease the influence of the disturbance for active magnetic bearings suspended turbomolecular pump in this paper. The model reference adaptive tuner was aimed to overcome the estimation error that is caused by the parameter uncertainty and the model uncertainty. The simulation results indicated that the turbomolecular pump suspended by active magnetic bearings with adaptive variable structure controller was successfully operated in wide rang, well resisted the unbalance or external disturbance during the rotational speed raising, and the amplitude of the displacement of system could quickly reach the center nearby when disturbance force was applied to the system suddenly.