1. MicroRNAs and Calcium Signaling in Heart Disease
- Author
-
Changwon Kho and Jaeho Park
- Subjects
Heart disease ,QH301-705.5 ,Myocardial Infarction ,Review ,Bioinformatics ,calcium signaling ,Catalysis ,Inorganic Chemistry ,microRNA ,Atrial Fibrillation ,Medicine ,Animals ,Humans ,Myocardial infarction ,Biology (General) ,Physical and Theoretical Chemistry ,QD1-999 ,Molecular Biology ,Spectroscopy ,Calcium signaling ,Regulation of gene expression ,Calcium metabolism ,Heart Failure ,business.industry ,cardiac hypertrophy ,Organic Chemistry ,Atrial fibrillation ,General Medicine ,medicine.disease ,Myocardial Contraction ,Computer Science Applications ,Chemistry ,MicroRNAs ,Gene Expression Regulation ,Heart failure ,Calcium ,business - Abstract
In hearts, calcium (Ca2+) signaling is a crucial regulatory mechanism of muscle contraction and electrical signals that determine heart rhythm and control cell growth. Ca2+ signals must be tightly controlled for a healthy heart, and the impairment of Ca2+ handling proteins is a key hallmark of heart disease. The discovery of microRNA (miRNAs) as a new class of gene regulators has greatly expanded our understanding of the controlling module of cardiac Ca2+ cycling. Furthermore, many studies have explored the involvement of miRNAs in heart diseases. In this review, we aim to summarize cardiac Ca2+ signaling and Ca2+-related miRNAs in pathological conditions, including cardiac hypertrophy, heart failure, myocardial infarction, and atrial fibrillation. We also discuss the therapeutic potential of Ca2+-related miRNAs as a new target for the treatment of heart diseases.
- Published
- 2021