1. Clinical Characteristics of Pruritus in Systemic Sclerosis Vary According to the Autoimmune Subtype
- Author
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Laurent Misery, Greta Gourier, Alain Saraux, Elisabeth Pasquier, Margaux Mazeas, H. Sonbol, Yves Renaudineau, Claire Abasq-Thomas, Valérie Devauchelle-Pensec, Emmanuelle Le Moigne, F. Huet, Julie Lemerle, Elize Campillo, C. Théréné, Emilie Brenaut, Service de dermatologie (Dermato - BREST), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Centre National de Référence CERAINO, Service de Rhumatologie (Hôpital de la Cavale Blanche), Laboratoire d'Immunologie et Immunothérapie, Service de dermatologie ( Dermato - BREST ), Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Lymphocyte B et Auto-immunité ( LBAI ), Université de Brest ( UBO ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Département de Médecine Interne et Pneumologie [Brest] ( DMIP - Brest ), Centre National de Référence CERAINO, Service de Rhumatologie ( Hôpital de la Cavale Blanche ), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), and Université de Brest (UBO)
- Subjects
Male ,0301 basic medicine ,Time Factors ,autoantibodies ,[SDV]Life Sciences [q-bio] ,Disease ,medicine.disease_cause ,Severity of Illness Index ,Scleroderma ,Autoimmunity ,Surveys and Questionnaires ,systemicsclerosis ,Registries ,itch ,skin and connective tissue diseases ,integumentary system ,autoimmunity ,General Medicine ,Middle Aged ,Pathophysiology ,3. Good health ,Antibodies, Antinuclear ,RL1-803 ,Female ,medicine.medical_specialty ,Dermatology ,03 medical and health sciences ,Severity of illness ,medicine ,Humans ,Serologic Tests ,Aged ,Retrospective Studies ,Scleroderma, Systemic ,[ SDV ] Life Sciences [q-bio] ,business.industry ,Autoantibody ,qualityoflife ,Retrospective cohort study ,pruritus ,medicine.disease ,eye diseases ,body regions ,stomatognathic diseases ,030104 developmental biology ,inflammation ,Concomitant ,business ,Biomarkers - Abstract
International audience; Pruritus is a frequent symptom in systemic sclerosis (SSc), with a prevalence of 40-65%, but its pathophysiology is poorly understood. This study investigated the immunological component of pruritus. Fifty-six patients with SSc responded to a standardized questionnaire regarding both SSc disease and pruritus characteristics. Among patients with SSc, those with pruritus did not display a particular immunological profile (inflammatory, humoral, and/or cellular factors), but pruritus was, in most cases, concomitant with the development of SSc. Thus, pruritus characteristics were evaluated further, according to the detection of anti-centromere autoantibodies (ACA), into ACA+ (n = 17) and ACA- (n = 19). The ACA+ subgroup was characterized by a longer evolution of SSc and pruritus, pruritus present outside the sclerotic area, and a shorter daily duration of pruritus. In conclusion, the concomitant appearance of the 2 processes and the differences observed between ACA+ and ACA- subgroups support the presence of an immunological component in pruritus.
- Published
- 2018