1. 99mTc-2GAM: A tracer for renal imaging
- Author
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Danuta Stepniak-Biniakiewicz, Ferruccio Fazio, Edward Deutsch, Giovanni Lucignani, Cathy Cutler, Mario Matarrese, A. Savi, Flaviano Dosio, L. Gianolli, Fabio Colombo, Gianolli, L, Dosio, F, Matarrese, M, Colombo, F, Cutler, C, Stepniak Biniakiewicz, D, Deutsch, E, Savi, A, Lucignani, G, and Fazio, F
- Subjects
Adult ,Male ,Cancer Research ,Biodistribution ,medicine.medical_specialty ,Urinary system ,Glycine ,Urology ,chemistry.chemical_element ,Urine ,Kidney ,Technetium ,Mice ,medicine ,Animals ,Humans ,Tissue Distribution ,Radiology, Nuclear Medicine and imaging ,Radionuclide Imaging ,Animal ,business.industry ,Organotechnetium Compounds ,medicine.disease ,Rats ,medicine.anatomical_structure ,chemistry ,Isotope Labeling ,Technetium Tc 99m Dimercaptosuccinic Acid ,Toxicity ,Rat ,Radiopharmaceutical ,Molecular Medicine ,Female ,Radiopharmaceuticals ,Succimer ,Nuclear medicine ,business ,Human ,Kidney disease - Abstract
We propose a renal imaging agent, the 99m Tc complex of the bidentate- N ,S chelate N -(mercaptoacetyl) glycine ( 99m Tc-2GAM), with the imaging characteristics of 99m Tc-DMSA but a faster kidney uptake; chemical evidence supports the formulation of 99m Tc-2GAM as [Tc V (O)(GAM) 2 ] โ . After biodistribution and toxicity studies in animals, 99m Tc-2GAM was evaluated in five normal volunteers. 99m Tc-2GAM is rapidly cleared from the blood (t12 = 9 min) and 50% of the ID is excreted in the urine in the first 2 h. Dynamic data show a rapid renal uptake that increases up to 1 h with no significant wash-out between 1 and 8 h. The uptake in each kidney ranges from 11.3% to 20.7% ID. Low, stable liver uptake is observed. No significant activity is detected in other organs. We showed no differences between 99m Tc-2GAM and 99m Tc-DMSA compared in three patients with unilateral kidney disease. We conclude that 99m Tc-2GAM has good practical and dosimetric features for renal imaging.
- Published
- 1996
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