6 results on '"Catherine Griffin"'
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2. Diagnostic tumor methylation profiles
- Author
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Catherine Griffin
- Subjects
Oncology ,medicine.medical_specialty ,Multidisciplinary ,Diagnostic methods ,business.industry ,food and beverages ,Cancer ,Methylation ,medicine.disease ,Patient care ,Internal medicine ,DNA methylation ,Medicine ,Tumor biopsy ,business ,Histological examination - Abstract
Cancer Diagnosis of specific types of cancer is vital for decisions regarding treatment and monitoring plans. However, acquiring sufficient tissue from a tumor biopsy to perform a histological examination and diagnosis can be difficult because of limited tumor accessibility or ambiguous tissue samples. Methods that allow minimally invasive biopsies are required to improve patient care. Hao et al. identified DNA methylation profiles associated with four common cancers that can be used to identify tumors from smaller tissue samples with accuracy comparable to that of current diagnostic methods. These methylation markers can also be used to identify the tissue of origin of metastasized cancers, which can be critical for treatment, and as predictors of prognosis and survival to improve standards of diagnosis. Proc. Natl. Acad. Sci. U.S.A. 10.1073/pnas.1703577114 (2017).
- Published
- 2017
- Full Text
- View/download PDF
3. Balanced diets can prevent binge-like eating
- Author
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Catherine Griffin
- Subjects
Eating disorders ,medicine.medical_specialty ,Multidisciplinary ,Endocrinology ,business.industry ,Internal medicine ,medicine ,Early life stress ,medicine.disease ,business ,Late adolescence ,Clinical psychology - Abstract
Diet Binge-like eating (BE) predominantly affects females and usually manifests in late adolescence. Previous studies have linked eating disorders to early life stress, and it is known that perinatal stress increases susceptibility to a variety of psychiatric disorders. Schroeder et al. have
- Published
- 2017
- Full Text
- View/download PDF
4. HIV reprograms progenitor cells
- Author
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Catherine Griffin
- Subjects
COPD ,Multidisciplinary ,business.industry ,Cell ,respiratory system ,medicine.disease ,Phenotype ,respiratory tract diseases ,Extracellular matrix ,Basal (phylogenetics) ,medicine.anatomical_structure ,Immunology ,medicine ,Progenitor cell ,Protein kinase A ,business ,Airway - Abstract
HIV Survival rates of patients with HIV have improved enormously as a result of antiretroviral therapy, but increased life expectancy is now associated with a high risk of comorbidities. HIV–1-associated chronic obstructive pulmonary disease (COPD) often manifests as emphysema, originating around the airways and extending into lung tissue. Chung et al. have discovered that this is caused by HIV binding to basal cells in the airway and activating a tissue-destructive phenotype through a mitogen-activated protein kinase signaling cascade. HIV binding triggers up-regulation of matrix metalloproteinase 9, which is known to be elevated in COPD patients and may contribute to the degradation of extracellular matrix seen in emphysema sufferers. Cell Rep. 19 , 1091 (2017).
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- 2017
- Full Text
- View/download PDF
5. Caffeine Awareness in Children: Insights from a Pilot Study
- Author
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Ketan Deoras, Petra Podmore, Catherine Griffin, Tushar P Thakre, Aarthi Vemana, and Jyoti Krishna
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Pulmonary and Respiratory Medicine ,Male ,Sleep Wake Disorders ,medicine.medical_specialty ,Health Knowledge, Attitudes, Practice ,Adolescent ,Psychoactive substance ,Pilot Projects ,Risk Assessment ,Beverages ,chemistry.chemical_compound ,Sex Factors ,Caffeine ,Surveys and Questionnaires ,medicine ,Humans ,Psychiatry ,Child ,Students ,business.industry ,Incidence ,Age Factors ,food and beverages ,Awareness ,Sleep in non-human animals ,Scientific Investigations ,United States ,Cross-Sectional Studies ,Neurology ,chemistry ,Female ,Neurology (clinical) ,Caffeine intake ,business ,Needs Assessment - Abstract
Caffeine, a commonly consumed psychoactive substance, can have significant effects on sleep. Caffeine intake among children is increasing, mainly in the form of sodas. However, adolescent caffeine consumers may lack knowledge about the caffeine content in common beverages. If true, this very fact may hamper the assessment of the effects of caffeine consumption on sleep in children if such assessments are a priori dependent on responders being able to reliably distinguish between caffeinated and noncaffeinated beverages. This preliminary study investigated adolescents' caffeine knowledge and intake at a Cleveland-area public middle school.Seventh- and eighth-grade students were surveyed using: (1) the Caffeine Literacy and Sleep Study (CLASS), a 15-question pilot instrument designed to assess caffeine knowledge and intake by type, quantity and timing, as well as sleep habits; and (2) the Cleveland Adolescent Sleepiness Questionnaire (CASQ), a validated survey measuring excessive daytime sleepiness in adolescents. These questionnaires were distributed and collected during a specified class period.Of the 635 seventh- and eighth-grade students who attended school on the day of the study, 555 (87%) participated. Lack of knowledge about caffeine content of particular drinks was noted in seventh and eighth graders of both sexes with nearly 29% unaware that their favorite drinks contain caffeine and more than 50% unable to correctly identify the drinks with the most caffeine. A low percentage of students correctly identified light-colored sodas lacking caffeine: 7-Up (24.1%), Sierra Mist (38.9%), ginger ale (39.8%), Sprite (39.8%), and Fresca (53.7%). The percentages of students correctly identifying caffeinated light-colored beverages were: Arizona Green Tea (43.5%), Mello Yellow (50.9%), and AW cream soda (67.6%). However, Mountain Dew was correctly identified by most (93.5%) as caffeinated.Students were not consistently able to identify caffeine content or lack thereof in some common beverages. The results of this pilot study show that caffeine literacy in adolescents warrants further investigation and educational intervention.
- Published
- 2014
6. Extending the concept of transaction compensation
- Author
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Carla Ferreira, Catherine Griffin, Peter Henderson, David John Vines, Michael Butler, and M. Chessell
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Knowledge management ,Process modeling ,Process management ,General Computer Science ,Business process ,business.industry ,Business rule ,Artifact-centric business process model ,Computer science ,Business process modeling ,Computer Graphics and Computer-Aided Design ,Theoretical Computer Science ,Business Process Model and Notation ,Computational Theory and Mathematics ,Business activity monitoring ,business ,Database transaction ,Software ,Information Systems - Abstract
The ability to compensate for previous activities, often in the case of failure or exceptional events, is an important feature of long-running business transactions. In this paper, we present several extensions to existing notions of compensation for business transactions. The extensions are described using a business process modeling language called StAC (Structured Activity Compensation) but are also placed in the context of IBM's BPBeans (Business Process Beans) enterprise technology. The meaning of the compensation mechanisms is made precise, as are issues of compensation scoping in multilevel transactions. The compensation extensions result in flexible and powerful mechanisms for modeling and implementing long-running business transactions.
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