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1. The DICA Endoscopic Classification for Diverticular Disease of the Colon Shows a Significant Interobserver Agreement among Community Endoscopists: an International Study

Author

Tursi A., Brandimarte G., Di Mario F., Lanas A., Scarpignato C., Bafutto M., Barbara G., Bassotti G., Binda G. A., Biondi A., Biondo S., Cassieri C., Crucitti A., Dumitrascu D. L., Elisei W., Escalante R., Herszenyi L., Kruis W., Kupcinskas J., Lahat A., Lecca P. G., Maconi G., Malfertheiner P., Mazzarri A., Mearin F., Milosavljevic T., Nardone G., de Oliveira E. C., Papa A., Papagrigoriadis S., Pera M., Persiani R., Picchio M., Regula J., Stimac D., Stollman N., Strate L. L., Walker M. M. D., Allegretta L., Altavilla N., Amaro P., Annunziata M. L., Barberio F., Basile G., Bedogni G., Belfiori V., Benvenuti S., Bertolami C., Bisello M., El Dammak M. B., Bozzi R., Buono M., Cambie G., Capezzuto E., Casamassima C., Chavoushian A., Ciofani R., Citarella C., Compare D., Cotruta B., D'amico F., Dulk M. D., Dyrda B. E., Festa V., Gallina S., Grasso R., Hanzel J., Taieb J. M., Lai M. A., Latella G., Lisi D., Lodi L., Marangi S., Mardegan A., Marlicz W., Maurano A., Milazzo G., Militaru V., Miraglia S., Monica F., Moskalev A., Natale A., Nicolas C., Pancetti A., Penna A., Pepe A. S., Pisano M., Pontone S., Prati M., Prisco A., Rando L., Hernandez E. R., Rosati O., Rossi G., Passoni G. R., Papa V., Nesme N. S., Schiffino L., Schillaci D., Selvaggi G., Taborchi F., Tornar A., Trebuna F., Triggiani C., Testai F. V., Vassallo R., Violi A., Tursi, A., Brandimarte, G., Di Mario, F., Lanas, A., Scarpignato, C., Bafutto, M., Barbara, G., Bassotti, G., Binda, G. A., Biondi, A., Biondo, S., Cassieri, C., Crucitti, A., Dumitrascu, D. L., Elisei, W., Escalante, R., Herszenyi, L., Kruis, W., Kupcinskas, J., Lahat, A., Lecca, P. G., Maconi, G., Malfertheiner, P., Mazzarri, A., Mearin, F., Milosavljevic, T., Nardone, G., de Oliveira, E. C., Papa, A., Papagrigoriadis, S., Pera, M., Persiani, R., Picchio, M., Regula, J., Stimac, D., Stollman, N., Strate, L. L., Walker, M. M. D., Allegretta, L., Altavilla, N., Amaro, P., Annunziata, M. L., Barberio, F., Basile, G., Bedogni, G., Belfiori, V., Benvenuti, S., Bertolami, C., Bisello, M., El Dammak, M. B., Bozzi, R., Buono, M., Cambie, G., Capezzuto, E., Casamassima, C., Chavoushian, A., Ciofani, R., Citarella, C., Compare, D., Cotruta, B., D'Amico, F., Dulk, M. D., Dyrda, B. E., Festa, V., Gallina, S., Grasso, R., Hanzel, J., Taieb, J. M., Lai, M. A., Latella, G., Lisi, D., Lodi, L., Marangi, S., Mardegan, A., Marlicz, W., Maurano, A., Milazzo, G., Militaru, V., Miraglia, S., Monica, F., Moskalev, A., Natale, A., Nicolas, C., Pancetti, A., Penna, A., Pepe, A. S., Pisano, M., Pontone, S., Prati, M., Prisco, A., Rando, L., Hernandez, E. R., Rosati, O., Rossi, G., Passoni, G. R., Papa, V., Nesme, N. S., Schiffino, L., Schillaci, D., Selvaggi, G., Taborchi, F., Tornar, A., Trebuna, F., Triggiani, C., Testai, F. V., Vassallo, R., Violi, A., Tursi A., Brandimarte G., Di Mario F., Lanas A., Scarpignato C., Bafutto M., Barbara G., Bassotti G., Binda G.A., Biondi A., Biondo S., Cassieri C., Crucitti A., Dumitrascu D.L., Elisei W., Escalante R., Herszenyi L., Kruis W., Kupcinskas J., Lahat A., Lecca P.G., Maconi G., Malfertheiner P., Mazzari A., Mearin F., Milosavljevic T., Nardone G., Chavez De Oliveira E., Papa A., Papagrigoriadis S., Pera M., Persiani R., Picchio M., Regula J., Stimac D., Stollman N., Strate L.L., and Walker M.M.

Subjects
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, Diverticular Disease, Endoscopic classification, Video Recording, Colonoscopy, Gastroenterology, Severity of Illness Index, endoscopic classification, Diverticulum, classification, complications, Diverticular diseases, Endoscopy, methods, Colonic Diseases, 0302 clinical medicine, Community Health Services, Community Health Service, Observer Variation, 0303 health sciences, medicine.diagnostic_test, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, agreement − colonoscopy − community setting − diverticular disease of the colon− endoscopic classification, 3. Good health, Diverticulosis, Malalties del còlon, Diverticular disease of the colon, Diverticular disease, 616.344-007.64 [udc], Community setting, 030211 gastroenterology & hepatology, Human, medicine.medical_specialty, Scoring system, Colonic Disease, Settore MED/12 - GASTROENTEROLOGIA, Reproducibility of Result, agreement, colonoscopy, community setting, diverticular disease of the colon, Agreement, 03 medical and health sciences, Internal medicine, Severity of illness, medicine, Diverticulosis, Colonic, Humans, Colonic diseases, 030304 developmental biology, Diverticular Diseases, business.industry, Colonoscòpia, Reproducibility of Results, medicine.disease, Inter-rater reliability, business, Kappa
Abstract

Background and Aims: The Diverticular Inflammation and Complication Assessment (DICA) endoscopic classification of diverticulosis and diverticular disease (DD) is currently available. It scores severity of the disease as DICA 1, DICA 2 and DICA 3. Our aim was to assess the agreement on this classification in an international endoscopists community setting. Methods: A total of 96 doctors (82.9% endoscopists) independently scored a set of DD endoscopic videos. The percentages of overall agreement on DICA score and a free-marginal multirater kappa (κ) coefficient were reported as statistical measures of interrater agreement. Results: Overall agreement in using DICA was 91.8% with a free-marginal kappa of 88% (95% CI 80-95). The overall agreement levels were: DICA 1, 85.2%; DICA 2, 96.5%; DICA 3, 99.5%. The free marginal κ was: DICA 1 = 0.753, DICA 2 = 0.958, DICA 3 = 0.919. The agreement about the main endoscopic items was 83.4% (k 67%) for diverticular extension, 62.6% (k 65%) for number of diverticula for each district, 86.8% (k 82%) for presence of inflammation, and 98.5 (k 98%) for presence of complications. Conclusions: The overall interrater agreement in this study ranges from good to very good. DICA score is a simple and reproducible endoscopic scoring system for diverticulosis and DD.

Published
2019

2. Impact of nucleic acid testing for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus on the safety of blood supply in Italy: a 6-year survey

Author

Claudio, Velati, Luisa, Romano, Laura, Fomiatti, Lorella, Baruffi, Alessandro Remo Zanetti, Research Group: Sciariada, Simti L., Lobbiani, L., Prati, D., Marconi, M., Ravagnani, E., Rossi, E., Rossini, S., Bellavita, P., Moroni, G. A., Bodini, U., Pagliaro, P., Azzario, F., Rossi, D., Sciorelli, G., Salvaneschi, L., Cambie, G., Marini, M., Pizzoccolo, G., Gazzola, G. B., Peres, E., Mariottini, C., Graziani, G., Baicchi, U., Palla, P., Vacri, L., Strada, P., Miceli, M., Iudicone, P., Girelli, Gabriella, Ursitti, A., De Silvestro, G., Gentile, R., Di Paola, P., Manca, M., Martinelli, L., Bonomo, P., Calabrese, S., Pistolese, G., Aprili, G., Bressan, F., Ripamonti, M., Catalano, A., Gallerano, P., Giacalone, I., Fiorilla, A., Giannotti, G., Cantella, R., Di Persia, M. G., Esposito, V., Sardella, C., Di Monte, D., Bajorek, M., Reina, A., Silvani, C. M., Piani, M., Salvoni, G., De Felice, L., Macri, M., De Palma, M., Vecchi, C., Belloni, M., Bettini, C., Ghiazza, P., De Santis, D., Di Mauro, L., Antoncecchi, S., Rinaldi, C., Allegreita, G., Siracusano, L., Adami, R., Lanteri, M., Mazzei, C., Tagariello, G., Gajo, G. B., Berti, P., Giordano, C., Palazzesi, G., Del Gusto, B., Pavone, A., Vacchini, M., Tomasini, A., Vaselli, G., Fiorin, F., Bresolin, G., Bertola, F., Testa, D., Semino, G., Tomasini, I., Zucchelli, P., Chicchi, R., Peano, G., Franchi, D., Sabelli, M., Miloro, G., Di Gregorio, P., Reimondo, P., Cimino, G., Tripodi, G., Borzini, P., Tarditi, M., Cocchi, T., Pata, V., Santarelli, R., Geremicca, W., Minerva, A., Maccarione, F. P., Solanda, F., Rivasi, P., Carubia, F., Prinoth, O., Ostuni, A., Bossio, M., Maggiotto, A., Valentino, F., Puzzonia, P., and Source Musto, C.

Subjects
Adult, Male, Hepatitis B virus, Genotype, Hepacivirus, Hepatitis C virus, Immunology, Blood Donors, HIV Infections, medicine.disease_cause, Virus, Flaviviridae, Orthohepadnavirus, Risk Factors, Seroepidemiologic Studies, medicine, Humans, Mass Screening, Immunology and Allergy, Aged, biology, business.industry, HIV, virus diseases, Hematology, Middle Aged, Hepatitis B, biology.organism_classification, medicine.disease, Hepatitis C, Virology, digestive system diseases, Italy, Hepadnaviridae, Virus Diseases, Health Care Surveys, Blood Banks, Female, Morbidity, Safety, business, Risk Reduction Behavior
Abstract

BACKGROUND: Nucleic acid testing (NAT) for hepatitis C virus (HCV) and human immunodeficiency virus (HIV) has been implemented in several European countries and in the United States, while hepatitis B virus (HBV) NAT is still being questioned by opinions both in favor and against such an option, depending on the HBV endemicity, health care resources, and expected benefits. STUDY DESIGN AND METHODS: This survey was aimed to assess the NAT impact in improving the safety of blood supply in Italy, 6 years after implementation. The study involved 93 Italian transfusion centers and was carried out in 2001 through 2006. A total of 10,776,288 units were tested for the presence of HCV RNA, 7,932,430 for HIV RNA, and 3,405,497 for HBV DNA, respectively. RESULTS: Twenty-seven donations or 2.5 per million tested were HCV RNA–positive/anti-HCV–negative; 14 or 1.8 per million units tested were HIV RNA–positive/anti-HIV–negative; and 197 or 57.8 per million donations tested were HBV DNA–positive/hepatitis B surface antigen–negative. Of the latter, 8 (2.3/106) were collected from donors in the window phase of infection and 189 (55.5/106) from donors with occult HBV. Sixty-eight percent of the latter donors had hepatitis B surface antibody, 74.5 percent of whom with concentrations considered protective (≥10 mIU/mL). CONCLUSION: NAT implementation has improved blood safety by reducing the risk of entering 2.5 HCV and 1.8 HIV infectious units per million donations into the blood supply. The yield of NAT in detecting infectious blood before transfusion was higher for HBV than for HCV or HIV. However, the benefit of HBV NAT in terms of avoided HBV-related morbidity and mortality in blood recipients needs to be further evaluated.

Published
2008

3. Rationale and design of a multicenter prospective cohort study for the eVALuation and monitoring of HPV infections and relATEd cervical diseases in high-risk women (VALHIDATE study)

Author

Orlando, G., Tanzi, E., Chatenoud, L., Gramegna, M., Rizzardini, G., Antonacci, M. C., Arcidiacono, I., Bertuccio, P., Bianchi, S., Boero, V., Cambie, G., Cetin, I., Esposito, S., Falchetti, M., Fasolo, M. M., Galli, C., Bertazzoli, E., Lunghi, G., Matteelli, A., Tisi, G., Zanchetta, N., and Zuccotti, G.

Subjects
Cancer Research, Cross-sectional study, Epidemiology, Cervical cancer, Prevention, HPV, Cytology screening, Molecular screening, Uterine Cervical Neoplasms, Uterine Cervical Diseases, Study Protocol, Risk Factors, Mass Screening, Viral, Prospective Studies, Papillomaviridae, Prospective cohort study, Phylogeny, Human papillomavirus 16, biology, Human papillomavirus 18, HPV infection, Age Factors, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Italy, Oncology, Female, Adult, medicine.medical_specialty, Adolescent, Genotype, Cervical intraepithelial neoplasia, lcsh:RC254-282, Aged, Cervical Intraepithelial Neoplasia, Cross-Sectional Studies, DNA, Viral, Humans, Mutation, Papillomavirus Infections, Vaginal Smears, Young Adult, Internal medicine, medicine, Genetics, Mass screening, Gynecology, business.industry, DNA, medicine.disease, biology.organism_classification, Uterine Cervical Dysplasia, business
Abstract

Background Pap screening, an effective method for cervical cancer prevention, is now supported by molecular human papillomavirus (HPV) testing. Recently commercialised preventive vaccines also provide new tools for the primary prevention of cervical cancer. To determine appropriate prevention strategies, the Health General Direction, Lombardy Region, funded a project that aims to characterize and monitor HPV infections and related cervical diseases in high-risk women. Methods/design VALHIDATE is a 5-year multicentre open prospective cohort study. It will recruit 7000 consenting women aged 13–65 years to provide information about the local biomolecular epidemiology of HPV infection and cervical diseases in high-risk women recruited from nine clinical centres and one faith-based organisation. The study will estimate the overall and type-specific prevalence of HPV infection and cervical abnormalities. It also aims to compare standard Pap screening with biomolecular screening, and to assist in the design of targeted regional prevention programs directed specifically at high-risk groups. Three groups of high-risk women: 1000 HIV-infected women (aged 26–65 years), 1000 recent migrant women (aged 26–65 years) and 3000 young women (aged 13–26 years) and 1 control group: 2000 women (aged 26–45 years) attending a spontaneous screening program, will be recruited. Sample sizes will be revised after the first year. Adult participants will undergo conventional cervical cytology, HPV DNA screening and genotyping. Paediatric participants will undergo HPV DNA testing and genotyping of urine samples. HPV DNA, cytological abnormalities and HPV types will be analysed according to demographic, epidemiological, behavioural, and clinical data collected in an electronic case report form. Overall and stratified prevalences will be estimated to analyse the associations between HPV infection and selected characteristics. Logistic regression models will be used to estimate crude and adjusted odds ratios. Cox proportional hazard models will be used to estimate hazard ratios over time and between groups. Discussion/main expected results This study will provide substantial insight into HPV infections and related cervical diseases in high-risk groups and will help determine appropriate regional cervical cancer prevention strategies.

Published
2012

4. International consensus on diverticulosis and diverticular disease. Statements from the 3rd international symposium on diverticular disease

Author

Marjorie M. Walker, László Herszényi, Giovanni Barbara, Gabrio Bassotti, Wolfgang Kruis, Angel Lanas, G. Cambiè, Enio Chavez De Oliveira, Andrea Mazzari, A. Violi, Jaroslaw Regula, Giovanni Brandimarte, Roberto Persiani, Walter Elisei, Miguel Pera, Marcello Picchio, Sebastiano Biondo, Fermín Mearin, Claudio Cassieri, Juozas Kupcinskas, Savvas Papagrigoriadis, Antonio Tursi, Giovanni Maconi, Davor Štimac, Antonio Crucitti, Ricardo Escalante, Neil Stollman, Lisa L. Strate, P.G. Lecca, M. Bafutto, Gerardo Nardone, Tomica Milosavljeviċ, Carmelo Scarpignato, Alfredo Papa, Francesco Di Mario, Alberto Biondi, Gian Andrea Binda, Dan L. Dumitrascu, Adi Lahat, Peter Malfertheiner, Tursi A., Brandimarte G., Di Mario F., Lanas A., Scarpignato C., Bafutto M., Barbara G., Bassotti G., Binda G.A., Biondi A., Biondo S., Cambie G., Cassieri C., Crucitti A., Dumitrascu D.L., Elisei W., Escalante R., Herszenyi L., Kruis W., Kupcinskas J., Lahat A., Lecca P.G., Maconi G., Malfertheiner P., Mazzari A., Mearin F., Milosavljevic T., Nardone G., de Oliveira E.C., Papa A., Papagrigoriadis S., Pera M., Persiani R., Picchio M., Regula J., Stimac D., Stollman N., Strate L.L., Violi A., Walker M.M.D., Tursi, A., Brandimarte, G., Di Mario, F., Lanas, A., Scarpignato, C., Bafutto, M., Barbara, G., Bassotti, G., Binda, G. A., Biondi, A., Biondo, S., Cambie, G., Cassieri, C., Crucitti, A., Dumitrascu, D. L., Elisei, W., Escalante, R., Herszenyi, L., Kruis, W., Kupcinskas, J., Lahat, A., Lecca, P. G., Maconi, G., Malfertheiner, P., Mazzari, A., Mearin, F., Milosavljevic, T., Nardone, G., de Oliveira, E. C., Papa, A., Papagrigoriadis, S., Pera, M., Persiani, R., Picchio, M., Regula, J., Stimac, D., Stollman, N., Strate, L. L., Violi, A., and Walker, M. M. D.

Subjects
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, Medical therapy, Etiology, Disease, 0302 clinical medicine, Voting, Diagnosis, Medicine, Disease management (health), Diverticuliti, health care economics and organizations, media_common, Diverticulosis, Evidence-Based Medicine, Diverticulosi, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, Gastroenterology, Consensus, Diverticular disease, Diverticulitis, Surgical therapy, 3. Good health, Malalties inflamatòries intestinals, Hot topics, 030220 oncology & carcinogenesis, Etiologia, 030211 gastroenterology & hepatology, Diagnosi, medicine.medical_specialty, Settore MED/12 - GASTROENTEROLOGIA, media_common.quotation_subject, education, MEDLINE, Consensu, Therapeutics, Inflammatory bowel diseases, diverticulosis – diverticular disease – diverticulitis – consensus – diagnosis – medical therapy – surgical therapy, 03 medical and health sciences, Humans, Diverticular Diseases, business.industry, Evidence-based medicine, Congresses as Topic, medicine.disease, Terapèutica, Diverticulum, Family medicine, business
Abstract

The statements produced by the Chairmen and Speakers of the 3rd International Symposium on Diverticular Disease, held in Madrid on April 11th-13th 2019, are reported. Topics such as current and evolving concepts on the pathogenesis, the course of the disease, the news in diagnosing, hot topics in medical and surgical treatments, and finally, critical issues on the disease were reviewed by the Chairmen who proposed 39 statements graded according to level of evidence and strength of recommendation. Each topic was explored focusing on the more relevant clinical questions. The vote was conducted on a 6-point scale and consensus was defined a priori as 67% agreement of the participants. The voting group consisted of 124 physicians from 18 countries, and agreement with all statements was provided. Comments were added explaining some controversial areas.

Published
2019

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