1. Unilateral adrenalectomy improves urinary protein excretion but does not abolish its relationship to sodium excretion in patients with aldosterone-producing adenoma
- Author
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C. Kogovsek, Richard D. Gordon, Ashraf H. Ahmed, D. Robson, Eduardo Pimenta, Michael Stowasser, and David Cowley
- Subjects
Adenoma ,Adult ,Male ,medicine.medical_specialty ,Fludrocortisone ,medicine.medical_treatment ,Blood Pressure ,chemistry.chemical_compound ,Primary aldosteronism ,Mineralocorticoid receptor ,Internal medicine ,Hyperaldosteronism ,Internal Medicine ,medicine ,Humans ,Aldosterone ,Kidney ,business.industry ,Adrenalectomy ,Sodium ,Middle Aged ,medicine.disease ,Proteinuria ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Female ,business ,medicine.drug - Abstract
Experimental and human data suggest that adverse cardiovascular (CV) and renal effects of aldosterone excess are dependent on concomitant dietary salt intake. Increased urinary protein (Uprot) is an early sign of nephropathy independently associated with CV risk. We have previously reported a positive association between Uprot and urinary sodium (UNa) in patients with hyperaldosteronism, but not in patients with normal aldosterone levels. We aimed to determine whether Uprot is related to UNa in patients with aldosterone-producing adenoma (APA) and whether the degree of Uprot and strength of this relationship is reduced following correction of hyperaldosteronism. Subjects with APA (n=24) underwent measurement of 24 h Uprot and UNa before and after unilateral adrenalectomy (follow-up 15.0±11.9 months). Following surgery, mean clinic systolic blood pressure fell (150.4±18.2 vs 134.5±14.5 mm Hg, P=0.0008), despite a reduction in number of antihypertensive medications, and Uprot (211.2±101.6 vs 106.0±41.8 mg per day, P
- Published
- 2010