Author: "Baracca, A" / Topic: business - Searchworks@Jio Institute Digital Library Search Results

135 results on '"Baracca, A"'

1. Cell-Free and User-Centric Massive MIMO Architectures for Reliable Communications in Indoor Factory Environments

Author: Paolo Baracca, Stefano Buzzi, Saeed R. Khosravirad, and Mario Alonzo
Subjects: microwave, business.industry, Computer science, Reliability (computer networking), cell-free massive MIMO, MIMO, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Latency (audio), user-centric approach, TK5101-6720, Distributed MIMO, power control, Transmission (telecommunications), Telecommunications link, Telecommunication, Factory (object-oriented programming), Antenna (radio), business, Transportation and communications, signal-to-interference plus noise ratio, Computer network, Power control, HE1-9990
Abstract: Factory automation is one of the use cases for 5G-and-beyond mobile networks where strict requirements in terms of latency, availability and reliability are required. In this paper, we investigate the potentials of massive MIMO in delivering those promises for industrial automation. Namely, communications between actuators (ACs) and Access Points (APs) inside an industrial scenario is considered and different transmission modes are compared: joint transmission (JT) where the distributed antennas are used to communicate with each AC, cell-free transmission (CFT) where all the ACs are served by all APs, single AP transmission (SAT) where each AC is served by only one AP, and user-centric transmission (UCT) where each AC is served by a subset of APs. A power control strategy, aimed at maximizing the minimum signal-to-interference plus noise ratio (SINR), is also introduced. Numerical results, shown in terms of downlink SINR and achievable rate, evaluated using the final block length capacity formula (FBLC), demonstrate that the use of distributed antenna setting and of power control bring substantial performance improvements in terms of reliability and latency.
Published: 2021

2. Occurrence of persistent atrial fibrillation during pacing for sinus node disease: The influence of His bundle pacing versus managed ventricular pacing

Author: Gianni Pastore, Gianluca Rigatelli, Massimiliano Maines, Franco Noventa, Giorgio Corbucci, Francesco Zanon, Loris Roncon, Enrico Baracca, Lina Marcantoni, and Daniela Lanza
Subjects: Bundle of His, Pacemaker, Artificial, medicine.medical_specialty, Disease, 030204 cardiovascular system & hematology, 03 medical and health sciences, Basal (phylogenetics), 0302 clinical medicine, Physiology (medical), Internal medicine, Atrial Fibrillation, medicine, Humans, In patient, 030212 general & internal medicine, PR interval, Sinus (anatomy), Retrospective Studies, Sick Sinus Syndrome, business.industry, Cardiac Pacing, Artificial, Atrial fibrillation, Ventricular pacing, medicine.disease, medicine.anatomical_structure, Persistent atrial fibrillation, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract: Introduction In patients with sinus node disease (SND), the dual-chamber pacemaker (PM) is programmed in DDDR mode with an algorithm to avoid unnecessary right ventricular (RV) pacing. This pacing mode may prolong PR interval with consequently atrioventricular (AV) asynchrony which is associated with a higher risk of atrial fibrillation (AF). We evaluate whether preserving AV synchrony by setting a fixed AV delay during physiological RV pacing, that is, His bundle pacing (HBP), could reduce the risk of AF occurrence in comparison with a standard pacing mode with an algorithm to avoid unnecessary RV pacing (DDD-VPA). Methods and results We collected retrospective data from 313 consecutive patients who had undergone PM for SND. The first occurrence of persistent AF (>7 consecutive days) as a function of the pacing mode was evaluated. HBP and DDD-VPA were implemented in 82 and 231 patients, respectively. Persistent AF occurred in 128 (40.9%) patients over a median follow-up of 70 months (67-105). The DDD-VPA pacing mode was significantly correlated with the occurrence of persistent AF only when the basal PR was long (>180 ms). The risk of persistent AF was significantly lower in patients on HBP than in those on DDD-VPA, adjusted HR = .57 (95% CI, .36- .89, p=.014). Other independent predictors of persistent AF occurrence were: A history of AF (HR = 3.91; 95% CI, 2.48-6.19, p = .001), age, and long PR interval (HR = 2.98; 95% CI, 2.00-4.43, p=.001). Conclusion In SND patients and long basal PR interval, the HBP may reduce the risk of persistent AF in comparison with the DDD-VPA.
Published: 2020
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3. Left bundle branch pacing by standard stylet-driven lead: Preliminary experience of two case reports

Author: Gianni Pastore, Enrico Baracca, Francesco Zanon, and Lina Marcantoni
Subjects: Physiologic pacing, business.industry, Case Report, Conduction system pacing, Anatomy, Stylet, Stylet-driven lead, Left bundle branch, Delivery catheter, Left bundle branch pacing, Medicine, Cardiology and Cardiovascular Medicine, business, Lead (electronics)
Published: 2020
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4. Electrogram‐only guided approach to His bundle pacing with minimal fluoroscopy: A single‐center experience

Author: Paola Raffagnato, Graziano Boaretto, Antonella Tiribello, Gianni Pastore, Loris Roncon, Pugazhendhi Vijayaraman, Francesco Zanon, Marco Zuin, Lina Marcantoni, and Enrico Baracca
Subjects: medicine.diagnostic_test, business.industry, 030204 cardiovascular system & hematology, Single Center, Atrial Lead, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Total dose, Lead Dislodgement, Medicine, Fluoroscopy, 030212 general & internal medicine, Implant, Cardiology and Cardiovascular Medicine, Lead Placement, business, Lead (electronics), Nuclear medicine
Abstract: Introduction His bundle pacing (HBP) is the most physiological pacing. The standard technique based on fluoroscopic approach might be challenging and fluoro consuming. Targeting the His guided exclusively by the electrical signals could enable a precise lead implant, thus reducing fluoroscopy time (FT) and X-ray dose, desirable both for patients and operators. The aim of the study is to evaluate the feasibility, efficacy, and safety both acutely and at 30 days of the electrogram (EGM)-guided HBP with minimal or no fluoroscopy. Methods and results Between October and December 2018, 41 consecutive patients underwent EGM-guided HBP. Successful HBP was obtained in 39 (95%) patients, (30 males, 78 ± 10 years). Selective HBP (S-HBP) was achieved in 23 (59%), nonselective HBP (NS-HBP) in 16 (41%) patients. The final HBP lead position was reached in 31 (79.4%) patients without fluoroscopy, only guided by electrical signals. In eight patients a minimal fluoroscopy (mean, 8 seconds) has been required. The sheath's cutting and the slack of the lead were routinely performed under fluoroscopy. No difference was observed in FT for HBP lead placement in S-HBP and NS-HBP (mean, 8.1 ± 25 vs 7.5 ± 20 seconds, P = .8; median value 0 vs 0 seconds). No differences were observed in FT for the entire procedure, total dose area product and total procedural time in S-HBP and NS-HBP. Lead dislodgement occurred in one (2.6%) patient 1 day after the procedure. Conclusions HBP could be performed safely and efficiently using the EGMs, with minimal or no fluoroscopy. Fluoroscopy was required during sheath removal and atrial lead placement.
Published: 2020
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5. Functional Analysis of Upper-Limb Movements in the Cartesian Domain

Author: Marco Baracca, Giuseppe Averta, Ylenia Nisticò, Antonio Bicchi, Paolo Bonifati, Matteo Bianchi, Gaetano Valenza, and Vincenzo Catrambone
Subjects: Basis (linear algebra), business.industry, Computer science, Work (physics), Kinematics, Motion (physics), law.invention, Domain (software engineering), Computer Science::Robotics, Impedance control, law, Robot, Computer vision, Cartesian coordinate system, Artificial intelligence, business
Abstract: The characterization of human upper limb kinematics is fundamental not only in neuroscience and clinical practice, but also for the planning of human-like robot motions in rehabilitation and assistive robotics. One promising approach to endow anthropomorphic robotic manipulators with human motion characteristics is to directly embed human upper limb principal motion modes at joint level, which are computed through functional analysis, in the robot trajectory optimization. This planning method poses some challenges when the kinematics of the manipulator is different from the model used for human data acquisition. In a previous work, we proposed to tackle this issue by mapping human trajectories onto robotic systems relying on Cartesian impedance control. An alternative method could move from the application of the functional analysis to human upper limb kinematics, working directly in the Cartesian domain. In this work, we present the results of this characterization on the data from 33 healthy subjects during the execution of daily-living activities. We found statistical differences between the amount of variability explained by a given number of basis elements in different directions of the Cartesian space. This suggests that some directions of the space are associated with a more complex motion evolution with respect to others, opening interesting perspectives for robot planning, neuroscience and human motion control.
Published: 2022

6. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Author: Klionsky, Daniel, Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie, Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis, Adeli, Khosrow, Adolph, Timon, Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat, Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed, Agrotis, Alexander, Aguilar, Patricia, Ahmad, S Tariq, Ahmed, Zubair, Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus, Akoumianaki, Tonia, Akpinar, Hafize Aysin, Al-Abd, Ahmed, Al-Akra, Lina, Al-Gharaibeh, Abeer, Alaoui-Jamali, Moulay, Alberti, Simon, Alcocer-Gómez, Elísabet, Alessandri, Cristiano, Ali, Muhammad, Alim Al-Bari, M Abdul, Aliwaini, Saeb, Alizadeh, Javad, Almacellas, Eugènia, Almasan, Alexandru, Alonso, Alicia, Alonso, Guillermo, Altan-Bonnet, Nihal, Altieri, Dario, Álvarez, Élida, Alves, Sara, Alves Da Costa, Cristine, Alzaharna, Mazen, Amadio, Marialaura, Amantini, Consuelo, Amaral, Cristina, Ambrosio, Susanna, Amer, Amal, Ammanathan, Veena, An, Zhenyi, Andersen, Stig, Andrabi, Shaida, Andrade-Silva, Magaiver, Andres, Allen, Angelini, Sabrina, Ann, David, Anozie, Uche, Ansari, Mohammad, Antas, Pedro, Antebi, Adam, Antón, Zuriñe, Anwar, Tahira, Apetoh, Lionel, Apostolova, Nadezda, Araki, Toshiyuki, Araki, Yasuhiro, Arasaki, Kohei, Araújo, Wagner, Araya, Jun, Arden, Catherine, Arévalo, Maria-Angeles, Arguelles, Sandro, Arias, Esperanza, Arikkath, Jyothi, Arimoto, Hirokazu, Ariosa, Aileen, Armstrong-James, Darius, Arnauné-Pelloquin, Laetitia, Aroca, Angeles, Arroyo, Daniela, Arsov, Ivica, Artero, Rubén, Asaro, Dalia Maria Lucia, Aschner, Michael, Ashrafizadeh, Milad, Ashur-Fabian, Osnat, Atanasov, Atanas, Au, Alicia, Auberger, Patrick, Auner, Holger, Aurelian, Laure, Autelli, Riccardo, Avagliano, Laura, Ávalos, Yenniffer, Aveic, Sanja, Aveleira, Célia Alexandra, Avin-Wittenberg, Tamar, Aydin, Yucel, Ayton, Scott, Ayyadevara, Srinivas, Azzopardi, Maria, Baba, Misuzu, Backer, Jonathan, Backues, Steven, Bae, Dong-Hun, Bae, Ok-Nam, Bae, Soo Han, Baehrecke, Eric, Baek, Ahruem, Baek, Seung-Hoon, Baek, Sung Hee, Bagetta, Giacinto, Bagniewska-Zadworna, Agnieszka, Bai, Hua, Bai, Jie, Bai, Xiyuan, Bai, Yidong, Bairagi, Nandadulal, Baksi, Shounak, Balbi, Teresa, Baldari, Cosima, Balduini, Walter, Ballabio, Andrea, Ballester, Maria, Balazadeh, Salma, Balzan, Rena, Bandopadhyay, Rina, Banerjee, Sreeparna, Banerjee, Sulagna, Bánréti, Ágnes, Bao, Yan, Baptista, Mauricio, Baracca, Alessandra, Barbati, Cristiana, Bargiela, Ariadna, Barilà, Daniela, Barlow, Peter, Barmada, Sami, Barreiro, Esther, Barreto, George, Bartek, Jiri, Bartel, Bonnie, Bartolome, Alberto, Barve, Gaurav, Basagoudanavar, Suresh, Bassham, Diane, Bast, Robert, Basu, Alakananda, Batoko, Henri, Batten, Isabella, Baulieu, Etienne, Baumgarner, Bradley, Bayry, Jagadeesh, Beale, Rupert, Beau, Isabelle, Beaumatin, Florian, Bechara, Luiz, Beck, George, Beers, Michael, Begun, Jakob, Behrends, Christian, Behrens, Georg, Bei, Roberto, Bejarano, Eloy, Bel, Shai, Behl, Christian, Belaid, Amine, Belgareh-Touzé, Naïma, Bellarosa, Cristina, Belleudi, Francesca, Belló Pérez, Melissa, Bello-Morales, Raquel, Beltran, Jackeline Soares de Oliveira, Beltran, Sebastián, Benbrook, Doris Mangiaracina, Bendorius, Mykolas, Benitez, Bruno, Benito-Cuesta, Irene, Bensalem, Julien, Berchtold, Martin, Berezowska, Sabina, Bergamaschi, Daniele, Bergami, Matteo, Bergmann, Andreas, Berliocchi, Laura, Berlioz-Torrent, Clarisse, Bernard, Amélie, Berthoux, Lionel, Besirli, Cagri, Besteiro, Sebastien, Betin, Virginie, Beyaert, Rudi, Bezbradica, Jelena, Bhaskar, Kiran, Bhatia-Kissova, Ingrid, Bhattacharya, Resham, Bhattacharya, Sujoy, Bhattacharyya, Shalmoli, Bhuiyan, Md Shenuarin, Bhutia, Sujit Kumar, Bi, Lanrong, Bi, Xiaolin, Biden, Trevor, Bijian, Krikor, Billes, Viktor, Binart, Nadine, Bincoletto, Claudia, Birgisdottir, Asa, Bjorkoy, Geir, Blanco, Gonzalo, Blas-Garcia, Ana, Blasiak, Janusz, Blomgran, Robert, Blomgren, Klas, Blum, Janice, Boada-Romero, Emilio, Boban, Mirta, Boesze-Battaglia, Kathleen, Boeuf, Philippe, Boland, Barry, Bomont, Pascale, Bonaldo, Paolo, Bonam, Srinivasa Reddy, Bonfili, Laura, Bonifacino, Juan, Boone, Brian, Bootman, Martin, Bordi, Matteo, Borner, Christoph, Bornhauser, Beat, Borthakur, Gautam, Bosch, Jürgen, Bose, Santanu, botana, luis, Botas, Juan, Boulanger, Chantal, Boulton, Michael, Bourdenx, Mathieu, Bourgeois, Benjamin, Bourke, Nollaig, Bousquet, Guilhem, Boya, Patricia, Bozhkov, Peter, Bozi, Luiz, Bozkurt, Tolga, Brackney, Doug, Brandts, Christian, Braun, Ralf, Braus, Gerhard, Bravo-Sagua, Roberto, Bravo-San Pedro, José, Brest, Patrick, Bringer, Marie-Agnès, Briones-Herrera, Alfredo, Broaddus, V Courtney, Brodersen, Peter, Brodsky, Jeffrey, Brody, Steven, Bronson, Paola, Bronstein, Jeff, Brown, Carolyn, Brown, Rhoderick, Brum, Patricia, Brumell, John, Brunetti-Pierri, Nicola, Bruno, Daniele, Bryson-Richardson, Robert, Bucci, Cecilia, Buchrieser, Carmen, Bueno, Marta, Buitrago-Molina, Laura Elisa, Buraschi, Simone, Buch, Shilpa, Buchan, J Ross, Buckingham, Erin, Budak, Hikmet, Budini, Mauricio, Bultynck, Geert, Burada, Florin, Burgoyne, Joseph, Burón, M Isabel, Bustos, Victor, Büttner, Sabrina, Butturini, Elena, Byrd, Aaron, Cabas, Isabel, Cabrera-Benitez, Sandra, Cadwell, Ken, Cai, Jingjing, Cai, Lu, Cai, Qian, Cairó, Montserrat, Calbet, Jose, Caldwell, Guy, Caldwell, Kim, Call, Jarrod, Calvani, Riccardo, Calvo, Ana, Calvo-Rubio Barrera, Miguel, Camara, Niels OS, Camonis, Jacques, Camougrand, Nadine, Campanella, Michelangelo, Campbell, Edward, Campbell-Valois, François-Xavier, Campello, Silvia, Campesi, Ilaria, Campos, Juliane, Camuzard, Olivier, Cancino, Jorge, Candido de Almeida, Danilo, Canesi, Laura, Caniggia, Isabella, Canonico, Barbara, Cantí, Carles, Cao, Bin, Caraglia, Michele, Caramés, Beatriz, Carchman, Evie, Cardenal-Muñoz, Elena, Cardenas, Cesar, Cardenas, Luis, Cardoso, Sandra, Carew, Jennifer, Carle, Georges, Carleton, Gillian, Carloni, Silvia, Carmona-Gutierrez, Didac, Carneiro, Leticia, Carnevali, Oliana, Carosi, Julian, Carra, Serena, Carrier, Alice, Carrier, Lucie, Carroll, Bernadette, Carter, A Brent, Carvalho, Andreia Neves, Casanova, Magali, Casas, Caty, Casas, Josefina, Cassioli, Chiara, Castillo, Eliseo, Castillo, Karen, Castillo-Lluva, Sonia, Castoldi, Francesca, Castori, Marco, Castro, Ariel, Castro-Caldas, Margarida, Castro-Hernandez, Javier, Castro-Obregon, Susana, Catz, Sergio, Cavadas, Claudia, Cavaliere, Federica, Cavallini, Gabriella, Cavinato, Maria, Cayuela, Maria, Cebollada Rica, Paula, Cecarini, Valentina, Cecconi, Francesco, Cechowska-Pasko, Marzanna, Cenci, Simone, Ceperuelo-Mallafré, Victòria, Cerqueira, João, Cerutti, Janete, Cervia, Davide, Cetintas, Vildan Bozok, Cetrullo, Silvia, Chae, Han-Jung, Chagin, Andrei, Chai, Chee-Yin, Chakrabarti, Gopal, Chakrabarti, Oishee, Chakraborty, Tapas, Chakraborty, Trinad, Chami, mounia, Chamilos, Georgios, Chan, David, Chan, Edmond, Chan, Edward, Chan, H.Y. Edwin, Chan, Helen, Chan, Hung, Chan, Matthew, Chan, Yau Sang, Chandra, Partha, Chang, Chih-Peng, Chang, Chunmei, Chang, Hao-Chun, Chang, Kai, Chao, Jie, Chapman, Tracey, Charlet-Berguerand, Nicolas, Chatterjee, Samrat, Chaube, Shail, Chaudhary, Anu, Chauhan, Santosh, Chaum, Edward, Checler, Frédéric, Cheetham, Michael, Chen, Chang-Shi, Chen, Guang-Chao, Chen, Jian-Fu, Chen, Liam, Chen, Leilei, Chen, Lin, Chen, Mingliang, Chen, Mu-Kuan, Chen, Ning, Chen, Quan, Chen, Ruey-Hwa, Chen, Shi, Chen, Wei, Chen, Weiqiang, Chen, Xin-Ming, Chen, Xiong-Wen, Chen, Xu, Chen, Yan, Chen, Ye-Guang, Chen, Yingyu, Chen, Yongqiang, Chen, Yu-Jen, Chen, Yue-Qin, Chen, Zhefan Stephen, Chen, Zhi, Chen, Zhi-Hua, Chen, Zhijian, Chen, Zhixiang, Cheng, Hanhua, Cheng, Jun, Cheng, Shi-Yuan, Cheng, Wei, Cheng, Xiaodong, Cheng, Xiu-Tang, Cheng, Yiyun, Cheng, Zhiyong, Chen, Zhong, Cheong, Heesun, Cheong, Jit Kong, Chernyak, Boris, Cherry, Sara, Cheung, Chi Fai Randy, Cheung, Chun Hei Antonio, Cheung, King-Ho, Chevet, Eric, Chi, Richard, Chiang, Alan Kwok Shing, Chiaradonna, Ferdinando, Chiarelli, Roberto, Chiariello, Mario, Chica, Nathalia, Chiocca, Susanna, Chiong, Mario, Chiou, Shih-Hwa, Chiramel, Abhilash, Chiurchiù, Valerio, Cho, Dong-Hyung, Choe, Seong-Kyu, Choi, Augustine, Choi, Mary, Choudhury, Kamalika Roy, Chow, Norman, Chu, Charleen, Chua, Jason, Chua, John Jia En, Chung, Hyewon, Chung, Kin Pan, Chung, Seockhoon, Chung, So-Hyang, Chung, Yuen-Li, Cianfanelli, Valentina, Ciechomska, Iwona, Cifuentes, Mariana, Cinque, Laura, Cirak, Sebahattin, Cirone, Mara, Clague, Michael, Clarke, Robert, Clementi, Emilio, Coccia, Eliana, Codogno, Patrice, Cohen, Ehud, Cohen, Mickael, Colasanti, Tania, Colasuonno, Fiorella, Colbert, Robert, Colell, Anna, Čolić, Miodrag, Coll, Nuria, Collins, Mark, Colombo, María, Colón-Ramos, Daniel, Combaret, Lydie, Comincini, Sergio, Cominetti, Márcia, Consiglio, Antonella, Conte, Andrea, Conti, Fabrizio, Contu, Viorica Raluca, Cookson, Mark, Coombs, Kevin, Coppens, Isabelle, Corasaniti, Maria Tiziana, Corkery, Dale, Cordes, Nils, Cortese, Katia, Costa, Maria do Carmo, Costantino, Sarah, Costelli, Paola, Coto-Montes, Ana, Crack, Peter, Crespo, Jose, Criollo, Alfredo, Crippa, Valeria, Cristofani, Riccardo, Csizmadia, Tamas, Cuadrado, Antonio, Cui, Bing, Cui, Jun, Cui, Yixian, Cui, Yong, Culetto, Emmanuel, Cumino, Andrea, Cybulsky, Andrey, Czaja, Mark, Czuczwar, Stanislaw, D'Adamo, Stefania, D'Amelio, Marcello, D'Arcangelo, Daniela, D'Lugos, Andrew, D'Orazi, Gabriella, da Silva, James, Dafsari, Hormos Salimi, Dagda, Ruben, Dagdas, Yasin, Daglia, Maria, Dai, Xiaoxia, Dai, Yun, Dai, Yuyuan, Dal Col, Jessica, Dalhaimer, Paul, Dalla Valle, Luisa, Dallenga, Tobias, Dalmasso, Guillaume, Damme, Markus, Dando, Ilaria, Dantuma, Nico, Darling, April, Das, Hiranmoy, Dasarathy, Srinivasan, Dasari, Santosh, Dash, Srikanta, Daumke, Oliver, Dauphinee, Adrian, Davies, Jeffrey, Dávila, Valeria, Davis, Roger, Davis, Tanja, Dayalan Naidu, Sharadha, De Amicis, Francesca, De Bosscher, Karolien, De Felice, Francesca, De Franceschi, Lucia, De Leonibus, Chiara, de Mattos Barbosa, Mayara, De Meyer, Guido, De Milito, Angelo, De Nunzio, Cosimo, De Palma, Clara, De Santi, Mauro, De Virgilio, Claudio, De Zio, Daniela, Debnath, Jayanta, DeBosch, Brian, Decuypere, Jean-Paul, Deehan, Mark, Deflorian, Gianluca, DeGregori, James, Dehay, Benjamin, Del Rio, Gabriel, Delaney, Joe, Delbridge, Lea, Delorme-Axford, Elizabeth, Delpino, M Victoria, Demarchi, Francesca, Dembitz, Vilma, Demers, Nicholas, Deng, Hongbin, Deng, Zhiqiang, Dengjel, Joern, Dent, Paul, Denton, Donna, DePamphilis, Melvin, Der, Channing, Deretic, Vojo, Descoteaux, Albert, Devis, Laura, Devkota, Sushil, Devuyst, Olivier, Dewson, Grant, Dharmasivam, Mahendiran, Dhiman, Rohan, di Bernardo, Diego, Di Cristina, Manlio, Di Domenico, Fabio, Di Fazio, Pietro, Di Fonzo, Alessio, Di Guardo, Giovanni, Di Guglielmo, Gianni, Di Leo, Luca, Di Malta, Chiara, Di Nardo, Alessia, Di Rienzo, Martina, Di Sano, Federica, Diallinas, George, Diao, Jiajie, Diaz-Araya, Guillermo, Díaz-Laviada, Inés, Dickinson, Jared, Diederich, Marc, Dieudé, Mélanie, Dikic, Ivan, Ding, Shiping, Ding, Wen-Xing, Dini, Luciana, Dinić, Jelena, Dinic, Miroslav, Dinkova-Kostova, Albena, Dionne, Marc, Distler, Jörg, Diwan, Abhinav, Dixon, Ian, Djavaheri-Mergny, Mojgan, Dobrinski, Ina, Dobrovinskaya, Oxana, Dobrowolski, Radek, Dobson, Renwick, Đokić, Jelena, Dokmeci Emre, Serap, Donadelli, Massimo, Dong, Bo, Dong, Xiaonan, Dong, Zhiwu, Dorn Ii, Gerald, Dotsch, Volker, Dou, Huan, Dou, Juan, Dowaidar, Moataz, Dridi, Sami, Drucker, Liat, Du, Ailian, Du, Caigan, Du, Guangwei, Du, Hai-Ning, Du, Li-Lin, du Toit, André, Duan, Shao-Bin, Duan, Xiaoqiong, Duarte, Sónia, Dubrovska, Anna, Dunlop, Elaine, Dupont, Nicolas, Durán, Raúl, Dwarakanath, Bilikere, Dyshlovoy, Sergey, Ebrahimi-Fakhari, Darius, Eckhart, Leopold, Edelstein, Charles, Efferth, Thomas, Eftekharpour, Eftekhar, Eichinger, Ludwig, Eid, Nabil, Eisenberg, Tobias, Eissa, N Tony, Eissa, Sanaa, Ejarque, Miriam, El Andaloussi, Abdeljabar, El-Hage, Nazira, El-Naggar, Shahenda, Eleuteri, Anna Maria, El-Shafey, Eman, Elgendy, Mohamed, Eliopoulos, Aristides, Elizalde, María, Elks, Philip, Elsasser, Hans-Peter, Elsherbiny, Eslam, Emerling, Brooke, Emre, N., Eng, Christina, Engedal, Nikolai, Engelbrecht, Anna-Mart, Engelsen, Agnete, Enserink, Jorrit, Escalante, Ricardo, Esclatine, Audrey, Escobar-Henriques, Mafalda, Eskelinen, Eeva-Liisa, Espert, Lucile, Eusebio, Makandjou-Ola, Fabrias, Gemma, Fabrizi, Cinzia, Facchiano, Antonio, Facchiano, Francesco, Fadeel, Bengt, Fader, Claudio, Faesen, Alex, Fairlie, W Douglas, Falcó, Alberto, Falkenburger, Bjorn, Fan, Daping, Fan, Jie, Fan, Yanbo, Fang, Evandro, Fang, Yanshan, Fang, Yognqi, Fanto, Manolis, Farfel-Becker, Tamar, Faure, Mathias, Fazeli, Gholamreza, Fedele, Anthony, Feldman, Arthur, Feng, Du, Feng, Jiachun, Feng, Lifeng, Feng, Yibin, Feng, Yuchen, Feng, Wei, Fenz Araujo, Thais, Ferguson, Thomas, Fernández, Álvaro, Fernandez-Checa, Jose, Fernández-Veledo, Sonia, Fernie, Alisdair, Ferrante, Anthony, Ferraresi, Alessandra, Ferrari, Merari, Ferreira, Julio, Ferro-Novick, Susan, Figueras, Antonio, Filadi, Riccardo, Filigheddu, Nicoletta, Filippi-Chiela, Eduardo, Filomeni, Giuseppe, Fimia, Gian Maria, Fineschi, Vittorio, Finetti, Francesca, Finkbeiner, Steven, Fisher, Edward, Fisher, Paul, Flamigni, Flavio, Fliesler, Steven, Flo, Trude, Florance, Ida, Florey, Oliver, Florio, Tullio, Fodor, Erika, Follo, Carlo, Fon, Edward, Forlino, Antonella, Fornai, Francesco, Fortini, Paola, Fracassi, Anna, Fraldi, Alessandro, Franco, Brunella, Franco, Rodrigo, Franconi, Flavia, Frankel, Lisa, Friedman, Scott, Fröhlich, Leopold, Frühbeck, Gema, Fuentes, Jose, Fujiki, Yukio, Fujita, Naonobu, Fujiwara, Yuuki, Fukuda, Mitsunori, Fulda, Simone, Furic, Luc, Furuya, Norihiko, Fusco, Carmela, Gack, Michaela, Gaffke, Lidia, Galadari, Sehamuddin, Galasso, Alessia, Galindo, Maria, Gallolu Kankanamalage, Sachith, Galluzzi, Lorenzo, Galy, Vincent, Gammoh, Noor, Gan, Boyi, Ganley, Ian, Gao, Feng, Gao, Hui, Gao, Minghui, Gao, Ping, Gao, Shou-Jiang, Gao, Wentao, Gao, Xiaobo, Garcera, Ana, Garcia, Maria Noé, Garcia, Verónica, García-del Portillo, Francisco, Garcia-Escudero, Vega, Garcia-Garcia, Aracely, Garcia-Macia, Marina, García-Moreno, Diana, Garcia-Ruiz, Carmen, García-Sanz, Patricia, Garg, Abhishek, Gargini, Ricardo, Garofalo, Tina, Garry, Robert, Gassen, Nils, Gatica, Damian, Ge, Liang, Ge, Wanzhong, Geiss-Friedlander, Ruth, Gelfi, Cecilia, Genschik, Pascal, Gentle, Ian, Gerbino, Valeria, Gerhardt, Christoph, Germain, Kyla, Germain, Marc, Gewirtz, David, Ghasemipour Afshar, Elham, Ghavami, Saeid, Ghigo, Alessandra, Ghosh, Manosij, Giamas, Georgios, Giampietri, Claudia, Giatromanolaki, Alexandra, Gibson, Gary, Gibson, Spencer, Ginet, Vanessa, Giniger, Edward, Giorgi, Carlotta, Girao, Henrique, Girardin, Stephen, Giridharan, Mridhula, Giuliano, Sandy, Giulivi, Cecilia, Giuriato, 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Anna, Hernández, Agustín, Hernandez, Carlos, Hernandez-Diaz, Sergio, Hernandez-Gea, Virginia, Herpin, Amaury, Herreros, Judit, Hervás, Javier, Hesselson, Daniel, Hetz, Claudio, Heussler, Volker, Higuchi, Yujiro, Hilfiker, Sabine, Hill, Joseph, Hlavacek, William, Ho, Emmanuel, Ho, Idy, Ho, Philip Wing-Lok, Ho, Shu-Leong, Ho, Wan Yun, Hobbs, G Aaron, Hochstrasser, Mark, Hoet, Peter, Hofius, Daniel, Hofman, Paul, Höhn, Annika, Holmberg, Carina, Hombrebueno, Jose, Yi-Ren Hong, Chang-Won Hong, Hooper, Lora, Hoppe, Thorsten, Horos, Rastislav, Hoshida, Yujin, Hsin, I-Lun, Hsu, Hsin-Yun, Hu, Bing, Hu, Dong, Hu, Li-Fang, Hu, Ming Chang, Hu, Ronggui, Hu, Wei, Hu, Yu-Chen, Hu, Zhuo-Wei, Hua, Fang, Hua, Jinlian, Hua, Yingqi, Huan, Chongmin, Huang, Canhua, Huang, Chuanshu, Huang, Chuanxin, Huang, Chunling, Huang, Haishan, Huang, Kun, Huang, Michael, Huang, Rui, Huang, Shan, Huang, Tianzhi, Huang, Xing, Huang, Yuxiang Jack, Huber, Tobias, Hubert, Virginie, Hubner, Christian, Hughes, Stephanie, 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Chengyu, Liang, Qiangrong, Liang, Weicheng, Liang, Yongheng, Liang, YongTian, Liao, Guanghong, Liao, Lujian, Liao, Mingzhi, Liao, Yung-Feng, Librizzi, Mariangela, Lie, Pearl, Lilly, Mary, Lim, Hyunjung, Lima, Thania, Limana, Federica, Lin, Chao, Lin, Chih-Wen, Lin, Dar-Shong, Lin, Fu-Cheng, Lin, Jiandie, Lin, Kurt, Lin, Kwang-Huei, Lin, Liang-Tzung, LIN, Pei-Hui, Lin, Qiong, Lin, Shaofeng, Lin, Su-Ju, Lin, Wenyu, Lin, Xueying, Lin, Yao-Xin, Lin, Yee-Shin, Linden, Rafael, Lindner, Paula, Ling, Shuo-Chien, Lingor, Paul, Linnemann, Amelia, Liou, Yih-Cherng, Lipinski, Marta, Lipovšek, Saška, Lira, Vitor, Lisiak, Natalia, Liton, Paloma, Liu, Chao, Liu, Ching-Hsuan, Liu, Chun-Feng, Liu, Cui Hua, Liu, Fang, Liu, Hao, Liu, Hsiao-Sheng, Liu, Hua-feng, Liu, Huifang, Liu, Jia, Liu, Jing, Liu, Julia, Liu, Leyuan, Liu, Longhua, Liu, Meilian, Liu, Qin, Liu, Wei, Liu, Wende, Liu, Xiao-Hong, Liu, Xiaodong, Liu, Xingguo, Liu, Xu, Liu, Xuedong, Liu, Yanfen, Liu, Yang, Liu, Yueyang, Liu, Yule, 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Celeste, O’Donovan, Tracey, O’Leary, Seónadh, O’Rourke, Eyleen, O’Sullivan, Mary, O’Sullivan, Timothy, Omary, M. Bishr, Pereira, Gustavo J.S., Ratnayaka, J. Arjuna, Riazuddin, S. Amer, Rouschop, Kasper M.A., Sanderson, J. Thomas, Scaglione, K. Matthew, Schapira, Anthony H.V., Scovassi, A. Ivana, St. Clair, Daret, Sunahara, Karen K.S., Symons, J. David, Triola, Gemma, van Wijk, Sjoerd J.L., Vanrell, M. Cristina, Vasconcelos, M. Helena, Whitton, J. Lindsay, Williams, Robin S.B., Wong, W. Wei-Lynn, Wu, William K.K., Yakhine-Diop, Sokhna M.S., Yu, W. Haung, Zhang, Kalin Y.B., Dong, X. Charlie, Ain Shams University [ASU], Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University [JGU], Medical University Graz, Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)], Institut Pasteur d'Iran, Leibniz Institute of Plant Biochemistry [IPB], The University of Texas M.D. Anderson Cancer Center [Houston], Institut de pharmacologie moléculaire et cellulaire [IPMC], Lipides - Nutrition - Cancer [Dijon - U1231] [LNC], Centre méditerranéen de médecine moléculaire [C3M], Institut de Biologie Valrose [IBV], Petites Molécules de neuroprotection, neurorégénération et remyélinisation, Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique, Institut Cochin [IC UM3 (UMR 8104 / U1016)], Institut NeuroMyoGène [INMG], Paris-Centre de Recherche Cardiovasculaire [PARCC (UMR_S 970/ U970)], Marqueurs cardiovasculaires en situation de stress [MASCOT (UMR_S_942 / U942)], Institut de Recherche sur le Cancer et le Vieillissement [IRCAN], Centre de Recherche en Cancérologie de Marseille [CRCM], Centre for Integrative Biology - CBI [Inserm U964 - CNRS UMR7104 - IGBMC], Oncogenesis, Stress, Signaling [OSS], Institut Necker Enfants-Malades [INEM - UM 111 (UMR 8253 / U1151)], Institut de Biologie Intégrative de la Cellule [I2BC], Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte [M2iSH], Centre de Recherches en Cancérologie de Toulouse [CRCT], Physiopathologie et traitement des maladies du foie, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL], Institut de Génétique et de Biologie Moléculaire et Cellulaire [IGBMC], Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon] [BIO-PEROXIL], Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)], Unité de génétique et biologie des cancers [U830], Laboratoire d'Optique et Biosciences [LOB], Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC], Différenciation et communication neuronale et neuroendocrine [DC2N], Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM], Centre d'Immunologie de Marseille - Luminy [CIML], Physiopathologie et imagerie des troubles neurologiques [PhIND], Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée [LBFA], Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163], Institut Mondor de Recherche Biomédicale [IMRB], Franco-czech Laboratory for clinical research on obesity, University of Michigan [Ann Arbor], University of Michigan System, Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Institut de Biologie Valrose (IBV), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Nutrition, Métabolisme, Aquaculture (NuMéA), Université de Pau et des Pays de l'Adour (UPPA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Centre for Integrative Biology - CBI (Inserm U964 - CNRS UMR7104 - IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institute of genetics and molecular and cellular biology-Centre National de la Recherche Scientifique (CNRS), Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physiologie et Génomique des Poissons (LPGP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Laboratoire Bio-PeroxIL. Biochimie du peroxysome, inflammation et métabolisme lipidique [Dijon] (BIO-PEROXIL), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut Jean-Pierre Bourgin (IJPB), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Optique et Biosciences (LOB), École polytechnique (X)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epithelial biology and disease - Liliane Bettencourt Chair of Developmental Biology (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Biomécanique cellulaire et respiratoire (BCR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Charles University [Prague]-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the National Institute of General Medical Sciences [GM131919]., Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Université Sorbonne Paris Nord, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Département Plateforme (PF I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut Gustave Roussy (IGR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Chinese Academy of Medical Sciences [Suzhou, Chine] (CAMS), Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Department of Women's and Children's Health [Stockholm, Sweden], Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École polytechnique (X), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, FHU OncoAge - Pathologies liées à l’âge [CHU Nice] (OncoAge), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Institut de Pharmacologie Moléculaire et Cellulaire [UNIV Côte d'Azur] (UPMC), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Life Sciences Institute [Ann Arbor, MI, USA], University of Michigan System-University of Michigan System, European Institute of Oncology IRCCS [Milan, Italy] (EIO), Ain Shams University (ASU), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Réseau International des Instituts Pasteur (RIIP), Leibniz Institute of Plant Biochemistry (IPB), Hebrew University of Jerusalem, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Oncogenesis, Stress, Signaling (OSS), Institut des Maladies Métaboliques et Casdiovasculaires (UPS/Inserm U1297 - I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Charles University [Prague] (CU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., Adamopoulos, I. E., Adeli, K., Adolph, T. E., Adornetto, A., Aflaki, E., Agam, G., Agarwal, A., Aggarwal, B. B., Agnello, M., Agostinis, P., Agrewala, J. N., Agrotis, A., Aguilar, P. V., Ahmad, S. T., Ahmed, Z. M., Ahumada-Castro, U., Aits, S., Aizawa, S., Akkoc, Y., Akoumianaki, T., Akpinar, H. A., Al-Abd, A. M., Al-Akra, L., Al-Gharaibeh, A., Alaoui-Jamali, M. A., Alberti, S., Alcocer-Gomez, E., Alessandri, C., Ali, M., Alim Al-Bari, M. A., Aliwaini, S., Alizadeh, J., Almacellas, E., Almasan, A., Alonso, A., Alonso, G. D., Altan-Bonnet, N., Altieri, D. C., Alvarez, E. M. C., Alves, S., Alves da Costa, C., Alzaharna, M. M., Amadio, M., Amantini, C., Amaral, C., Ambrosio, S., Amer, A. O., Ammanathan, V., An, Z., Andersen, S. U., Andrabi, S. A., Andrade-Silva, M., Andres, A. M., Angelini, S., Ann, D., Anozie, U. C., Ansari, M. 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T., Balduini, W., Ballabio, A., Ballester, M., Balazadeh, S., Balzan, R., Bandopadhyay, R., Banerjee, S., Banreti, A., Bao, Y., Baptista, M. S., Baracca, A., Barbati, C., Bargiela, A., Barila, D., Barlow, P. G., Barmada, S. J., Barreiro, E., Barreto, G. E., Bartek, J., Bartel, B., Bartolome, A., Barve, G. R., Basagoudanavar, S. H., Bassham, D. C., Bast, R. C., Basu, A., Batoko, H., Batten, I., Baulieu, E. E., Baumgarner, B. L., Bayry, J., Beale, R., Beau, I., Beaumatin, F., Bechara, L. R. G., Beck, G. R., Beers, M. F., Begun, J., Behrends, C., Behrens, G. M. N., Bei, R., Bejarano, E., Bel, S., Behl, C., Belaid, A., Belgareh-Touze, N., Bellarosa, C., Belleudi, F., Bello Perez, M., Bello-Morales, R., Beltran, J. S. D. O., Beltran, S., Benbrook, D. M., Bendorius, M., Benitez, B. A., Benito-Cuesta, I., Bensalem, J., Berchtold, M. W., Berezowska, S., Bergamaschi, D., Bergami, M., Bergmann, A., Berliocchi, L., Berlioz-Torrent, C., Bernard, A., Berthoux, L., Besirli, C. 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A., Tencomnao, T., Tenreiro, S., Tepikin, A. V., Testillano, P. S., Tettamanti, G., Tharaux, P. -L., Thedieck, K., Thekkinghat, A. A., Thellung, S., Thinwa, J. W., Thirumalaikumar, V. P., Thomas, S. M., Thomes, P. G., Thorburn, A., Thukral, L., Thum, T., Thumm, M., Tian, L., Tichy, A., Till, A., Timmerman, V., Titorenko, V. I., Todi, S. V., Todorova, K., Toivonen, J. M., Tomaipitinca, L., Tomar, D., Tomas-Zapico, C., Tomic, S., Tong, B. C. -K., Tong, C., Tong, X., Tooze, S. A., Torgersen, M. L., Torii, S., Torres-Lopez, L., Torriglia, A., Towers, C. G., Towns, R., Toyokuni, S., Trajkovic, V., Tramontano, D., Tran, Q. -G., Travassos, L. H., Trelford, C. B., Tremel, S., Trougakos, I. P., Tsao, B. P., Tschan, M. P., Tse, H. -F., Tse, T. F., Tsugawa, H., Tsvetkov, A. S., Tumbarello, D. A., Tumtas, Y., Tunon, M. J., Turcotte, S., Turk, B., Turk, V., Turner, B. J., Tuxworth, R. I., Tyler, J. K., Tyutereva, E. V., Uchiyama, Y., Ugun-Klusek, A., Uhlig, H. H., Ulamek-Koziol, M., Ulasov, I. V., Umekawa, M., Ungermann, C., Unno, R., Urbe, S., Uribe-Carretero, E., Ustun, S., Uversky, V. N., Vaccari, T., Vaccaro, M. I., Vahsen, B. F., Vakifahmetoglu-Norberg, H., Valdor, R., Valente, M. J., Valko, A., Vallee, R. B., Valverde, A. M., Van den Berghe, G., van der Veen, S., Van Kaer, L., van Loosdregt, J., van Wijk, S. J. L., Vandenberghe, W., Vanhorebeek, I., Vannier-Santos, M. A., Vannini, N., Vanrell, M. C., Vantaggiato, C., Varano, G., Varela-Nieto, I., Varga, M., Vasconcelos, M. H., Vats, S., Vavvas, D. G., Vega-Naredo, I., Vega-Rubin-de-Celis, S., Velasco, G., Velazquez, A. P., Vellai, T., Vellenga, E., Velotti, F., Verdier, M., Verginis, P., Vergne, I., Verkade, P., Verma, M., Verstreken, P., Vervliet, T., Vervoorts, J., Vessoni, A. T., Victor, V. M., Vidal, M., Vidoni, C., Vieira, O. V., Vierstra, R. D., Vigano, S., Vihinen, H., Vijayan, V., Vila, M., Vilar, M., Villalba, J. M., Villalobo, A., Villarejo-Zori, B., Villarroya, F., Villarroya, J., Vincent, O., Vindis, C., Viret, C., Viscomi, M. T., Visnjic, D., Vitale, I., Vocadlo, D. J., Voitsekhovskaja, O. V., Volonte, C., Volta, M., Vomero, M., Von Haefen, C., Vooijs, M. A., Voos, W., Vucicevic, L., Wade-Martins, R., Waguri, S., Waite, K. A., Wakatsuki, S., Walker, D. W., Walker, M. J., Walker, S. A., Walter, J., Wandosell, F. G., Wang, B., Wang, C. -Y., Wang, C., Wang, D., Wang, F., Wang, G., Wang, H., Wang, H. -G., Wang, J., Wang, K., Wang, L., Wang, M. H., Wang, M., Wang, N., Wang, P., Wang, Q. J., Wang, Q., Wang, Q. K., Wang, Q. A., Wang, W. -T., Wang, W., Wang, X., Wang, Y., Wang, Y. -Y., Wang, Z., Warnes, G., Warnsmann, V., Watada, H., Watanabe, E., Watchon, M., Wawrzynska, A., Weaver, T. E., Wegrzyn, G., Wehman, A. M., Wei, H., Wei, L., Wei, T., Wei, Y., Weiergraber, O. H., Weihl, C. C., Weindl, G., Weiskirchen, R., Wells, A., Wen, R. H., Wen, X., Werner, A., Weykopf, B., Wheatley, S. P., Whitton, J. L., Whitworth, A. J., Wiktorska, K., Wildenberg, M. E., Wileman, T., Wilkinson, S., Willbold, D., Williams, B., Williams, R. S. B., Williams, R. L., Williamson, P. R., Wilson, R. A., Winner, B., Winsor, N. J., Witkin, S. S., Wodrich, H., Woehlbier, U., Wollert, T., Wong, E., Wong, J. H., Wong, R. W., Wong, V. K. W., Wong, W. W. -L., Wu, A. -G., Wu, C., Wu, J., Wu, K. K., Wu, M., Wu, S. -Y., Wu, S., Wu, W. K. K., Wu, X., Wu, Y. -W., Wu, Y., Xavier, R. J., Xia, H., Xia, L., Xia, Z., Xiang, G., Xiang, J., Xiang, M., Xiang, W., Xiao, B., Xiao, G., Xiao, H., Xiao, H. -T., Xiao, J., Xiao, L., Xiao, S., Xiao, Y., Xie, B., Xie, C. -M., Xie, M., Xie, Y., Xie, Z., Xilouri, M., Xu, C., Xu, E., Xu, H., Xu, J., Xu, L., Xu, W. W., Xu, X., Xue, Y., Yakhine-Diop, S. M. S., Yamaguchi, M., Yamaguchi, O., Yamamoto, A., Yamashina, S., Yan, S., Yan, S. -J., Yan, Z., Yanagi, Y., Yang, C., Yang, D. -S., Yang, H., Yang, H. -T., Yang, J. -M., Yang, J., Yang, L., Yang, M., Yang, P. -M., Yang, Q., Yang, S., Yang, S. -F., Yang, W., Yang, W. Y., Yang, X., Yang, Y., Yao, H., Yao, S., Yao, X., Yao, Y. -G., Yao, Y. -M., Yasui, T., Yazdankhah, M., Yen, P. M., Yi, C., Yin, X. -M., Yin, Y., Yin, Z., Ying, M., Ying, Z., Yip, C. K., Yiu, S. P. T., Yoo, Y. H., Yoshida, K., Yoshii, S. R., Yoshimori, T., Yousefi, B., Yu, B., Yu, H., Yu, J., Yu, L., Yu, M. -L., Yu, S. -W., Yu, V. C., Yu, W. H., Yu, Z., Yuan, J., Yuan, L. -Q., Yuan, S., Yuan, S. -S. F., Yuan, Y., Yuan, Z., Yue, J., Yue, Z., Yun, J., Yung, R. L., Zacks, D. N., Zaffagnini, G., Zambelli, V. O., Zanella, I., Zang, Q. S., Zanivan, S., Zappavigna, S., Zaragoza, P., Zarbalis, K. S., Zarebkohan, A., Zarrouk, A., Zeitlin, S. O., Zeng, J., Zeng, J. -D., Zerovnik, E., Zhan, L., Zhang, B., Zhang, D. D., Zhang, H., Zhang, H. -L., Zhang, J., Zhang, J. -P., Zhang, K. Y. B., Zhang, L. W., Zhang, L., Zhang, M., Zhang, P., Zhang, S., Zhang, W., Zhang, X., Zhang, X. -W., Zhang, X. D., Zhang, Y., Zhang, Y. -D., Zhang, Y. -Y., Zhang, Z., Zhao, H., Zhao, L., Zhao, S., Zhao, T., Zhao, X. -F., Zhao, Y., Zheng, G., Zheng, K., Zheng, L., Zheng, S., Zheng, X. -L., Zheng, Y., Zheng, Z. -G., Zhivotovsky, B., Zhong, Q., Zhou, A., Zhou, B., Zhou, C., Zhou, G., Zhou, H., Zhou, J., Zhou, K., Zhou, R., Zhou, X. -J., Zhou, Y., Zhou, Z. -Y., Zhou, Z., Zhu, B., Zhu, C., Zhu, G. -Q., Zhu, H., Zhu, W. -G., Zhu, Y., Zhuang, H., Zhuang, X., Zientara-Rytter, K., Zimmermann, C. M., Ziviani, E., Zoladek, T., Zong, W. -X., Zorov, D. B., Zorzano, A., Zou, W., Zou, Z., Zuryn, S., Zwerschke, W., Brand-Saberi, B., Dong, X. C., Kenchappa, C. S., Lin, Y., Oshima, S., Rong, Y., Sluimer, J. C., Stallings, C. L., Tong, C. -K., and Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Programmed cell death, Settore BIO/06, Autophagosome, Autolysosome, [SDV]Life Sciences [q-bio], lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Autophagy-Related Proteins, Review, Computational biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Settore MED/04, 03 medical and health sciences, stress, Chaperone-mediated autophagy, ddc:570, Autophagy, LC3, Animals, Humans, cancer, Settore BIO/10, flux, lysosome, macroautophagy, neurodegeneration, phagophore, vacuole, Set (psychology), Molecular Biology, 030102 biochemistry & molecular biology, business.industry, Interpretation (philosophy), Autophagosomes, Cell Biology, Multicellular organism, 030104 developmental biology, Knowledge base, Biological Assay, Lysosomes, business, Biomarkers, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Contains fulltext : 232759.pdf (Publisher’s version ) (Closed access) In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
Published: 2021
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7. Selectra 3D- guided conduction system pacing: single-center experience

Author: Loris Roncon, Gianluca Rigatelli, M Centioni, Lina Marcantoni, E Galuppi, M Bartolomei, Enrico Baracca, N Pellegrini, Gianni Pastore, Francesco Zanon, and S Andreaggi
Subjects: medicine.medical_specialty, Bundle branch block, business.industry, Single Center, medicine.disease, Bundle of His, Stylet, Bone screws, medicine.anatomical_structure, Heart failure, Internal medicine, Cardiology, medicine, Ohm, Electrical conduction system of the heart, Cardiology and Cardiovascular Medicine, business
Abstract: Background Conduction system pacing (CSP)is becoming increasingly popular thanks to the ability to both maintain physiological electrical activation in patients with narrow QRS and restore ventricular synchrony in patients with bundle branch block (BBB). The Selectra3D introducer is a new tool able to support the correct positioning and screwing of the catheter on the bundle of His (HBP) or on the left branch (LBBP). It does exist in 3 different shapes: S, M, L (Fig. 1) based on the radius of main curvature. The internal diameter of 7.3 Fr allows it to support both the 3830 lumen-less catheter historically used for CSP, as well as standard 6Fr stylet-driven leads. Objective To evaluate the effectiveness of the Selectra3D introducer for CSP (including both HBP and LBBP), considering the procedural success rate and the lead stability (stability of electrical parameters or need for implant revision) in the medium-term follow-up. Methods and results The Selectra3D introducer was used in 56 patients' candidates for CSP (mean age 80±6 years). Pacing indications included A-V block in 21 patients, AF with slow ventricular response in 9 patients; SND in 8 patients and HF and severe ventricular dysfunction in 18 patients (of which 4 were PICM). The mean baseline EF was 40±15%. A PM was implanted in 40 patients and an ICD in 16. A standard stylet-driven lead was used in 48 cases, a fixed exposed screw lead was used in 8 patients. HBP was obtained in 21 cases and LBBP in 30 cases, while in 5 cases (8.9%) neither HBP nor LBBP could be obtained. Implants were performed via a left-sided approach in 55 cases and a right-sided approach in 1 case. The baseline QRS duration was 144±38 ms and the paced QRS duration was 118±21 ms. The electrical parameters were optimal with sensing 8.7±8 mV; impedance 625±276 ohm; threshold 1±0.5 V. During follow-up, 2 lead dislodgement (3.9%) (1 HBP and 1 LBBP) were recorded, both within 7 days after implantation. All the others showed stability of the electrical parameters at a mean follow-up of 8.4±4.2 months. Conclusions The new Selectra3D introducer supports effectively and safely the lead implant on conduction system catheters (HBP and LBBP), allowing the implant of both exposed fixed screw leads and standard stylet-driven leads, leading to procedural success>90%. The electrical parameters were optimal at implantation and remained stable during follow-up. Funding Acknowledgement Type of funding sources: None. Figure 1
Published: 2021
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8. Conduction system pacing in cardiac resynchronization: short-mid term follow-up

Author: M Bartolomei, E Galuppi, Gianluca Rigatelli, N Pellegrini, Enrico Baracca, M Centioni, Loris Roncon, Gianni Pastore, Lina Marcantoni, S Andreaggi, and Francesco Zanon
Subjects: medicine.medical_specialty, Mid term follow up, business.industry, Internal medicine, Cardiac resynchronization, medicine, Cardiology, Electrical conduction system of the heart, Cardiology and Cardiovascular Medicine, business
Abstract: Background Conduction system pacing (CSP) includes both His Bundle Pacing (HBP) and left bundle branch pacing (LBBP). It engages the conduction system ensuring synchronous activation of ventricles, potentially acting as cardiac resynchronization. Purpose The aim of the study is to report technical and clinical outcomes of CSP (HBP or LBBP) utilized in patients referred for cardiac resynchronization therapy. Methods CSP was applied in 51 patients (mean age 75±9 years; 47 males) referred for cardiac resynchronization therapy. 41 cases were de-novo implant and 10 were up-grading after PICM. Ischemic aetiology was present in 23 (45%) patients, hypertension in 31 (61%); diabetes in 19 (37%), severe kidney disease in 4 (8%). Devices were checked 48 hours and 1 month after implant and then remotely. Clinical, echocardiographic, electrocardiographic data were also collected. Results Conduction system pacing was successfully obtained in 45 (88.3%) patients. In 28 (62%) cases the lead was implanted in the His Bundle and in 17 (38%) in the left bundle. In 6 (11.7%) patients it was not possible to fix the lead in the His Bundle neither in the Left bundle, in these cases a standard quadripolar lead in the coronary sinus was implanted. In 28 (62%) patients was utilized the 3830 4 Fr lumen-less lead and in the remaining 17 (38%) cases a standard stylet-driven lead. Basal mean EF was 33±9% and improved to 42±9% (P Conclusions Conduction system pacing can act effectively as cardiac resynchronization in patients with severe cardiac disfunction and bundle branch block with high success rate, significantly narrowed QRS and improved EF at short-medium term follow-up. Funding Acknowledgement Type of funding sources: None. Case report: CRT-D including LB lead
Published: 2021
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9. 3D electro-anatomical mapping to guide conduction system pacing in complex cardiac anatomies

Author: E Galuppi, N Pellegrini, M Bartolomei, S Andreaggi, Gianluca Rigatelli, Gianni Pastore, M Centioni, Enrico Baracca, Francesco Zanon, Lina Marcantoni, and Loris Roncon
Subjects: business.industry, Medicine, Electrical conduction system of the heart, Cardiology and Cardiovascular Medicine, business, Biomedical engineering
Abstract: Background Conduction System Pacing (CSP) includes both His Bundle Pacing (HBP) and Left Bundle Branch Pacing (LBBP). It guarantees physiological cardiac activation and it is essential to avoid pacing-induced dyssynchrony. Markedly dilated atria, up-grading to CRT, and congenital cardiopathies still represent complex anatomical scenarios in which the available tools could often result inadequate and graved by suboptimal results. Objective To evaluate the feasibility and effectiveness of 3D electro-anatomical mapping (EAM) to guide CSP (both HBP and LBBP) in patients with characteristics that allows “a priori” classification as complex anatomical scenario with low probability of success using only fluoroscopic guidance and available tools. Left atrium area >40 cm2; post-PICM up-grading and congenital heart disease were considered signs of anatomical complexity. Methods and results The study includes 25 patients (19 males, mean age 76–11 years; mean baseline EF 34.2–12.6%; 17 BBB; 5 post-PICM up-grading), candidates for CSP. 16 and 9 were respectively implanted with PM and ICD (13/12 dual/three-chamber devices). CARTO system was used in 6 ptss and EnsiteTM Precision in 19. EAM involved reconstruction of the right atrium and sub-tricuspid septum with the use of a decapolar catheter. Several “tags” have been placed on the His signals, in order to reconstruct the “His Cloud” and distinguish within it the proximal, medium, and distal area (Fig. 1). The sub-tricuspid septum was always reconstructed so that intra-procedurally operator could easily move from HBP to LBBP based on electrical parameters or paced QRS morphology. The mapping catheter was removed after the mapping phase and replaced with the pacing lead. Both exposed fixed screw 3830 leads and standard stylet-driven leads were used. HBP was achieved in 10 pts and LBBP in 13 pts. Three failures were resolved by CS lead implant. The time spend for His cloud mapping was 18±7 min. The mean threshold was 1.1±0.5 V; sensing 11.6±9.3 mV and impedance 786±339 ohm. Baseline QRS 155±19 ms and paced QRS 119±7 ms. In cases of LBBP we were also able to measure on the EAM map the depth of the catheter within the septum, resulting in 11.5±3.1 mm and the distance of the initial screw site from the His of 26.5±10.3 mm. Conclusions The electro-anatomical mapping allows the accurate reconstruction of “His cloud” by properly distinguishing proximal, middle, distal His. The sub-tricuspid zone of the interventricular septum is also reconstructed in high definition, so that intra-procedurally it is possible to easily move from HBP to LBBP and vice-versa based on the electrical parameters and paced QRS morphology. This method appears safe and effective even in complex cardiac anatomies possibly saving time and fluoroscopy use. The tags on the His cloud and sub-tricuspid septum can satisfactorily guide lead placement with high reproducibly. Funding Acknowledgement Type of funding sources: None. Figure 1. 3D-EAM used to guide HBP implant
Published: 2021
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10. Left bundle branch pacing: 2 year single-centre experience

Author: M Centioni, Loris Roncon, N Pellegrini, Gianni Pastore, Francesco Zanon, S Andreaggi, Enrico Baracca, Lina Marcantoni, M Bartolomei, E Galuppi, and Gianluca Rigatelli
Subjects: Single centre, business.industry, Left bundle branch, Medicine, Anatomy, Cardiology and Cardiovascular Medicine, business
Abstract: Background Left Bundle Branch Pacing (LBBP) ensures a physiologic ventricular activation and shows better electrical parameters compared to His bundle pacing (HBP). A growing body of experience is encouraging a large applicability. Objective To analyse feasibility and technical outcomes of LBBP in the daily clinical practice. Methods During 2019 and 2020, 132 patients (mean age 79±10 years; 72 males) with standard indication for pacing, received the lead deeply intraseptal aiming to pace the left bundle. The indication for pacing were AV block 72 (55%) pts, SND 14 (11%), AF and slow ventricular rate 21 (16%), ablate&pace in 4 (3%); HF in 10 (7.5%), PICM 6 (4%) pts, lead revision in 5 (3.5%). 75% of pts had ischemic cardiopathy; 82% hypertension, 30% diabetes and 21% severe kidney disease. Baseline QRS was 141±38 ms and 68% of pts had bundle branch block. The basal mean EF 49±15%. 91 (69%) of the pts were in sinus rhythm at implant. Criteria for LBBP were: RBB morphology in V1 together with left ventricular activation time (LVAT) Results The lead was successfully implanted in the left bundle in 129 (97,7%) patients. In the remaining 3 patients the cathode only penetrated the septum. In 90 cases LBBP was the first choice, in the remaining 42 patients LBBP was aimed after unsatisfactory HBP (His threshold>2V or paced QRS>140 ms). In 107 cases we utilized the 3830 4Fr lumenless lead; in 25 cases the stylet-driven 6 Fr leads. The LBBP lead was connected to the RV port in the 92 dual-chamber PMs; in the LV port in the 22 three-chamber devices as part of cardiac resynchronization therapy; in the only port in 18 single-chamber PM. Mean fluoroscopy time was 10±6 min including implant of all leads. Electrical parameters were highly favourable (R wave sensing 10,5±5 mV; threshold 0,9±0,2 V@0,5 ms; impedance 829±234 ohm). Paced QRS duration was 114±20 ms (P Conclusion The new technique of pacing the left bundle of the conduction system (LBBP), is safe and feasible in the clinical practice. It is applicable in all pacing indications including heart failure and resynchronization. In our experience lead dislodgement were 2,2% (3/132, all in the first week after implant) whereas paced QRS duration was significantly shortened and ejection fraction remained normal. Funding Acknowledgement Type of funding sources: None.
Published: 2021
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11. Long-Term Clinical Outcomes of Isolated Ostial Left Anterior Descending Disease Treatment: Ostial Stenting Versus Left Main Cross-Over Stenting

Author: Loris Roncon, Marco Zuin, Mauro Carraro, Gianluca Rigatelli, Daniela Lanza, Ramesh Daggubati, Paola Galasso, Enrico Baracca, and Alberto Mazza
Subjects: Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Coronary Artery Disease, 030204 cardiovascular system & hematology, Anterior Descending Coronary Artery, Coronary Angiography, Coronary Restenosis, Coronary artery disease, 03 medical and health sciences, Percutaneous Coronary Intervention, 0302 clinical medicine, Restenosis, Risk Factors, Angioplasty, medicine, Humans, Fluoroscopy, cardiovascular diseases, 030212 general & internal medicine, Vascular Calcification, Ultrasonography, Interventional, Aged, Retrospective Studies, Aged, 80 and over, medicine.diagnostic_test, business.industry, Drug-Eluting Stents, General Medicine, medicine.disease, Surgery, Contrast medium, Ostium, Treatment Outcome, surgical procedures, operative, Female, Cardiology and Cardiovascular Medicine, business, Mace
Abstract: BACKGROUND The optimal strategy for treating ostial left anterior descending coronary artery (LAD) disease remains matter of speculation. We evaluated the impact on long-term outcomes of ostial LAD disease treated by means of ostial stenting (the floating-stent) or left main (LM)-to-LAD cross-over stenting. METHODS Clinical and instrumental records of 74 consecutive patients with isolated ostial LAD disease, enrolled between the 1st January 2012 and the 1st January 2017 were reviewed. Patients have been stratified according the stenting techniques adopted: ostial stenting (OS) or LM cross-over (CO). RESULTS Seventy-four consecutive patients (54 males, mean age 73.39 ± 9.54 years old) have been analyzed. In CO patients the SYNTAX score (16.2 ± 3.3 vs 24.1 ± 2.5, p
Published: 2019
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12. Measured Distributed vs Co-located Massive MIMO in Industry 4.0 Environments

Author: Paolo Baracca, Frank Schaich, S. ten Brink, Maximilian Arnold, and Thorsten Wild
Subjects: business.industry, Computer science, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, MIMO, Data_CODINGANDINFORMATIONTHEORY, Propagation delay, Electronic engineering, Factory (object-oriented programming), Wireless, Fading, Antenna (radio), business, 5G, Computer Science::Information Theory, Communication channel
Abstract: Massive multiple-input multiple-output (MIMO), the cornerstone of 5G, is in theory well understood, but many parts of the practical challenge remain unclear, e.g. what antenna configuration is suitable for which scenario. Inheriting from the over-provisioning of antennas and thus the possibility of creating an ultra-reliable wireless link, Massive MIMO is also intended for industrial scenarios. In these environments, a large number of reflectors, movements, and distortions are to be expected, which results in a high variation of fading and propagation delay. We show that in the case of distributed antennas these channel outages through fading/blockage are minimized. Comparing this case to the standard co-located approach, the link-reliability is increased by more than 3 dB for the same amount of antennas. This is verified in two different, yet typical, future factory environments by using standard channel parameters. Through these measurements we show that the requirement of perfectly syncing the distributed antenna arrays can be relaxed, still achieving reasonable gains.
Published: 2021
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13. Power Optimization for Low Interference and Throughput Enhancement for 5G and 6G systems

Author: Paolo Baracca, Silvio Mandelli, Andreas Weber, Thorsten Wild, and Alessandro Lieto
Subjects: Computer science, business.industry, Distributed computing, 020206 networking & telecommunications, Link adaptation, 02 engineering and technology, Spectral efficiency, Transmitter power output, Interference (wave propagation), Power optimization, 0202 electrical engineering, electronic engineering, information engineering, Wireless, business, Throughput (business), 5G
Abstract: While the first 5G releases have been defined, it is expected that future Beyond 5G (B5G) and 6G networks will further reduce inter-site distances between access points. Accordingly, ensuring co-existence and controlling interference in such scenarios is pivotal for the success of future wireless systems. In this work all the unused wireless time-frequency resources in non-congested cells are leveraged to propose a novel Link Adaptation (LA) scheme, whose paradigm is to maximize resource utilization and reduce transmit power as much as possible. Note that this contrasts currently considered mechanisms that simply maximize spectral efficiency, demanding power optimization with long-term updates from other procedures. The proposed scheme does not require inter-cell coordination and is transparent to other MAC procedures, making its practical implementation trivial. We analytically establish that the mechanism achieves at least the same capacity in all cells and reduces transmit power when compared to state of the art LA mechanisms. In addition, extensive 3GPP-compliant system level simulations are conducted to assess the performance of the proposal, showing substantial gains in terms of achievable cell throughput in congested cells and overall transmit power reduction.
Published: 2021
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14. Extreme Communication in 6G: Vision and Challenges for ‘in-X’ Subnetworks

Author: Harish Viswanathan, Paolo Baracca, Frank Schaich, Tao Tao, Karthik Upadhya, Ramoni Adeogun, Gilberto Berardinelli, Saeed R. Khosravirad, Preben Mogensen, and Dong Li
Subjects: business.industry, Radio access technology, Computer science, Air interface, Reliability (computer networking), Wireless, Systems design, Throughput, Jamming, business, Subnetwork, Computer network
Abstract: The 6th Generation (6G) radio access technology is expected to support extreme communication requirements in terms of throughput, latency and reliability, which can only be achieved by providing capillary wireless coverage. In this paper, we present our vision for short-range low power 6G 'in-X' subnetworks, with the 'X' standing for the entity in which the cell in which the subnetwork is deployed, e.g., a production module, a robot, a vehicle, a house or even a human body. Such cells can support services that can be life-critical and that traditionally relied on wired systems. We discuss potential deployment options, as well as candidate air interface components and spectrum bands. Interference management is identified as a major challenge in dense deployments, which needs to handle also non-cellular types of interference like jamming attacks and impulsive noise. A qualitative example of interference-robust system design is also presented.
Published: 2021
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15. The back-up lead in his bundle pacing: evolution over the years

Author: Claudio Picariello, Daniela Lanza, Lina Marcantoni, Francesco Zanon, Gianni Pastore, A Maddalozzo, Loris Roncon, and Enrico Baracca
Subjects: medicine.medical_specialty, business.industry, medicine.disease, Bundle of His, QRS complex duration, medicine.anatomical_structure, Internal medicine, Bundle, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business, Lead (electronics), Atrioventricular block
Abstract: Background His bundle pacing (HBP) can be affected by high thresholds and low sensing. Thus, in selected patients including a back-up lead is advisable. Objective Single-centre retrospective analysis of a large HBP experience, focusing on the back-up lead utilization over the years. Methods 677 pts (76±8 years; 433 males) were implanted with HBP from 2004 to 2019 July. The pts received S-HBP (67%) or NS-HBP by the 3830 lead. The pacing indications were AV block 54%, sinus node disease 17%, slow atrial fibrillation 23%, heart failure 6%. Ischemic cardiopathy was found in 26%; hypertension in 83%, diabetes in28% pts. Baseline QRS duration was 123±32 ms and EF 56±12%. Results 266 (39%) pts received the back-up lead. In sinus rhythm we implanted 3-chamber PM (His lead:LV port; VV delay 80 ms: His pulses and apical pacing during the refractory period). 30 pts (11%) received a particular type of 3-chamber PM which provides back-up pacing only if His capture fails, thus saving energy. In atrial fibrillation 2-chamber PM was implanted (His lead: atrial port, DVI). We recorded a significant decrease of back-up lead use over the years, strictly related to operators/centre experience (>70% during the first years, nearly 10% during the last year). The C315 fixed curve sheath, strongly contributed to the rapid reduction of back-up lead use thanks to better lead fixation and stability. Conclusion The back-up lead utilization is progressively decreasing. It is strictly related to the operator/centre experience. The presence of the back-up lead could strengthen the Hisian pacing reliability, potentially impacting pacing indication even in advanced conduction disturbances and saving device longevity. Funding Acknowledgement Type of funding source: None
Published: 2020
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16. Electrograms guided his bundle pacing implant: moving from radiology to electrical signals

Author: Daniela Lanza, Claudio Picariello, Lina Marcantoni, Loris Roncon, A Maddalozzo, Francesco Zanon, Gianni Pastore, and Enrico Baracca
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Bundle of His, medicine.anatomical_structure, Bundle, medicine, Fluoroscopy, Implant, Radiology, Atrium (heart), Cardiology and Cardiovascular Medicine, business, Diagnostic radiologic examination
Abstract: Background The standard technique to His Bundle Pacing (HBP) based on a fluoroscopic approach might be challenging and fluoro consuming. The electrical signals could lead to a precise and rapid lead implant, thus reducing the fluoroscopy time (FT) and X-ray dose. Objective To evaluate the feasibility, efficacy and safety of the electrogram-guided technique to obtain His Bundle pacing (HBP) with minimal or no fluoroscopy use. Methods Between October and December 2018, 41 consecutive patients with indication for pacing underwent HBP with the electrogram-guided approach. Results Successful HBP was obtained in 39/41 (95%) pts, which is the study population (mean age 78±10 years). S-HBP and NS-HBP were achieved in 23 (59%) and 16 (41%) pts, respectively. Final HBP lead position was achieved in 31/39 (79.4%) pts with zero fluoroscopy, only guided by the electrical signals. In the remaining 8 pts a minimal dose of fluoro (mean 8 sec) has been required to locate the His. Fluoroscopy has been routinely used to remove the sheath and to ensure the slack. The atrial lead has been implanted in a standard fashion. No difference was observed in the FT for HBP lead placement in patients with S-HBP and NS-HBP (mean 8.1±25 sec vs 7.5±20 sec, p=0.8; median value 0 sec vs 0 sec). Moreover, no significant differences were observed in the FT needed for the entire procedure, total Dose Area Product (DAP) and total procedural time among both S-HBP and NS-HBP. The His lead dislodgement occurred in 1 (2.6%) patient one day after the procedure. Conclusion HBP could be performed safely and efficiently using the electrograms, with minimal or no fluoroscopy. Fluoroscopy was required during sheath removal and atrial lead placement. Funding Acknowledgement Type of funding source: None
Published: 2020
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17. The challenge of education in conduction system pacing: results from single or dual operators

Author: Loris Roncon, Francesco Zanon, Gianni Pastore, Enrico Baracca, and Lina Marcantoni
Subjects: business.industry, Medicine, Electrical conduction system of the heart, Cardiology and Cardiovascular Medicine, Topology, business, Dual (category theory)
Abstract: Background The his bundle pacing (HBP) and Left bundle branch pacing (LBBp) techniques are quickly increasing in the cardiovascular interest being the most physiological mode of pacing. Education in these new conduction system pacing (CSP) is mandatory in the modern EP programs. Achieving acceptable implant success rate, together with electrical parameters adequacy is required. Objective The aim of the study was to compare clinical and technical outcomes in 2 groups of patients, those implanted by a single operator with large expertise in CSP and those implanted by two operators (one of them during his learning curve). Methods Data from 255 consecutive patients (mean age 78±9 years; 186 males) who underwent successful HBP or LBBp implants were collected and analyzed. The operators were classified as expert after performing more than 50 procedures. Baseline caracteristics were not significantly different between the two groups. Results After a mean follow-up of 20±10months, we found that there were no differences between patients implanted by 1 single expert operator and 2 operators (1 beginner during his learning cirve supervised by 1 expert operator) in terms of clinical end point (composite of death or heart failure hospitalizations) and technical end point (need for surgical revision of the implant for reason other than battery replacement). Fluoroscopy time (16±17 min vs 9.8±11 min; p 0.004) and procedural time (113±48 min vs 16±17 min; p 0.003) were significantly prolonged when the implant was performed by 2 operators. Conclusions Skill acquisition in physiological pacing (both HBP and LBBp) is a nowadays process which cannot put patient's safety at risk. Our experience shows that clinical and technical outcomes were equivalent when the implant was performed by an expert operator or a beginner operator supervised by 1 expert operator. Fluoroscopy time and duration of the procedure were significantly prolonged by the presence of a trainees. Kaplan Meyer curves Funding Acknowledgement Type of funding source: None
Published: 2020
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18. Implantation technique of His bundle pacing

Author: Graziano Boaretto, Lina Marcantoni, Francesco Zanon, Antonella Tiribello, Paola Raffagnato, Marco Zuin, Gianni Pastore, and Enrico Baracca
Subjects: medicine.medical_specialty, Bundle of His, Heart Ventricles, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Physiology (medical), Internal medicine, medicine, Fluoroscopy, Humans, In patient, 030212 general & internal medicine, Cardiac imaging, medicine.diagnostic_test, business.industry, Cardiac Pacing, Artificial, Ventricular pacing, Cardiac surgery, Treatment Outcome, Bundle, Cardiology, Implant, Cardiology and Cardiovascular Medicine, business
Abstract: His bundle pacing (HBP) preserves physiological ventricular synchrony, with clinical benefits particularly evident when a high percentage of ventricular pacing is required. First experiences with standard leads and manually shaped stylets produced the impression that HBP is highly complex and time-consuming. However, with dedicated leads and sheaths, reliable HBP can be achieved in routine clinical practice. Implantation success in more than 90% of patients can be reached with current technology and has been shown to be reliable and effective, both at implantation and during long-term follow-up. At the same time, fluoroscopy and total procedural time can be reduced. New customized technologies will continue to improve the implant success rate and system performance. Large randomized trials will prove the long-term clinical benefits of HBP definitively and may render HBP the first choice in patients requiring ventricular pacing.
Published: 2020

19. Hemodynamic comparison of different multisites and multipoint pacing strategies in cardiac resynchronization therapies

Author: Gianluca Rigatelli, Gianni Pastore, Claudio Picariello, Giuseppina Giau, Silvio Aggio, Frits W. Prinzen, Loris Roncon, Franco Noventa, Enrico Baracca, Lina Marcantoni, Francesco Zanon, Daniela Lanza, Domenico Pacetta, Sara Giatti, Marco Zuin, Fysiologie, and RS: CARIM - R2.08 - Electro mechanics
Subjects: Male, STIMULATION, Haemodynamic response, Myocardial Ischemia, Mean QRS Duration, Hemodynamics, 030204 cardiovascular system & hematology, Multipoint pacing, Severity of Illness Index, Cardiac Resynchronization Therapy, Cohort Studies, 0302 clinical medicine, Prospective Studies, 030212 general & internal medicine, Electrical delay, Dual LV site pacing, Aged, 80 and over, Ejection fraction, Ventricular Remodeling, MECHANICAL DYSSYNCHRONY, Cardiac Pacing, Artificial, Prognosis, Survival Rate, Treatment Outcome, cardiovascular system, Cardiology, HEART-FAILURE, Female, Cardiology and Cardiovascular Medicine, LEFT-VENTRICULAR LEAD, medicine.medical_specialty, QUADRIPOLAR LEAD IMPROVES, Heart failure, TRIPLE-SITE, Risk Assessment, Article, 03 medical and health sciences, QRS complex, Physiology (medical), Internal medicine, medicine, Humans, OPTIMIZATION, Coronary sinus, Aged, Ischemic cardiomyopathy, business.industry, Patient Selection, CLINICAL-RESPONSE, Stroke Volume, medicine.disease, Multisite pacing, IMPLANTATION, Hemodynamic optimization, business, FOLLOW-UP, Heart Failure, Systolic
Abstract: PurposeIn order to increase the responder rate to CRT, stimulation of the left ventricular (LV) from multiple sites has been suggested as a promising alternative to standard biventricular pacing (BIV). The aim of the study was to compare, in a group of candidates for CRT, the effects of different pacing configurationsBIV, triple ventricular (TRIV) by means of two LV leads, multipoint (MPP), and multipoint plus a second LV lead (MPP + TRIV) pacingon both hemodynamics and QRS duration.MethodsFifteen patients (13 male) with permanent AF (mean age 767years; left ventricular ejection fraction 337%; 7 with ischemic cardiomyopathy; mean QRS duration 178 +/- 25ms) were selected as candidates for CRT. Two LV leads were positioned in two different branches of the coronary sinus. Acute hemodynamic response was evaluated by means of a RADI pressure wire as the variation in LVdp/dtmax.Resultsp id="Par3"Per patient, 2.7 +/- 0.7 veins and 5.2 +/- 1.9 pacing sites were evaluated. From baseline values of 998 +/- 186mmHg/s, BIV, TRIV, MPP, and MPP-TRIV pacing increased LVdp/dtmax to 1200 +/- 281mmHg/s, 1226 +/- 284mmHg/s, 1274 +/- 303mmHg, and 1289 +/- 298mmHg, respectively (p
Published: 2018
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20. Endoscopic and phoniatric evaluation in singing students

Author: Maria Denise Cavaliere, Francesco Ursino, Salvatore Osvaldo Romeo, Maria Rosaria Barillari, Stefano Berrettini, Bruno Fattori, Giovanna Baracca, Andrea Nacci, Nacci, Andrea, Baracca, Giovanna, Romeo, Salvatore Osvaldo, Cavaliere, Maria Denise, Barillari, Maria Rosaria, Berrettini, Stefano, Ursino, Francesco, and Fattori, Bruno
Subjects: Adult, Male, medicine.medical_specialty, Voice Quality, education, Singing, Audiology, Laryngeal Diseases, Young Adult, 030507 speech-language pathology & audiology, 03 medical and health sciences, Speech and Hearing, 0302 clinical medicine, medicine, Fiber Optic Technology, Humans, Reflux symptom, Stroboscopy, Students, 030223 otorhinolaryngology, Singing student, S-VHI, Voice Disorders, Laryngoscopy, business.industry, Otorhinolaryngology2734 Pathology and Forensic Medicine, Laryngostroboscopy, Fiberoptic endoscopy, LPN and LVN, Dysphonia, Self Concept, humanities, medicine.anatomical_structure, nervous system, Otorhinolaryngology, Case-Control Studies, Vocal folds, Auditory Perception, behavior and behavior mechanisms, Female, Phoniatric evaluation, Larynx, 0305 other medical science, business, Laryngostroboscopy, Phoniatric evaluation, Dysphonia, Singing students, S-VHI, psychological phenomena and processes, Singing students
Abstract: Objectives: In To analyze laryngostroboscopic findings and ENT/phoniatric examination results in a group of singing students and in a control group of non-singing subjects to emphasize the importance of ENT/phoniatric examination and of laryngostroboscopy before taking up singing. Methods: 56 singing students and 60 healthy euphonic non-singer volunteers were recruited. In each subject a perceptual assessment and a self-assessment (VHI) of the voice were performed. The singing students filled out the Singing-VHI. All subjects underwent flexible fiberoptic endoscopy and laryngostroboscopy. All subjects were evaluated through the Reflux Symptom Index (RSI) and the Reflux Finding Score (RFS). Results: At laryngostroboscopy, 60.7% of students presented pathological findings, versus 20% of controls (P < 0.0001). Incomplete glottic closure (35.7% vs. 13.3%), supraglottic hypertonus (16.1% vs. 5%), organic lesions (bilateral nodules, cysts, sulcus vergeture) (17.9% vs. 3.3%), posterior erythema (16.1% vs. 5%) and laryngeal edema (14.3% vs 3.3%) were more frequent in the students. The most common symptoms in singers were phonasthenia (37.5 % vs 6.7%; P = 0.0001) and mucus sensation (17.9% vs. 5%, P = 0.03). S-VHI showed higher values in students with pathological laryngostroboscopy (P < 0.0001). Finally, average RSI and RFS were higher in students. Conclusions: Due to the high percentage of organic and functional voice disorders in singing students, it would be desirable that every subject who is going to start singing underwent an ENT/phoniatric investigation with videostrobolaryngoscopy to ascertain vocal folds healthy condition.
Published: 2019

21. Diagnosis and Differential Diagnosis of Voice Disorders

Author: Renate Haubrich, Tamás Hacki, Jitka Vydrová, Katarzyna Karmelita-Katulska, Philippe H. Dejonckere, U. Eysholdt, Frantisek Sram, Wolfgang Angerstein, Giovanna Baracca, Jan G. Švec, Bożena Wiskirska-Woźnica, Ahmed Geneid, Franco Fussi, and Matthias Echternach
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Laryngoscopy, Visible Speech, Videokymography, Audiology, Loudness, medicine, Voice, Phonation, business, Electroglottograph, Nasality
Abstract: Basic information for diagnosis and differential diagnosis of voice disorders is drawn from medical history (the nature of the change in the sound of the voice, pitch, extent and loudness of voice, frequently reported hoarseness and its severity, any occurrence of episodes of voice loss, fatigability of voice) and auditory evaluation (mean speaking pitch, voice onset, pitch range, capability of increasing loudness, perceptual scale of the sound of the voice including nasality, stability). Self-administered questionnaires have proven to be important instruments for the evaluation of the impact of a voice problem on the quality of life of patients. Objective data are available from acoustic analyses (phonetography [voice range profile], visible speech [spectrography], quantification of Fo, voicing %, perturbation parameters, harmonics-to-noise ratio, etc.) and from aerodynamic measurements (maximum phonation time, body plethysmography). In addition to the classic assessment of the laryngeal structures by means of laryngoscopy, stroboscopy is a widely used standard as a subjective tool for the visualisation of vocal fold vibration. Among objective approaches, videokymography is increasingly being used, and high-speed video with consecutive vibrogram display and electroglottography are other options. Vibrational analyses are particularly useful for the detection of beginning malignomas and hidden lesions. They may be also helpful for the evaluation of the vibrating lips within the practice of musician’s medicine for assessing the occupational (in)capacity of professional brass musicians. Electromyography (EMG) is indicated for vocal fold immobility of unknown origin to distinguish paralysis from mechanical fixation. Ultrasound sonography may concern spoken articulation as well as phonation. Proposals for voice loading tests, because of the complexity of the issue, need further improvement and standardisation.
Published: 2019
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22. P6547The energy cost of His bundle pacing can be curtailed

Author: Daniela Lanza, Claudio Picariello, F. Di Gregorio, Lina Marcantoni, S Giatti, Gianni Pastore, A. Barbetta, A Maddalozzo, Enrico Baracca, Mauro Carraro, Francesco Zanon, and Loris Roncon
Subjects: medicine.medical_specialty, Pulse (signal processing), business.industry, Atrial fibrillation, medicine.disease, Bundle of His, law.invention, medicine.anatomical_structure, law, Internal medicine, Bundle, Heart failure, medicine, Cardiology, Energy cost, Artificial cardiac pacemaker, Diffusion (business), Cardiology and Cardiovascular Medicine, business
Abstract: Introduction His bundle pacing (HBP) allows physiological ventricular activation and prevents the electrical and mechanical desynchronization generally induced by myocardial stimulation, which can increase the risk of atrial fibrillation and heart failure. On the other hand, reliable HBP capture often requires higher energy than conventional myocardial pacing. This reduces the expected life of the stimulator and might limit the diffusion of HBP in the clinical practice. Purpose Decreasing HBP current drain by careful management of stimulation safety margin and pulse duration. Methods In 28 patients undergoing DDD pacing with HBP, a third lead was implanted in RV apex to provide back-up pacing on demand. HBP and apical leads were connected, respectively, to the V1 and V2 channels of a 3-chamber stimulator. When HBP was effective, apical sensing occurred within the VV delay and prevented V2 stimulation. In contrast, in case of HBP failure, V2 sensing was missing and apical back-up pacing was promptly delivered at the end of the VV delay. The availability of a back-up pulse on demand allowed reducing the HBP safety margin with no risk. Furthermore, the individual HBP strength-duration curve was derived in the aim of optimizing the Hisian pulse parameters, which are the major determinants of the device current drain. Results Correct back-up inhibition by successful HBP and stimulation in the event of capture loss was achieved in all the patients. The latency from Hisian pacing to apical sensing averaged 96±14 ms. According to the pacemaker counters, no back-up pulse was delivered in daily life in 59% of patients. In the remaining, the prevalence of back-up stimulation never exceeded 15% of paced ventricular cycles. The high HBP threshold was essentially due to an increased rheobase (1.2±0.6 V), while the chronaxie ranged from 0.30 to 0.53 ms in 71% of patients (median 0.44 ms), exceeding 0.6 ms only in 29% of the cases. An average current saving of 5.4±3.0 μA was obtained at the expense of a mild reduction in HBP safety margin (from 1.6±0.2 to 1.4±0.1 times). HBP and apical back-up Conclusions Back-up stimulation on demand is a reliable option to decrease HBP current drain and prolong the stimulator service life with full safety. In most of the cases, significant saving can be achieved by pulse shortening, as the chronaxie time is in the same range as with myocardial stimulation and longer pulses are not required. A pulse duration exceeding 0.6 ms is indicated in less than 1/3 of the implants.
Published: 2019
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23. Downlink Power Control in Cell-free Massive MIMO with Partially Distributed Access Points

Author: Paolo Baracca, Jobin Francis, Gerhard Fettweis, and Stefan Wesemann
Subjects: Computer science, business.industry, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, 05 social sciences, MIMO, 050801 communication & media studies, 020206 networking & telecommunications, 02 engineering and technology, Spectral efficiency, Precoding, Backhaul (telecommunications), 0508 media and communications, Telecommunications link, 0202 electrical engineering, electronic engineering, information engineering, Cellular network, business, Power control, Communication channel, Computer network
Abstract: Cell-free massive multiple-input multiple-output (MIMO) is a promising cellular technology in which a large number of distributed access points (APs) jointly serve a small number of user equipments (UEs). In this work, we investigate the impact of the spatial distribution of APs on the performance of a cell-free massive MIMO system, considering different downlink power control policies. Further, we analyze the performance for the case where only subsets of all APs serve the individual UEs: this scenario has lower backhaul requirements and associated CAPEX/OPEX costs. In this framework, we first propose a novel, tractable approximation for the average spectral efficiency (SE) of the transmission to a UE conditioned on the estimated channel gains. This approximation is then used to develop different downlink power control policies. Further, we extend the policies to the scenario when power control is coordinated only among subsets of APs and not across the subsets. Through extensive system-level simulations, we evaluate the improvement in SE by spreading out the APs and the SE loss when a subset of all APs serve a UE and coordination across subsets is absent.
Published: 2019
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24. Enabling Ultra Reliable Wireless Communications for Factory Automation with Distributed MIMO

Author: Gianluca Casciano, Paolo Baracca, and Stefano Buzzi
Subjects: Signal Processing (eess.SP), FOS: Computer and information sciences, Beamforming, Computer science, business.industry, Information Theory (cs.IT), Computer Science - Information Theory, 05 social sciences, MIMO, Signal-to-interference-plus-noise ratio, 050801 communication & media studies, 020206 networking & telecommunications, 02 engineering and technology, Interference (wave propagation), Automation, 0508 media and communications, FOS: Electrical engineering, electronic engineering, information engineering, 0202 electrical engineering, electronic engineering, information engineering, Electronic engineering, Wireless, Electrical Engineering and Systems Science - Signal Processing, business, Communication channel, Computer Science::Information Theory
Abstract: Factory automation is one of the most challenging use cases for 5G-and-beyond mobile networks due to strict latency, availability and reliability constraints. In this work, an indoor factory scenario is considered, and distributed multiple-input multiple-output (MIMO) schemes are investigated in order to enable reliable communication to the actuators (ACs) active in the factory. Different levels of coordination among the access points serving the ACs and several beamforming schemes are considered and analyzed. To enforce system reliability, a max-min power allocation (MPA) algorithm is proposed, aimed at improving the signal to interference plus noise ratio (SINR) of the ACs with the worst channel conditions. Extensive system simulations are performed in a realistic scenario, which includes a new path-loss model based on recent measurements in factory scenarios, and, also, the presence of non-Gaussian impulsive noise. Numerical results show that distributed MIMO schemes with zero-forcing (ZF) beamforming and MPA have the potential of providing SINR gains in the order of tens of dB with respect to a centralized MIMO deployment, as well as that the impulsive noise can strongly degrade the system performance and thus requires specific detection and mitigation techniques., Accepted at the IEEE Vehicular Technology Conference (VTC-Fall), Honolulu (HI), Sep. 2019
Published: 2019

25. Long term performance and safety of His bundle pacing: A multicenter experience

Author: Graziano Boaretto, Antonella Tiribello, Gianni Pastore, Mohamed A.E. Abdel-Rahman, Lina Marcantoni, Faiz A. Subzposh, Gopi Dandamudi, Pugazhendhi Vijayaraman, Angela Naperkowski, Paola Raffagnato, Francesco Zanon, and Enrico Baracca
Subjects: Bradycardia, Male, medicine.medical_specialty, Bundle of His, Pacemaker, Artificial, Time Factors, medicine.medical_treatment, Cardiac resynchronization therapy, Action Potentials, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Median follow-up, Heart Rate, Physiology (medical), Internal medicine, medicine, Humans, 030212 general & internal medicine, Atrioventricular Block, Aged, Retrospective Studies, Aged, 80 and over, Sick Sinus Syndrome, business.industry, Cardiac Pacing, Artificial, Atrial fibrillation, Retrospective cohort study, Middle Aged, Pennsylvania, medicine.disease, Treatment Outcome, Italy, Cardiology, Equipment Failure, Female, Implant, medicine.symptom, Cardiology and Cardiovascular Medicine, Complication, business
Abstract: INTRODUCTION Several single-center short-term studies have demonstrated the feasibility, safety, and positive clinical outcomes of permanent His bundle pacing (HBP). We performed a retrospective study to evaluate long-term technical and safety performances of HBP in a large population of pacemaker patients from two different centers. METHODS AND RESULTS The analysis includes 844 patients (345 female, mean age = 75 ± 9 years) who underwent successful permanent HBP for pacemaker indications from 2004 to 2016. The main endpoints were long term electrical performances including pacing threshold, sensing, impedance, and freedom from pacing related complications. The pacing indication was AV Block in 348 (41.2%) patients, sinus node disease in 147 (17.4%), any bradycardia indication in patients with atrial fibrillation in 335 (39.7%) patients and need for cardiac resynchronization therapy in 14 (1.7%) patients. Mean pacing capture thresholds and sensed R waves were 1.6 V and 5.8 mV, respectively at implant and 2.0 V and 6.1 mV at chronic follow-up. During the median follow up of 3 years (interquartile range = 1-6 years), HBP was free of any complication in 91.6% of patients. In the first 368 patients, HBP was achieved using a deflectable curve delivery system, while in 476 using the fixed curve sheath. A significant difference was found in the thresholds (2.4 ± 1.0 V and 1.7 ± 1.1 V, P
Published: 2019

26. ECG parameters predict left ventricular conduction delay in patients with left ventricular dysfunction

Author: Silvio Aggio, Francesco Zanon, Gianni Pastore, Massimiliano Maines, Lina Marcantoni, S. Serge Barold, Giorgio Corbucci, Franco Noventa, Loris Roncon, Daniela Lanza, Gianluca Rigatelli, Claudio Picariello, Mauro Carraro, and Enrico Baracca
Subjects: Male, medicine.medical_specialty, Heart Ventricles, medicine.medical_treatment, Bundle-Branch Block, Statistics as Topic, Cardiac resynchronization therapy, 030204 cardiovascular system & hematology, Cardiac Resynchronization Therapy, Electrocardiography, Ventricular Dysfunction, Left, 03 medical and health sciences, 0302 clinical medicine, Notching, Heart Conduction System, Physiology (medical), Internal medicine, Humans, Medicine, In patient, 030212 general & internal medicine, Aged, Aged, 80 and over, business.industry, Left bundle branch block, Intrinsicoid deflection, Middle Aged, Right bundle branch block, medicine.disease, Italy, Heart failure, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Left Ventricular Conduction Delay
Abstract: Estimating left ventricular electrical delay (Q-LV) from a 12-lead ECG may be important in evaluating cardiac resynchronization therapy (CRT).The purpose of this study was to assess the impact of Q-LV interval on ECG configuration.One hundred ninety-two consecutive patients undergoing CRT implantation were divided electrocardiographically into 3 groups: left bundle branch block (LBBB), right bundle branch block (RBBB), and nonspecific intraventricular conduction delay (IVCD). The IVCD group was further subdivided into 81 patients with left (L)-IVCD and 15 patients with right (R)-IVCD (resembling RBBB, but without S wave in leads I and aVL). The Q-LV interval in the different groups and the relationship between ECG parameters and the maximum Q-LV interval were analyzed.Patients with LBBB presented a long Q-LV interval (147.7 ± 14.6 ms, all exceeding cutoff value of 110 ms), whereas RBBB patients presented a very short Q-LV interval (75.2 ± 16.3 ms, all110 ms). Patients with an IVCD displayed a wide range of Q-LV intervals. In L-IVCD, mid-QRS notching/slurring showed the strongest correlation with a longer Q-LV interval, followed, in decreasing order, by QRS duration150 ms and intrinsicoid deflection60 ms. Isolated mid-QRS notching/slurring predicted Q-LV interval110 ms in 68% of patients. The R-IVCD group presented an unexpectedly longer Q-LV interval (127.0 ± 12.5 ms; 13/15 patients had Q-LV110 ms).Patients with LBBB have a very prolonged Q-LV interval. Mid-QRS notching in lateral leads strongly predicts a longer Q-LV interval in L-IVCD patients. Patients with R-IVCD constitute a subgroup of patients with a long Q-LV interval.
Published: 2016
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27. P991Long term follow-up of the hisian pacing system: technical and clinical outcomes in a single centre experience

Author: Lina Marcantoni, Silvio Aggio, Mauro Carraro, Daniela Lanza, K D'elia, Enrico Baracca, Gianni Pastore, Claudio Picariello, Loris Roncon, Luca Conte, Francesco Zanon, M P Galasso, and M. Rinuncini
Subjects: 03 medical and health sciences, medicine.medical_specialty, Single centre, 0302 clinical medicine, business.industry, Physiology (medical), Physical therapy, Medicine, 030212 general & internal medicine, 030204 cardiovascular system & hematology, Cardiology and Cardiovascular Medicine, business, Term (time)
Published: 2017
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28. Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit

Author: Mara Serrano-Soto, Valentina Corradi, Antonio Baracca, Ana Castro, Ottavia Eleonora Ferraro, Marta Scarpa, Claudio Ronco, Mara Senzolo, Eva Muraro, Mariangela Valentina Puci, Alejandra Molano Triviño, Raffaele Bonato, Massimo de Cal, Lilia Rizo-Topete, Alessandra Brendolan, Fiorenza Ferrari, Davide Giavarina, Giorgio Antonio Iotti, Maria Rosa Carta, Anna Lorenzin, Gregorio Romero-González, and Faeq Husain-Syed
Subjects: Male, Physiology, 030232 urology & nephrology, Blood Pressure, Urine, Vascular Medicine, Biochemistry, law.invention, chemistry.chemical_compound, 0302 clinical medicine, law, Chronic Kidney Disease, Medicine and Health Sciences, Registries, Aged, 80 and over, Multidisciplinary, Framingham Risk Score, Acute kidney injury, Acute Kidney Injury, Middle Aged, Intensive care unit, Hospitals, Body Fluids, Intensive Care Units, Physiological Parameters, Nephrology, Creatinine, Medicine, Female, Anatomy, Research Article, Glomerular Filtration Rate, medicine.medical_specialty, Critical Care, Science, Renal function, 03 medical and health sciences, Internal medicine, medicine, Humans, Obesity, Derivation, Aged, Retrospective Studies, business.industry, Body Weight, Biology and Life Sciences, Kidneys, 030208 emergency & critical care medicine, Retrospective cohort study, Renal System, medicine.disease, Health Care, chemistry, Health Care Facilities, business, Biomarkers, Kidney disease
Abstract: AKI is associated with increased risk of death, prolonged length of stay and development of de-novo chronic kidney disease. The aim of our study is the development and validation of prediction models to identify the risk of AKI in ICU patients up to 7 days. We retrospectively recruited 692 consecutive patients admitted to the ICU at San Bortolo Hospital (Vicenza, Italy) from 1 June 2016 to 31 March 2017: 455 patients were treated as the derivation group and 237 as the validation group. Candidate variables were selected based on a literature review and expert opinion. Admission eGFR< 90 ml/min /1.73 mq (OR 2.78; 95% CI 1.78-4.35; p
Published: 2019

29. Performance of Massive MIMO Self-Backhauling for Ultra-Dense Small Cell Deployments

Author: Andrea Bonfante, Nicola Marchetti, Lorenzo Galati Giordano, Adrian Garcia-Rodriguez, Merim Dzaferagic, David Lopez-Perez, Paolo Baracca, Giovanni Geraci, and M. Majid Butt
Subjects: Networking and Internet Architecture (cs.NI), FOS: Computer and information sciences, Ultra dense, Computer science, business.industry, Information Theory (cs.IT), Computer Science - Information Theory, MIMO, 020206 networking & telecommunications, 020302 automobile design & engineering, 02 engineering and technology, Computer Science - Networking and Internet Architecture, Backhaul (telecommunications), 0203 mechanical engineering, 0202 electrical engineering, electronic engineering, information engineering, Resource allocation, Wireless, business, Heterogeneous network, Computer network
Abstract: A key aspect of the fifth-generation wireless communication network will be the integration of different services and technologies to provide seamless connectivity. In this paper, we consider using massive multiple-input multiple-output (mMIMO) to provide backhaul links to a dense deployment of self-backhauling (s-BH) small cells (SCs) that provide cellular access within the same spectrum resources of the backhaul. Through a comprehensive system-level simulation study, we evaluate the interplay between access and backhaul and the resulting end-to-end user rates. Moreover, we analyze the impact of different SCs deployment strategies, while varying the time resource allocation between radio access and backhaul links. We finally compare the above mMIMO-based s-BH approach to a mMIMO direct access (DA) architecture accounting for the effects of pilot reuse schemes, together with their associated overhead and contamination mitigation effects. The results show that dense SCs deployments supported by mMIMO s-BH provide significant rate improvements for cell-edge users (UEs) in ultra-dense deployments with respect to mMIMO DA, while the latter outperforms mMIMO s-BH from the median UEs' standpoint.
Published: 2018
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30. 5G Massive MIMO Architectures: Self-Backhauled Small Cells versus Direct Access

Author: Adrian Garcia-Rodriguez, Nicola Marchetti, Lorenzo Galati Giordano, David Lopez-Perez, Paolo Baracca, Andrea Bonfante, Giovanni Geraci, and M. Majid Butt
Subjects: Signal Processing (eess.SP), FOS: Computer and information sciences, Computer Networks and Communications, Wireless ad hoc network, Computer science, Network capacity, MIMO, Small cell deployment, Aerospace Engineering, 02 engineering and technology, Computer Science - Networking and Internet Architecture, 0203 mechanical engineering, 5G mobile communication, 0202 electrical engineering, electronic engineering, information engineering, FOS: Electrical engineering, electronic engineering, information engineering, Wireless, Electrical and Electronic Engineering, Electrical Engineering and Systems Science - Signal Processing, Networking and Internet Architecture (cs.NI), business.industry, 020206 networking & telecommunications, 020302 automobile design & engineering, Partition (database), Backhaul (telecommunications), Automotive Engineering, Massive MIMO, Wireless backhaul, business, 5G, Access time, Computer network
Abstract: In this paper, we focus on one of the key technologies for the fifth-generation wireless communication networks, massive multiple-input-multiple-output (mMIMO), by investigating two of its most relevant architectures: 1) to provide in-band backhaul for the ultra-dense network (UDN) of self-backhauled small cells (SCs), and 2) to provide direct access (DA) to user equipments (UEs). Through comprehensive 3GPP-based system-level simulations and analytical formulations, we show the end-to-end UE rates achievable with these two architectures. Differently from the existing works, we provide results for two strategies of self-backhauled SC deployments, namely random and ad-hoc, where in the latter SCs are purposely positioned close to UEs to achieve line-of-sight (LoS) access links. We also evaluate the optimal backhaul and access time resource partition due to the in-band self-backhauling (s-BH) operations. Our results show that the ad-hoc deployment of self-backhauled SCs closer to the UEs with optimal resource partition and with directive antenna patterns, provides rate improvements for cell-edge UEs that amount to 30% and tenfold gain, as compared to mMIMO DA architecture with pilot reuse 3 and reuse 1, respectively. On the other hand, mMIMO s-BH underperforms mMIMO DA above the median value of the UE rates when the effect of pilot contamination is less severe, and the LoS probability of the DA links improves., The paper is published at IEEE Transactions on Vehicular Technology (TVT 2019). arXiv admin note: text overlap with arXiv:1806.10969
Published: 2018

31. P5739LV lead apical position could be the best option in selected CRT patients

Author: Loris Roncon, C Picariello, S Giatti, Lina Marcantoni, Silvio Aggio, M Carraro, D Lanza, Enrico Baracca, Francesco Zanon, Gianni Pastore, K D'elia, and M P Galasso
Subjects: medicine.medical_specialty, Position (obstetrics), business.industry, medicine, Radiology, Cardiology and Cardiovascular Medicine, business, Lead (electronics)
Published: 2018
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32. P3215Dual-chamber pacing with His bundle stimulation and apical back-up on demand

Author: Francesco Zanon, F. Di Gregorio, Lina Marcantoni, A. Tiribello, A. Barbetta, Loris Roncon, Graziano Boaretto, Gianni Pastore, P. Raffagnato, and Enrico Baracca
Subjects: medicine.medical_specialty, business.industry, Internal medicine, On demand, Bundle, Cardiology, medicine, Stimulation, Cardiology and Cardiovascular Medicine, business
Published: 2018
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33. 5310His bundle pacing in patients with low ejection fraction at implant: long-term follow-up

Author: Loris Roncon, D Lanza, K D'elia, M Carraro, Silvio Aggio, Gianni Pastore, Francesco Zanon, C Picariello, Enrico Baracca, Lina Marcantoni, and S Giatti
Subjects: medicine.medical_specialty, Ejection fraction, business.industry, Long term follow up, Internal medicine, Bundle, Cardiology, Medicine, In patient, Implant, Cardiology and Cardiovascular Medicine, business
Published: 2018
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34. 3289His bundle pacing in left bundle branch block patients

Author: D Lanza, Gianni Pastore, S Giatti, Lina Marcantoni, C Picariello, Enrico Baracca, Loris Roncon, M Carraro, and Francesco Zanon
Subjects: medicine.medical_specialty, business.industry, Left bundle branch block, Bundle, Internal medicine, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business, medicine.disease
Published: 2018
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35. P5736MPP reduces the ventricular arrhythmias burden compared to standard biventricular pacing in CRT patients

Author: Gianni Pastore, C Picariello, M Carraro, Francesco Zanon, K D'elia, S Giatti, Loris Roncon, Lina Marcantoni, D Lanza, Luca Conte, and Enrico Baracca
Subjects: medicine.medical_specialty, business.industry, Internal medicine, Cardiology, medicine, Cardiology and Cardiovascular Medicine, business
Published: 2018
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36. Indoor massive MIMO deployments for uniformly high wireless capacity

Author: Paolo Baracca, Giovanni Geraci, David Lopez-Perez, Adrian Garcia-Rodriguez, Lorenzo Galati Giordano, and Holger Claussen
Subjects: FOS: Computer and information sciences, Computer science, business.industry, Information Theory (cs.IT), Computer Science - Information Theory, 020208 electrical & electronic engineering, MIMO, 020206 networking & telecommunications, 02 engineering and technology, Effective radiated power, Base station, Signal-to-noise ratio, Interference (communication), 0202 electrical engineering, electronic engineering, information engineering, Electronic engineering, Zero Forcing Equalizer, Wireless, business
Abstract: Providing consistently high wireless capacity is becoming increasingly important to support the applications required by future digital enterprises. In this paper, we propose Eigen-direction-aware ZF (EDA-ZF) with partial coordination among base stations (BSs) and distributed interference suppression as a practical approach to achieve this objective. We compare our solution with Zero Forcing (ZF), entailing neither BS coordination or inter-cell interference mitigation, and Network MIMO (NeMIMO), where full BS coordination enables centralized inter-cell interference management. We also evaluate the performance of said schemes for three sub-6 GHz deployments with varying BS densities -- sparse, intermediate, and dense -- all with fixed total number of antennas and radiated power. Extensive simulations show that: (i) indoor massive MIMO implementing the proposed EDA-ZF provides uniformly good rates for all users; (ii) indoor network densification is detrimental unless full coordination is implemented; (iii) deploying NeMIMO pays off under strong outdoor interference, especially for cell-edge users.
Published: 2018
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37. Prevalence of thoracic vertebral fractures in hospitalized elderly patients with heart failure

Author: Andrea Giustina, Gherardo Mazziotti, Mauro Doga, Pier Paolo Vescovi, Teresa Porcelli, Matteo Baracca, Mazziotti, G, Baracca, M, Doga, M, Porcelli, T, Vescovi, Pp, and Giustina, Andrea
Subjects: Male, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Context (language use), Disease, Endocrinology, Internal medicine, Diabetes mellitus, Prevalence, medicine, Humans, Aged, Aged, 80 and over, Heart Failure, Ejection fraction, business.industry, General Medicine, Odds ratio, Loop diuretic, medicine.disease, Surgery, Radiography, Cross-Sectional Studies, Heart failure, Radiological weapon, Cardiology, Spinal Fractures, Female, business
Abstract: ObjectiveHeart failure (HF) has been associated with increased risk of fragility fractures. Indeed, most literature data on fractures were based on an historical and clinical approach focused on the identification of peripheral fractures, whereas the risk of vertebral fractures in this clinical setting is still unclear.DesignCross-sectional study.AimTo evaluate the prevalence and determinants of radiological thoracic vertebral fractures in patients with HF.MethodsThe study includes 1031 elderly hospitalized patients (491 females and 540 males; median age, 75 years; range, 65–90; 430 patients with HF) who were evaluated for the presence of thoracic vertebral fractures by quantitative morphometric analysis, using chest X-ray routinely performed in the diagnostic work-up of HF.ResultsVertebral fractures were found in 166 patients (16.1%), the prevalence being significantly higher in patients with HF as compared with those without HF, both in females (30.9 vs 15.8%; PP=0.001). The association between HF and vertebral fractures remained statistically significant (odds ratio, 2.14; 95% CI, 1.25–3.66; P=0.01) even after adjustment for age, sex, loop diuretic therapy, anticoagulant therapy, proton pump therapy, coexistent chronic obstructive pulmonary disease, diabetes mellitus, renal insufficiency, and chronic liver diseases. In patients with HF, vertebral fractures were positively correlated with female sex, duration of HF, ischemic heart disease, cigarette smoking, and treatment with anti-osteoporotic drugs, and inversely correlated with left ventricular ejection fraction.ConclusionsHospitalized patients suffering from HF are at higher risk of vertebral fractures than patients without HF in the same clinical context.
Published: 2012
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38. Uplink Sounding Reference Signal Coordination to Combat Pilot Contamination in 5G Massive MIMO

Author: Giovanni Geraci, David Lopez-Perez, Lorenzo Galati Giordano, Maurizio Magarini, Adrian Garcia-Rodriguez, Luca Campanalonga, and Paolo Baracca
Subjects: FOS: Computer and information sciences, Scheme (programming language), business.industry, Computer science, Orthogonal frequency-division multiplexing, Information Theory (cs.IT), Computer Science - Information Theory, MIMO, 020302 automobile design & engineering, 020206 networking & telecommunications, 02 engineering and technology, Engineering (all), 0203 mechanical engineering, Transmission (telecommunications), Telecommunications link, 0202 electrical engineering, electronic engineering, information engineering, Overhead (computing), business, computer, 5G, Computer network, computer.programming_language
Abstract: To guarantee the success of massive multiple-input multiple-output (MIMO), one of the main challenges to solve is the efficient management of pilot contamination. Allocation of fully orthogonal pilot sequences across the network would provide a solution to the problem, but the associated overhead would make this approach infeasible in practical systems. Ongoing fifth-generation (5G) standardisation activities are debating the amount of resources to be dedicated to the transmission of pilot sequences, focussing on uplink sounding reference signals (UL SRSs) design. In this paper, we extensively evaluate the performance of various UL SRS allocation strategies in practical deployments, shedding light on their strengths and weaknesses. Furthermore, we introduce a novel UL SRS fractional reuse (FR) scheme, denoted neighbour-aware FR (FR-NA). The proposed FR-NA generalizes the fixed reuse paradigm, and entails a tradeoff between i) aggressively sharing some UL SRS resources, and ii) protecting other UL SRS resources with the aim of relieving neighbouring BSs from pilot contamination. Said features result in a cell throughput improvement over both fixed reuse and state-of-the-art FR based on a cell-centric perspective.
Published: 2017

39. P1351Long-term follow-up of His pacing in a single center experience

Author: Gianni Pastore, Loris Roncon, Enrico Baracca, C Picariello, M Carraro, Silvio Aggio, L. Marcantoni, Francesco Zanon, G. Giau, and D Lanza
Subjects: 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, business.industry, Physical therapy, Medicine, 030212 general & internal medicine, 030204 cardiovascular system & hematology, Cardiology and Cardiovascular Medicine, Single Center, business, Term (time)
Published: 2017
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40. Determination of the Longest Intrapatient Left Ventricular Electrical Delay May Predict Acute Hemodynamic Improvement in Patients After Cardiac Resynchronization Therapy

Author: Gianni Pastore, Frits W. Prinzen, Franco Noventa, Enrico Baracca, Chiara Fraccaro, Silvio Aggio, Francesco Zanon, Alberto Mazza, Loris Roncon, Fysiologie, and RS: CARIM - R2 - Cardiac function and failure
Subjects: Male, cardiomyopathies, medicine.medical_specialty, medicine.medical_treatment, Cardiac resynchronization therapy, Myocardial Ischemia, Hemodynamics, cardiac resynchronization therapy, heart failure, hemodynamics, Ventricular Function, Left, Contractility, Cohort Studies, QRS complex, Electrocardiography, Heart Conduction System, Predictive Value of Tests, Physiology (medical), Internal medicine, medicine, Humans, Coronary sinus, Aged, Aged, 80 and over, Inpatients, Ischemic cardiomyopathy, Ejection fraction, business.industry, Cardiac Pacing, Artificial, Stroke Volume, Recovery of Function, Middle Aged, medicine.disease, Myocardial Contraction, Defibrillators, Implantable, Survival Rate, Treatment Outcome, Heart failure, Cardiology, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract: Background— One of the reasons for patient nonresponse to cardiac resynchronization therapy is a suboptimal left ventricular (LV) pacing site. LV electric delay (Q-LV interval) has been indicated as a prognostic parameter of cardiac resynchronization therapy response. This study evaluates the LV delay for the optimization of the LV pacing site. Methods and Results— Thirty-two consecutive patients (23 men; mean age, 71±11 years; LV ejection fraction, 30±6%; 18 with ischemic cardiomyopathy; QRS, 181±25 ms; all mean±SD) underwent cardiac resynchronization therapy device implantation. All available tributary veins of the coronary sinus were tested, and the Q-LV interval was measured at each pacing site. The hemodynamic effects of pacing at different sites were evaluated by invasive measurement of LV d P /d t max at baseline and during pacing. Overall, 2.9±0.8 different veins and 6.4±2.3 pacing sites were tested. In 31 of 32 (96.8%) patients, the highest LV d P /d t max coincided with the maximum Q-LV interval. Q-LV interval correlated with the increase in LV d P /d t max in all patients at each site (AR1 ρ=0.98; P 95 ms corresponded to a >10% in LV d P /d t max . An inverse correlation between paced QRS duration and improvement in LV d P /d t max was seen in 24 patients (75%). Conclusions— Pacing the LV at the latest activated site is highly predictive of the maximum increase in contractility, expressed as LV d P /d t max . A positive correlation between Q-LV interval and hemodynamic improvement was found in all patients at every pacing site, a value of 95 ms corresponding to an increase in LV d P /d t max of ≥10%.
Published: 2014

41. Backhaul Rate Allocation in Uplink SC-FDMA Systems with Multicell Processing

Author: Nevio Benvenuto, Stefano Tomasin, and Paolo Baracca
Subjects: Frequency-division multiple access, Computer science, Iterative method, business.industry, Applied Mathematics, Quantization (signal processing), ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Throughput, Computer Science Applications, Backhaul (telecommunications), Base station, Telecommunications link, Electrical and Electronic Engineering, Greedy algorithm, business, Communication channel, Computer network
Abstract: For a cellular system where mobile terminals transmit in the uplink to base stations (BSs) using single carrier-frequency division multiple access (SC-FDMA), we consider multicell processing among BSs. Received signals are first quantized on a per-subcarrier basis and then forwarded to the serving BS on a backhaul with limited rate. With the aim of maximizing the network throughput we a) design an efficient composite signal representation and b) propose a rate allocation algorithm for the backhaul. Using a closed-form expression of the achievable throughput in the presence of quantization noise, an iterative greedy algorithm for the backhaul rate allocation is developed, where at each iteration we select the signal to be exchanged as the one providing the maximum network throughput increase per backhaul bit. In order to determine how many quantization bits are used for each received signal, we consider either a static bit allocation with a fixed number of bits, or a dynamic bit allocation (which ensures a predetermined network percentage throughput loss with respect to the unquantized case). In an LTE scenario, it is seen that the proposed bit allocation methods flexibly adapt to channel and backhaul conditions and yield similar performance, hence the static approach is preferred due to its lower complexity.
Published: 2014
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42. 42His bundle pacing in BBB patients: outcomes over a long-term follow-up

Author: Gianni Pastore, S Giatti, Silvio Aggio, Lina Marcantoni, Luca Conte, M. Rinuncini, Francesco Zanon, Loris Roncon, Mauro Carraro, Daniela Lanza, Claudio Picariello, Enrico Baracca, M P Galasso, and K D'elia
Subjects: medicine.medical_specialty, Long term follow up, business.industry, Physiology (medical), Bundle, Internal medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business
Published: 2018
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43. P1132LV lead apical placement could be the best option in selected patients candidate to CRT

Author: Silvio Aggio, Francesco Zanon, S Giatti, Enrico Baracca, Gianni Pastore, M. Rinuncini, Mauro Carraro, Loris Roncon, M P Galasso, Lina Marcantoni, Franco Noventa, K D'elia, Luca Conte, Claudio Picariello, and Daniela Lanza
Subjects: medicine.medical_specialty, business.industry, Physiology (medical), Medicine, Radiology, Cardiology and Cardiovascular Medicine, business, Lead (electronics)
Published: 2018
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44. Base station selection and per-cell codebook optimization for CoMP with joint processing

Author: Antonia M. Tulino, Paolo Baracca, Federico Boccardi, Volker Braun, Baracca, P., Boccardi, F., Braun, V., Tulino, ANTONIA MARIA, IEEE, P., Baracca, F., Boccardi, and V., Braun
Subjects: business.industry, Computer science, Data_CODINGANDINFORMATIONTHEORY, Spectral efficiency, Frequency-division multiplexing, Base station, User equipment, Transmission (telecommunications), Telecommunications link, Cellular network, Bandwidth (computing), Frequency division duplex, Fading, Telecommunications, business, Computer Science::Information Theory, Computer network, Communication channel
Abstract: In cellular networks coordination among base stations (BSs) has been recognized as an important solution to handle inter-cell interference and increase spectral efficiency. In frequency division duplex systems one of the main issue that sensibly degrades the performance of coordinated multipoint (CoMP) transmission techniques is the imperfect channel state information (CSI) due to the limited bandwidth available for the feedback transmission. In this paper we focus on a CoMP scenario with data and CSI sharing among the BSs and we consider a feedback transmission scheme where each user equipment (UE) quantizes the different channels by using codebooks designed for a single-cell scenario. Due to the different propagation characteristics of the channels between a UE and each BS and by considering a constraint on the number of available feedback bits, we propose two practical algorithms depending on the large-scale fading to a) select the subset of BSs from whom the UE prefers to be served and b) optimize the number of feedback bits allocated to each channel. The developed techniques allow a UE to send more feedback bits to the BSs with a stronger signal and numerical results show the merits of the proposed approach.
Published: 2012

45. Hisian area and right ventricular apical pacing differently affect left atrial function: an intra-patients evaluation

Author: Franco Noventa, Claudio Picariello, Gianni Pastore, Chiara Fraccaro, Silvio Aggio, Giorgio Corbucci, Loris Roncon, Enrico Baracca, and Francesco Zanon
Subjects: Male, Cardiac function curve, Bundle of His, Time Factors, Contraction (grammar), Heart Ventricles, Diastole, Ventricular Function, Left, Electrocardiography, Ventricular Dysfunction, Left, Left atrial, Physiology (medical), Humans, Medicine, Atrioventricular Block, Isovolumetric contraction, Aged, Echocardiography, Doppler, Pulsed, business.industry, Cardiac Pacing, Artificial, Hemodynamics, Stroke Volume, Atrial arrhythmias, Middle Aged, Myocardial Contraction, Echocardiography, Doppler, Color, Treatment Outcome, Blood pressure, Anesthesia, Ventricular Function, Right, Early diastolic, Atrial Function, Left, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Aims Right ventricular apex (RVA) pacing has adverse effects on left atrial (LA) function and may contribute to atrial arrhythmias. The effects of Hisian area (HA) pacing on LA function are still lacking. The objective of this study is to assess the left ventricular (LV) electromechanical activation/relaxation, systolic (S), diastolic (D) phases, and their effects on LA function during pacing from HA and RVA. Methods and results Thirty-seven patients with normal cardiac function underwent permanent HA pacing. In all patients, a RVA backup lead was added. The patients first underwent 3 months of HA pacing, followed by 3 months of RVA pacing. After each 3-month period, we compared by echocardiography: S–D LV electromechanical delay (S–D EMD), S–D intra-LV dyssynchrony, LV S–D phases, and their function evaluated by myocardial performance index (MPI) and mitral annular tissue Doppler early diastolic velocity ( E ′), pulmonary arterial systolic pressure (PASP), and LA function (LA phasic volumes and their emptying fraction). Right ventricular apex compared with HA pacing increased S–D EMD ( P < 0.001) and intra-LV dyssynchrony ( P < 0.001). As a consequence, a significant longer LV isovolumetric contraction time ( P < 0.001) and LV isovolumetric relaxation time ( P = 0.05) were measured during RVA compared with HA pacing, whereas LV ejection time was shorter ( P = 0.033). Moreover, HA pacing resulted in significantly better MPI ( P = 0.039), higher value of E ′ ( P = 0.049), and lower PASP ( P < 0.001). Finally, RVA compared with HA pacing was associated to higher LA volumes pre-atrial contraction ( P = 0.001) and minimal volume ( P = 0.003) with reduction in passive emptying fraction ( P < 0.001) and total emptying fraction ( P = 0.005). Conclusion Hisian area compared with RVA pacing resulted in a more physiological LV electromechanical activation/relaxation and consequently better LA function.
Published: 2014
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46. Validation of the Italian version of the Singing Voice Handicap Index

Author: Stella Forti, Lorenzo Pignataro, Giovanna Cantarella, Giovanna Baracca, and Franco Fussi
Subjects: Adult, Male, medicine.medical_specialty, Psychometrics, Voice Quality, Laryngoscopy, Singing, Context (language use), Audiology, Severity of Illness Index, Young Adult, Cronbach's alpha, Quality of life, Surveys and Questionnaires, medicine, Humans, Stroboscopy, Voice Handicap Index, Voice Disorders, medicine.diagnostic_test, business.industry, Reproducibility of Results, General Medicine, Occupational Diseases, medicine.anatomical_structure, Otorhinolaryngology, Vocal folds, Quality of Life, Female, Self Report, business
Abstract: Singers constitute a specific population that is particularly sensitive to vocal disability, which may have a higher impact on their quality of life compared to non-singers. A specific questionnaire, the Singing Voice Handicap Index (SVHI), was created and validated aimed to measure the physical, social, emotional and economic impacts of voice problems on the lives of singers. The aim of this study was to validate the Italian version of the SVHI. The validated English version of the SVHI was translated into Italian and then discussed with several voice care professionals. The Italian version of the SVHI was administered to 214 consecutive singers (91 males and 123 females, mean age: 32.62 ± 10.85). Voice problem complaints were expressed by 97 of the singers, while 117 were healthy and had no voice conditions. All subjects underwent a phoniatric consultation with videolaryngostroboscopy to ascertain the condition of the vocal folds. Internal consistency of the Italian version of the SVHI showed a Cronbach's α of 0.97. The test-retest reliability was assessed by comparing the responses obtained by all subjects in two different administrations of the questionnaire; the difference was not significant (p = ns). The SVHI scores in healthy singers was significantly lower than the one obtained in the group of singers with a vocal fold abnormality (29.26 ± 25.72 and 45.62 ± 27.95, p < 0.001, respectively). The Italian version of the SVHI was successfully validated as an instrument with proper internal consistency and reliability. It is a suitable instrument for the self-evaluation of handicaps related to voice problems in the context of singing.
Published: 2013
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47. Traffic Profile Based Clustering for Dynamic TDD in Dense Mobile Networks

Author: Paolo Baracca
Subjects: Engineering, Optimization problem, Traffic profile, business.industry, Network packet, 05 social sciences, Traffic variability, Duplex (telecommunications), 050801 communication & media studies, 020206 networking & telecommunications, 02 engineering and technology, Base station, 0508 media and communications, Homogeneous, 0202 electrical engineering, electronic engineering, information engineering, business, Cluster analysis, Computer network
Abstract: The traffic profile of future mobile networks is foreseen as becoming more variable both in time and among base stations (BSs) due to the widespread heterogeneity in applications and services. Dynamic time division duplex (TDD) has been recognized as an important enabler to cope with this traffic variability, especially in dense networks with many BSs and a small number of user equipments (UEs) served by each BS. In this context, one of the main issues is to develop an incisive scheme to manage the BS-to-BS and UE-to- UE interference that arises. In this work, we propose a novel long-term BS clustering scheme that groups BSs that have a similar traffic profile and would be characterized, without clustering, by strong BS-to-BS interference. Due to the complexity of the optimal solution, we propose a heuristic algorithm which solves the optimization problem efficiently. Numerical evaluations in a dense homogeneous pico BS network show that the proposed scheme strongly outperforms even the baseline dynamic TDD without clustering by ensuring a reduction in packet delay of up to 55% and a gain in the UE packet throughput of about 75%.
Published: 2016
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48. Optimization of left ventricular pacing site plus multipoint pacing improves remodeling and clinical response to cardiac resynchronization therapy at 1 year

Author: Domenico Pacetta, Luca Conte, Gianni Pastore, Daniela Lanza, Chiara Fraccaro, Frits W. Prinzen, Franco Noventa, Loris Roncon, Claudio Picariello, Lina Marcantoni, Francesco Zanon, Enrico Baracca, Nima Badie, Silvio Aggio, RS: CARIM - R2.08 - Electro mechanics, and Fysiologie
Subjects: Male, medicine.medical_specialty, Time Factors, Haemodynamic response, medicine.medical_treatment, Heart Ventricles, Cardiac resynchronization therapy, Hemodynamics, Heart failure, 030204 cardiovascular system & hematology, Multipoint pacing, Ventricular Function, Left, 03 medical and health sciences, Electrocardiography, Hemodynamic response, 0302 clinical medicine, Internal medicine, Physiology (medical), medicine, Humans, 030212 general & internal medicine, Electrical delay, Ventricular remodeling, Lead (electronics), Aged, Retrospective Studies, medicine.diagnostic_test, Ventricular Remodeling, business.industry, Left ventricular pacing, Retrospective cohort study, medicine.disease, Treatment Outcome, Echocardiography, Cardiology, Female, business, Cardiology and Cardiovascular Medicine, Follow-Up Studies
Abstract: Background Approximately one-third of the patients with heart failure (HF) treated with cardiac resynchronization therapy (CRT) fail to respond. Positioning the left ventricular (LV) pacing lead in the area of the latest electrical delay may improve the response to CRT. Multipoint pacing (MPP) of the LV has been shown to improve the acute hemodynamic response. Objective The purpose of this study was to test the hypothesis that patients treated with MPP in whom LV pacing location is optimized have better long-term clinical outcomes than do patients treated with conventional CRT. Methods We evaluated the echocardiographic and clinical response of 110 patients with HF treated for nearly 1 year with either conventional CRT (standard [STD] group, n=54, 49%), CRT with hemodynamic and electrical optimization of the LV pacing site (optimized [OPT] group, n=36, 33%), or OPT combined with MPP (OPT + MPP group, n=20, 18%). Responders were classified in terms of reduction in end-systolic volume index ≥15%, reduction in New York Heart Association (NYHA) class ≥1, and Packer score variation (NYHA response with no HF-related hospitalization events or death). Results In STD, OPT, and OPT + MPP groups, 56%, 72%, and 90% of patients, respectively, were end-systolic volume index responders ( P = .004) and 67%, 78%, and 95% were NYHA class responders ( P = .012); 59%, 67%, and 90% of patients exhibited a 1-year Packer score of 0 ( P = .018). These trends remained significant after adjustment for confounding factors by multivariate logistic analysis. Conclusion Combining MPP with optimal positioning of the LV lead on the basis of electrical delay and hemodynamics enhances reverse remodeling and improves clinical outcomes beyond the effect due to conventional CRT.
Published: 2016

49. On OFDM and SC-FDE Transmissions in Millimeter Wave Channels with Beamforming

Author: Meng Wu, Paolo Baracca, Volker Braun, Dirk Wubben, Armin Dekorsy, and Hardy Halbauer
Subjects: Beamforming, Engineering, Minimum mean square error, Orthogonal frequency-division multiplexing, business.industry, 0208 environmental biotechnology, Electrical engineering, Equalization (audio), 020206 networking & telecommunications, 02 engineering and technology, Precoding, 020801 environmental engineering, Delay spread, 0202 electrical engineering, electronic engineering, information engineering, Electronic engineering, SC-FDE, business, Communication channel
Abstract: The air interface for millimeter wave (mmWave) communications must be designed by properly taking into account the specific characteristics of the wireless channel at higher frequencies. In this work, we start by considering a channel model recently proposed in the literature for mmWave communications in outdoor urban scenarios. First, on top of this channel model we implement a sectorized beamforming model necessary to compensate the large path-loss at mmWave range and study how channel statistics, namely, delay spread and angle spread, are influenced by employing different beamwidths. Subsequently, adopting this beamforming model in the mmWave channel, orthogonal frequency division multiplexing (OFDM) and single carrier frequency domain equalization (SC-FDE) systems are compared. Extensive link level simulations are performed by considering different beamwidths, line-of-sight (LOS) coverage and channel coding. Numerical results show that SC-FDE using minimum mean square error (MMSE) equalization performs close to OFDM in coded systems. However, SC-FDE might be beneficial in practice due to much lower peak to average power ratio (PAPR) than OFDM.
Published: 2016
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50. Valsartan for prevention of recurrent atrial fibrillation

Author: GISSI AF Investigators, Disertori M, Latini R, Barlera S, Franzosi MG, Staszewsky L, Maggioni AP, Lucci D, Di Pasquale G, Tognoni G, Delise P, Bertocchi F, Maiocchi G, Geraci E, Correale E, Lombardi F, Mugelli A, Urso R, Scardi S, Fabbri G, Bartolomei B, Barbato G, Carbonieri E, Ciricugno S, Cosmi F, Pratola C, Rossi MG, Sciarra L, Zeni P, Ceseri M, Atzori A, Bambi F, Baviera M, Bianchini F, Fenicia E, Gianfriddo M, Lonardo G, Luise A, Nota R, Orlando ME, Petrolo R, Pierattini C, Pierota V, Ragno A, Serio C, Tafi A, Tellaroli E, Masson S, Vago T, Gramenzi S, Orso F, Suliman I, Nicolis E, Casola C, Dall'Osso D, Gorini M, Bianchini E, Cabiddu S, Cangioli I, Carnaghi A, Cipressa ML, Cipressa L, Galbiati L, Lorimer A, Priami P, Moccetti T, Vaghi F, Capello AF, Rossetti G, Viada E, Morena L, Delucchi M, Reynaud SG, Allemano P, Massobrio N, Gavazzi A, Taddei F, Mor DA, Bortolini F, Lorini M, Inama G, Durin O, Pirelli S, Spotti A, Procopio R, Cuzzucrea D, Gentile G, Margonato A, Bassanelli G, Tavazzi L, Buzzi MP, Rordorf R, Gualco A, Opasich C, Gronda E, Genovese L, Mattioli R, Donatelli F, Uriarte JA, Rauhe W, Bertagnolli C, Canestrini S, Stefenelli C, Cioffi G, Giovanelli C, Rigatelli G, Boni S, Pasini A, Sitta N, Sacchetta A, Borgese L, Sciascia R, Targa L, Raviele A, Madalosso M, Bertaglia E, Zoppo FC, Capanna M, Fiorencis R, Baracca E, Rossi R, Rossi I, Trappolin R, Morgera T, Barducci E, Baldin MG, Gobbo G, Zardo F, Hrovatin E, Mos L, Vriz O, Sinagra G, Aleksova A, Mazzone C, Fresco C, Rubartelli P, Moroni LA, Camerieri A, Piana M, Mureddu R, Bertoli D, Petacchi R, Pancaldi LG, Gabrieli L, Urbinati S, Pedone C, Di Niro M, Brunelli A, Bosi S, Censi S, Moruzzi P, Pastori P, Modena MG, Malavasi V, Mezzetti M, Melandri F, Zuppiroli A, Fazi A, Testa R, Venturini E, Mazzinghi F, Cosmi D, Santoro GM, Minneci C, Galli M, Paperini L, Bovenzi FM, Cortigiani L, Cocchieri M, Severini D, Arcuri GM, Bagliani G, Bernardinangeli M, Proietti G, Bocconcelli P, Pierantozzi A, Monti F, Giamundo L, Tancredi P, Rossini E, Bianchi C, Bettiol F, Giovannini E, Fera MS, Santini M, Bianconi L, Boccanelli A, Morosetti P, Volpe M, Facciolo C, Vacri A, Romanazzi F, Napoletano C, Piccioni LL, Candelmo F, De Marco G, Arnese MR, Vetrano A, Prinzi D, De Rosa P, Capuano V, Torre S, D'Onofrio A, Ammendola E, Battista R, De Fusco A, Molero U, Iervoglini A, Stefanelli S, Fattore L, Bosco B, Liguori A, Padula G, De Luca I, Sorino M, Colonna P, D'Agostino C, Pierfelice O, Pettinati G, Muscella A, De Lorenzi E, Falco M, Giannattasio C, Baldi N, Clemente MA, D'Alessandro B, Truncellito L, Arabia F, Ciconte VA, Perticone F, Ruberto C, Buffon A, Tomaselli C, De Rosa F, Mazza S, Zampaglione G, Pirozzi AM, Butera A, Levato M, Musacchio D, Polimeni RM, Lacquaniti V, Pulitanò G, Ruggeri A, Provenzano A, Cuccurullo O, Musolino M, Marrari A, Anastasio L, Schiavello M, Comito MG, Gulizia MM, Francese GM, Vasquez L, Coppolino C, Casale A, D'Urso G, Oliva G, Giordano U, Andolina S, Sanfilippo N, Ingrillì F, Accardo S, Grasso S, Buffa L, Serra E., CHIARIELLO, MASSIMO, PERRONE FILARDI, PASQUALE, Delise, P., Bertocchi, F., Maiocchi, G., Geraci, E., Correale, E., Lombardi, F., Mugelli, A., Urso, R., Scardi, S., Fabbri, G., Bartolomei, B., Barbato, G., Carbonieri, E., Ciricugno, S., Cosmi, F., Pratola, C., Rossi, M. G., Sciarra, L., Zeni, P., Ceseri, M., Atzori, A., Bambi, F., Baviera, M., Bianchini, F., Fenicia, E., Gianfriddo, M., Lonardo, G., Luise, A., Nota, R., Orlando, M. E., Petrolo, R., Pierattini, C., Pierota, V., Ragno, A., Serio, C., Tafi, A., Tellaroli, E., Masson, S., Vago, T., Gramenzi, S., Orso, F., Suliman, I., Nicolis, E., Casola, C., Dall'Osso, D., Gorini, M., Bianchini, E., Cabiddu, S., Cangioli, I., Carnaghi, A., Cipressa, M. L., Cipressa, L., Galbiati, L., Lorimer, A., Priami, P., Moccetti, T., Vaghi, F., Capello, A. F., Rossetti, G., Viada, E., Morena, L., Delucchi, M., Reynaud, S. G., Allemano, P., Massobrio, N., Gavazzi, A., Taddei, F., Mor, D. A., Bortolini, F., Lorini, M., Inama, G., Durin, O., Pirelli, S., Spotti, A., Procopio, R., Cuzzucrea, D., Gentile, G., Margonato, A., Bassanelli, G., Tavazzi, L., Buzzi, M. P., Rordorf, R., Gualco, A., Opasich, C., Gronda, E., Genovese, L., Mattioli, R., Donatelli, F., Uriarte, J. A., Rauhe, W., Bertagnolli, C., Canestrini, S., Stefenelli, C., Cioffi, G., Giovanelli, C., Rigatelli, G., Boni, S., Pasini, A., Sitta, N., Sacchetta, A., Borgese, L., Sciascia, R., Targa, L., Raviele, A., Madalosso, M., Bertaglia, E., Zoppo, F. C., Capanna, M., Fiorencis, R., Baracca, E., Rossi, R., Rossi, I., Trappolin, R., Morgera, T., Barducci, E., Baldin, M. G., Gobbo, G., Zardo, F., Hrovatin, E., Mos, L., Vriz, O., Sinagra, G., Aleksova, A., Mazzone, C., Fresco, C., Rubartelli, P., Moroni, L. A., Camerieri, A., Piana, M., Mureddu, R., Bertoli, D., Petacchi, R., Pancaldi, L. G., Gabrieli, L., Urbinati, S., Pedone, C., Di Niro, M., Brunelli, A., Bosi, S., Censi, S., Moruzzi, P., Pastori, P., Modena, M. G., Malavasi, V., Mezzetti, M., Melandri, F., Zuppiroli, A., Fazi, A., Testa, R., Venturini, E., Mazzinghi, F., Cosmi, D., Santoro, G. M., Minneci, C., Galli, M., Paperini, L., Bovenzi, F. M., Cortigiani, L., Cocchieri, M., Severini, D., Arcuri, G. M., Bagliani, G., Bernardinangeli, M., Proietti, G., Bocconcelli, P., Pierantozzi, A., Monti, F., Giamundo, L., Tancredi, P., Rossini, E., Bianchi, C., Bettiol, F., Giovannini, E., Fera, M. S., Santini, M., Bianconi, L., Boccanelli, A., Morosetti, P., Volpe, M., Facciolo, C., Vacri, A., Romanazzi, F., Napoletano, C., Piccioni, L. L., Candelmo, F., De Marco, G., Arnese, M. R., Vetrano, A., Prinzi, D., De Rosa, P., Capuano, V., Torre, S., D'Onofrio, A., Ammendola, E., Chiariello, M., Filardi, Pp., Battista, R., De Fusco, A., Molero, U., Iervoglini, A., Stefanelli, S., Fattore, L., Bosco, B., Liguori, A., Padula, G., De Luca, I., Sorino, M., Colonna, P., D'Agostino, C., Pierfelice, O., Pettinati, G., Muscella, A., De Lorenzi, E., Falco, M., Giannattasio, C., Baldi, N., Clemente, M. A., D'Alessandro, B., Truncellito, L., Arabia, F., Ciconte, V. A., Perticone, F., Ruberto, C., Buffon, A., Tomaselli, C., De Rosa, F., Mazza, S., Zampaglione, G., Pirozzi, A. M., Butera, A., Levato, M., Musacchio, D., Polimeni, R. M., Lacquaniti, V., Pulitano, G., Ruggeri, A., Provenzano, A., Cuccurullo, O., Musolino, M., Marrari, A., Anastasio, L., Schiavello, M., Comito, M. G., Gulizia, M. M., Francese, G. M., Vasquez, L., Coppolino, C., Casale, A., D'Urso, G., Oliva, G., Giordano, U., Andolina, S., Sanfilippo, N., Ingrilli, F., Accardo, S., Grasso, S., Buffa, L., Serra, E., Disertori, Marcello, Latini, Roberto, Barlera, Simona, Franzosi, Maria Grazia, Staszewsky, Lidia, Maggioni, Aldo Pietro, Lucci, Donata, Di Pasquale, Giuseppe, Tognoni, Gianni, GISSI AF, Investigator, Disertori, M, Latini, R, Barlera, S, Franzosi, Mg, Staszewsky, L, Maggioni, Ap, Lucci, D, Di Pasquale, G, Tognoni, G, Delise, P, Bertocchi, F, Maiocchi, G, Geraci, E, Correale, E, Lombardi, F, Mugelli, A, Urso, R, Scardi, S, Fabbri, G, Bartolomei, B, Barbato, G, Carbonieri, E, Ciricugno, S, Cosmi, F, Pratola, C, Rossi, Mg, Sciarra, L, Zeni, P, Ceseri, M, Atzori, A, Bambi, F, Baviera, M, Bianchini, F, Fenicia, E, Gianfriddo, M, Lonardo, G, Luise, A, Nota, R, Orlando, Me, Petrolo, R, Pierattini, C, Pierota, V, Ragno, A, Serio, C, Tafi, A, Tellaroli, E, Masson, S, Vago, T, Gramenzi, S, Orso, F, Suliman, I, Nicolis, E, Casola, C, Dall'Osso, D, Gorini, M, Bianchini, E, Cabiddu, S, Cangioli, I, Carnaghi, A, Cipressa, Ml, Cipressa, L, Galbiati, L, Lorimer, A, Priami, P, Moccetti, T, Vaghi, F, Capello, Af, Rossetti, G, Viada, E, Morena, L, Delucchi, M, Reynaud, Sg, Allemano, P, Massobrio, N, Gavazzi, A, Taddei, F, Mor, Da, Bortolini, F, Lorini, M, Inama, G, Durin, O, Pirelli, S, Spotti, A, Procopio, R, Cuzzucrea, D, Gentile, G, Margonato, A, Bassanelli, G, Tavazzi, L, Buzzi, Mp, Rordorf, R, Gualco, A, Opasich, C, Gronda, E, Genovese, L, Mattioli, R, Donatelli, F, Uriarte, Ja, Rauhe, W, Bertagnolli, C, Canestrini, S, Stefenelli, C, Cioffi, G, Giovanelli, C, Rigatelli, G, Boni, S, Pasini, A, Sitta, N, Sacchetta, A, Borgese, L, Sciascia, R, Targa, L, Raviele, A, Madalosso, M, Bertaglia, E, Zoppo, Fc, Capanna, M, Fiorencis, R, Baracca, E, Rossi, R, Rossi, I, Trappolin, R, Morgera, T, Barducci, E, Baldin, Mg, Gobbo, G, Zardo, F, Hrovatin, E, Mos, L, Vriz, O, Sinagra, G, Aleksova, A, Mazzone, C, Fresco, C, Rubartelli, P, Moroni, La, Camerieri, A, Piana, M, Mureddu, R, Bertoli, D, Petacchi, R, Pancaldi, Lg, Gabrieli, L, Urbinati, S, Pedone, C, Di Niro, M, Brunelli, A, Bosi, S, Censi, S, Moruzzi, P, Pastori, P, Modena, Mg, Malavasi, V, Mezzetti, M, Melandri, F, Zuppiroli, A, Fazi, A, Testa, R, Venturini, E, Mazzinghi, F, Cosmi, D, Santoro, Gm, Minneci, C, Galli, M, Paperini, L, Bovenzi, Fm, Cortigiani, L, Cocchieri, M, Severini, D, Arcuri, Gm, Bagliani, G, Bernardinangeli, M, Proietti, G, Bocconcelli, P, Pierantozzi, A, Monti, F, Giamundo, L, Tancredi, P, Rossini, E, Bianchi, C, Bettiol, F, Giovannini, E, Fera, M, Santini, M, Bianconi, L, Boccanelli, A, Morosetti, P, Volpe, M, Facciolo, C, Vacri, A, Romanazzi, F, Napoletano, C, Piccioni, Ll, Candelmo, F, De Marco, G, Arnese, Mr, Vetrano, A, Prinzi, D, De Rosa, P, Capuano, V, Torre, S, D'Onofrio, A, Ammendola, E, Chiariello, Massimo, PERRONE FILARDI, Pasquale, Battista, R, De Fusco, A, Molero, U, Iervoglini, A, Stefanelli, S, Fattore, L, Bosco, B, Liguori, A, Padula, G, De Luca, I, Sorino, M, Colonna, P, D'Agostino, C, Pierfelice, O, Pettinati, G, Muscella, A, De Lorenzi, E, Falco, M, Giannattasio, C, Baldi, N, Clemente, Ma, D'Alessandro, B, Truncellito, L, Arabia, F, Ciconte, Va, Perticone, F, Ruberto, C, Buffon, A, Tomaselli, C, De Rosa, F, Mazza, S, Zampaglione, G, Pirozzi, Am, Butera, A, Levato, M, Musacchio, D, Polimeni, Rm, Lacquaniti, V, Pulitanò, G, Ruggeri, A, Provenzano, A, Cuccurullo, O, Musolino, M, Marrari, A, Anastasio, L, Schiavello, M, Comito, Mg, Gulizia, Mm, Francese, Gm, Vasquez, L, Coppolino, C, Casale, A, D'Urso, G, Oliva, G, Giordano, U, Andolina, S, Sanfilippo, N, Ingrillì, F, Accardo, S, Grasso, S, and Buffa, L
Subjects: Male, medicine.medical_specialty, medicine.medical_treatment, Tetrazoles, Cardiomegaly, Comorbidity, Placebo, Cardioversion, Double-Blind Method, Recurrence, Multicenter trial, Internal medicine, Angiotensin II Type 1 Receptor Blocker, Cardiovascular Disease, Atrial Fibrillation, medicine, Left atrial enlargement, Diabetes Mellitus, Humans, Sinus rhythm, cardiovascular diseases, Prospective Studies, Tetrazole, Proportional Hazards Models, Aged, business.industry, Medicine (all), Hazard ratio, Atrial fibrillation, Diabetes Mellitu, Valine, General Medicine, Middle Aged, medicine.disease, valsartan, atrial fibrillation, Prospective Studie, Valsartan, Cardiovascular Diseases, cardiovascular system, Cardiology, Proportional Hazards Model, Female, business, Angiotensin II Type 1 Receptor Blockers, medicine.drug, Human
Abstract: BACKGROUND: Atrial fibrillation is the most common cardiac arrhythmia, and no current therapy is ideal for control of this condition. Experimental studies suggest that angiotensin II-receptor blockers (ARBs) can influence atrial remodeling, and some clinical studies suggest that they may prevent atrial fibrillation. METHODS: We conducted a large, randomized, prospective, placebo-controlled, multicenter trial to test whether the ARB valsartan could reduce the recurrence of atrial fibrillation. We enrolled patients who were in sinus rhythm but had had either two or more documented episodes of atrial fibrillation in the previous 6 months or successful cardioversion for atrial fibrillation in the previous 2 weeks. To be eligible, patients also had to have underlying cardiovascular disease, diabetes, or left atrial enlargement. Patients were randomly assigned to receive valsartan or placebo. The two primary end points were the time to a first recurrence of atrial fibrillation and the proportion of patients who had more than one recurrence of atrial fibrillation over the course of 1 year. RESULTS: A total of 1442 patients were enrolled in the study. Atrial fibrillation recurred in 371 of the 722 patients (51.4%) in the valsartan group, as compared with 375 of 720 (52.1%) in the placebo group (adjusted hazard ratio, 0.97; 96% confidence interval [CI], 0.83 to 1.14; P = 0.73). More than one episode of atrial fibrillation occurred in 194 of 722 patients (26.9%) in the valsartan group and in 201 of 720 (27.9%) in the placebo group (adjusted odds ratio, 0.89; 99% CI, 0.64 to 1.23; P = 0.34). The results were similar in all predefined subgroups of patients, including those who were not receiving angiotensin-converting-enzyme inhibitors. CONCLUSIONS: Treatment with valsartan was not associated with a reduction in the incidence of recurrent atrial fibrillation. (ClinicalTrials.gov number, NCT00376272.) Copyright © 2009 Massachusetts Medical Society.
Published: 2009

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