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The prognosis of children with neuroblastoma (NBL) can be dismal with significant variations depending on the stage and biology of the tumor. We assessed the event-free (EFS) and overall (OS) survival using harmonized data from three Southern-Eastern European (SEE) countries. Data for 520 incident NBL cases (2009-2018) were collected from Greece, Slovenia and Russia. Kaplan-Meier curves were fitted, and EFS/OS were derived from Cox proportional models by study variables including the protocol-based risk-group (low/observation, intermediate, high). Over one-third of cases were coded in the high-risk group, of which 23 children (4.4%) received treatment with anti-ganglioside 2 (GD2) mAb. Survival rates were inferior in older (OS 5-year; 1.5-4.9 years: 61%; EFS 5-year; 1.5-4.9 years: 48%) compared to children younger than 1.5 years (OS 5-year

Background Despite overall striking advances in survival of childhood liver tumors, outcomes remain poor for specific patient segments. We aimed to assess overall survival (OS) of this rare disease and evaluate the generalizability of prognostic variables included in international collaborative systems using, for the first time, harmonized clinical data from two geographically different cohorts (Greece and Moscow). Methods Data for children (0-14 years) with liver tumors were retrieved from two Southern-Eastern European areas (Greece; 2001-2019 and Moscow; 2012-2019). Kaplan-Meier curves were constructed, and OS values were derived from Cox proportional models controlling for study variables. Results A total of 171 newly diagnosed cases (54.4% males) were included. The OS5-year exceeded 80% in patients Conclusions Outcomes of patients with liver tumors registered in two SEE areas were comparable to those reported by major collaborative trials. Ongoing clinical cancer registration could facilitate comparison of outcomes between different study groups in order to shape state of the art of treatment.

Intracranial dermoid cysts are uncommon lesions with characteristic imaging appearances. Although they are characterized by slow growth rate, they are often associated with serious complications due to the location and pressure of the adjacent structures. Rarely, rupture of dermoid cysts in the CNS can cause a variety of clinical presentation that vary from no symptoms to sudden death. We report a case of spontaneously ruptured intracranial dermoid cyst in a 10-year-old boy, who presented due to daily partial seizures, strabismus, unilateral eyelid drooping, headaches, walking abnormalities and poor school performance, with progressive deterioration in the past two years. Brain MRI was performed, which led to the diagnosis. Partial surgical removal and VP shunting was placed and anticonvulsant therapy was started. Two years after diagnosis, our patient has neurological deficits. Diplopia and eyelid drooping as well as unsteady gait still consist disability. Keywords: Ruptured intracranial cyst, Children, Neurological symptoms