940 results on '"Andrea, Rossi"'
Search Results
2. The PURPLE N study: objective and perceived nutritional status in children and adolescents with cerebral palsy
- Author
-
Andras, Fogarasi, Elisa, Fazzi, Ana R P, Smorenburg, Maria, Mazurkiewicz-Beldzinska, Argirios, Dinopoulos, Alena, Pobiecka, Dea, Schröder-van den Nieuwendijk, Josef, Kraus, Hasan, Tekgül, Maria, Koutsaki, Giovanni, Baranello, Simona, Bertoli, Elisa, Caramaschi, Duccio Maria, Cordelli, Ramona, De Amicis, Maria Luisa, Forchielli, Azzurra, Guerra, Althea, Lividini, Maddalena, Marchiò, Andrea, Rossi, Dea Schröder-van den, Nieuwendijk, Jędrzej, Fliciński, Barbara, Gurda, Anna, Lemska, Agnieszka, Matheisel, Zuzanna, Niwinska, Małgorzata, Pawłowicz, Agnieszka, Sawicka, Barbara, Steinborn, Marta, Szmuda, Anna, Winczewska-Wiktor, Marta, Zawadzka, Ebru, Arhan, Kursad, Aydin, Erhan, Bayram, Kursat Bora, Carman, Pinar, Edem, Deniz, Ertem, Özben Akıncı, Goktas, Serdal, Gungor, Goknur, Haliloglu, Aydan, Kansu, Mustafa, Kömür, Akmer, Mutlu, Ceyda Tuna, Kırsaçlıoğlu, Çetin, Okuyaz, Bilge, Özgör, Yesim, Ozturk, Safiye Gunes, Sager, Esra, Sarıgeçili, Mukadder Ayse, Selimoglu, Hepsen Mine Öztürk, Serin, Serap Tıraş, Teber, Gülten, Thomas, Dilsad, Turkdogan, Burcu, Volkan, Coşkun, Yarar, Sanem Keskin, Yilmaz, Fogarasi A., Fazzi E., Smorenburg A.R.P., Mazurkiewicz-Beldzinska M., Dinopoulos A., Pobiecka A., Schroder-van den Nieuwendijk D., Kraus J., Tekgul H, and the PUrple study group Giovanni Baranello, Simona Bertoli, Elisa Caramaschi, Duccio Maria Cordelli, Ramona De Amici, Maria Luisa Forchielli, Azzurra Guerra, Althea Lividini, Maddalena Marchi, Andrea Rossi, Dea Schr€oder-van den Nieuwendijk, JeR drzej Flicinsk, Barbara Gurda, Anna Lemska, Agnieszka Matheisel, Maria Mazurkiewicz-Beldzinska, Zuzanna Niwinska, Małgorzata Pawłowicz, Agnieszka Sawicka, Barbara Steinborn, Marta Szmuda, Anna Winczewska-Wiktor, Marta Zawadzka: Alena Pobiecka, Ebru Arhan, Erhan Bayram, Eskis ehir Osmangazi, Pinar Edem, Deniz Ertem, €Ozben Akı ncı Gokta, Serdal Gungor, Goknur Haliloglu, Aydan Kansu, Mustafa K€om€ur, Akmer Mutlu, Ceyda Tuna Kırsac lıoglu, Cetin Okuyaz, Bilge €Ozg€or, Yesim Ozturk, Safiye Gunes Sagel, Esra Sarıgec ili, Mukadder Ayse Selimoglu, Hepsen Mine €Ozt€urk, Serap Tı ras Teber, Hasan Tekg€ul, G€ulten Thoma, Dilsad Turkdogan, Burcu Volkan, Coskun Yarar, and Sanem Keskin Yilmaz.
- Subjects
Gerontology ,Body-Composition ,System ,Referral ,genetic structures ,Adolescent ,Physical-Activity ,Cerebral palsy ,concerns ,feeding ,nutrition ,perceived nutritional status ,medicine.medical_treatment ,Nutritional Status ,Growth ,Continuous variable ,Gross Motor Function ,Surveys and Questionnaires ,medicine ,Humans ,Child ,Ability ,Rehabilitation ,business.industry ,Malnutrition ,People ,Gross Motor Function Classification System ,Nutritional status ,Anthropometry ,medicine.disease ,Reliability ,Preschool-Aged Children ,Clinical trial ,Caregivers ,concern ,business ,Classify - Abstract
Purpose: To obtain information on characteristics, management, current objective nutritional status and perception of nutritional status of children with cerebral palsy (CP) from healthcare professionals (HCPs) and caregivers. Materials and methods: A detailed survey of several items on eight main topics (general characteristics, motor function, comorbidities, therapies, anthropometry, feeding mode and problems and perceived nutritional status) was developed and tested for the study. Correlation between nutritional status and Gross Motor Function Classification System (GMFCS) levels was assessed using continuous variables (Z-scores for weight-for-age, height-for-age, weight-for-height, and body mass index-for-age), and categorical variables (being malnourished, stunted, or wasted). HCP and caregiver perceptions of the child's nutritional status as well as agreement between perceived and objective nutritional status and agreement between perceived nutritional status and concerns about the nutritional status were analyzed. Results: Data were available for 497 participants from eight European countries. Poorer nutritional status was associated with higher (more severe) GMFCS levels. There was minimal agreement between perceived and objective nutritional status, both for HCPs and caregivers. Agreement between HCP and caregiver perceptions of the child's nutritional status was weak (weighted kappa 0.56). However, the concerns about the nutritional status of the child were in line with the perceived nutritional status. Conclusions: The risk of poor nutritional status is associated with more severe disability in children and adolescents with CP. There is a mismatch between HCP and caregiver perceptions of participants' nutritional status as well as between subjective and objective nutritional status. Our data warrant the use of a simple and objective screening tool in daily practice to determine nutritional status in children and adolescents with CP., Danone Nutricia Research, Utrecht, the Netherlands; Nutricia Advanced Medical Nutrition in Czech Republic; Nutricia Advanced Medical Nutrition in Greece; Nutricia Advanced Medical Nutrition in Hungary; Nutricia Advanced Medical Nutrition in Italy; Nutricia Advanced Medical Nutrition in Poland; Nutricia Advanced Medical Nutrition in Slovakia; Nutricia Advanced Medical Nutrition in The Netherlands; Nutricia Advanced Medical Nutrition in Turkey; Danone Nutricia Research, This study was sponsored by Danone Nutricia Research, Utrecht, the Netherlands. Local financial support was provided by the local business units of Nutricia Advanced Medical Nutrition in Czech Republic, Greece, Hungary, Italy, Poland, Slovakia, The Netherlands, and Turkey. Medical writing support was provided by Tim Kelly, Medi-Kelsey Limited, funded by Danone Nutricia Research.
- Published
- 2022
3. External ventricular drainage for posthemorrhagic ventricular dilatation in preterm infants: insights on efficacy and failure
- Author
-
Alessandro Parodi, Laura Costanza De Angelis, Giuseppe Marcello Ravegnani, Domenico Tortora, Marianna Sebastiani, Mariasavina Severino, Diego Minghetti, Andrea Rossi, Alessandro Consales, Gianluca Piatelli, Armando Cama, Luca A Ramenghi, and Mariya Malova
- Subjects
Male ,Intracerebral hemorrhage ,medicine.medical_specialty ,Catheter insertion ,business.industry ,Birth weight ,Infant, Newborn ,Gestational age ,General Medicine ,medicine.disease ,Ventriculoperitoneal Shunt ,Treatment Outcome ,Intraventricular hemorrhage ,Internal medicine ,Cohort ,Cerebrospinal fluid diversion ,medicine ,Cardiology ,Humans ,Female ,business ,Infant, Premature ,Cerebral Hemorrhage ,Retrospective Studies ,External ventricular drain - Abstract
OBJECTIVE The objective of this study was to describe the clinical and neuroradiological characteristics of a cohort of preterm infants who had undergone external ventricular drain insertion as a temporary measure to treat posthemorrhagic ventricular dilatation. In addition, the authors investigated the factors predicting permanent shunt dependency. METHODS The authors retrospectively reviewed the medical records of a cohort of preterm infants who had undergone external ventricular drain insertion at Gaslini Children’s Hospital (Genoa, Italy) between March 2012 and February 2018. They also analyzed clinical characteristics and magnetic resonance imaging data, including diffusion- and susceptibility-weighted imaging studies, which were obtained before both catheter insertion and removal. RESULTS Twenty-eight infants were included in the study. The mean gestational age was 28.2 ± 2.7 weeks, and the mean birth weight was 1209 ± 476 g. A permanent ventriculoperitoneal shunt was inserted in 15/28 (53.6%) infants because of the failure of external ventricular drainage as a temporary treatment option. Compared with the shunt-free group, the shunt-dependent group had a significantly lower gestational age (29.3 ± 2.3 vs 27.2 ± 2.7 weeks, p = 0.035) and tended toward a lower birth weight (p = 0.056). None of the clinical and neuroradiological characteristics significantly differed between the shunt-free and shunt-dependent groups at the time of catheter insertion. As expected, ventricular parameters as well as the intraventricular extension of intracerebral hemorrhage, as assessed using the intraventricular hemorrhage score, were reportedly higher in the shunt-dependent group than in the shunt-free group before catheter removal. CONCLUSIONS External ventricular drainage is a reliable first-line treatment for posthemorrhagic hydrocephalus. However, predicting its efficacy as a unique treatment remains challenging. A lower gestational age is associated with a higher risk of posthemorrhagic hydrocephalus progression, suggesting that the more undeveloped the mechanisms for the clearance of blood degradation products, the greater the risk of requiring permanent cerebrospinal fluid diversion, although sophisticated MRI investigations are currently unable to corroborate this hypothesis.
- Published
- 2021
4. Clinical impact of mitral regurgitation in aortic valve stenosis: Insight from effective regurgitant orifice area
- Author
-
Giovanni Benfari, Stefano Nistri, Andrea Rossi, Flavio Ribichini, and Caterina Maffeis
- Subjects
medicine.medical_specialty ,Population ,heart failure ,aortic valve stenosis ,Effective Regurgitant Orifice Area ,Severity of Illness Index ,Ventricular Function, Left ,Afterload ,Mitral valve ,Internal medicine ,medicine ,Humans ,echocardiography ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,education ,education.field_of_study ,Mitral regurgitation ,Ejection fraction ,business.industry ,Mitral Valve Insufficiency ,Stroke Volume ,Stroke volume ,medicine.disease ,medicine.anatomical_structure ,Aortic valve stenosis ,cardiovascular system ,Cardiology ,Mitral Valve ,mitral regurgitation ,Cardiology and Cardiovascular Medicine ,business - Abstract
PURPOSE Mechanisms leading to heart failure (HF) symptoms in aortic valve stenosis (AS) are contentious. We examined the impact of secondary mitral regurgitation (MR) on the symptomatic status in patients with AS. METHODS Outpatients performing echocardiography with any degree of AS, without organic mitral valve disease, mitral valve intervention, or aortic insufficiency were enrolled. MR was quantitatively defined through mitral effective regurgitant orifice area (EROA) using the proximal isovelocity surface area method. Patients were divided into two groups (New York Heart Association [NYHA] class I-II vs. NYHA class III-IV). RESULTS Five hundred and eighty-four patients were enrolled (484 NYHA I-II, 100 NYHA III-IV). More symptomatic patients had smaller aortic valve area (AVA), lower left ventricular ejection fraction (LVEF) and stroke volume, higher E/E', and LV global afterload. MR was present in 178 (30%) patients and EROA was
- Published
- 2021
5. Relationships between subendocardial perfusion impairment, arterial stiffness and orthostatic hypotension in hospitalized elderly individuals
- Author
-
Giulia Amadio, Francesco Fantin, Anna Giani, Elena Zoico, Andrea Rossi, Gloria Mazzali, Mauro Zamboni, and Federica Macchi
- Subjects
medicine.medical_specialty ,Mean arterial pressure ,Physiology ,Renal function ,Blood Pressure ,Orthostatic hypotension, SEVR, PWV ,Pulse Wave Analysis ,Hypotension, Orthostatic ,Orthostatic vital signs ,Vascular Stiffness ,Internal medicine ,Heart rate ,Internal Medicine ,medicine ,Humans ,Pulse wave velocity ,Aged ,Aged, 80 and over ,PWV ,Orthostatic hypotension ,business.industry ,Odds ratio ,medicine.disease ,SEVR ,Perfusion ,Blood pressure ,Arterial stiffness ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Orthostatic hypotension is an independent risk factor for cardiovascular morbidity and mortality. Arterial stiffness has been shown to be a pathophysiological mechanism linking orthostatic hypotension and increased cardiovascular risk. This study aims to evaluate the relationship between arterial stiffness, orthostatic hypotension and subendocardial viability ratio (SEVR) and moreover to identify the main predictors of orthostatic hypotension, carotid-femoral pulse wave velocity (PWV-cf) and SEVR. Methods Seventy-five patients were enrolled (mean age 82.95 ± 6.45) in Verona's AOUI Geriatric ward. They underwent blood pressure, heart rate, body weight measurements and also comorbidity, arterial stiffness (PWV-cf measured by applanation tonometry), SEVR and biochemical indexes. Results Prevalence of orthostatic hypotension was 46.6%. Even after adjustment for age, sex, glomerular filtration rate and mean arterial pressure, SEVR values corrected for arterial oxygen and haemoglobin content were statistically lower in orthostatic hypotension patients (P = 0.05) and PWV-cf values were statistically higher in orthostatic hypotension individuals (P = 0.042). In a binary logistic regression, PWV-cf was the only significant predictor of orthostatic hypotension (odds ratio 1.123; P = 0.039; confidence interval = 1.006--1.17).In a backward logistic regression model sex, creatinine clearance and orthostatic hypotension were significant predictors of SEVR corrected for O2 content. Mean arterial pressure, creatinine clearance and orthostatic hypotension were significant predictors of PWV-cf. Conclusion This study shows that orthostatic hypotension is related to increased arterial stiffness, confirming its higher prevalence in elderly patients. Orthostatic hypotension was also associated with reduced values of corrected SEVR, showing a relevant consequence of orthostatic hypotension on subendocardial perfusion impairment.
- Published
- 2021
6. What Do Mutual Fund Investors Really Care About?
- Author
-
Andrea Rossi, Yang Song, Itzhak Ben-David, and Jiacui Li
- Subjects
Economics and Econometrics ,business.industry ,Financial economics ,Accounting ,Capital (economics) ,Systematic risk ,Economics ,Capital asset pricing model ,Risk factor (finance) ,business ,Finance ,Mutual fund - Abstract
Rational investors should account for risk factor exposure when allocating capital to mutual funds. Two recent influential studies use mutual fund flows to test whether investors distinguish between performance driven by managers' skill and systematic risk factors. Both studies found that investors use the Capital Asset Pricing Model (CAPM), and one concluded that the CAPM is the "closest to the true asset pricing model." We re-examine these results and show that, in fact, fund flow data are most consistent with investors relying blindly on fund rankings (specifically, Morningstar ratings) and chasing recent returns. We find no evidence that investors account for any of the common systematic risk factors when allocating capital among mutual funds.
- Published
- 2021
7. Upfront intensive chemo-immunotherapy with autograft in 199 adult mantle cell lymphoma patients: prolonged survival and cure potentiality at long term
- Author
-
Andrea Rossi, Corrado Tarella, Paolo Corradini, Anna Maria Barbui, Andrea Evangelista, Umberto Vitolo, Simone Ferrero, Claudia Castellino, Alessandro Massimo Gianni, Sergio Cortelazzo, Liliana Devizzi, Caterina Patti, Andrés J.M. Ferreri, Paolo Nicoli, Luigi Rigacci, Michele Magni, Michael Mian, Alessandro Costa, Marco Ladetto, Alessandro Rambaldi, Annalisa Chiappella, and Fabio Benedetti
- Subjects
Oncology ,Adult ,Transplantation ,medicine.medical_specialty ,business.industry ,Stem-cell therapies ,Hematology ,Lymphoma, Mantle-Cell ,medicine.disease ,Combined Modality Therapy ,Transplantation, Autologous ,Stem-cell research ,Risk factors ,Internal medicine ,Correspondence ,Antineoplastic Combined Chemotherapy Protocols ,Medicine ,Humans ,Mantle cell lymphoma ,Immunotherapy ,business ,Autografts ,Chemo immunotherapy - Published
- 2021
8. Focal status and acute encephalopathy in a 13-year-old boy with de novo DNM1L mutation: Video-polygraphic pattern and clues for differential diagnosis
- Author
-
Lino Nobili, Francesca Febbo, Tiziana Granata, Claudia Nesti, Filippo M. Santorelli, Gianvittorio Luria, Andrea Rossi, Gianluca Marucci, Silvia Buratti, Maria Margherita Mancardi, Thea Giacomini, Laura Siri, Elisabetta Lampugnani, Ramona Cordani, and Alessandro Consales
- Subjects
Rasmussen encephalitis ,Pediatrics ,medicine.medical_specialty ,Encephalopathy ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,Developmental Neuroscience ,Acute mitochondrial encephalopathy ,Autoimmune encephalitis ,Focal myoclonic jerks ,Super refractory status epilepticus ,Medicine ,Missense mutation ,Genetic testing ,Coma ,Mutation ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Phenotype ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,medicine.symptom ,Differential diagnosis ,business ,030217 neurology & neurosurgery - Abstract
Background Pathogenic variants in the dynamin 1 like gene are related to abnormal mitochondrial dynamics and distributions and are associated to variable clinical phenotypes. A few patients harboring the p.Arg403Cys missense variant appears to be different from the classical, more severe phenotypes, showing sudden onset of drug resistant seizures after a previously normal or slightly delayed development. Case report We report on a boy with abrupt onset of focal status and coma at the age of 13, initially treated as autoimmune encephalitis, with final diagnosis of de novo missense p.Arg403Cys variant in the DNM1L gene. Discussion We compare his clinical, electrophysiological, biochemical, neuroradiological and histopathological picture to the rare cases reported to date and provide diagnostic clues that can help clinicians in differentiate p.Arg403Cys-related phenotype from that of immune-mediated encephalopathies. Conclusion The clinical picture related to p.Arg403Cys mutations should be considered alongside acquired pathologies in the differential diagnosis of young patients with focal refractory epilepsy and encephalopathy, also occurring during late childhood or adolescence. Prompt genetic testing allows to avoid unnecessary treatments and procedures and to better define the prognosis and management strategies.
- Published
- 2021
9. Coexisting Retrocerebellar Arachnoid Cyst and Chiari Type 1 Malformation: 3 Pediatric Cases of Surgical Management Tailored to the Pathogenic Mechanism and Systematic Review of the Literature
- Author
-
Andrea Rossi, Gianluca Piatelli, Alessandro Consales, Marco Pavanello, Margherita Castaldo, Giuseppe Di Perna, and Pietro Fiaschi
- Subjects
Male ,medicine.medical_specialty ,Posterior cranial fossa ,Adolescent ,Ventriculostomy ,03 medical and health sciences ,0302 clinical medicine ,Arachnoid cyst ,medicine ,Humans ,Cyst ,Peritoneal Cavity ,Axis, Cervical Vertebra ,Chiari malformation ,business.industry ,Endoscopic third ventriculostomy ,Infant ,CSF flow ,Decompression, Surgical ,medicine.disease ,Cerebrospinal Fluid Shunts ,Arnold-Chiari Malformation ,Surgery ,Hydrocephalus ,Chiari malformation 1 ,Arachnoid Cysts ,Tonsillar herniation ,medicine.anatomical_structure ,Arachnoid cysts ,Cranial Fossa, Posterior ,030220 oncology & carcinogenesis ,Neuroendoscopy ,Neurology (clinical) ,Subarachnoid space ,business ,030217 neurology & neurosurgery ,Syringomyelia - Abstract
Introduction Arachnoid cysts are benign cerebrospinal fluid collection within a duplication of arachnoid membrane and, when found in the retrocerebellar site, they may be associated with tonsils herniation. This rare situation of coexisting retrocerebellar arachnoid cyst (AC) and Chiari malformation type 1 (CM-1) have been previously reported in few cases (10 patients) with syringomyelia and hydrocephalus described to be the most relevant issues. The aim of this paper is to describe 3 pediatric cases of this condition with a systematic review of the literature, underlining the importance of surgical management tailored to the pathogenic mechanism. Methods A restrospective analysis of patients treated for coexisting CM-1 and ACs at the authors' institution has been carried out. Results A case of a 10-month-old baby with coexisting AC and CM-1 with tri-ventricular hydrocephalus treated with endoscopic third ventriculostomy, a case of a 1-year-old child with a huge retrocerebellar AC and CM-1 treated with a cysto-peritoneal shunt, and a case of a 15-year-old child with retrocerebellar AC causing symptomatic CM-1 treated with C0-C2 decompression, AC fenestration and duraplasty are described. A long-term follow-up is reported. Conclusions Surgical management of coexisting ACs and CM-1 should not aim at the complete resolution of the cyst or of tonsil herniation, especially when pediatric patients are treated. Rather, the purpose of the neurosurgeon should be to understand the underlying pathogenic mechanism, and then restoring both the cerebrospinal fluid flow in the posterior fossa and the dynamic equilibrium between ventricles, cyst, and subarachnoid space.
- Published
- 2021
10. Ganglionic Eminence Anomalies and Coexisting Cerebral Developmental Anomalies on Fetal MR Imaging: Multicenter-Based Review of 60 Cases
- Author
-
Andrea Righini, M. Di Maurizio, Fabio Triulzi, Paul D. Griffiths, Andrea Rossi, Mariasavina Severino, Elisa Scola, Cecilia Parazzini, I. D'Errico, Lorenzo Pinelli, Giovanni Palumbo, and M. Scarabello
- Subjects
Male ,Hemimegalencephaly ,Microcephaly ,Ganglionic eminence ,Unilateral polymicrogyria ,Pediatrics ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,symbols.namesake ,Fetus ,0302 clinical medicine ,Pregnancy ,Prenatal Diagnosis ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Fisher's exact test ,Retrospective Studies ,business.industry ,Macrocephaly ,Brain ,Anatomy ,medicine.disease ,Magnetic Resonance Imaging ,symbols ,Female ,sense organs ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Ventriculomegaly - Abstract
BACKGROUND AND PURPOSE: The ganglionic eminences are transient fetal brain structures that produce a range of neuron types. Ganglionic eminence anomalies have been recognized on fetal MR imaging and anecdotally found in association with a number of neurodevelopmental anomalies. The aim of this exploratory study was to describe and analyze the associations between ganglionic eminence anomalies and coexisting neurodevelopmental anomalies. MATERIALS AND METHODS: This retrospective study includes cases of ganglionic eminence anomalies diagnosed on fetal MR imaging during a 20-year period from 7 centers in Italy and England. Inclusion criteria were cavitation or increased volume of ganglionic eminences on fetal MR imaging. The studies were analyzed for associated cerebral developmental anomalies: abnormal head size and ventriculomegaly, reduced opercularization or gyration, and abnormal transient layering of the developing brain mantle. The results were analyzed using χ(2) and Fisher exact tests. RESULTS: Sixty fetuses met the inclusion criteria (21 females, 24 males, 15 sex unknown). Thirty-four had ganglionic eminence cavitations (29 bilateral and 5 unilateral), and 26 had increased volume of the ganglionic eminences (19 bilateral, 7 unilateral). Bilateral ganglionic eminence cavitations were associated with microcephaly (P = .01), reduced opercularization, (P < .001), reduced gyration (P < .001), and cerebellar anomalies (P = .01). Unilateral ganglionic eminence cavitations were not significantly associated with any particular feature. Bilateral increased volume of the ganglionic eminences showed an association with macrocephaly (P = .03). Unilateral increased volume was associated with macrocephaly (P = .002), abnormal transient layering (P = .001), unilateral polymicrogyria (P = .001), and hemimegalencephaly (P < .001). CONCLUSIONS: Ganglionic eminence anomalies are associated with specific neurodevelopmental anomalies with ganglionic eminence cavitations and increased ganglionic eminence volume apparently having different associated abnormalities.
- Published
- 2021
11. Heart valve calcification and cardiac hemodynamics
- Author
-
Antonella Moreo, Pompilio Faggiano, Nicola Gaibazzi, Andrea Rossi, Silvia Frattini, Monica Beraldi, Pier Luigi Temporelli, Giacomo Faden, Francesco Agostini, Marcella Manicardi, Valentina Lazzarini, Gregg S. Pressman, Giovanna Magni, Gian Francesco Mureddu, Andrea Barbieri, Andrea Erlicher, and Giovanni Benfari
- Subjects
Male ,medicine.medical_specialty ,Population ,Heart Valve Diseases ,Hemodynamics ,030204 cardiovascular system & hematology ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Calcinosis ,Internal medicine ,medicine.artery ,80 and over ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,education ,Aged ,Aged, 80 and over ,education.field_of_study ,Ejection fraction ,heart valve calcification ,business.industry ,diastolic function ,Middle Aged ,medicine.disease ,Heart Valves ,pulmonary artery pressure ,Echocardiography ,Pulmonary artery ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Kidney disease ,Calcification - Abstract
PURPOSE Heart valve calcification (VC) is associated with increased cardiovascular risk, but the hemodynamic and functional profile of patients affected by VC has not been fully explored. METHODS The study population was formed by consecutive unselected patients included in seven echocardiographic laboratories in a 2-week period. A comprehensive echocardiographic examination was performed. VC was defined by the presence of calcification on at least one valve. RESULTS Population was formed of 1098 patients (mean age 65 ± 15 years; 47% female). VC was present in 31% of the overall population. Compared with subjects without VC, VC patients were older (60 ± 14 vs 75 ± 9; P
- Published
- 2021
12. Widening the Neuroimaging Features of Adenosine Deaminase 2 Deficiency
- Author
-
Sara Signa, Carlo Gandolfo, Isabella Ceccherini, Giovanni Conti, Silvana Martino, A.F. Geraldo, R. Ammendola, Andrea Rossi, Antonella Insalaco, Roberta Caorsi, Domenico Tortora, Mariasavina Severino, Marco Gattorno, M Alessio, Serena Pastore, Geraldo, Af, Caorsi, R, Tortora, D, Gandolfo, C, Ammendola, R, Alessio, M, Conti, G, Insalaco, A, Pastore, S, Martino, S, Ceccherini, I, Signa, S, Gattorno, M, Rossi, A, and Severino, M.
- Subjects
Male ,Adenosine Deaminase 2 Deficiency ,Pathology ,medicine.medical_specialty ,Disease onset ,Adolescent ,Adenosine Deaminase ,Neuroimaging ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Basal (phylogenetics) ,0302 clinical medicine ,Agammaglobulinemia ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Family history ,business.industry ,Brain ,Magnetic Resonance Imaging ,Phenotype ,Spinal Cord ,Female ,Severe Combined Immunodeficiency ,Tumor necrosis factor alpha ,Neurology (clinical) ,Genetic diagnosis ,business ,030217 neurology & neurosurgery - Abstract
SUMMARY: Adenosine deaminase 2 deficiency (OMIM #615688) is an autosomal recessive disorder characterized by a wide clinical spectrum, including small- and medium-sized vessel vasculopathies, but data focusing on the associated neuroimaging features are still scarce in the literature. Here, we describe the clinical neuroimaging features of 12 patients with genetically proven adenosine deaminase 2 deficiency (6 males; median age at disease onset, 1.3 years; median age at genetic diagnosis, 15.5 years). Our findings expand the neuroimaging phenotype of this condition demonstrating, in addition to multiple, recurrent brain lacunar ischemic and/or hemorrhagic strokes, spinal infarcts, and intracranial aneurysms, also cerebral microbleeds and a peculiar, likely inflammatory, perivascular tissue in the basal and peripontine cisterns. Together with early clinical onset, positive family history, inflammatory flares and systemic abnormalities, these findings should raise the suspicion of adenosine deaminase 2 deficiency, thus prompting genetic evaluation and institution of tumor necrosis factor inhibitors, with a potential great impact on neurologic outcome.
- Published
- 2021
13. Full characterisation of knee extensors’ function in ageing: effect of sex and obesity
- Author
-
Valentina Muollo, Carlo Capelli, Valentina Cavedon, Mauro Zamboni, Massimo Teso, Andrea Rossi, Silvia Pogliaghi, Chiara Milanese, Federico Schena, and Andrea Zignoli
- Subjects
Male ,Aging ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Isometric exercise ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Internal medicine ,medicine ,sex ,Humans ,Knee ,Muscle Strength ,Obesity ,030212 general & internal medicine ,Muscle, Skeletal ,Normal range ,Aged ,Aged, 80 and over ,Leg ,Nutrition and Dietetics ,Anthropometry ,Knee extensors ,muscle function ,business.industry ,medicine.disease ,Endocrinology ,translational research ,Italy ,Torque ,ageing ,Ageing ,Sarcopenia ,Body Composition ,Female ,Sedentary Behavior ,business ,Body mass index ,Muscle Contraction - Abstract
Background/objectives Muscle function is a marker of current and prospective health/independence throughout life. The effects of sex and obesity (OB) on the loss of muscle function in ageing remain unresolved, with important implications for the diagnosis/monitoring of sarcopenia. To characterise in vivo knee extensors' function, we compared muscles torque and power with isometric and isokinetic tests in older men (M) and women (W), with normal range (NW) of body mass index (BMI) and OB. Subjects/methods In 70 sedentary older M and W (69 ± 5 years), NW and OB (i.e. BMI Results In absolute units, relative to BM and LLMR, sex differences were found in favour of M for all parameters of muscle function (main effect for sex, p 0.05); however, muscle function indices, when adjusted for BM, were lower in both M and W with OB compared to NW counterparts (p Conclusions We confirmed sex differences in absolute, relative to BM and LLMR muscle function in favour of men. While overall muscle function and muscle contractile quality is conserved in individuals with class I OB, muscle function normalised for BM, which defines the ability to perform independently and safely the activities of daily living, is impaired in comparison with physiological ageing.
- Published
- 2021
14. The Mini Sarcopenia Risk Assessment (MSRA) Questionnaire score as a predictor of skeletal muscle mass loss
- Author
-
Elena Zoico, Gloria Mazzali, Stefano Gattazzo, Marwan El Ghoch, Andrea Rossi, Silvia Urbani, Nicole Nori, Valentina Muollo, Mauro Zamboni, and Francesco Fantin
- Subjects
Male ,Sarcopenia ,Aging ,medicine.medical_specialty ,Population ,Risk Assessment ,Body Mass Index ,03 medical and health sciences ,Absorptiometry, Photon ,0302 clinical medicine ,Muscular Diseases ,Surveys and Questionnaires ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Physical limitations ,Muscle, Skeletal ,education ,Aged ,education.field_of_study ,Muscle strength ,business.industry ,Skeletal muscle ,medicine.disease ,Skeletal muscle mass ,medicine.anatomical_structure ,Body Composition ,Screening ,Cardiology ,Female ,Analysis of variance ,Geriatrics and Gerontology ,Risk assessment ,business ,Body mass index ,030217 neurology & neurosurgery ,MSRA - Abstract
Previous studies showed a strong relationship between reduction of appendicular muscle mass and worsening disability; hence, accuracy in assessing muscle mass is considered a key feature for a sarcopenia screening tool. The aim of the study was to evaluate if the 7 items of Mini Sarcopenia Risk Assessment (MSRA) questionnaire predict muscle mass loss in a population of community-dwelling elderly subjects over a 5.5-y follow-up. The study included 159 subjects, 92 women and 67 men aged 71.5 ± 2.2 years and with mean body mass index of 26.7 ± 4.0 kg/m2. Appendicular skeletal muscle mass (ASMM) as measured with Dual-Energy X-ray absorptiometry (DXA), was obtained at baseline and after 2 and 5.5 years of follow-up where the skeletal muscle index (SMI) was calculated. A significant reduction of ASMM and SMI was observed at two and 5.5 years of follow-up, in both, men and women. Repeated-measures analysis of variance (ANOVA) found a significant time effect on ASMM for both subjects with MSRA > 30 and ≤ 30 (P
- Published
- 2021
15. Echocardiographic Strain Imaging in Coronary Artery Disease
- Author
-
Flavio Ribichini, Alessandro Albini, Alessandro Malagoli, Andrea Rossi, Giovanni Benfari, and Diego Fanti
- Subjects
medicine.medical_specialty ,Ischemic cardiomyopathy ,Ejection fraction ,business.industry ,Strain imaging ,Speckle tracking echocardiography ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,Coronary artery disease ,Clinical Practice ,03 medical and health sciences ,0302 clinical medicine ,Left atrial ,Internal medicine ,Cardiology ,Medicine ,030212 general & internal medicine ,Wall motion ,Cardiology and Cardiovascular Medicine ,business - Abstract
For more than 30 years, echocardiography, through the measurement of ejection fraction and wall motion assessment, has played a crucial role in the diagnosis and management of patients with acute and chronic ischemic heart disease. The introduction of myocardial strain, measured by speckle tracking echocardiography, is shifting this paradigm. Strain imaging catches something pathophysiologically deeper into myocardial function, facing a wide range of clinical applications. This review summarizes the basic concepts of strain imaging and its applicability in clinical practice for the evaluation of the ventricular and the left atrial function in ischemic cardiomyopathy.
- Published
- 2020
16. The role of marketing and innovation in services
- Author
-
Luigi M. De Luca and Dennis Herhausen, Gabriele Troilo, Andrea Rossi
- Subjects
Business ,Marketing - Abstract
Big data technologies and analytics enable new digital services and are often associated with superior performance. However, firms investing in big data often fail to attain those advantages. To answer the questions of how and when big data pay off, marketing scholars need new theoretical approaches and empirical tools that account for the digitized world. Building on affordance theory, the authors develop a novel, conceptually rigorous, and practice-oriented framework of the impact of big data investments on service innovation and performance. Affordances represent action possibilities, namely what individuals or organizations with certain goals and capabilities can do with a technology. The authors conceptualize and operationalize three important big data marketing affordances: customer behavior pattern spotting, real-time market responsiveness, and data-driven market ambidexterity. The empirical analysis establishes construct validity and offers a preliminary nomological test of direct, indirect, and conditional effects of big data marketing affordances on perceived big data performance.
- Published
- 2020
17. Pre-existing type 2 diabetes is associated with increased all-cause death independently of echocardiographic predictors of poor prognosis only in ischemic heart disease
- Author
-
Giovanni Targher, Pier Luigi Temporelli, Erberto Carluccio, Calogero Falletta, Catherine Klersy, Olga Vriz, Angela Beatrice Scardovi, Marco Guazzi, Andrea Rossi, Laura Scelsi, Egidio Traversi, Frank Lloyd Dini, Stefano Ghio, and Pompilio Faggiano
- Subjects
Male ,medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,Myocardial Ischemia ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Risk Assessment ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Cause of Death ,Internal medicine ,Diabetes mellitus ,Type 2 diabetes mellitus ,medicine ,Risk of mortality ,Humans ,cardiovascular diseases ,Aged ,Retrospective Studies ,Cause of death ,Heart Failure ,Nutrition and Dietetics ,Ejection fraction ,business.industry ,Troponin I ,Hemodynamics ,nutritional and metabolic diseases ,Retrospective cohort study ,Prognosis ,medicine.disease ,Chronic heart failure ,Cardiac biomarkers ,Diabetes Mellitus, Type 2 ,Heart Disease Risk Factors ,Echocardiography ,Heart failure ,Cardiology ,Etiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
Background and aims It is unknown whether the prognostic role of diabetes (T2DM) in outpatients with chronic heart failure (CHF) is independent of the most important echocardiographic markers of poor prognosis. The aims of this analysis were to evaluate whether T2DM modifies the risk of mortality in CHF patients stratified by etiology of disease or by right-ventricular to pulmonary arterial coupling at echocardiography and to evaluate how T2DM interacts with the prognostic role of cardiac plasma biomarkers. Methods and results This is a retrospective analysis of 1627 CHF outpatients who underwent a complete echocardiographic examination. During a median follow-up period of 63 months 255 patients died. Poor right-ventricular to pulmonary arterial coupling and reduced left ventricular ejection fraction were independent predictors of outcome, whereas ischemic etiology and T2DM were not. T2DM interacted with etiology increasing the risk of mortality by 32% among patients with ischemic disease (p = 0.003). Elevated hsTNI plasma levels were associated with poor survival in T2DM but not in non-diabetic patients. Conclusion T2DM signals a worse outcome in ischemic CHF patients regardless of the echocardiographic phenotype. High plasma levels of hsTNI are stronger predictors of mortality in CHF patients with T2DM than in patients without diabetes.
- Published
- 2020
18. Changes in appearance of cortical formation abnormalities in the foetus detected on sequential in utero MR imaging
- Author
-
Giorgio Conte, Fabio Triulzi, Maurilio Genovese, Marco Di Maurizio, Andrea Rossi, Laura Mandefield, Renzo Guerrini, Elisa Scola, Cecilia Parazzini, Deborah Jarvis, Mariasavina Severino, Paul D. Griffiths, Giovanni Palumbo, Andrea Righini, and Lorenzo Pinelli
- Subjects
medicine.medical_specialty ,Nervous System Malformations ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Fetus ,0302 clinical medicine ,Pregnancy ,Prenatal Diagnosis ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Clinical significance ,Child ,reproductive and urinary physiology ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Brain ,Magnetic resonance imaging ,General Medicine ,Magnetic Resonance Imaging ,In utero ,030220 oncology & carcinogenesis ,embryonic structures ,Laterality ,Cohort ,Female ,Radiology ,Abnormality ,business - Abstract
We describe 64 foetuses with cortical formation abnormalities (CFA) who had two in utero magnetic resonance (iuMR) exams, paying particular detail to those in which the original classification of CFA category changed between the two studies. The goal was to attempt to quantify the value of third-trimester follow-up studies in CFA foetuses on second-trimester iuMR imaging. The 64 foetuses reviewed came from a CFA cohort of 374 foetuses reported in an earlier publication, which detailed a classification for foetal CFA. A consensus panel of senior paediatric neuroradiologists reviewed both studies, described any change in the category of CFA between them, and attempted to predict the possible clinical significance of any differences based on the combined clinical experience of the panel. In 40/64 (62%) foetuses, the CFA description was the same on both studies. In 24/64 (38%) cases, there was a category change which included three foetuses without CFA on first examination, six foetuses where the difference involved change in laterality/symmetry, and in 15 cases the re-classification involved categorical change within the same group. Brain abnormalities other than CFA were present in 30/64 (47%) foetuses on the first study and in 33/64 (52%) on the second. We predicted that prognosis would have changed on the basis of the second study in 8% of cases, all indicating worse prognosis. We have shown that the extra diagnostic and predicted prognostic yield justifies follow-up studies in the third trimester if a CFA is shown on the second-trimester iuMR imaging. • Sixty-four foetuses with cortical formation abnormalities had two iuMR studies, for the vast majority the baseline in the second trimester and the sequential in the third. • In three foetuses, the cortical formation abnormality (CFA) was not visible on the first study. In a further 21 foetuses, the categorical description of the CFA changed between the two studies. Prognosis changed in 8% of the cases following the second iuMR study, and in all cases, the prognosis was worse. • Multiple iuMR studies provide information about the natural history of CFA; the extra diagnostic and predicted prognostic yield justifies follow-up studies.
- Published
- 2020
19. Action Observation Treatment in a tele-rehabilitation setting: a pilot study in children with cerebral palsy
- Author
-
Elisa Fazzi, Gioacchino Garofalo, Anna Molinaro, Andrea Rossi, Federica Pagani, Giovanni Buccino, Serena Micheletti, Jessica Galli, Molinaro, A., Micheletti, S., Pagani, F., Garofalo, G., Galli, J., Rossi, A., Fazzi, E., and Buccino, G.
- Subjects
030506 rehabilitation ,medicine.medical_specialty ,Action Observation Treatment ,cerebral palsy ,mirror neuron system ,neuro-rehabilitation ,telerehabilitation ,medicine.medical_treatment ,Pilot Projects ,Cerebral palsy ,Upper Extremity ,03 medical and health sciences ,0302 clinical medicine ,Tele-rehabilitation ,Physical medicine and rehabilitation ,Telerehabilitation ,medicine ,Humans ,Child ,Neurorehabilitation ,Mirror neuron ,Rehabilitation ,business.industry ,Hand ,medicine.disease ,Action (philosophy) ,Action observation ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
Objective: Action Observation Treatment is a novel rehabilitation approach exploiting a neurophysiological mechanism that allows one to recruit the neural structures sub-serving action execution during the mere observation of those same actions. Action Observation Treatment is effective in the rehabilitation of several neurological diseases. In this pilot study, we used Action Observation Treatment in a telerehabilitation setting in children with Cerebral Palsy. Materials and methods: Ten children with Cerebral Palsy, aged 5–12years, entered the study. They followed the Action Observation Treatment rehabilitation program at home with remote supervision by a child neurologist located at the hospital. Outcome measures were the scores at the Melbourne Assessment of Unilateral Upper Limb Function Scale and the Assisting Hand Assessment. Results: Scores obtained after treatment and at a two months’ follow-up significantly differed from baseline and overlapped those obtained in randomized controlled studies carried out in a conventional setting. Conclusions: Action Observation Treatment is therefore a promising approach that can be used on a large scale in a telerehabilitation setting.IMPLICATIONS FOR REHABILITATION Tele-rehabilitation has the potential to enhance early intervention service provision for children with Cerebral Palsy. Action Observation Treatment has the potential to become a routine approach in a telerehabilitation setting.
- Published
- 2020
20. Regional impairment of cortical and deep gray matter perfusion in preterm neonates with low-grade germinal matrix-intraventricular hemorrhage: an ASL study
- Author
-
Paolo Massirio, Luca A Ramenghi, Mariasavina Severino, Alessandro Parodi, Domenico Tortora, Andrea Rossi, and Francesco Maria Lo Russo
- Subjects
Male ,medicine.medical_specialty ,Caudate nucleus ,Perfusion scanning ,Germinal matrix ,Infant, Premature, Diseases ,Cerebral blood flow ,Germinal matrix hemorrhage ,Magnetic resonance ,Neonate ,Perfusion ,Cerebral Ventricles ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Neonatal Screening ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Gray Matter ,Cerebral Hemorrhage ,Retrospective Studies ,business.industry ,Infant, Newborn ,Gestational age ,medicine.disease ,Magnetic Resonance Imaging ,Subcortical gray matter ,Cerebrovascular Circulation ,Cerebral hemisphere ,Cardiology ,Female ,Spin Labels ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Infant, Premature ,030217 neurology & neurosurgery - Abstract
The long-term impact of low-grade germinal matrix-intraventricular hemorrhage (GMH-IVH) on brain perfusion has not been fully investigated. We aimed to compare cortical and deep gray matter (GM) cerebral blood flow (CBF) obtained with pseudo-continuous arterial spin labeling (pCASL), among preterm neonates with and without low-grade GMH-IVH and full-term controls. 3T-pCASL examinations of 9 healthy full-term neonates (mean gestational age 38.5 weeks, range 38–39) and 28 preterm neonates studied at term-equivalent age were analyzed. Eighteen preterm neonates presented normal brain MRI (mean gestational age 30.50 weeks, range 29–31) and 10 low-grade GMH-IVH according to Volpe’s grading system (mean gestational age 32 weeks, range 28–34). A ROI-based mean CBF quantification was performed in 5 cortical (frontal, parietal, temporal, insula, occipital), and 4 subcortical GM regions (caudate, putamen, pallidum, thalamus) for each cerebral hemisphere. CBF differences were explored using a nonparametric analysis of covariance. Low-grade GMH-IVH hemispheres showed consistently lower CBF in all GM regions when compared with healthy preterm neonates, after controlling the confounding effect of gestational age, postmenstrual age, and birth weight P
- Published
- 2020
21. Obesity and Higher Risk for Severe Complications of Covid-19: What to do when the two pandemics meet
- Author
-
Tiziana Todesco, Marwan El Ghoch, Alessandra Valerio, Massimo Pellegrini, Andrea Rossi, and Enzo Nisoli
- Subjects
obesity ,medicine.medical_specialty ,media_common.quotation_subject ,Pneumonia, Viral ,severe complications ,Overweight ,Severity of Illness Index ,Betacoronavirus ,Risk Factors ,Hygiene ,Intervention (counseling) ,Intensive care ,Severity of illness ,Pandemic ,medicine ,overweight ,Humans ,Viral ,Obesity ,Intensive care medicine ,Pandemics ,media_common ,SARS-CoV-2 ,business.industry ,pandemic ,Social distance ,COVID-19 ,mortality ,Pneumonia ,medicine.disease ,Coronavirus Infections ,medicine.symptom ,business - Abstract
The coronavirus disease 2019 (COVID-19) pandemic has spread around the globe, infecting more than ten million individuals, with more than 500,000 dead; about one half of the infected people have recovered. Despite this fact, a subgroup of individuals affected by COVID-19 is at greater risk of developing worse outcomes and experience a high rate of mortality. Data on the association between obesity and COVID-19 are growing; the available studies, have reported a high prevalence of overweight and obesity in patients experiencing a severe COVID-19 course, with serious complications requiring hospitalization and admission to intensive care units. This paper attempts to highlight potential mechanisms behind the greater vulnerability to COVID-19 of individuals with obesity. The presence of uncontrolled chronic obesity-related comorbidities, particularly pulmonary diseases, can present a primary fertile soil for respiratory tract infection. Combined with immune system impairments, such as alteration in the T-cell proliferation and macrophage differentiation, and the high pro-inflammatory cytokine production by the adipose organ, this may worsen the general condition toward a systemic diffusion of infection. Prevention remains the first line of intervention in these patients that can be achieved by adhering to social distancing and adopting hygiene precautions, combined with a healthy lifestyle. Patients with obesity require preferential access dedicated to primary care services to ensure they are regularly taking their medications for the treatment of any concurrent chronic diseases. Finally, their physicians must promptly manage any medical signs or symptoms in the case of suspected severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) infection to prevent the risk of severe outcomes.
- Published
- 2020
22. Cortical formation abnormalities on foetal MR imaging: a proposed classification system trialled on 356 cases from Italian and UK centres
- Author
-
Renzo Guerrini, Mariasavina Severino, Ignazio Derrico, Marco Di Maurizio, Giorgio Conte, Giovanni Palumbo, Deborah Jarvis, Cecilia Parazzini, Andrea Rossi, Laura Mandefield, Giacomo Talenti, Andrea Righini, Fabio Triulzi, Paul D. Griffiths, Maurilio Genovese, Lorenzo Pinelli, and Elisa Scola
- Subjects
Male ,medicine.medical_specialty ,Gestational Age ,Nervous System Malformations ,030218 nuclear medicine & medical imaging ,Cohort Studies ,03 medical and health sciences ,Fetus ,0302 clinical medicine ,Pregnancy ,Prenatal Diagnosis ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,reproductive and urinary physiology ,Retrospective Studies ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Brain ,Gestational age ,Foetus ,Magnetic resonance imaging ,Interventional radiology ,Retrospective cohort study ,General Medicine ,Magnetic Resonance Imaging ,United Kingdom ,Italy ,Magnetic resonance ,030220 oncology & carcinogenesis ,Cohort ,Etiology ,Female ,Radiology ,business ,Cohort study - Abstract
To formulate a classification system for foetal cortical formation abnormalities (CFAs) based on in utero magnetic resonance (iuMR) appearances and trial it in 356 cases. This retrospective study included all cases of foetal CFA diagnosed between 2000 and 2017 from seven centres in Italy and UK. All of the studies were reviewed by a panel of paediatric neuroradiologists experienced in iuMR with the aid of an algorithm designed to categorise the abnormalities. Consensus expert review confirmed 356 foetuses with CFA and the first level of classification distinguished bilateral CFA (229/356–64%) from unilateral CFA (127/356–36%) cases with sub-classification of the bilateral cases into asymmetric (65/356–18%) and symmetric (164/356–46%) involvement. There was a statistically significant excess of foetuses with small head size, e.g. 17% of the cohort had a bi-parietal diameter
- Published
- 2020
23. The extent and location of late gadolinium enhancement predict defibrillator shock and cardiac mortality in patients with non-ischaemic dilated cardiomyopathy
- Author
-
Marcello Piacenti, Michele Emdin, Andrea Ripoli, Luca Panchetti, Andrea Rossi, Giovanni Donato Aquaro, Alberto Aimo, Andrea Barison, Vincenzo Castiglione, Umberto Startari, Gianluca Mirizzi, and Alberto Giannoni
- Subjects
Cardiomyopathy, Dilated ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Cardiac resynchronization therapy ,Contrast Media ,Gadolinium ,030204 cardiovascular system & hematology ,Defibrillator ,Late gadolinium enhancement ,Prognosis ,Shock ,Ventricular arrhythmias ,Sudden cardiac death ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,medicine ,Clinical endpoint ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Aged ,Retrospective Studies ,Ejection fraction ,business.industry ,Dilated cardiomyopathy ,medicine.disease ,Implantable cardioverter-defibrillator ,Defibrillators, Implantable ,Heart failure ,embryonic structures ,Ventricular fibrillation ,Cardiology ,Female ,Cardiomyopathies ,Cardiology and Cardiovascular Medicine ,business - Abstract
In non-ischaemic dilated cardiomyopathy (NIDCM), it is uncertain which late gadolinium enhancement (LGE) pattern, extent and location predict ventricular arrhythmias.We analysed 183 NIDCM patients (73% men, median age 66 years) receiving an implantable cardioverter defibrillator (ICD) for primary prevention, undergoing cardiac magnetic resonance within 1 month before implantation. The primary endpoint was appropriate ICD shock, the secondary endpoint was a composite of appropriate ICD shock and cardiac death.LGE was found in 116 patients (63%), accounting for 9% of LV mass (5-13%). Over a 30-month follow-up (10-65), 20 patients (11%) experienced the primary and 30 patients (16%) the secondary endpoint. LGE presence, inferior wall LGE, diffuse (≥2 wall) LGE, the number of segments with LGE, the number of segments with 50-75% transmural LGE, and percent LGE mass were univariate predictors of both endpoints. Also septal LGE predicted the primary, and lateral LGE predicted the secondary endpoint. LGE limited to right ventricular insertion points did not predict any endpoint. Percent LGE mass had an area under the curve of 0.734 for the primary endpoint, with 13% as the best cut-off (55% sensitivity, 86% specificity, 32% PPV, 94% NPV), conferring a 7-fold higher risk compared to patients with no LGE or LGE13%. Survival free from both endpoints was significantly worse for patients with LGE ≥13%.In patients with NIDCM receiving a defibrillator for primary prevention, LGE presence and extent predicted appropriate ICD shock and cardiac mortality; also specific LGE patterns and locations predicted a worse prognosis.
- Published
- 2020
24. Central role of left atrial dynamics in limiting exercise cardiac output increase and oxygen uptake in heart failure: insights by cardiopulmonary imaging
- Author
-
Eleonora Alfonzetti, Tadafumi Sugimoto, Marco Guazzi, Marina Rovida, Greta Generati, Tomaso Gnecchi Ruscone, Marta Barletta, Francesco Bandera, Andrea Rossi, and Mariantonietta Cicoira
- Subjects
medicine.medical_specialty ,Cardiac output ,Haemodynamic response ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Heart rate ,medicine ,Humans ,Heart Atria ,Exertion ,Cardiac Output ,Heart Failure ,Ejection fraction ,business.industry ,Hazard ratio ,Stroke Volume ,Stroke volume ,medicine.disease ,Oxygen ,Heart failure ,Exercise Test ,Cardiology ,Atrial Function, Left ,Cardiology and Cardiovascular Medicine ,business - Abstract
AIMS In heart failure (HF), the haemodynamic response to exercise in relation to left atrial (LA) dynamics is unexplored. We sought to define whether abnormal LA dynamics during exercise may play a role in cardiac output (CO) limitation and tested its ability to predict outcome. METHODS AND RESULTS A total of 195 HF patients with reduced (n = 105), mid-range (n = 48), and preserved (n = 42) left ventricular ejection fraction (LVEF) and 46 non-cardiac dyspnoea (NCD) subjects underwent cardiopulmonary imaging with assessment of LA strain and strain rate (sra). HF patients, irrespective of LVEF, exhibited a significantly impaired LA strain and LA sra at rest, during exercise and recovery compared to NCD subjects with a blunted response in CO and right ventricular to pulmonary circulation coupling. LA strain and LA sra during exertion were significantly correlated with peak stroke volume index, peak CO and peak cardiac power output (R = 0.33, 0.48, 0.50 and R = 0.36, 0.51, 0.52 for LA strain and LA sra, respectively; all P 2, peak LVEF and peak heart rate, a higher LA strain (1% increase) during exercise was associated with a higher peak stroke volume index (mL/m2 ), CO (L/min) and cardiac power output (mmHg L/min) at multivariable analyses (β-coefficients ± standard error = 0.23 ± 0.07, 0.046 ± 0.014 and 0.012 ± 0.004, respectively; P
- Published
- 2020
25. Catheter cryoablation of ventricular ectopy originating from his region
- Author
-
Bruno Antonio Formichi, Antonio Frontera, Gianluca Mirizzi, Marcello Piacenti, Andrea Rossi, U. Startari, and L. Panchetti
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Early detection ,lcsh:Medicine ,Case Report ,Case Reports ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,premature ventricular complexes ,medicine ,Ventricular ectopy ,Premature ventricular complexes ,lcsh:R5-920 ,business.industry ,lcsh:R ,Cryoablation ,General Medicine ,Ablation ,Catheter ,cryoablation ,030220 oncology & carcinogenesis ,Av conduction ,Cardiology ,business ,lcsh:Medicine (General) - Abstract
Careful mapping, early detection of AV conduction damage and cryothermal energy availability are essential in dealing with ablation procedures at the parahisian region.
- Published
- 2020
26. Prenatal magnetic resonance imaging within the 26th week of gestation may predict the fate of isolated upward rotation of the cerebellar vermis: insights from a multicentre study
- Author
-
Giacomo Talenti, Giana Izzo, Mariasavina Severino, Simona Boito, Giorgio Conte, Amanda Antonelli, Claudia Cinnante, Francesca Ormitti, Cecilia Parazzini, Andrea Righini, Lorenzo Pinelli, Luca Caschera, Giovanni Palumbo, Lucia Manganaro, Fabio Triulzi, and Andrea Rossi
- Subjects
Torsion Abnormality ,Cerebellum ,medicine.medical_specialty ,brain ,Remission, Spontaneous ,cerebellar vermis ,foetus ,magnetic resonance imaging ,posterior cranial fossa ,Gestational Age ,Prenatal diagnosis ,Cisterna magna ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,Diagnosis, Differential ,03 medical and health sciences ,Fetus ,0302 clinical medicine ,Pregnancy ,Prenatal Diagnosis ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Retrospective Studies ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Gestational age ,Magnetic resonance imaging ,General Medicine ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Cranial Fossa, Posterior ,Posterior cranial fossa ,030220 oncology & carcinogenesis ,Cerebellar vermis ,Female ,Radiology ,business ,Brain Stem ,Cerebellar Vermis - Abstract
We investigated whether prenatal magnetic resonance imaging (MRI) within 26 weeks of gestation (GW) may predict the fate of isolated upward rotation of the cerebellar vermis (URCV). This retrospective multicentre observational study included foetuses diagnosed with isolated URCV in prenatal MRI performed within 26 GW. Isolated URCV was defined by a brainstem-vermis angle (BVA) ≥ 12° in the MR midline sagittal view without abnormalities of the supratentorial structures, brainstem, or cerebellum hemispheres. The assessments included the BVA, clival-supraoccipital angle, transverse diameter of the posterior cranial fossa, tentorial angle, width of the cisterna magna (WCM), ventricular width, vermian diameters, hypointense stripes, and cerebellar tail sign. Late prenatal or postnatal MRI was used as a reference standard to assess the final vermian fate (rotated/de-rotated). Forty-five foetuses (mean GW at prenatal MRI = 21.5 ± 1.4 weeks) were included. In the reference standard, the vermis was de-rotated in 26 cases (57.7%). At least two of the following criteria were used to predict the persistence of URCV at imaging follow-up: BVA ≥ 23°, WCM ≥ 9 mm, and the cerebellar tail sign. The results were a sensitivity of 84.21% (95% CI, 60.4–96.6%), specificity of 80.8% (95% CI, 60.6–93.4%), positive predictive value of 76% (95% CI, 58.7–87.8%), and negative predictive value of 87.5% (95% CI, 70.9–95.2%). MRI within 26 GW on foetuses diagnosed with isolated URCV may predict delayed cerebellar vermis de-rotation, which is associated with good neurodevelopmental outcome in most cases. • Foetal MRI is a valuable tool in predicting the fate of isolated upward-rotated cerebellar vermis. • A wider angle between the brainstem and vermis is associated with higher risk of persistence of vermian rotation. • The presence of ≥ 2 factors among a brainstem-to-vermis angle ≥ 23°, width of the cisterna magna ≥ 9 mm, and the presence of the “cerebellar tail sign” has a sensitivity of 84.21% (95% CI, 60.4–96.6%) and specificity of 80.8% (95% CI, 60.6–93.4%) in predicting the persistence of the vermian rotation at imaging follow-up.
- Published
- 2020
27. Definitions and classification of malformations of cortical development: Practical guidelines
- Author
-
James Barkovich, Mariasavina Severino, Fabio Triulzi, Filippo Arrigoni, Grazia M.S. Mancini, Richard J. Leventer, Kshitij Mankad, Domenico Tortora, Norbert Utz, Ana Filipa Geraldo, Maarten H. Lequin, Wlodzimierz Klonowski, Ivana Pogledic, Andrea Rossi, and Clinical Genetics
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Consensus ,Brain development ,Context (language use) ,Genetic pathways ,Cerebral palsy ,Terminology ,03 medical and health sciences ,Epilepsy ,0302 clinical medicine ,Neuroimaging ,medicine ,Humans ,Intensive care medicine ,Neuroradiology ,Cerebral Cortex ,classification ,epilepsy ,malformations of cortical development ,neuroimaging ,AcademicSubjects/SCI01870 ,business.industry ,medicine.disease ,Magnetic Resonance Imaging ,Corrigenda ,Europe ,030104 developmental biology ,Practice Guidelines as Topic ,AcademicSubjects/MED00310 ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Malformations of cortical development are a group of rare disorders commonly manifesting with developmental delay, cerebral palsy or seizures. The neurological outcome is extremely variable depending on the type, extent and severity of the malformation and the involved genetic pathways of brain development. Neuroimaging plays an essential role in the diagnosis of these malformations, but several issues regarding malformations of cortical development definitions and classification remain unclear. The purpose of this consensus statement is to provide standardized malformations of cortical development terminology and classification for neuroradiological pattern interpretation. A committee of international experts in paediatric neuroradiology prepared systematic literature reviews and formulated neuroimaging recommendations in collaboration with geneticists, paediatric neurologists and pathologists during consensus meetings in the context of the European Network Neuro-MIG initiative on Brain Malformations (https://www.neuro-mig.org/). Malformations of cortical development neuroimaging features and practical recommendations are provided to aid both expert and non-expert radiologists and neurologists who may encounter patients with malformations of cortical development in their practice, with the aim of improving malformations of cortical development diagnosis and imaging interpretation worldwide.
- Published
- 2020
28. Neonatal developmental venous anomalies: Clinicoradiologic characterization and follow-up
- Author
-
Mariya Malova, S S Messina, E Herkert, A.F. Geraldo, Alessandro Parodi, Domenico Tortora, Andrea Rossi, Alessandra D'Amico, Mariasavina Severino, Carlo Gandolfo, Giovanni Morana, Luca A. Ramenghi, Paul Govaert, and Pediatrics
- Subjects
Male ,medicine.medical_specialty ,Vascular Malformations ,Neuroimaging ,Pediatrics ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Corrected Age ,Developmental venous anomaly ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Fisher's exact test ,Retrospective Studies ,Fetus ,business.industry ,Infant, Newborn ,Brain ,Retrospective cohort study ,Mr imaging ,Magnetic Resonance Imaging ,symbols ,Female ,Neurology (clinical) ,Radiology ,Mr images ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
BACKGROUND AND PURPOSE: Although developmental venous anomalies have been frequently studied in adults and occasionally in children, data regarding these entities are scarce in neonates. We aimed to characterize clinical and neuroimaging features of neonatal developmental venous anomalies and to evaluate any association between MR imaging abnormalities in their drainage territory and corresponding angioarchitectural features. MATERIALS AND METHODS: We reviewed parenchymal abnormalities and angioarchitectural features of 41 neonates with developmental venous anomalies (20 males; mean corrected age, 39.9 weeks) selected through a radiology report text search from 2135 neonates who underwent brain MR imaging between 2008 and 2019. Fetal and longitudinal MR images were also reviewed. Neurologic outcomes were collected. Statistics were performed using χ(2), Fisher exact, Mann-Whitney U, or t tests corrected for multiple comparisons. RESULTS: Developmental venous anomalies were detected in 1.9% of neonatal scans. These were complicated by parenchymal/ventricular abnormalities in 15/41 cases (36.6%), improving at last follow-up in 8/10 (80%), with normal neurologic outcome in 9/14 (64.2%). Multiple collectors (P = .008) and larger collector caliber (P
- Published
- 2020
29. Neurodevelopmental Profile in Children Affected by Ocular Albinism
- Author
-
Giulio Ruberto, Jessica Galli, Alessandra Morandi, Andrea Rossi, Vera Scaglioni, Erika Loi, Francesco Semeraro, Elisa Fazzi, Nadia Pasini, and Anna Molinaro
- Subjects
Ocular albinism ,medicine.medical_specialty ,Visual acuity ,Language delay ,Neurological examination ,autism spectrum disorder ,Audiology ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,Evoked potential ,Eye Proteins ,ocular albinism ,Retrospective Studies ,Membrane Glycoproteins ,medicine.diagnostic_test ,business.industry ,GPR143 gene mutations ,Cognition ,General Medicine ,medicine.disease ,Albinism, Ocular ,neurodevelopmental profile ,Autism spectrum disorder ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,030221 ophthalmology & optometry ,Evoked Potentials, Visual ,Observational study ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Aim The aim of this study was to detail the neurodevelopmental profile of subjects affected by ocular albinism (OA) and to collect data on GPR143 gene analysis. Design The design of the study involves a retrospective longitudinal observational case series. Methods We collected data on the neurodevelopmental profile of 13 children affected by OA from clinical annual assessments conducted for a period of 6 years after the first evaluation. We described visual profile, neuromotor development and neurological examination, cognitive profile, communication and language skills and behavioral characteristics. The GPR143 gene analysis was performed as well. Results Children presented a variable combination of ocular and oculomotor disorders unchanged during the follow-up, a deficit in visual acuity and in contrast sensitivity that progressively improved. Abnormalities in pattern visual evoked potential were found. No deficits were detected at neurological examination and neuromotor development except for a mild impairment in hand-eye coordination observed in five cases. A language delay was observed in five cases, two of whom had also a developmental quotient delay at 2 years evolving to a borderline/deficit cognitive level at preschool age, difficulties in adaptive behavior and autistic-like features were found. Mutations in the GPR143 gene were identified in the two patients who presented the most severe clinical phenotype. Conclusion Children with OA may share, in addition to a variable combination of ocular signs and symptoms, a neurodevelopment impairment regarding mostly the cognitive, communicative, and social area, especially those with GPR143 mutation.
- Published
- 2022
30. Tonsillar herniation spectrum: more than just Chiari I. Update and controversies on classification and management
- Author
-
Marco Pavanello, Pietro Fiaschi, Alessandro Consales, Pasquale Anania, Gianluca Piatelli, Andrea Rossi, Giovanni Morana, and Armando Cama
- Subjects
medicine.medical_specialty ,Hernia ,Klippel–Feil syndrome ,Goldenhar syndrome ,Neurosurgical Procedures ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,Cerebellar Diseases ,Humans ,Medicine ,Foramen magnum ,business.industry ,General surgery ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Arnold-Chiari Malformation ,Hydrocephalus ,medicine.anatomical_structure ,Tonsil ,Etiology ,Surgery ,Neurology (clinical) ,Neurosurgery ,business ,030217 neurology & neurosurgery ,Syringomyelia - Abstract
Cerebellar tonsil herniation comprises a spectrum of disorders sharing a common neuroimaging finding consisting of downward displacement of the cerebellar tonsils through the foramen magnum and into the upper cervical spinal canal. This not uncommon condition may result from a large host of congenital or acquired causes, and confusion regarding its classification and pathogenesis still exists. Terminology also remains heterogeneous, including inconsistencies in the usage of the "Chiari 1" monicker. In this paper, the hypothesized mechanisms of development of tonsillar herniation are reviewed and strategies of management are discussed, with particular attention to surgical options adapted to the underlying etiology. A focus will be placed on acquired causes of tonsillar herniation.
- Published
- 2019
31. Duesselpore™: a full-stack local web server for rapid and simple analysis of Oxford Nanopore Sequencing data
- Author
-
Andrea Rossi, Thach Nguyen, Christian Vogeley, Thomas Haarmann-Stemmann, Selina Woeste, and Jean Krutmann
- Subjects
Web server ,business.product_category ,Exploit ,Computer science ,Computational biology ,computer.software_genre ,DNA sequencing ,Deep sequencing ,Software portability ,Workflow ,Internet access ,Nanopore sequencing ,business ,computer - Abstract
Genome-wide analysis of transcriptomes offers extensive insights into the molecular mechanisms underlying the physiology of all known species and discover those that are still hidden. Oxford Nanopore Technologies (ONT) has recently been developed as a fast, miniaturized, portable and a cost effective alternative to Next Generation Sequencing. However, RNA-seq data analysis software that exploit ONT portability and allows scientists to easily analyze ONT data everywhere without bioinformatic expertise is not widely available. We developed Duesselpore™, an easy-to-follow deep sequencing workflow that runs as a local webserver and allows the analysis of ONT data everywhere without requiring additional bioinformatic tools or internet connection. Duesselpore™ output includes differentially expressed genes and further downstream analyses, such as variance heatmap, disease and gene ontology plots, gene concept network plots and exports customized pathways for different cellular processes. We validated Duesselpore™ by analyzing the transcriptomic changes induced by PCB126, a dioxin-like PCB and a potent aryl hydrocarbon receptor (AhR) agonist in human HaCaT keratinocytes, a well characterized model system. Duesselpore™ was specifically developed to analyze ONT data but we also implemented NGS data analysis. Duesselpore™ is compatible with Microsoft and Mac operating systems, allows convenient, reliable and cost-effective analysis of ONT and NGS data.
- Published
- 2021
32. Author response for 'Brentuximab vedotin consolidation after autologous stem cell transplantation for Hodgkin lymphoma: a Fondazione Italiana Linfomi real‐life experience'
- Author
-
Ombretta Annibali, Annalisa Arcari, E. Prete, Maria Cantonetti, Francesco Merli, Mario Luppi, Vincenzo Pavone, Antonino Mulè, Piero Maria Stefani, Fulvio Massaro, G. Gini, Giuseppe Pietrantuono, Donato Mannina, Sara Galimberti, Michele Cimminiello, Agostino Tafuri, Marco Sorio, C. Patti, Potito Rosario Scalzulli, Alberto Fabbri, Andrea Rossi, Stefano Luminari, Vittorio Ruggero Zilioli, Maurizio Musso, A Pulsoni, Barbara Botto, Luigi Marcheselli, Elisa Barbolini, and Andrea Visentin
- Subjects
Oncology ,medicine.medical_specialty ,Autologous stem-cell transplantation ,business.industry ,Internal medicine ,medicine ,Hodgkin lymphoma ,Brentuximab vedotin ,business ,medicine.drug - Published
- 2021
33. Pros and Cons of Inhaled Corticosteroids Withdrawal in Chronic Obstructive Pulmonary Disease
- Author
-
Erika Zanardi, Robert Rodriguez-Roisin, and Andrea Rossi
- Subjects
medicine.medical_specialty ,business.industry ,cons ,General Engineering ,medicine ,General Earth and Planetary Sciences ,Pulmonary disease ,Inhaled corticosteroids ,Intensive care medicine ,business ,General Environmental Science - Published
- 2021
34. The Common Combination of Aortic Stenosis with Mitral Regurgitation: Diagnostic Insight and Therapeutic Implications in the Modern Era of Advanced Echocardiography and Percutaneous Intervention
- Author
-
Francesca Mantovani, Diego Fanti, Simone Fezzi, Martina Setti, Andrea Barbieri, Niccolò Bonini, Andrea Rossi, Flavio Ribichini, Alessandro Albini, and Giovanni Benfari
- Subjects
medicine.medical_specialty ,Percutaneous ,diagnosis ,medicine.medical_treatment ,Review ,Valve replacement ,Valvular disease ,Internal medicine ,Intervention (counseling) ,medicine ,echocardiography ,In patient ,Mitral regurgitation ,treatment ,business.industry ,Mitral valve replacement ,aortic stenosis ,General Medicine ,medicine.disease ,combined heart valve disease ,Stenosis ,Cardiology ,cardiovascular system ,Medicine ,mitral regurgitation ,business - Abstract
The combination of aortic stenosis (AS) and mitral regurgitation (MR) is common in patients with degenerative valvular disease. It is characterized by having complex pathophysiology, leading to potential diagnostic pitfalls. Evidence is scarce in the literature to direct the diagnostic framework and treatment of patients with this particular combination of multiple valvular diseases. In this complex scenario, the appropriate use of advanced echocardiography and multimodality imaging methods plays a central role. Transcatheter mitral valve replacement or repair and transcatheter aortic valve replacement widen the surgical options for valve diseases. Therefore, there is an increasing need to reconsider the function, timing, and mode intervention for patients with a combination of AS with MR towards more personalized treatment.
- Published
- 2021
35. An Outbreak of COVID-19 among mRNA-Vaccinated Nursing Home Residents
- Author
-
Quenya Ristagno, Maicol Andrea Rossi, Tiziana Cena, Virginia Silano, Fabrizio Faggiano, Antonella Barale, and Fulvia Milano
- Subjects
medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Immunology ,COVID-19 vaccines ,Case Report ,macromolecular substances ,Serology ,Internal medicine ,Drug Discovery ,Health care ,Medicine ,Pharmacology (medical) ,Pharmacology ,business.industry ,SARS-CoV-2 ,Risk of infection ,Outbreak ,COVID-19 ,Long-term care ,Titer ,nursing home ,Infectious Diseases ,long-term care ,Nursing homes ,business - Abstract
An outbreak was described among the guests of a Long-Term Care Facility in the North of Italy. Among 23 guests, 20 of whom were fully vaccinated with BNT162b2 vaccine, the outbreak led to a final count of 11 positive guests, 9 of whom were vaccinated, and 4 positive healthcare workers, of whom only 1 was vaccinated. Eight of the positive guests (six vaccinated and two unvaccinated) had symptoms that in five cases (three vaccinated and two unvaccinated) led to death. The risk of infection and the risk of death appeared not to be correlated with the health status neither with the serological titer, but only with age.
- Published
- 2021
36. Diagnosis and Management of Aortic Valve Stenosis: The Role of Non-Invasive Imaging
- Author
-
Pompilio Faggiano, Filippo Toriello, Andrea Rossi, David Messika Zeitoun, Gloria Santangelo, Luigi P. Badano, Santangelo, G, Rossi, A, Toriello, F, Badano, L, Zeitoun, D, and Faggiano, P
- Subjects
medicine.medical_specialty ,Noninvasive imaging ,Percutaneous ,diagnostic imaging ,Aortic valve stenosi ,aortic valve stenosis ,Review ,Disease ,Aortic valve replacement ,Internal medicine ,medicine ,Medical imaging ,echocardiography ,Heart valve ,business.industry ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,General Medicine ,medicine.disease ,Stenosis ,medicine.anatomical_structure ,classification ,Aortic valve stenosis ,Cardiology ,cardiovascular system ,Medicine ,business - Abstract
Aortic stenosis is the most common heart valve disease necessitating surgical or percutaneous intervention. Imaging has a central role for the initial diagnostic work-up, the follow-up and the selection of the optimal timing and type of intervention. Referral for aortic valve replacement is currently driven by the severity and by the presence of aortic stenosis-related symptoms or signs of left ventricular systolic dysfunction. This review aims to provide an update of the imaging techniques and seeks to highlight a practical approach to help clinical decision making.
- Published
- 2021
37. When Aortic Stenosis Is Not Alone: Epidemiology, Pathophysiology, Diagnosis and Management in Mixed and Combined Valvular Disease
- Author
-
Martina Setti, Flavio Ribichini, Diego Fanti, Elvin Tafciu, Simone Fezzi, Francesca Mantovani, Andrea Rossi, and Giovanni Benfari
- Subjects
medicine.medical_specialty ,combined valve disease ,Hemodynamics ,Disease ,Regurgitation (circulation) ,Review ,Cardiovascular Medicine ,Internal medicine ,Epidemiology ,Diseases of the circulatory (Cardiovascular) system ,Medicine ,echocardiography ,Heart valve ,tricuspid regurgitation ,Mitral regurgitation ,business.industry ,aortic stenosis ,medicine.disease ,Pathophysiology ,aortic regurgitation ,Stenosis ,medicine.anatomical_structure ,mixed valve disease ,RC666-701 ,Cardiology ,mitral regurgitation ,Cardiology and Cardiovascular Medicine ,business ,mitral stenosis - Abstract
Aortic stenosis (AS) may present frequently combined with other valvular diseases or mixed with aortic regurgitation, with peculiar physio-pathological and clinical implications. The hemodynamic interactions between AS in mixed or combined valve disease depend on the specific combination of valve lesions and may result in diagnostic pitfalls at echocardiography; other imaging modalities may be helpful. Indeed, diagnosis is challenging because several echocardiographic methods commonly used to assess stenosis or regurgitation have been validated only in patients with the single-valve disease. Moreover, in the developed world, patients with multiple valve diseases tend to be older and more fragile over time; also, when more than one valvular lesion needs to address the surgical risk rises together with the long-term risk of morbidity and mortality associated with multiple valve prostheses, and the likelihood and risk of reoperation. Therefore, when AS presents mixed or combined valve disease, the heart valve team must integrate various parameters into the diagnosis and management strategy, including suitability for single or multiple transcatheter valve procedures. This review aims to summarize the most critical pathophysiological mechanisms underlying AS when associated with mitral regurgitation, mitral stenosis, aortic regurgitation, and tricuspid regurgitation. We will focus on echocardiography, clinical implications, and the most important treatment strategies.
- Published
- 2021
38. Aortic valve stenosis burden: Where we are now?
- Author
-
Pompilio Faggiano, Andrea Rossi, and Caterina Maffeis
- Subjects
Transcatheter Aortic Valve Replacement ,medicine.medical_specialty ,business.industry ,Internal medicine ,Aortic valve stenosis ,Cardiology ,MEDLINE ,Medicine ,Humans ,Aortic Valve Stenosis ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease - Published
- 2021
39. How and when do big data investments pay off? The role of marketing affordances and service innovation
- Author
-
Dennis Herhausen, Gabriele Troilo, Luigi M. De Luca, Andrea Rossi, and Marketing
- Subjects
Economics and Econometrics ,Big data ,Affordance theory ,Big data technologies and analytics ,Marketing affordances ,0502 economics and business ,Business and International Management ,Marketing ,Service innovation ,Affordance ,Big data performance ,Consumer behaviour ,Ambidexterity ,Industry digitalization ,Operationalization ,business.industry ,05 social sciences ,Action (philosophy) ,Analytics ,050211 marketing ,BIG DATA TECHNOLOGIES AND ANALYTICS, AFFORDANCE THEORY. MARKETING AFFORDANCES, SERVICE INNOVATION, BIG DATA PERFORMANCE, INDUSTRY DIGITALIZATION ,business ,AFFORDANCE THEORY. MARKETING AFFORDANCES ,050203 business & management - Abstract
Big data technologies and analytics enable new digital services and are often associated with superior performance. However, firms investing in big data often fail to attain those advantages. To answer the questions of how and when big data pay off, marketing scholars need new theoretical approaches and empirical tools that account for the digitized world. Building on affordance theory, the authors develop a novel, conceptually rigorous, and practice-oriented framework of the impact of big data investments on service innovation and performance. Affordances representaction possibilities, namely what individuals or organizations with certain goals and capabilities can do with a technology. The authors conceptualize and operationalize three important big data marketing affordances: customer behavior pattern spotting, real-time market responsiveness, and data-driven market ambidexterity. The empirical analysis establishes construct validity and offers a preliminary nomological test of direct, indirect, and conditional effects of big data marketing affordances on perceived big data performance.
- Published
- 2021
40. Prolonged care delivery time and reduced rate of electrophysiological procedures during the lockdown period due to Covid-19 outbreak
- Author
-
Attilio Del Rosso, Francesca Menichetti, Antonio Fazi, Marzia Giaccardi, Marcello Piacenti, Ernesto Casorelli, Maria Grazia Bongiorni, Martina Nesti, Andrea Rossi, T. Giovannini, Gianluca Solarino, Federica La Pira, Pasquale Notarstefano, Giuseppe Arena, Amato Santoro, Davide Giorgi, and Luca Segreti
- Subjects
Male ,medicine.medical_specialty ,Pacemaker, Artificial ,Time Factors ,Biomedical Engineering ,030204 cardiovascular system & hematology ,Disease Outbreaks ,03 medical and health sciences ,0302 clinical medicine ,Epidemiology ,medicine ,Humans ,Disease management (health) ,Pandemics ,Atrial tachycardia ,Aged ,Retrospective Studies ,business.industry ,SARS-CoV-2 ,Cardiac arrhythmia ,Outbreak ,COVID-19 ,Retrospective cohort study ,Arrhythmias, Cardiac ,General Medicine ,Reentry ,Defibrillators, Implantable ,Italy ,Emergency medicine ,cardiovascular system ,Surgery ,Female ,medicine.symptom ,business ,Risk assessment ,Electrophysiologic Techniques, Cardiac ,Delivery of Health Care ,030217 neurology & neurosurgery - Abstract
OBJECTIVES: The aim of this study is to demonstrate how Electrophysiology activity has been impacted by the pandemic Coronavirus disease 2019 (COVID-19). METHODS: In this multicenter retrospective study, we analyze all consecutive patients admitted for electrophysiological procedures during the COVID-19 lockdown in the Tuscany region of Italy, comparing them to patients hospitalized in the corresponding period of the previous year. RESULTS: The impact of COVID-19 on cardiac arrhythmia management was impressive, with a reduction of more than 50% in all kinds of procedures. A gender gap was observed, with a more relevant reduction for female patients. Arrhythmic urgencies requiring a device implant showed a reduced time from symptoms to first medical contact but the time from first medical contact to procedure was significantly prolonged. CONCLUSION: Hospitals need to consider how outbreaks may affect health systems beyond the immediate infection. Routine activity should be based on a risk assessment between the prompt performance of procedure and its postponement. Retrospective observational analysis such as this study could be decisive in evidence-based medicine of any future pathogen outbreak.Nonstandard Abbreviations and Acronyms PM= pacemakerICD= implantable cardioverter defibrillatorECV= electrical cardioversionEPS= electrophysiological studyAP= ablations proceduresCIED= cardiac implantable electronic devicesWCD= wearable cardioverter defibrillatorEP Lab= Electrophysiology LaboratoriesAVNRT =atrioventricular nodal reentry tachycardiaAVRT= atrioventricular reentry tachycardiaAFL= atrial flutterAF= atrial fibrillationVT= ventricular tachycardiaAT= atrial tachycardia.
- Published
- 2021
41. First emittance measurement of the beam-driven plasma wakefield accelerated electron beam
- Author
-
C. Vaccarezza, Michele Croia, Angelo Biagioni, Arie Zigler, Anna Giribono, Mostafa Behtouei, M. Cesarini, Riccardo Pompili, A. Liedl, S. Romeo, E. Chiadroni, L. Magnisi, G. Costa, M. Bellaveglia, J. Scifo, Maria Pia Anania, Vladimir Shpakov, Mario Galletti, V. Lollo, G. Di Pirro, M. Ferrario, M. Diomede, A. Del Dotto, Andrea Rossi, Luca Piersanti, Alessandro Cianchi, Andrea Mostacci, F. Dipace, and Fabio Villa
- Subjects
Accelerator Physics (physics.acc-ph) ,Nuclear and High Energy Physics ,Physics and Astronomy (miscellaneous) ,FOS: Physical sciences ,QC770-798 ,Electron ,01 natural sciences ,Acceleration ,Plasma accelerator ,Optics ,Physics::Plasma Physics ,Nuclear and particle physics. Atomic energy. Radioactivity ,Emittance measurement ,beam-driven plasma weakfield acceleration ,high-quaity beam ,0103 physical sciences ,Thermal emittance ,010306 general physics ,Settore FIS/01 ,Physics ,emittance ,measurements ,010308 nuclear & particles physics ,business.industry ,Settore FIS/07 ,Surfaces and Interfaces ,Plasma ,Plasma acceleration ,Cathode ray ,Physics::Accelerator Physics ,Physics - Accelerator Physics ,Laser beam quality ,business ,Beam (structure) - Abstract
Next-generation plasma-based accelerators can push electron beams to GeV energies within centimeter distances. The plasma, excited by a driver pulse, is indeed able to sustain huge electric fields that can efficiently accelerate a trailing witness bunch, which was experimentally demonstrated on multiple occasions. Thus, the main focus of the current research is being shifted towards achieving a high quality of the beam after the plasma acceleration. In this paper we present a beam-driven plasma wakefield acceleration experiment, where initially preformed high-quality witness beam was accelerated inside the plasma and characterized. In this experiment the witness beam quality after the acceleration was maintained on high level, with 0.2% final energy spread and 3.8 μm resulting normalized transverse emittance after the acceleration. In this article, for the first time to our knowledge, the emittance of the plasma wakefield accelerated beam was directly measured
- Published
- 2021
42. Intermuscular Adipose Tissue as a Risk Factor for Mortality and Muscle Injury in Critically Ill Patients Affected by COVID-19
- Author
-
Piero Brandimarte, Enrico Polati, Andrea Rossi, Katia Donadello, Alessandro Florio, Leonardo Gottin, Giulia Zamboni, Riccardo Boetti, Gaia Pavan, Mauro Zamboni, and Vittorio Schweiger
- Subjects
medicine.medical_specialty ,obesity ,Coronavirus disease 2019 (COVID-19) ,Physiology ,Adipose tissue ,intermuscular adipose tissue ,intensive care unit ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Physiology (medical) ,Internal medicine ,QP1-981 ,Medicine ,030212 general & internal medicine ,Risk factor ,Survival analysis ,biology ,business.industry ,SARS-CoV-2 ,COVID-19 ,Brief Research Report ,medicine.disease ,Intensive care unit ,Obesity ,Cardiology ,biology.protein ,Creatine kinase ,business ,Body mass index ,030217 neurology & neurosurgery - Abstract
BackgroundMuscular fatigue and injury are frequently observed in critically ill COVID-19 patients. The aim of this study was to determine whether different muscle adipose tissue depots are associated with mortality and muscle damage in patients affected by COVID-19 admitted to the ICU.MethodsCT images were obtained in 153 ICU patients with COVID-19 (121 males and 32 females). Height, weight, body mass index (BMI), C-reactive protein, Creatine PhosphoKinase (CPK), muscle density, and intermuscular adipose tissue (IMAT) were measured.ResultsParticipants in the highest tertile of IMAT/muscle had the shorter 28-day survival from ICU admission as compared to subjects in the first tertile. Estimates derived from the Cox proportional hazard models, after adjustment for age, sex, and BMI, confirmed the results of the survival analysis (HR 3.94, 95% CI: 1.03–15.09). Participants in the lowest tertile of muscle density had the shorter survival at 28 days from ICU admission as compared to subjects in the highest tertile (HR 3.27, 95% CI: 1.18–4.61), but the relationship was no longer significant when age was included in the model. Subjects in the second muscle density tertile did not show an increased risk.Participants in the highest tertile of IMAT/muscle and those in the lowest tertile of muscle density showed both significantly higher CPK adjusted for weight values as evaluated during the first 8 days of hospitalization.ConclusionOur data seem to suggest that higher levels of IMAT/muscle and low muscle density are both associated with higher risk of ICU mortality and muscle injury as evaluated with CPK level.
- Published
- 2021
43. Heterogeneity of right ventricular refractory period: a novel prognostic predictor in type-1 Brugada
- Author
-
Marcello Piacenti, U. Startari, G Casolo, Luciano Teresi, Michele Emdin, Russo, L. Panchetti, M. Nesti, Castiglione, Andrea Rossi, A Santoro, Alberto Giannoni, G Mirizzi, Gianluca Solarino, and A Ripoli
- Subjects
medicine.medical_specialty ,biology ,business.industry ,Refractory period ,Syncope (genus) ,biology.organism_classification ,medicine.disease ,Implantable defibrillators ,Sustained ventricular tachycardia ,Physiology (medical) ,Internal medicine ,Ventricular fibrillation ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Brugada syndrome - Abstract
Funding Acknowledgements Type of funding sources: None. Risk stratification in Brugada syndrome (BrS) is needed especially for the choice of an Implantable Cardiac Defibrillator (ICD). To date the predictive value of either clinical or conventional electrophysiological indexes in type 1 electrocardiographic pattern BrS is rather low. We aimed to evaluate the eventual prognostic significance of refractoriness heterogeneity of right ventricular outflow tract, an emergent relevant pathophysiological substrate, at electrophysiological study (EPS) in patients with BrS. From 5 centers 348 patients were retrospectively selected (age 44 ± 15 years, males 68%). Eighty-five (24%) patients had an ICD. EPS was proposed in patients with spontaneous type-1 ECG pattern regardless of symptoms, or in patients with drug-induced type-1 ECG pattern with symptoms (n = 174). The difference in the refractory period between the right ventricular outflow tract and the apex (ΔRPRVOT-apex) at EPS was evaluated as a prognostic factor. The optimal ΔRPRVOT-apex cutpoint for prognosis prediction was calculated through a P-spline hazard ratio analysis. Thus, ΔRPRVOT-apex was compared through different statistical analyses to other other clinical or conventional electrophysiological prognostic indexes previosly described in literature. During a 36-month median follow-up (range 6-228) 3 SCD and 10 appropriate ICD shocks (aborted SCD, aSCD) occurred. Fifty patients (29%) had a positive EPS (induction of sustained ventricular tachycardia, VT, or ventricular fibrillation, VF, during the procedure). At multivariable logistic analysis, only ΔRPRVOT-apex and late potentials remained independent predictors of a positive EPS. At Cox Proportional Hazard analysis, family history of SCD, history of syncope, VT/VF inducibility and a ΔRPRVOT-apex >60 ms were all univariate predictors of SCD/aSCD. At bivariate analysis, a ΔRPRVOT-apex >60 ms remained an independent predictor of SCD/aSCD even when adjusted the other univariate predictors. At C-Statistic analysis, the strongest predictive model was the one using ΔRPRVOT-apex >60 ms as covariate with a C-statistics (95% CI) of 0.72 (0.51-0.93). At Kaplan-Meyer curves, ΔRPRVOT-apex >60 ms was confirmed a strong predictor of SCD/aSCD and another very interesting observation was possible: patients with positive EPS, but a ΔRPRVOT-apex 60 ms were found to be at a higher risk of events. Refractory period heterogeneity of the right ventricle defined as ΔRPRVOT-apex > 60 ms at EPS is a strong and independent predictor of SCD/aSCD in patients with BrS, beyond VT/VF inducibility at EPS and common clinical predictors. Abstract Figure.
- Published
- 2021
44. Autism in Children With Cerebral and Peripheral Visual Impairment: Fact or Artifact?
- Author
-
Filippo Gitti, Serena Micheletti, Andrea Rossi, Elisa Fazzi, Anna Molinaro, and Jessica Galli
- Subjects
Male ,medicine.medical_specialty ,Optic Neuritis ,Adolescent ,genetic structures ,Autism Spectrum Disorder ,Visual impairment ,Population ,Vision Disorders ,Audiology ,Prevalence ,medicine ,Humans ,Child ,education ,education.field_of_study ,Artifact (error) ,business.industry ,Infant ,medicine.disease ,eye diseases ,Peripheral ,Autism spectrum disorder ,Child, Preschool ,Clinical diagnosis ,Pediatrics, Perinatology and Child Health ,Autism ,Female ,Neurology (clinical) ,medicine.symptom ,Artifacts ,business ,Autistic symptoms - Abstract
The aim of this study was to evaluate the occurrence and clinical characteristics of autism spectrum disorder in visually impaired children. In total, 273 participants, 214 with cerebral causes of vision impairment and 59 with peripheral causes, were assessed using multiple assessment methods and adapted for individuals with vision loss. We found that autism spectrum disorder was more prevalent in the visually impaired compared to general population, and that the prevalence varied according to the type of visual disorder (2.8% for cerebral and 8.4% for peripheral visual impairment). In subjects with cerebral visual impairment, the presence of autistic symptoms was consistent with the diagnosis of autism spectrum disorder. In children with peripheral visual impairment, certain symptoms related to visual loss overlapped with the clinical features of autism spectrum disorder, thus making clinical diagnosis more challenging. The development of assessment tools that take into account the type and level of visual impairment and validation testing in a larger population sample are needed in order to confirm these initial findings regarding the diagnosis of autism spectrum disorder in visually impaired children.
- Published
- 2019
45. Punctate white matter lesions of preterm infants: Risk factor analysis
- Author
-
Valentina Cardiello, Domenico Tortora, Martina Re, Maria Grazia Calevo, Mariya Malova, Mariasavina Severino, Alessandro Parodi, Luca A. Ramenghi, Sarah Raffa, Andrea Rossi, and Giovanni Morana
- Subjects
Male ,medicine.medical_specialty ,Birth weight ,Diseases ,Infant, Premature, Diseases ,Antenatal steroid ,03 medical and health sciences ,0302 clinical medicine ,Preterm ,Pregnancy ,Risk Factors ,Brain lesion ,MRI ,Neonatology ,White matter ,Brain ,Factor Analysis, Statistical ,Female ,Humans ,Infant ,Infant, Newborn ,Infant, Premature ,Magnetic Resonance Imaging ,Retrospective Studies ,White Matter ,Infant, Very Low Birth Weight ,030225 pediatrics ,Medicine ,Risk factor ,Premature ,business.industry ,Obstetrics ,Very Low Birth Weight ,General Medicine ,Statistical ,Newborn ,Hyperintensity ,Low birth weight ,Pediatrics, Perinatology and Child Health ,Susceptibility weighted imaging ,Apgar score ,Neurology (clinical) ,medicine.symptom ,business ,Factor Analysis ,030217 neurology & neurosurgery - Abstract
Aim Punctate white matter lesions (PWML) are frequently detected in preterm infants undergoing brain MRI at term equivalent age (TEA). The aims of this study were to assess prevalence of PWML and to identify risk factors for PWML in VLBW infants. Methods Brain MRI scans obtained at TEA and clinical charts of a consecutive sample of very low birth weight (VLBW) infants admitted to Gaslini Children's Hospital NICU between 2012 and 2016 were retrospectively analyzed. MRI protocol included Susceptibility Weighted Imaging (SWI) sequence in order to identify hemosiderin depositions as a result of previous microbleeds. PWML were classified according to their number (≤6 lesions and >6 lesions) and signal characteristics (SWI+ lesions and SWI− lesions). Univariate and multivariable analysis were performed in order to identify risk factors for PWML (as a whole) and for each subgroup of PWML. Results 321 VLBW infants were included. PWML were identified in 61 subjects (19%), 26 of whom (8% of the study population) had more than 6 lesions. Risk factors for PWML (as a whole) were higher birth weight (OR = 1.001; p = 0.04) and absent or incomplete antenatal steroid course (OR = 2.13; p = 0.02). Risk factors for >6 PWML were need for intubation (OR = 11.9; p = 0.003) and higher Apgar score at 5 min (OR = 1.8; p = 0.02). Presence of GMH-IVH was the only identified risk factor for SWI + lesions. Conclusions Our results confirm the high prevalence of PWML among VLBW infants. Differentiation between SWI+ and SWI− lesions is crucial as they have different risk factors and may likely represent two different entities.
- Published
- 2019
46. The effects of exercise and diet program in overweight people – Nordic walking versus walking
- Author
-
Chiara Milanese, Mauro Zamboni, Miriam Taylor, Federico Schena, Andrea Rossi, Raffaela Rosa, Valentina Muollo, Barbara Pellegrini, and Elena Masciocchi
- Subjects
medicine.medical_specialty ,Waist ,business.industry ,General Medicine ,Overweight ,Anthropometry ,medicine.disease ,Obesity ,03 medical and health sciences ,0302 clinical medicine ,Weight loss ,medicine ,Physical therapy ,030212 general & internal medicine ,Android fat distribution ,Geriatrics and Gerontology ,medicine.symptom ,business ,Body mass index ,030217 neurology & neurosurgery ,Aerobic capacity - Abstract
Purpose Nordic walking (NW) has been recommended as a form of exercise for clinical populations. Despite intervention programs designed to face a clinical status may last several months, no longitudinal studies have compared the effect of NW to another usual form of exercise, like walking (W). We evaluated the effects of diet combined with a long-supervised NW versus W training on body composition, aerobic capacity and strength in overweight adults. Patients and methods Thirty-eight participants, randomized into a NW (n=19, 66±7 years, body mass index (BMI) 33±5)) and a W (n=19, 66±8 years, BMI 32±5) group, followed a diet and a supervised training routine 3 times/week for 6 months. The variables assessed at baseline, after 3 and 6 months were: anthropometric indexes (ie, BMI and waist circumference (WC)), body composition, aerobic capacity (oxygen consumption (VO2peak), peak power output (PPO), 6-min walking test (6MWT)) and strength (maximal voluntary contraction of biceps brachialis (MVCBB) and quadriceps femoris (MVCQF), chair stand and arm curl (AC)). Results After 6 months both NW and W group decreased significantly BMI (6% and 4%, respectively) and WC (8% and 4%, respectively), but only the NW group reduced (P
- Published
- 2019
47. Excess Mortality Associated With Functional Tricuspid Regurgitation Complicating Heart Failure With Reduced Ejection Fraction
- Author
-
Andrea Rossi, Hector I. Michelena, Sorin V. Pislaru, Clemence Antoine, Wayne L. Miller, Giovanni Benfari, Maurice Enriquez-Sarano, Yan Topilsky, and Prabin Thapa
- Subjects
Male ,medicine.medical_specialty ,Comorbidity ,Functional tricuspid regurgitation ,Cohort Studies ,Tricuspid Valve Insufficiency ,left ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,atrial fibrillation ,Prospective Studies ,Mortality ,Aged ,Retrospective Studies ,mitral valve insufficiency ,left ventricular dysfunction ,Aged, 80 and over ,Heart Failure ,Excess mortality ,Ejection fraction ,business.industry ,heart failure, systolic ,prognosis ,tricuspid valve insufficiency ,ventricular dysfunction, left ,ventricular dysfunction ,Stroke Volume ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Pulmonary hypertension ,Heart failure ,Cardiology ,systolic ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Background: Functional tricuspid regurgitation (FTR) is common in heart failure with reduced ejection fraction and mostly consequent to pulmonary hypertension. However, the intrinsic clinical implications of FTR are not fully understood. Methods: The cohort of all Mayo Clinic patients from 2003 to 2011 diagnosed with heart failure stage B-C and ejection fraction Results: Among 13 026 patients meeting inclusion criteria, FTR was detected in 88% (N=11 507: 33% trivial, 32% mild, 17% moderate, and 6% severe), aged 68±14 years, 35% women, ejection fraction 36±10%, systolic pulmonary artery pressure 41±14 mm Hg with 20% atrial fibrillation. Covariates independently associated with FTR included elevated systolic pulmonary artery pressure, older age, female sex, lower ejection fraction, mitral regurgitation, and atrial fibrillation (all P P Conclusions: In this large cohort of patients with heart failure with reduced ejection fraction, FTR was common and independently associated with pulmonary hypertension, atrial fibrillation, and more severe heart failure presentation. Long-term, higher FTR severity is associated with considerably worse survival, independently of baseline characteristics. Given these untoward outcomes associated with FTR in patients with heart failure with reduced ejection fraction, clinical trials should be directed at testing FTR treatment.
- Published
- 2019
48. Wine Index of Salubrity and Health (WISH): an evidence-based instrument to evaluate the impact of good wine on well-being
- Author
-
Andrea Rossi and Ferdinando Fusco
- Subjects
Wine ,Evidence-based practice ,Index (economics) ,media_common.quotation_subject ,digestive, oral, and skin physiology ,food and beverages ,Scientific literature ,Health benefits ,Environmental health ,Well-being ,Quality (business) ,Business ,Food Science ,media_common ,Medical literature - Abstract
Wine, as any other alcoholic drink, should be consumed in moderate dosages. The scientific literature reports a huge number of articles describing the various health benefits of moderate wine drinking, but none have so far summarized the different types of evidence supporting these effects. Furthermore, there is no proof that any specific wine might be more or less beneficial than any other according to its content of specific nutrients and components. The aim of this article was to identify the individual components of wine that are known to have a potential to effect on health, in order to create a wine-specific index to grossly estimate the impact of moderate wine drinking on well-being. A deep search was performed on the medical literature to choose those articles that could explain the role of the main components of wine on health. The proper dosages and the instruments to evaluate the quality of wines were identified and are described herein. Evidence supporting the role of alcohol, acidity, sulfur dioxide, malic acid, metals, polyphenols, and other components of wine on health was identified and summarized, and the various links with health benefits are described. Then a Wine Index of Salubrity and Health (WISH) was developed which, as a rapidly available and effective instrument, will help to understand at a glance the potential beneficial effect of a specific wine.
- Published
- 2019
49. Weight Cycling as a Risk Factor for Low Muscle Mass and Strength in a Population of Males and Females with Obesity
- Author
-
Simona Calugi, Mauro Zamboni, Francesco Pedelini, Elisa Chignola, Sofia Rubele, Paola Vittoria Bazzani, Fabio Soave, Gloria Mazzali, Cesare Caliari, Riccardo Dalle Grave, and Andrea Rossi
- Subjects
education.field_of_study ,Nutrition and Dietetics ,business.industry ,Endocrinology, Diabetes and Metabolism ,Population ,Medicine (miscellaneous) ,Physiology ,030209 endocrinology & metabolism ,medicine.disease ,Logistic regression ,Obesity ,03 medical and health sciences ,Low muscle mass ,0302 clinical medicine ,Endocrinology ,Sarcopenia ,Medicine ,Sarcopenic obesity ,030212 general & internal medicine ,Risk factor ,business ,education ,Cycling - Abstract
OBJECTIVE This study aimed to determine whether multiple weight cycles in adulthood are an independent predictor of lower muscle mass and reduced strength, with potential implication for sarcopenia in adults with obesity. METHODS A total of 60 males and 147 females with obesity were included, with a mean BMI of 37.9 ± 6.0 kg/m2 and a mean age of 52.6 ± 12.4 years. Muscle strength was evaluated with handgrip and appendicular skeletal muscle mass was measured with dual-energy x-ray absorptiometry. RESULTS Participants were categorized into the following three groups: non-weight cyclers, mild weight cyclers, and severe weight cyclers. From a binary logistic regression that considered muscle mass categories as a dependent variable and weight cycling categories, age, and sex as independent variables, severe weight cyclers showed a 3.8-times increased risk of low muscle mass (95% CI: 1.42-10.01). Considering handgrip strength categories as a dependent variable and weight cycling categories, age, sex, and BMI as independent variables, severe weight cycling was associated with an increased risk of low muscle mass (about 6.3 times, 95% CI: 1.96-20.59). Severe weight cyclers showed a 5.2-times greater risk of developing sarcopenia. CONCLUSIONS In adults with obesity, weight cycling is associated with lower muscle mass and strength and a greater likelihood of developing sarcopenic obesity.
- Published
- 2019
50. Asymmetric cavernous sinus enlargement: a novel finding in Sturge–Weber syndrome
- Author
-
Domenico Tortora, Lorenzo Figà-Talamanca, Andrea Rossi, Giovanni Morana, Luca Pasquini, Mariasavina Severino, Maria Camilla Rossi Espagnet, Corrado Occella, and Francesca Manunza
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,Sturge–Weber syndrome ,Contrast Media ,030218 nuclear medicine & medical imaging ,Young Adult ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Atrophy ,Sturge-Weber Syndrome ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Asymmetry Index ,Child ,Fisher's exact test ,Retrospective Studies ,Neuroradiology ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,Magnetic Resonance Imaging ,Italy ,Child, Preschool ,Cavernous sinus ,symbols ,Cavernous Sinus ,Female ,Choroid plexus ,Neurology (clinical) ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Abstract
Enlargement of deep cerebral veins and choroid plexus engorgement are frequently reported in Sturge–Weber syndrome. We aim to describe cavernous sinus involvement in patients with this syndrome and to identify possible clinical-neuroimaging correlations. Sixty patients with Sturge–Weber syndrome (31 females, mean age 4.5 years) and 120 age/sex-matched controls were included in this retrospective study. We performed a visual analysis to identify patients with asymmetric cavernous sinus enlargement. Then, we measured on axial T2WI the left (A), right (B), and bilateral (LL) transverse diameters of the cavernous sinus. We calculated the module of the difference |A-B| and the cavernous sinus asymmetry index as the ratio |A-B|/LL. Differences among groups were assessed by Mann–Whitney U and Kruskal–Wallis tests. Clinicoradiological associations were evaluated by Fisher exact test. We found seven subjects (11.6%) with asymmetric CS enlargement. The |A-B| and cavernous sinus asymmetry index were higher in patients with asymmetric CS enlargement compared with controls and patients without visible CS abnormalities (pB
- Published
- 2019
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.