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Decades of advances in computer architecture, software-intensive applications and system integration have created significant challenges for embedded systems designers and test engineers. Intrusive software instrumentation and breakpoint-based debugging are often viewed as the primary options for observing operational system internals. This narrow sight creates complicated test flows and convoluted debugging procedures. Modern embedded computing systems offer Embedded Trace as the technological answer to the encountered observability conundrum. Although an integral part of virtually all modern processors, it is frequently overlooked. Its technical foundations are little known to application engineers, test engineers, and project managers. This article explains Embedded Trace as an essential technology in the testing and debugging toolbox. It highlights its capabilities, limitations and opportunities.

Background The challenge of managing acute postoperative pain is the well tolerated and effective administration of analgesics with a minimum of side effects. The standard therapeutic approach is patient-controlled analgesia (PCA) with systemic opioids. To overcome problems of oscillating opioid concentrations, we studied patient-controlled analgesia by target-controlled infusion (TCI-PCA) as an alternative. Objective To compare efficacy, safety and side effects of standard PCA with TCI-PCA for postoperative pain therapy with hydromorphone. Design Single-blinded, randomised trial. Setting University Hospital, Germany from December 2013 to April 2015. Participants Fifty adults undergoing cardiac surgery. Interventions Postoperative pain therapy on the ICU was managed with intravenous (i.v.) hydromorphone and patients randomised to TCI-PCA with target plasma concentrations between 0.8 and 10 ng ml, or PCA with bolus doses of 0.2 mg. Pain was regularly assessed using the 11-point numerical rating scale (NRS). Blood pressure, heart rate, oxygen saturation and cardiac output were continuously monitored, and adverse events were registered throughout the study. Main outcome measures NRS pain ratings, hydromorphone doses, haemodynamic effects and side effects. Results NRS pain ratings, total doses of hydromorphone and haemodynamic data did not differ significantly between TCI-PCA and PCA. The number of bolus doses during PCA was significantly higher than the number of target increases during TCI-PCA (P = 0.006). The number of negative requests was also significantly higher during PCA than during TCI-PCA (P = 0.02). The respiratory rate on the first postoperative morning was 25 ± 6 min during TCI-PCA, compared with 19 ± 4 min during PCA (P = 0.022). Nausea occurred in 30% after TCI-PCA and 24% after PCA (P = 0.46). Conclusion TCI-PCA was effective and well tolerated in acute postoperative pain management after cardiac surgery. Further studies are needed to evaluate this approach in clinical practice. Trial registration EudraCT Number: 2013-002875-16, and ClinicalTrials.gov Identifier: NCT02035709.

Objectives Patients with cannabinoid hyperemesis syndrome (CHS) present frequently to the emergency department. Previous case studies suggest dramatic symptomatic improvement with topical capsaicin treatment. This exploratory study examined the potential effectiveness of topical capsaicin in patients with nausea and vomiting due to a suspected CHS exacerbation. Methods This was a double-blind, randomized placebo-controlled pilot trial. Adults who presented with vomiting suspected to be from CHS were eligible for enrollment. We excluded pregnant women and those with resolution of symptoms. Following randomization, topical 0.1% capsaicin or placebo cream was applied to the anterior abdomen in a uniform manner. The primary outcome was the severity of nausea on a visual analog scale (VAS) of 0 to 10 cm assessed at 30 minutes. Secondary outcomes were adverse events, occurrence of posttreatment vomiting, nausea by VAS at 60 minutes, and hospital admission. Results This pilot trial enrolled 30 patients, 17 in the capsaicin arm and 13 in the placebo arm. One patient in the capsaicin arm did not tolerate treatment due to skin irritation. Mean ± SD nausea severity at 30 minutes was 4.1 ± 2.3 cm in the capsaicin arm and 6.1 ± 3.3 cm in the placebo arm (difference = -2.0 cm, 95% confidence interval [CI] = 0.2 to -4.2 cm). At 60 minutes, mean ± SD nausea severity was 3.2 ± 3.2 cm versus 6.4 ± 2.8 cm (difference = -3.2 cm, 95% CI = -0.9 to -5.4 cm). The percent reduction in nausea at 60 minutes from baseline was 46.0% in the capsaicin arm and 24.9% in the placebo arm (difference = 21.1%, 95% CI = -5.6% to 47.9%). A higher proportion of capsaicin group patients (29.4% vs. 0%) had complete resolution of nausea (relative risk = 3.4, 95% CI = 1.6 to 7.1). Conclusion In this pilot trial, the application of topical capsaicin cream was associated with a significant reduction in nausea at 60 minutes but not at 30 minutes and provided more complete relief of nausea.

Petrinovich’s target article focused on how behavioral science is done, including how it is often done wrong, and how it should be done. I identify another malign influence on behavioral science, which, so far as I know, has, until now, been ignored (I would be happy to be shown that I am wrong on this). To wit, the way that Introductions to papers are written creates a niche that can be exploited for the purposes of promoting one’s work to obtain resources or status, or for self-aggrandizement. I offer a few, probably wrongheaded, suggestions for ending this practice.

Runtime verification is an area of formal methods that studies the dynamic analysis of execution traces against formal specifications. Typically, the two main activities in runtime verification efforts are the process of creating monitors from specifications, and the algorithms for the evaluation of traces against the generated monitors. Other activities involve the instrumentation of the system to generate the trace and the communication between the system under analysis and the monitor. Most of the applications in runtime verification have been focused on the dynamic analysis of software, even though there are many more potential applications to other computational devices and target systems. In this paper we present a collection of challenges for runtime verification extracted from concrete application domains, focusing on the difficulties that must be overcome to tackle these specific challenges. The computational models that characterize these domains require to devise new techniques beyond the current state of the art in runtime verification., Formal Methods in System Design, 54 (3), ISSN:0925-9856, ISSN:1572-8102

Surfactant proteins (SP) are multi-systemic proteins playing crucial roles in the regulation of rheological properties of physiological fluids, host defense, and the clearance of potentially harmful metabolites. Hydrocephalus patients suffer from disturbed central nervous system (CNS) fluid homeostasis and exhibit remarkably altered SP concentrations within the cerebrospinal fluid (CSF). A connection between CSF-SPs, CSF flow, and ventricular dilatation, a morphological hallmark of hydrocephalus, has been reported previously. However, currently there are no studies investigating the link between rheologically active SPs and periventricular white matter changes caused by impaired CSF microcirculation in hydrocephalic conditions. Thus, the aim of this study was to assess their possible relationships. The present study included 47 individuals (27 healthy subjects and 20 hydrocephalus patients). CSF specimens were analyzed for concentrations of SP-A, SP-C, and SP-D by using enzyme-linked immunosorbent assays (ELISAs). Axial T2w turbo inversion recovery magnitude (TIRM) magnetic resonance imaging was employed in all cases. Using a custom-made MATLAB-based tool for quantification of magnetic resonance signal intensities in the brain, parameters related to disturbed deep white matter CSF microcirculation were estimated (TIRM signal intensity (SI)-mean, minimum, maximum, median, mode, standard deviation, and percentiles, p10th, p25th, p75th, p90th, as well as kurtosis, skewness, and entropy of the SI distribution). Subsequently, statistical analysis was performed (IBM SPSS 24™) to identify differences between hydrocephalic patients and healthy individuals and to further investigate the connections between CSF-SP changes and deep white matter signal intensities. SP-A (0.38 ± 0.23 vs. 0.76 ± 0.49 ng/ml) and SP-C (0.54 ± 0.28 vs. 1.27 ± 1.09 ng/ml) differed between healthy controls and hydrocephalus patients in a statistically significant manner. Also, corresponding quantification of white matter signal intensities revealed statistically significant differences between hydrocephalus patients and healthy individuals: SImean (370.41 ± 188.15 vs. 222.27 ± 99.86, p = 0.001), SImax (1115.30 ± 700.12 vs. 617.00 ± 459.34, p = 0.005), SImedian (321.40 ± 153.17 vs. 209.52 ± 84.86, p = 0.001), SImode (276.55 ± 125.63 vs. 197.26 ± 78.51, p = 0.011), SIstd (157.09 ± 110.07 vs. 81.71 ± 64.94, p = 0.005), SIp10 (229.10 ± 104.22 vs. 140.00 ± 63.12, p = 0.001), SIp25 (266.95 ± 122.62 vs. 175.63 ± 71.42, p = 0.002), SIp75 (428.80 ± 226.88 vs. 252.19 ± 110.91, p = 0.001), SIp90 (596.47 ± 345.61 vs. 322.06 ± 176.00, p = 0.001), skewness (1.19 ± 0.68 vs. 0.43 ± 1.19, p = 0.014), and entropy (5.36 ± 0.37 vs. 4.92 ± 0.51, p = 0.002). There were no differences regarding SP-D levels in hydrocephalus patients vs. healthy controls. In the acute hydrocephalic subgroup, correlations were as follows: SP-A showed a statistically significant correlation with SImax (r = 0.670, p = 0.024), SIstd (r = 0.697, p = 0.017), SIp90 (r = 0.621, p = 0.041), and inverse correlation with entropy (r = - 0.700, p = 0.016). SP-C correlated inversely with entropy (r = - 0.686, p = 0.020). For the chronic hydrocephalus subgroup, the following correlations were identified: SP-A correlated with kurtosis of the TIRM histogram (r = - 0.746, p = 0.021). SP-C correlated with SImean (r = - 0.688, p = 0.041), SImax (r = - 0.741, p = 0.022), SImedian (r = - 0.716, p = 0.030), SImode (r = - 0.765, p = 0.016), SIstd (r = - 0.671, p = 0.048), SIp25 (r = - 0.740, p = 0.023), SIp75 (r = - 0.672, p = 0.048), and SIp90 (r = - 0.667, p = 0.050). SP-D apparently does not play a major role in CSF fluid physiology. SP-A and SP-C are involved in different aspects of CNS fluid physiology. SP-A appears to play an essential compensatory role in acute hydrocephalus and seems less involved in chronic hydrocephalus. In contrary, SP-C profile and white matter changes are remarkably connected in CSF of chronic hydrocephalus patients. Considering the association between CSF flow phenomena, white matter changes, and SP-C profiles, the latter may especially contribute to the regulation of paravascular glymphatic physiology.

Content-Addressable Memory (CAM) is a powerful abstraction for building memory caches, routing tables and hazard detection logic. Without a native CAM structure available on FPGA devices, their functionality must be emulated using the structural primitives at hand. Such an emulation causes significant overhead in the consumption of the underlying resources, typically general-purpose fabric and on-chip block RAM (BRAM). This often motivates mitigating trade-offs, such as the reduction of the associativity of memory caches. This paper describes a technique to implement the hazard resolution in a memory update queue that hides the off-chip memory readout latency of read-modify-write cycles while guaranteeing the delivery of the full memory bandwidth. The innovative use of DSP slices allows them to assume and combine the functions of (a) the tag and data storage, (b) the tag matching, and (c) the data update in this key-value storage scenario. The proposed approach provides designers with extra flexibility by adding this resource type as another option to implement CAM., Comment: Submitted to FPL 2020

In order to meet the challenges of digitalization in law and to create greater benefits for everybody involved, all relevant legal stakeholders need to collaborate. A digital platform could offer a suitable environment for this form of cooperation, especially since the market is currently dominated by rather isolated applications that offer only limited options, e.g. with regard to the use of data. These single approaches fall short and are not capable of providing appropriate answers to future legal issues. It is therefore suggested that establishing a Common Legal Platform that brings together all participants, and aligns both common and commercial interests, will be beneficial. This involves a business model that supports both of these pillars by design, so that every stakeholder’s interest is taken into consideration and that all such interests complement one another. Only joined forces can make a Common Legal Platform thrive and advance innovation, as well as further development in the legal industry.

Twenty-first century organizations often rely on teams to enact their strategy and to enhance their flexibility in interacting with their external environment over time. Team composition, or the configuration of team member attributes, can influence team effectiveness and is an important consideration in the management of teams. To date, however, there is limited guidance on how seemingly smaller team composition decisions can contribute to organizational effectiveness and competitive advantage. We draw on strategic human resource management (HRM), HRM, and industrial and organizational psychology literatures to develop a conceptual framework for strategic team composition decisions. We describe how organizations use teams to enact their strategy (i.e., fit), and use adaptive teams and networks of teams to achieve fit in a dynamic environment (i.e., flexibility). Using the concepts of fit and flexibility, we develop four guiding principles for strategic team composition decisions.

Surfactant proteins (SPs) are a multifunctional group of proteins, responsible for the regulation of rheological properties of body fluids, host defense, and cellular waste clearance. Their concentrations are changed in cerebrospinal fluid (CSF) of patients suffering from communicating hydrocephalus. Hydrocephalic conditions are accompanied by altered CSF flow dynamics; however, the association of CSF-SP concentrations and CSF flow has not yet been investigated. Hence, the aim of this study was to evaluate the association between SP concentrations in the CSF and marked CSF flow phenomena at different anatomical landmarks of CSF spaces. Sixty-one individuals (15 healthy subjects and 46 hydrocephalus patients) were included in this study. CSF specimens were analyzed for SP-A, SP-B, SP-C, and SP-D concentrations by the use of enzyme-linked immunosorbent assays (ELISA). CSF flow was evaluated in axial T2_turbo inversion recovery magnitude (TIRM)-weighted and sagittal T2-weighted magnetic resonance imaging sections using a 4-grade scale (1—no flow, 2—subtle flow, 3—moderate flow, and 4—strong flow). CSF-SP concentrations (mean ± standard deviation) of the overall collective were as follows: SP-A = 0.73 ± 0.58 ng/ml, SP-B = 0.17 ± 0.93 ng/ml, SP-C = 0.95 ± 0.75 ng/ml, and SP-D = 7.43 ± 5.17 ng/ml. The difference between healthy controls and hydrocephalic patients regarding CSF concentrations of SP-A (0.34 ± 0.22 vs. 0.81 ± 0.59 ng/ml) and SP-C (0.48 ± 0.29 vs. 1.10 ± 0.79 ng/ml) revealed to be statistically significant as calculated by means of ANOVA (p values of 0.022 and 0.007, respectively). CSF flow voids were detectable at all investigated landmarks of the CSF spaces (foramina of Monro, third ventricle, mesencephalic aqueduct, prepontine cistern, fourth ventricle, cisterna magna, and craniocervical junction). CSF flow voids, reported as mean ± standard deviation, revealed to be significantly increased in hydrocephalic patients compared to controls as calculated by means of ANOVA (respective p values are given in brackets following values of descriptive statistics) at the following sites: foramina of Monro (1.60 ± 0.91 vs. 2.37 ± 0.99, p = 0.01), fourth ventricle (1.67 ± 0.98 vs. 2.52 ± 1.05, p = 0.007), and the cisterna magna (1.93 ± 1.10 vs. 2.72 ± 1.13, p = 0.022). Spearman’s rank order calculation identified significant correlations for CSF flow voids at the foramina of Monro and the third ventricle with SP-A (r = 0.429, p = 0.001 and r = 0.464, p

Intensity-modulated radiotherapy (IMRT) techniques are now standard practice. IMRT or volumetric-modulated arc therapy (VMAT) allow treatment of the tumor while simultaneously sparing organs at risk. Nevertheless, treatment plan quality still depends on the physicist’s individual skills, experiences, and personal preferences. It would therefore be advantageous to automate the planning process. This possibility is offered by the Pinnacle3 treatment planning system (Philips Healthcare, Hamburg, Germany) via its scripting language or Auto-Planning (AP) module. AP module results were compared to in-house scripts and manually optimized treatment plans for standard head and neck cancer plans. Multiple treatment parameters were scored to judge plan quality (100 points = optimum plan). Patients were initially planned manually by different physicists and re-planned using scripts or AP. Script-based head and neck plans achieved a mean of 67.0 points and were, on average, superior to manually created (59.1 points) and AP plans (62.3 points). Moreover, they are characterized by reproducibility and lower standard deviation of treatment parameters. Even less experienced staff are able to create at least a good starting point for further optimization in a short time. However, for particular plans, experienced planners perform even better than scripts or AP. Experienced-user input is needed when setting up scripts or AP templates for the first time. Moreover, some minor drawbacks exist, such as the increase of monitor units (+35.5% for scripted plans). On average, automatically created plans are superior to manually created treatment plans. For particular plans, experienced physicists were able to perform better than scripts or AP; thus, the benefit is greatest when time is short or staff inexperienced.

This demo showcases the ZUSPRL302 platform that was developed as the hardware vehicle enabling the work of the EU-funded H2020 Project COEMS (https://www.coems.eu/). This platform features an extensive amount of large and fast external reduced-latency RLDRAM modules, which mitigate the critical memory access times of pointer-chasing algorithms. We demonstrate that this platform enables the online reconstruction of the control flow of an application running on a standard off-the-shelf processor monitored via its execution trace interface. This reconstruction has to traverse the prepped control flow graph of the application on the basis of minimal highly-compressed execution trace data and does so at the pace of the processor for the purpose of coverage monitoring and integrity checking. The ZUSPRL302 platform is valuable contribution to the FPGA community as it enables the FPGA acceleration of fine-grained pointer chasing algorithms, which have traditionally been considered a misfit for this domain.

Background: Radioembolization (RE) with yttrium-90 (90Y) resin microspheres yields heterogeneous response rates in with primary or secondary liver cancer. Radiation-induced liver disease (RILD) is a potentially life-threatening complication with higher prevalence in cirrhotics or patients exposed to previous chemotherapies. Advances in RILD prevention may help increasing tolerable radiation doses to improve patient outcomes. This study aimed to evaluate the impact of post-therapeutic RILD-prophylaxis in a cohort of intensely pretreated liver metastatic breast cancer patients, Methods: Ninety-three patients with liver metastases of breast cancer received RE between 2007 and 2016. All Patients received RILD prophylaxis for 8 weeks post-RE. From January 2014, RILD prophylaxis was changed from ursodeoxycholic acid (UDCA) and prednisolone (standard prophylaxis [SP], n = 59) to pentoxifylline (PTX), UDCA and low-dose low molecular weight heparin (LMWH) (modified prophylaxis (MP), n = 34). The primary endpoint was toxicity including symptoms of RILD, Results: Dose exposure of normal liver parenchyma was higher in the modified vs. standard prophylaxis group (47.2 Gy (17.8–86.8) vs. 40.2 Gy (12.5–83.5), p = 0.017). All grade RILD events (mild: bilirubin ≥ 21 µmol/L (but &lt, 30 μmol/L), severe: (bilirubin ≥ 30 µmol/L and ascites)) were observed more frequently in the SP group than in the MP group, albeit without significance (7/59 vs. 1/34, p = 0.140). Severe RILD occurred in the SP group only (n = 2, p &gt, 0.1). ALBI grade increased in 16.7% patients in the MP and in 27.1% patients in the SP group, respectively (group difference not significant), Conclusions: At established dose levels, mild or severe RILD events proved rare in our cohort. RILD prophylaxis with PTX, UDCA and LMWH appears to have an independent positive impact on OS in patients with metastatic breast cancer and may reduce the frequency and severity of RILD. Results of this study as well as pathophysiological considerations warrant further investigations of RILD prophylaxis presumably targeting combinations of anticoagulation (MP) and antiinflammation (SP) to increase dose prescriptions in radioembolization.

Modern multi-core Systems-on-Chip (SoC) provide very high computational power. On the downside, they are hard to debug and it is often very difficult to understand what is going on in these chips because of the limited observability inside the SoC. Chip manufacturers try to compensate this difficulty by providing highly compressed trace data from the individual cores. In the past, the common way to deal with this data was storing it for later offline analysis, which severely limits the time span that can be observed. In this contribution, we present an FPGA-based solution that is able to process the trace data in real-time, enabling continuous observation of the state of a core. Moreover, we discuss applications enabled by this technology.

Introduction: Management of the immunosuppressed patient with diverticular disease remains controversial. We report the largest series of colon cancer patients undergoing chemotherapy and hospitalized for acute diverticulitis, to determine whether recent treatment with systemic chemotherapy is associated with increased risk for/increased severity of recurrent diverticulitis. Methods: Retrospective cohort study of adult patients hospitalized for an initial episode of acute colonic diverticulitis at Memorial Sloan Kettering Cancer Center, 1988–2004. Outcomes in patients receiving systemic chemotherapy within one month of admission for diverticulitis (“Chemo”) were compared to outcomes of patients not receiving chemotherapy within the past month (“No-chemo”). Results: A total 131 patients met inclusion criteria. Chemo patients did not differ significantly from No-chemo group in terms of severity of acute diverticulitis at index admission (13.2% vs. 4.4%, respectively, p = 0.12), resumption of chemotherapy (median 2 months), failure of non-operative management (13.2% vs 4.4%, respectively, p = 0.12), frequency of recurrence (20.5% vs 18.5%), hospital length of stay (p = 0.08), and likelihood of interval resection (24.0% vs. 16.2%, respectively, p = 0.39). Chemo patients recurred with more severe disease, were more likely to undergo emergent surgery (75.0% vs. 23.5%, respectively, p = 0.03), and were more likely to be diverted (100.0% vs. 25.0%, respectively, p = 0.03). Chemo patients were significantly more likely to incur a postoperative complication (100% vs 9.1% p

Police agencies take a variety of approaches to determining their staffing allocation needs. Among these are the per-capita, minimum staffing, authorized level, and workload-based methods. Based on a review of the literature, interviews with practitioners representing 20 diverse agencies across the USA and national focus group of 21 staffing experts, this article assesses current trends and experiences in staffing allocation. Additionally, it examines the strengths and weaknesses of alternative approaches to determining staffing need and to managing workload demand in ways that that minimize the use of sworn officers.

Multicore System-on-Chip (SoC) implementations of embedded systems are becoming very popular. In these systems it is possible to spread out computations over many cores. On one hand this leads to better energy efficiency if clock frequencies and core voltages are reduced. On the other hand this delivers very high performance to the software developer and thus enables complex software systems to be implemented. Unfortunately, debugging and validation of these systems becomes extremely difficult. Various technological approaches try to solve this dilemma. In this contribution we will show a new approach to observe multi-core SoCs and make their internal operations visible to external analysis tools. Also, we show that runtime verification can be employed to analyze and validate these internal operations while the system operates in its normal environment. The combination of these two approaches delivers unprecedented options to the developer to understand and verify system behavior even in complex multicore SoCs.

Statistical learning theory (SLT) is the statistical formulation of machine learning theory, a body of analytic methods common in "big data" problems. Regression-based SLT algorithms seek to maximize predictive accuracy for some outcome, given a large pool of potential predictors, without overfitting the sample. Research goals in psychology may sometimes call for high dimensional regression. One example is criterion-keyed scale construction, where a scale with maximal predictive validity must be built from a large item pool. Using this as a working example, we first introduce a core principle of SLT methods: minimization of expected prediction error (EPE). Minimizing EPE is fundamentally different than maximizing the within-sample likelihood, and hinges on building a predictive model of sufficient complexity to predict the outcome well, without undue complexity leading to overfitting. We describe how such models are built and refined via cross-validation. We then illustrate how 3 common SLT algorithms-supervised principal components, regularization, and boosting-can be used to construct a criterion-keyed scale predicting all-cause mortality, using a large personality item pool within a population cohort. Each algorithm illustrates a different approach to minimizing EPE. Finally, we consider broader applications of SLT predictive algorithms, both as supportive analytic tools for conventional methods, and as primary analytic tools in discovery phase research. We conclude that despite their differences from the classic null-hypothesis testing approach-or perhaps because of them-SLT methods may hold value as a statistically rigorous approach to exploratory regression. (PsycINFO Database Record

We describe a complete system for animating realistic clothing on synthetic bodies of any shape and pose without manual intervention. The key component of the method is a model of clothing called DRAPE (DRessing Any PErson) that is learned from a physics-based simulation of clothing on bodies of different shapes and poses. The DRAPE model has the desirable property of "factoring" clothing deformations due to body shape from those due to pose variation. This factorization provides an approximation to the physical clothing deformation and greatly simplifies clothing synthesis. Given a parameterized model of the human body with known shape and pose parameters, we describe an algorithm that dresses the body with a garment that is customized to fit and possesses realistic wrinkles. DRAPE can be used to dress static bodies or animated sequences with a learned model of the cloth dynamics. Since the method is fully automated, it is appropriate for dressing large numbers of virtual characters of varying shape. The method is significantly more efficient than physical simulation.

Although physicians and nurses are best positioned to recognize and diagnose cases of elder abuse, the level of reporting these cases is much lower than its true incidence. Our aim was to assess and compare knowledge and attitudes of physicians and nurses toward this phenomenon. Two hundred and thirty-five nurses and physicians were asked to participate in the study. One hundred nurses and 57 physicians ultimately completed the questionnaires. The main finding was that participants had a low level of knowledge of elder abuse issues and the relevant laws and regulations (mean correct answers 5.36+/-1.45 of 10 and 4.67+/-1.34 of 8, respectively). No significant differences were found in the physicians' knowledge according to medical specialty, hospital type, years in the profession and geriatric experience. Licensed practical nurses knew less than registered and academic nurses relating to the abuse issue and state reporting laws (p=0.003 and 0.02, respectively). No significant differences relating to the knowledge of elder abuse were found between nurses and physicians nor between general and geriatric hospital employees. Both physicians and nurses tended to have neutral attitudes regarding this issue. However, employees of geriatric hospitals had better attitudes than general hospital workers (p=0.008). Most responders believed that the unwillingness to get legally involved had been the main reason of not reporting suspected cases. This study emphasizes the need to take more efficient measures to improve the knowledge of the medical and nursing staff concerning elder abuse and to encourage medical personnel to be more concerned and involved in the safeguarding of the elderly.

A shock train inside a diverging duct is analyzed at different pressure levels and Mach numbers. Nonreactive pressurized cold gas is used as fluid. The structure and pressure recovery inside the shock train is analyzed by means of wall pressure measurements, Schlieren images and total pressure probes. During the course of the experiments, the total pressure of the flow, the back pressure level and the Mach number upstream of the compression region have been varied. It is shown that the Reynolds number has some small effect on the shock position and length of the shock train. However, more dominant is the effect of the confinement level and Mach number. The results are compared with analytical and empirical models from the literature. It was found that the empirical pseudo-shock model from Billig and the analytical mass averaging model from Matsuo are suitable to compute the pressure gradient along the shock train and total pressure loss, respectively.

Objectives: To determine whether neuroticism, cognitive ability, and their interaction predicted mortality and to test whether neuroticism or cognitive ability effects were mediated by socioeconomic status (SES), physical health, mental health, or health behaviors. Methods: Participants were 4200 men followed up for > 15 years. Participants took part in telephone interviews and medical and psychological evaluations. The neuroticism measure was based on the Minnesota Multiphasic Personality Inventory, which was administered during the psychological examination. Cognitive ability was measured via the Army General Technical Test given at induction and Wechsler Adult Intelligence Scale subtests administered during the psychological examination, approximately 17 years later. We used covariance structure modeling to analyze the data because it enabled us to conduct Cox proportional hazards analyses with latent variables and mediator variables. Results: Even after adjusting for age, ethnicity, and marital status, high neuroticism and low cognitive ability were independent mortality risk factors. A significant interaction indicated that participants high in neuroticism and low in cognitive ability were particularly at risk. In a second series of models, we examined whether education, income, seven physical health measures, two mental health measures, drinking, and smoking were related to mortality. SES and physical health variables attenuated the effect of cognitive ability but not that of neuroticism. A third series of models revealed that cognitive ability was related to mortality via its direct effects on income and health. Conclusions: The effects of high neuroticism, low cognitive ability, and their interaction predict mortality. Cognitive ability effects are mediated by health, income, and education.

This study evaluates the order of magnitude of the monetary cost of achieving an international strategic limitation agreement on weapons of mass destruction (WMD) in an asymmetric arms race, with applications to the Israeli–Syrian and the North versus South Korean conflicts. It extends the Kagan et al. (2005) framework and develops a model of resource allocation between expenditure on civilian government consumption and on security in a non‐cooperative (Cournot) arms race between a developed country and a less‐developed country. The model is used to predict the optimal mix of weapons of the two countries engaged in the arms race, and to evaluate the applicability of international strategic WMD limitation agreements. Applying the model to the arms race between Israel and Syria shows that if considered from a purely monetary perspective, such an agreement, in which the monetary transfer to Syria is made by either Israel or a third party, is within reach. A strategic agreement to limit North Korea’s WMD is a...

In a continuous cold gas wind tunnel, with a convergent-divergent nozzle geometry similar to a pilot facility for the gas-phase synthesis of nanoparticles [3] the recompression from supersonic to subsonic flow conditions is conducted by a shock train. A principle sketch of a typical shock train is depicted in Fig. 1 while a detailed description of the shock train phenomenon and a comprehensive review of its timeaveraged behaviour can be found in [6].

Although there is a very large body of research examining community policing practices in the United States, no study has yet to examine the efforts by police departments to promote community policing in the news media. This study fills this gap. Specifically, this study presents the results from a national survey of public information officers and media personnel in large-sized cities to examine the efforts by police departments to promote innovative programs such as community policing in the news and document how community policing is presented in the news. The results indicate that although police departments and media personnel agree that they have a very good working relationship and that there are many opportunities to promote community policing, most police departments make only minimal effort to do so. The analysis of newspaper coverage of community policing finds that it is rarely presented in the news and the coverage that occurs is isolated.

Police organizations must strategically control their external environment in order to maintain organizational legitimacy. Exploiting their relationship with the news media is one way to accomplish this goal effectively. Despite the documented importance of crime, justice, and social control as a news topic, there is a limited understanding of the variables driving how police and media evaluate this relationship. This study used data collected from a national sample of police media personnel to fill this gap, and concluded that the police and media valued their interdependent relationship, but for different reasons. Police public information officers recognize the power of the media and attempt to use this power to promote the organization. News personnel are satisfied because the police provide data so they can easily produce crime stories. The implications for understanding how police organizations control their external organization are discussed.

Some of the most active arms races are taking place between developed and less developed countries. The inability of less developed countries to compete financially, as well as technologically, with developed countries may be forcing the former to acquire terror weapons (TWP). The Iran–Iraq war in the 1980s and the events of 9/11 proved that the use of TWP is no longer a mere threat; there are several organizations and countries that will not hesitate to use them. This study develops a model of resource allocation in an arms race between a developed country that is characterized by state‐of‐the‐art technology and high GDP, and a less developed country whose technological capability and GDP are much lower. The model is used to predict the optimal mix of weapons of the two countries that are engaged in the arms race. Applying the model to the arms race between Israel and Syria demonstrates its use.

In this Letter, we describe the realization of a tracked line-of-sight optical wireless communication system for indoor data distribution. We built a laser-based transmitter with adaptive focus and ray steering by a microelectromechanical systems mirror. To execute the alignment procedure, we used a CMOS image sensor at the transmitter side and developed an algorithm for image recognition to localize the receiver’s position. The receiver is based on a self-developed optoelectronic integrated chip with low requirements on the receiver optics to make the system economically attractive. With this system, we were able to set up the communication link automatically without any back channel and to perform error-free (bit error rate

Objective:\ud \ud Studies examining the relation of information processing speed, as measured by reaction time, with mortality are scarce. We explored these associations in a representative sample of the US population.\ud \ud Methods:\ud \ud Participants were 5,134 adults (2,342 men) aged 20–59 years from the Third National Health and Nutrition Examination Survey (NHANES III, 1988–94).\ud \ud Results:\ud \ud Adjusted for age, sex, and ethnic minority status, a 1 SD slower reaction time was associated with a raised risk of mortality from all-causes (HR = 1.25, 95% CI 1.12, 1.39) and cardiovascular disease (CVD) (HR = 1.36, 95% CI 1.17, 1.58). Having 1 SD more variable reaction time was also associated with greater risk of all-cause (HR = 1.36, 95% CI 1.19, 1.55) and CVD (HR = 1.50, 95% CI 1.33, 1.70) mortality. No associations were observed for cancer mortality. The magnitude of the relationships was comparable in size to established risk factors in this dataset, such as smoking.\ud \ud Interpretation:\ud \ud Alongside better-established risk factors, reaction time is associated with increased risk of premature death and cardiovascular disease. It is a candidate risk factor for all-cause and cause-specific mortality.

Research Summary: This evaluation of a directed police patrol project utilizes a pre-post quasi-experimental design with a non-equivalent control group as well as an interrupted time series analysis. The results suggest that directed patrol had an impact on firearms crime in one of the target areas but not the other. Policy Implications: The results suggest that a specific deterrence strategy whereby the police utilize directed patrol to focus on suspicious activities and locations reduced violent gun crime. In contrast, a general deterrence strategy focused on maximizing vehicle stops did not have an apparent effect.

In this study we examine citizens' support for aggressive traffic enforcement strategies and discuss whether the implementation of two different types of traffic enforcement decreases public support. We also examine whether citizens' perceptions of crime, quality of life, and the police are influenced by an increased police presence in their neighborhood. The public opinion data presented here are taken from two experimental target areas and one comparison area. Overall the findings suggest that citizens strongly support aggressive traffic enforcement practices and that the implementation of such strategies does not reduce their support. Residents of areas where police are using these types of tactics do not think that the police are harassing them. Citizens living in one of the experimental areas are significantly more likely to support the police, and think that the police work well with the neighborhood. Residents of the areas that experienced two types of aggressive enforcement, however, did not think...

Many obstacles are involved in teaching statistics to undergraduates, including high attrition rates, students' anxiety, and a limited ability to grasp difficult concepts. These concerns can be addressed effectively by implementing strategies that require students to be actively engaged in the learning of statistics. First, we discuss how activity-based strategies and information technology can be an effective way to teach a statistics course. Second, we discuss how we changed a statistics course to include activity-based strategies. Finally, we discuss how cooperative learning, as a type of activity-based strategy, can increase students' understanding of statistics.

This article examines the news media's role in federal criminal justice policy-making. Specifically, we examine how news coverage of cele brated events affected the gun control policy-agenda over a twenty-five year period by linking the presentation of gun issues in the New York Times to corresponding changes in the number of congressional hearings on gun control. Moreover, we examine the implementation of two pieces of federal gun legislation as case studies to more clearly identify the role of the media in federal criminal justice policy-making. Our results indi cate that the media affect the federal policy process in three ways: first, the media can open a window of opportunity to consider policy change; second, the media can promote a limited range of policy alternatives; and third, the media can promote the interests of policy entrepreneurs.

Reports on the innovations process in American policing. Explores how information about innovation is communicated among police organizations and the factors which influence adoption. Reports the findings of a survey of police chiefs and executives. Develops a model with four elements: cosmopolitanism; risk mediation; peer emulation; and innovativeness. Finds that many police departments use informal networks of communication to support organizational decision making and are often influenced by executives’ participation in policy communities and by efforts to reduce the organization’s perceived risk of civil liability. Recommends that police organizations strengthen their networks of communication in a more formal manner.

The 3D shape of the human body is useful for applications in fitness, games, and apparel. Accurate body scanners, however, are expensive, limiting the availability of 3D body models. Although there has been a great deal of interest recently in the use of active depth sensing cameras, such as the Microsoft Kinect, for human pose tracking, little has been said about the related problem of human shape estimation. We present a method for human shape reconstruction from noisy monocular image and range data using a single inexpensive commodity sensor. The approach combines low-resolution image silhouettes with coarse range data to estimate a parametric model of the body. Accurate 3D shape estimates are obtained by combining multiple monocular views of a person moving in front of the sensor. To cope with varying body pose, we use a SCAPE body model which factors 3D body shape and pose variations. This enables the estimation of a single consistent shape, while allowing pose to vary. Additionally, we describe a novel method to minimize the distance between the projected 3D body contour and the image silhouette that uses analytic derivatives of the objective function. We use a simple method to estimate standard body measurements from the recovered SCAPE model and show that the accuracy of our method is competitive with commercial body scanning systems costing orders of magnitude more.

Reports on a field experiment in Dayton, Ohio, where the police department has no specialized traffic division, hence traffic enforcement is part of the routine assignment. Aims to measure the effects of traffic law enforcement on crime, arrests and traffic accidents. Presents data covering all index arrests and special arrests involving weapons, drugs and offenders driving under influence, plus all reported traffic accidents. Contrary to other research, fails to detect a relationship between traffic enforcement and crime. Investigates possible reasons for this.

Researchers often seek to understand how organizations make decisions. To obtain data about these organization-level issues, they traditionally have interviewed one or two key persons in the organizations. Information obtained in this manner, however, is subject to several sources of bias. In this article, an analytical technique is reviewed that allows the researcher to decompose these informant reports into their respective trait, informant bias, and measure-specificity components, using LISREL An illustration of the technique, based on a survey of police executives, is provided

The Timed Up and Go (TUG) test is a widely used measure of mobility and fall risk among older adults that is typically scored using a stopwatch. We tested the hypothesis that a body-fixed accelerometer can enhance the ability of the TUG to identify community-living older adults with a relatively high fall risk of unknown origin. Twenty-three community-living elderly fallers (76.0 ± 3.9 years) and 18 healthy controls (68.3 ± 9.1 years) performed the TUG while wearing a 3D-accelerometer on the lower back. Acceleration-derived parameters included Sit-to-Stand and Stand-to-Sit times, amplitude range (Range), and slopes (Jerk). Average step duration, number of steps, average step length, gait speed, acceleration-median, and standard-deviation were also calculated. While the stopwatch-based TUG duration was not significantly different between the groups, acceleration-derived TUG duration was significantly higher (p = 0.007) among the fallers. Fallers generally exhibited lower Range and Jerk (p0.01). While TUG stopwatch duration successfully identified 63% of the subjects, an accelerometer-derived three-measure-combination correctly classified 87% of the subjects. Accelerometer-derived measures were generally not correlated with TUG duration. These findings demonstrate that fallers have difficulty with specific TUG aspects that can be quantified using an accelerometer. Without compromising simplicity of testing, an accelerometer can apparently be combined with TUG duration to provide complementary, objective measures that allow for a more complete, sensitive TUG-based fall risk assessment.

The 3D shape of the human body is useful for applications in fitness, games and apparel. Accurate body scanners, however, are expensive, limiting the availability of 3D body models. We present a method for human shape reconstruction from noisy monocular image and range data using a single inexpensive commodity sensor. The approach combines low-resolution image silhouettes with coarse range data to estimate a parametric model of the body. Accurate 3D shape estimates are obtained by combining multiple monocular views of a person moving in front of the sensor. To cope with varying body pose, we use a SCAPE body model which factors 3D body shape and pose variations. This enables the estimation of a single consistent shape while allowing pose to vary. Additionally, we describe a novel method to minimize the distance between the projected 3D body contour and the image silhouette that uses analytic derivatives of the objective function. We propose a simple method to estimate standard body measurements from the recovered SCAPE model and show that the accuracy of our method is competitive with commercial body scanning systems costing orders of magnitude more.

The statistical analysis of large corpora of human body scans requires that these scans be in alignment, either for a small set of key landmarks or densely for all the vertices in the scan. Existing techniques tend to rely on hand-placed landmarks or algorithms that extract landmarks from scans. The former is time consuming and subjective while the latter is error prone. Here we show that a model-based approach can align meshes automatically, producing alignment accuracy similar to that of previous methods that rely on many landmarks. Specifically, we align a low-resolution, artist- created template body mesh to many high-resolution laser scans. Our alignment procedure employs a robust iterative closest point method with a regularization that promotes smooth and locally rigid deformation of the template mesh. We evaluate our approach on 50 female body models from the CAESAR dataset that vary significantly in body shape. To make the method fully automatic, we define simple feature detectors for the head and ankles, which provide initial landmark locations. We find that, if body poses are fairly similar, as in CAESAR, the fully automated method provides dense alignments that enable statistical analysis and anthropometric measurement.

Objective: To develop a predictive model of lymph node yield in a series of colon cancer resection specimens with detailed anatomic and surgical technique data. Background: Lymph node yield in colon resection specimens has been associated with accuracy of staging and cancer outcomes. We hypothesized that lymph node yield is associated with multiple factors including, patient, tumor, and surgical variables. Methods: The pathology specimens from 152 elective colon neoplasm resections were prepared so that the lymph nodes were separated according to their anatomic relationship to the vascular pedicles and to the tumor. Prior to dissection, the specimen was measured. A linear regression analysis of a priori identified predictors and confounders of lymph node quantity was performed. Potential predictors in the model were age, gender, tumor stage, size, location, and differentiation, presence of lymphovascular or perineural invasion, mucinous histology, number of vascular pedicles, and use of endoscopic tattoo. Potential confounders were American Society of Anesthesiologists class, body mass index, count of lymph node metastasis, and specimen length. Results: Tumor size, tumor location, number of resected pedicles, and use of tattoo had a significant linear or quadratic relationship with lymph node yield when controlling other variables. 23% of the variation in lymph node count was explained by the 15 variables in the model. A model with the 4 significant variables explained 19% of the variation. Conclusion: Multiple tumor and surgical factors are associated with lymph node yields in colon specimens. A standard minimum of lymph nodes may not be applicable to all colon cancer resections.

Negative surgical margins are important for local control of rectal cancer treated with sphincter-preserving surgery. However, the association of rectal cancer recurrence with close distal margin is not well established.Data were extracted from a prospective database of patients collected between 1991 and 2003. Included were 627 patients who underwent curative low anterior resection with total mesorectal excision for rectal cancer 2 to 12 cm from the anal verge. Three hundred ninety-nine patients received neoadjuvant therapy, 65 received postoperative adjuvant therapy alone, and 163 were treated with surgery alone. Median follow-up was 5.8 years.On multivariable analysis, overall recurrence was associated with pathologic stage, lymphovascular invasion, and distal margin. Mucosal recurrence was uncommon; only 16 events were recorded, and of those only 8 were at the initial site of isolated tumor recurrence; 7 of the 8 were surgically salvaged. On univariable analysis, mucosal recurrence was associated with close distal margin (5 vs 2% at 5 y) and lymphovascular invasion (7 vs 2%). Pelvic recurrence, other than isolated mucosal recurrence, was associated with distal location (6 vs 4% at 5 y) and lymphovascular invasion (11 vs 4%). Distal margin as a continuous variable was associated with overall recurrence (excluding isolated mucosal recurrence).Close distal resection margin identifies patients with increased risk of mucosal and overall cancer recurrence. Although neither causality nor a minimally acceptable margin length can be defined, the data support the importance of achieving a clear distal resection margin in the surgical management of rectal cancer.

The authors recommend paracetamol as first-line treatment as well as long-term treatment for symptomatic osteoarthritis of the knee, in accordance with the analgesic/therapeutic guideline set out by EULAR. In 30 years of clinical practice, I have found paracetamol almost completely ineffective for arthritis pain. Non-steroidal anti-inflammatory drugs (NSAIDs) were notably more effective, if necessary in combination with proton pump inhibitors and for short-term combination treatment with metamizole. At low dosages, NSAIDs have a low side effect profile, even during long-term treatment. With paracetamol, there is a risk of liver damage if maximum doses are taken regularly. This is one of the reasons why paracetamol is now available on prescription only. In own my clinical practice, intra-articular injection of a steroid has always proved the best treatment for acute severe pain.

We define a new "contour person" model of the human body that has the expressive power of a detailed 3D model and the computational benefits of a simple 2D part-based model. The contour person (CP) model is learned from a 3D SCAPE model of the human body that captures natural shape and pose variations; the projected contours of this model, along with their segmentation into parts forms the training set. The CP model factors deformations of the body into three components: shape variation, viewpoint change and part rotation. This latter model also incorporates a learned non-rigid deformation model. The result is a 2D articulated model that is compact to represent, simple to compute with and more expressive than previous models. We demonstrate the value of such a model in 2D pose es- timation and segmentation. Given an initial pose from a standard pictorial-structures method, we refine the pose and shape using an objective function that segments the scene into foreground and background regions. The result is a parametric, human-specific, image segmentation.