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Immune therapy is one of the most promising areas of cancer treatment. It is aimed at a cascade of processes responsible for the antitumor immune response. The involved regulatory mechanisms become targets for various therapeutic approaches aimed at restoring the impaired functions of immune cells that eliminate cancer cells. The ability of malignant cells to affect receptors of immune checkpoints is one of the most important mechanisms for suppressing antitumor immunity. The development of immune check-point inhibitors (ICIs) based on monoclonal antibodies, as well as the methods of adoptive cell therapy (ACT), are a breakthrough in the immunotherapy of malignant diseases, but it carries a number of limitations such as insufficient efficiency, safety and cost-effectiveness. The use of RNA interference technologies opens up prospects for the development of fundamentally new class of ICIs and, as a consequence, the development of more efficient ACT methods. This review presents the main problems and prospects of the use of small interfering RNA (siRNA) as the ICIs are highlighted in order to optimize modern AKT approaches

We consider quality (Q) factor of accidental bound states in the continuum in bilayer resonators consisting of low-index dielectric rods. The dependence of Q factor on the number of periods shows that Q factors increase with the increasing number of rods. We calculated the dependence of the resonator Q factor on the disorder by two methods: analytical (multiple scattering theory) and numerical (finite difference method) and showed that the results are in good agreement. Also, we investigated the dependence of the resonance frequency on disorder.

This paper discusses the design of a state observer for an electric drive with pulse-width modulation of control signal and time division of reconstruction and control processes. An equation was formulated as the basis for the operation algorithm of the switching device, which provides switching on the control action of the electric drive when the transient processes in the state observer are over. The efficiency of the state observer operation algorithm was estimated for the direct current electric drive with a speed regulator.