Author: "A. Veiga" / Topic: business - Searchworks@Jio Institute Digital Library Search Results

4,881 results on '"A. Veiga"'

1. DETERMINANTS OF AFRICA'S DEVELOPMENT: AN EXPLORATORY STUDY

Author: Veiga, Jose Augusto Lopes da, Ferreira-Lopes, Alexandra, Carvalho, Helena, Sequeira, Tiago Neves, and Monteiro, Henrique
Subjects: Sustainable development -- Analysis, Economic growth -- Analysis, Algorithms -- Analysis, Algorithm, Business, Economics, Business, international, Regional focus/area studies, World Bank Group. World Bank
Abstract: The increasing sustainability and the causes of economic growth in African countries, provide a set of new research questions for development scholars around the World. The possible determinants of this phenomenon are usually considered to be of economic, social, and institutional natures. In this work is assessed which economic, social, and institutional determinants of economic development are important to the development of Africa countries, for the years 1996 and 2014. The similarities amongst countries and the evolution between the two years are also analyzed. A principal components analysis for categorical data to examine the inter-relationships between the indicators in 1996 and also in 2014. An agglomerative clustering algorithm was used through two different methods: ward's method and complete linkage method (also called furthest neighbor). The Hierarchical Cluster Analysis (HCA) was suited by a k-means algorithm, to obtain an optimal solution and a typology of countries was identified for each year. The main contribution of the work is to make a joint analysis of the three determinants of economic growth and development--economic, social, and institutional, in which the literature is extremely scarce. Results indicate a positive association amongst institutional, economic, and social determinants of development, which means that countries that exhibit a good performance in institutional indicators also have a good performance in economic and social indicators, and vice-versa, although results are not as clear for 2014 as they are for 1996. Additionally, a higher concentration of countries in the two clusters in which these three indicators are better in 2014 (31 countries in 1996 and 49 countries in 2014), seems to indicate a positive evolution for development of African countries from 1996 to 2014. Results show that policy makers should take an integrated view regarding development and economic growth policies and take in consideration both the economic, social, and institutional characteristics of each country. If an economic, social, or institutional policy is designed independently of the other two, this policy will probably fail in reaching its development or economic growth goal, since all these three factors are interconnected. JEL Classifications: C00, E02, O11, O55 Keywords: determinants of development; Africa; institutional, social, and economic dimensions; Principal Components Analysis for Categorical Data; Cluster Analysis Corresponding Author's Email Address: amnfl@iscte-iul, INTRODUCTION In this work the study of the main economic, social, and institutional determinants of development for the African Continent is done. The assessment of which of these determinants matters [...]
Published: 2022

2. ENVIRONMENTAL MARKETING AS A BUSINESS STRATEGY: DETERMINING FACTORS BY BRAZILIAN ADVERTISERS/MARKETING AMBIENTAL COMO ESTRATEGIA EMPRESARIAL: FATORES DETERMINANTES SEGUNDO PUBLICITARIOS BRASILEIROS/MARKETING AMBIENTAL COMO ESTRATEGIA EMPRESARIAL: FACTORES DETERMINANTES SEGUN PUBLICITARIOS BRASILENOS

Author: Neto, Alipio Ramos Veiga, Costa, Francisco de Paula, da Silva, Arthur William Pereira, Aouar, Walid Abbas El-, and Dantas, Bruna Lourena de Lima
Published: 2019
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3. Neural network-based limiter with transfer learning

Author: Rémi Abgrall, Maria Han Veiga, and University of Zurich
Subjects: Artificial neural network, Computer science, business.industry, Applied Mathematics, Function (mathematics), Computational fluid dynamics, Computational Mathematics, 10123 Institute of Mathematics, 510 Mathematics, Discontinuous Galerkin method, Computational mechanics, Limiter, Applied mathematics, Polygon mesh, Transfer of learning, business
Abstract: Recent works have shown that neural networks are promising parameter-free limiters for a variety of numerical schemes (Morgan et al. in A machine learning approach for detecting shocks with high-order hydrodynamic methods. https://doi.org/10.2514/6.2020-2024 ; Ray et al. in J Comput Phys 367: 166–191. https://doi.org/10.1016/j.jcp.2018.04.029 , 2018; Veiga et al. in European Conference on Computational Mechanics and VII European Conference on Computational Fluid Dynamics, vol. 1, pp. 2525–2550. ECCM. https://doi.org/10.5167/uzh-168538 , 2018). Following this trend, we train a neural network to serve as a shock-indicator function using simulation data from a Runge-Kutta discontinuous Galerkin (RKDG) method and a modal high-order limiter (Krivodonova in J Comput Phys 226: 879–896. https://doi.org/10.1016/j.jcp.2007.05.011 , 2007). With this methodology, we obtain one- and two-dimensional black-box shock-indicators which are then coupled to a standard limiter. Furthermore, we describe a strategy to transfer the shock-indicator to a residual distribution (RD) scheme without the need for a full training cycle and large dataset, by finding a mapping between the solution feature spaces from an RD scheme to an RKDG scheme, both in one- and two-dimensional problems, and on Cartesian and unstructured meshes. We report on the quality of the numerical solutions when using the neural network shock-indicator coupled to a limiter, comparing its performance to traditional limiters, for both RKDG and RD schemes.
Published: 2023

4. Herpes simplex virus esophagitis-clinical challenges in the elderly

Author: Sara Fernandes Custódio, Fátima Cruz, Manuela Zita Veiga, and Catarina Félix
Subjects: medicine.medical_specialty, Abdominal pain, Acyclovir, Case Report, Anorexia, medicine.disease_cause, Esophageal Diseases, Gastroenterology, Malaise, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Esophagitis, Humans, Simplexvirus, Aged, business.industry, Herpes Simplex, General Medicine, medicine.disease, Dysphagia, Herpes simplex virus, 030220 oncology & carcinogenesis, Vomiting, 030211 gastroenterology & hepatology, Female, Liver function, medicine.symptom, business
Abstract: A 77-year-old woman presented with a 2-week history of malaise, prostration, anorexia, abdominal pain, vomiting and diarrhoea. She had been taking systemic corticosteroids for the past year. During hospitalisation, renal insufficiency, ionic changes and liver function abnormalities were detected and corrected. However, the patient developed total dysphagia. UGE revealed multiple shallow ulcers below the cricopharyngeal level and in the distal oesophagus, with normal-appearing intervening mucosa. Histological examination allowed the diagnosis of herpes simplex virus esophagitis. Treatment with intravenous acyclovir was instituted for 14 days. In the elderly, herpetic esophagitis may present with non-specific complains, such as prostration or anorexia. In the reported case, dysphagia was only detected as a late symptom, addressing the importance of maintaining a high degree of suspicion for the diagnosis of herpes simplex virus esophagitis.
Published: 2023

5. Studies in ancient gypsum based plasters towards their repair: Physical and mechanical properties

Author: Freire, Maria Teresa, Veiga, Maria do Rosario, Silva, Antonio Santos, and de Brito, Jorge
Subjects: Gypsum -- Mechanical properties -- Properties, Adhesive bandages -- Usage, Porosity, Business, Construction and materials industries
Abstract: ABSTRACT The study of the physical and mechanical properties of 44 ancient gypsum-based plaster samples is the base for the design of compatible solutions to be used in restoration and [...]
Published: 2019
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6. Evolution of Acoustical, Geometrical, Physical, and Mechanical Parameters from Seedling to Cutting Age in Eucalyptus Clones Used in the Pulp and Paper Industries in Brazil

Author: Goncalves, Raquel, Gustavo, Rafael, Lorensani, Mansini, Ruy, Monica, Veiga, Nadia Schiavon, Muller, Gabriela, Alves, Cilene da Silva, and Martins, Guilherme Alonso
Subjects: Seedlings -- Analysis, Wood pulp industry -- Forecasts and trends, Ultrasound, Cloning, Wave propagation, Paper industry, Production management, Market trend/market analysis, Business, Forest products industry
Abstract: Wood-processing industries must be able to estimate the properties of wood to properly manage the wood production chain. For this estimation, changes in certain characteristics over time must be identified so that they can be used to rapidly differentiate a clone or species. Of interest are acoustical, geometrical, physical, and mechanical properties, all measurable in seedlings. Thus, the objective of this research was to analyze the evolution of the ultrasonic wave propagation velocity, diameter, height, basic density, strength, and stiffness starting in nursery seedlings at 3 months of age to trees at 6 years of age, which is the cutting age used by the pulp and paper industry in Brazil. The experiment was conducted in 121 seedlings and 270 trees of three Eucalyptus clones. Within the age range analyzed, the results indicated that all parameters have the potential to be used in a predictive model to estimate the future quality of clones, although the predictive value of these parameters varies. The ultrasonic wave propagation velocity was the only property that maintained the coherent differences among clones from the seedling to the cutting age (6 yr old). The strength, stiffness, diameter, and height maintained coherence from 12 months to the cutting age, whereas the basic density was maintained from the age of 24 months to the cutting age. We hope that these results will contribute to improving the methods to select clones., The quality of the raw materials evaluated in the forest will determine the future of the forest industry. The increased competitiveness of the timber sector will be dependent on technological [...]
Published: 2019
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7. Studies in ancient gypsum based plasters towards their repair: Mineralogy and microstructure

Author: Freire, Maria Teresa, Silva, Antonio Santos, Veiga, Maria do Rosario, and de Brito, Jorge
Subjects: Microstructures -- Analysis, Plaster -- Research -- Properties, Backup software, Gypsum, Business, Construction and materials industries
Abstract: ABSTRACTThere is little information about ancient gypsum-based plasters and no products in the market especially designed for its preservation.To fill this lacuna, a set of 44 samples of plastered elements [...]
Published: 2019
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8. The Moderating Effects of Co-Rumination on the Relationships between Goal Orientations and Anxiety, Satisfaction and Deviance

Author: Haggard, Dana L., Carr, Jon C., and Veiga, Serge P. da Motta
Subjects: Job satisfaction -- Analysis, Anxiety -- Analysis, Business, Human resources and labor relations
Abstract: The purpose of this study was to examine the moderating effects of co-rumination (i.e., the excessive discussion of problems, their causes, and potential consequences), on the relations between goal orientations and organizational outcomes of interest (anxiety, job satisfaction, and supervisor-targeted deviance). A two-wave panel study (n = 408) tested these effects and found that co-rumination moderated these relationships, such that the positive relationships between avoid performance goal orientation and anxiety and deviance were stronger when co-rumination was high (vs. low). Furthermore, results also indicated that the negative relationships between avoid performance goal orientation and job satisfaction and between learning goal orientation and anxiety were stronger when co-rumination was high (vs. low). This study provides additional evidence to support consideration of goal orientation in recruiting and selecting individuals for the workplace, as well as considering the important role of co-rumination at work., Goal orientation describes how individuals seek to achieve goals or to avoid failure (VandeWalle, 1997). Inherent in the concept of goal orientation is the idea that people react to problems [...]
Published: 2018

9. Evolution of the microstructure of lime based mortars and influence on the mechanical behaviour: The role of the aggregates

Author: Santos, Ana Rita, Veiga, Maria do Rosario, Silva, Antonio Santos, de Brito, Jorge, and Alvarez, Jose Ignacio
Subjects: Microstructures -- Analysis, Porosity -- Analysis, Mortar -- Structure -- Mechanical properties -- Analysis, Business, Construction and materials industries
Abstract: ABSTRACT The pore structure of air lime mortars, formulated with aggregates of different mineralogy and grain size distribution, was evaluated with the aim of studying the influence of sand type [...]
Published: 2018
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10. Manufacturing system: optimization of processes in a manufacturing unit of cement through the theory of queues/Sistema de manufatura: otimizacao de processos em uma unidade fabril de cimento atraves da teoria das filas

Author: Perdona, Igor Idalgo, Nunes, Rodrigo Veiga, Neves, Rafael Martins das, Naimer, Simone Caberte, and Godoy, Leoni Pentiado
Published: 2017
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11. Avances en Uro-Oncología «OncoUrology Forum Special Edition»: lo mejor del 2020

Author: F.J. Cózar-Olmo, A. Alcaraz-Asensio, J. Burgos-Revilla, and F. Gómez-Veiga
Subjects: business.industry, Urology, Medicine, business, Humanities
Abstract: Resumen Contexto y objetivo Conocer las ultimas evidencias sobre Urologia oncologica de tumores de prostata, rinon y vejiga, analizando su impacto en la practica clinica diaria, ademas de los esquemas futuros a medio y largo plazo. Materiales y metodos Se revisan los resumenes sobre Uro-Oncologia presentados en los Congresos del ano 2020 (EUA, AUA, ASCO, ESMO y ASTRO), las publicaciones de mayor impacto y especialmente las nuevas lineas de desarrollo y avance en Uro-Oncologia valoradas por el comite de OncoForum. Resultados El uso de los radioligandos de antigeno de membrana especifico de prostata en el diagnostico de cancer de prostata puede tener gran cabida y utilidad en los proximos anos gracias a su mejor sensibilidad y especificidad. La caracterizacion genetica del tumor es importante tanto a nivel germinal como somatico, dado que las mutaciones en BRCA2 son especialmente importantes por su significado en riesgo. El diseno de estudio mas conveniente a nivel de cancer genitourinario es el ensayo controlado aleatorizado multiple de cohortes. La aplicacion del big data traera mejoras en procesos, ahorros en costes sanitarios y una potenciacion de los estudios en vida real gracias a la facilidad de comparacion, gestion y almacenamiento de datos. Conclusiones El uso de las nuevas tecnicas diagnosticas con ligandos de antigeno de membrana especifico de prostata aportara una modalidad diagnostica mas completa y el aumento de los estudios del perfil genetico del tumor y la calidad de los estudios realizados. La aplicacion practica de la inteligencia artificial mejorara el tratamiento del cancer genitourinario.
Published: 2022

12. Outcomes of SARS-CoV-2 infected pregnancies after medically assisted reproduction

Author: Edgar Mocanu, Saria Mcheik, Satu Rautakallio-Hokkanen, Kersti Lundin, Anna Veiga, Baris Ata, Juha S. Tapanainen, Luca Gianaroli, Nathalie Vermeulen, HUS Gynecology and Obstetrics, Reproductive Disease Modeling, Department of Obstetrics and Gynecology, Clinicum, Ata, Mustafa Barış (ORCID 0000-0003-1106-3747 & YÖK ID 182910), Gianaroli, Luca, Lundin, Kersti, Mcheik, Saria, Mocanu, Edgar, Rautakallio-Hokkanen, Satu, Tapanainen, Juha S., Vermeulen, Nathalie, Veiga, Anna, Eshre COVID-19 Working Group, and School of Medicine
Subjects: medically assisted reproduction, medicine.medical_specialty, viruses, ESHRE, education, Context (language use), 03 medical and health sciences, Human reproduction, 0302 clinical medicine, Pregnancy, 3123 Gynaecology and paediatrics, Pandemic, medicine, Humans, Reproducció assistida, 030212 general & internal medicine, Pandemics, SARS-CoV-2, COVID-19, Medically assisted reproduction, IVF, 030219 obstetrics & reproductive medicine, Data collection, business.industry, Reproduction, Rehabilitation, Conflict of interest, virus diseases, Obstetrics and Gynecology, Original Articles, Reproductive technology, medicine.disease, AcademicSubjects/MED00905, 3. Good health, Abortion, Spontaneous, Reproductive Medicine, Infertility, Family medicine, Female, Maternal death, pregnancy, Obstetrics and gynecology, Reproductive biology, business, Live birth
Abstract: Study question: what is the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the outcome of a pregnancy after medically assisted reproduction (MAR)?. Summary answer: our results suggest that MAR pregnancies are not differentially affected by SARS-CoV-2 infection compared to spontaneous pregnancies. What is known already: information on the effects of coronavirus disease 2019 (COVID-19) on pregnancy after MAR is scarce when women get infected during MAR or early pregnancy, even though such information is vital for informing women seeking pregnancy. Study design, size, duration: data from SARS-CoV-2 affected MAR pregnancies were collected between May 2020 and June 2021 through a voluntary data collection, organised by the European Society of Human Reproduction and Embryology (ESHRE). Participants/materials, setting, methods: all ESHRE members were invited to participate to an online data collection for SARS-CoV-2-infected MAR pregnancies. Main results and the role of chance: the dataset includes 80 cases from 32 countries, including 67 live births, 10 miscarriages, 2 stillbirths and 1 maternal death. An additional 25pregnancies were ongoing at the time of writing. Limitations, reasons for caution: an international data registry based on voluntary contribution can be subject to selective reporting with possible risks of over- or under-estimation. Wider implications of the findings: the current data can be used to guide clinical decisions in the care of women pregnant after MAR, in the context of the COVID-19 pandemic., NA
Published: 2021

13. ASPECTOS COMPORTAMENTAIS: DECISÕES FINANCEIRAS COM BASE EM HIGGINS

Author: Jean Gleyson Farias Martins, Rodrigo José Guerra Leone, Walid Abbas El-Aouar, Alípio Ramos Veiga Neto, and Ahiram Brunni Cartaxo de Castro
Subjects: Commerce, HF1-6182, Business, HF5001-6182
Abstract: O objetivo desse trabalho foi identificar a diferença do “foco de promoção” e do “foco prevenção” utilizados para a tomada de decisão entre os graduandos de Ciências Contábeis e de Administração, por meio do modelo proposto por Higgins (2000). Trata-se de uma pesquisa com método quantitativo com modo de investigação na pesquisa survey de propósito descritivo e corte-transversal. O quadro de análise utilizado foi o modelo de Higgins (2000). Os resultados sinalizaram que: os discentes de Ciências Contábeis são mais conservadores do que os de administração quando tomam decisões em “foco de prevenção”, enquanto que, os alunos de contabilidade se sentem mais entusiasmados no “foco promoção”. A pesquisa demonstrou que os alunos ao tomarem decisões, procuram mecanismos e mapas mentais (subjetividade) e, ao utilizarem o “método de ajuste”, os alunos perceberam que o resultado econômico positivo nem sempre é a melhor decisão.
Published: 2018

14. Prevalence of osteoarthritis of the knee in a random population sample of people aged 40 and older

Author: María Barreiro-Quintás, Cristina González-Martín, Sonia Pértega-Díaz, Teresa Seoane-Pillado, David Rodriguez-Veiga, and Vanesa Balboa-Barreiro
Subjects: business.industry, medicine, Sample (statistics), General Medicine, Osteoarthritis, medicine.disease, business, Random population, Demography
Published: 2023

15. Governance, institutional autonomy and leadership in Portuguese higher education

Author: Amélia Veiga and António M. Magalhães
Subjects: Higher education, business.industry, media_common.quotation_subject, Corporate governance, Political science, language, Public administration, Portuguese, business, Autonomy, language.human_language, media_common
Published: 2023

16. Evaluation of composite restorations in primary molars subjected to selective caries removal associated with antimicrobial photodynamic therapy: A randomized controlled trial

Author: Lívia Azeredo Alves Antunes, Karla Bianca Fernandes Da Costa Fontes, Laís Veiga Faria, Liz Helena Moraes Pinheiro, Caio Luiz Bitencourt Reis, Jéssica Agathá Coelho Homem Dias, Leonardo Santos Antunes, Marlus Roberto Rodrigues Cajazeira, and Luciana Ribeiro Reis Pio
Subjects: Molar, Dental Caries Susceptibility, medicine.medical_treatment, Dentistry, Photodynamic therapy, Dental Caries, Logistic regression, Composite Resins, law.invention, Anti-Infective Agents, Randomized controlled trial, law, medicine, Humans, Tooth, Deciduous, Child, Dental Restoration, Permanent, General Dentistry, business.industry, Antimicrobial, Anti-Bacterial Agents, Clinical trial, Photochemotherapy, business, Dental restoration, Caries Removal
Abstract: Background Antimicrobial photodynamic therapy (aPDT) has been used as adjunct treatment of deep caries lesions however the effects on the longevity of restorations are still limited. Aim to evaluate the performance of composite restorations in primary molars subjected to selective caries removal (SCR) associated with aPDT. Design randomized clinical trial was designed. Primary molars of patients (mean age 6.15 years) with deep carious lesions without signs and symptoms of pulp involvement were selected. A total of 64 teeth were randomly divided into groups G1 (SCR, 32 teeth) and G2 (SCR+ aPDT, 32 teeth) for treatment, restored with composite and evaluated after a week (T0 ), 6 months (T1 ), and 12 months (T2 ) according to the criteria of FDI. Groups were compare using the Rao-Scott chi-square test and logistic regression for complex designs to account for multiple observation subject (alpha = 0.05) RESULTS: Marginal adaptation for the SCR + aPDT group was significantly better in comparison to SCR group at T0 and T2 in Logistic Regression (T0: OR= 0.151; 95% CI = 0.03 - 0.068; p = 0.015. T2: OR= 0.201; 95% CI= 0.05 - 0.79; p = 0.022). Conclusion The marginal adaptation of primary molar resin restorations was positively affected by aPDT after 12 months of follow-up.
Published: 2022

17. Reprocessing of loaned surgical instruments/implants in Australia and Brazil: A survey of those at the coalface

Author: Dulcelene de Sousa Melo, Honghua Hu, Thais Rodrigues Veloso, Karen Vickery, Luiz Antônio Pereira, Lillian Kelly de Oliveira Lopes, Anaclara Ferreira Veiga Tipple, Júnnia Pires de Amorim Trindade, and Dayane de Melo Costa
Subjects: Process quality, Teamwork, business.industry, media_common.quotation_subject, Australia, Public Health, Environmental and Occupational Health, Sterilization, Surgical Instruments, Unit (housing), Cross-Sectional Studies, Infectious Diseases, Work (electrical), Surveys and Questionnaires, Service (economics), Health care, Humans, Quality (business), Operations management, Business, Brazil, General Nursing, media_common
Abstract: Background Acquisition of surgical instruments (SI) and implants by loaner system is a worldwide practice. Although quality of device reprocessing has been reported to be lower in low and middle-income countries compared with higher income countries, few investigations have been conducted on the management and reprocessing of loaned devices. Thus, in this study we evaluate the practices of management and reprocessing of loaner SI and non-sterile implants (NSI) in a high (Australia) and a middle-income (Brazil) country. Methods Cross-sectional surveys (hardcopy or online form) was self-administered by sterilising service unit's personnel of Brazilian and Australian hospitals. Only those units that sourced orthopaedic surgical instruments and non-sterile loaned implants from independent companies were eligible. Results A total of 65 questionnaires from Australia and 168 from Brazil were analysed. Quality indicators regarding structure and work process for the management and reprocessing of loaned SI and NSI was of a higher standard in Australia than in Brazil. However, failures were detected in both countries, for instance delivery delays and improper point-of-use pre-cleaning practices. Conclusion There are key challenges inherent of the multifaceted reusable medical devices loaner system in both countries, such as communication failures, implementation of non-recommended practices, reprocessing of NSI, and other related to structure and process quality indicators, that must be faced. Initial and ongoing education and training should be provided and should embrace the themes of technical proficiency, effective communication and teamwork, and should include all personnel involved in this process, even loaner company staff.
Published: 2022

18. Progestin-Primed Ovarian Stimulation is a non-inferior alternative to the GnRH Antagonist Protocol in patients undergoing assisted reproductive techniques: a retrospective study

Author: Leonardo Matheus Ribeiro Pereira, Leci Veiga Caetano Amorim, Ricardo Mello Marinho, João Pedro Junqueira Caetano, Ana Luisa Menezes Campos, Luciana Campomizzi Calazans, Bruna Barbosa Coimbra, and Erica Becker de Sousa Xavier
Subjects: Infertility, medicine.drug_class, medicine.medical_treatment, Fertilization in Vitro, Andrology, Gonadotropin-Releasing Hormone, Ovulation Induction, Pregnancy, Medicine, Humans, Blastocyst, reproductive and urinary physiology, Retrospective Studies, In vitro fertilisation, business.industry, urogenital system, Antagonist, medicine.disease, progestin, Pregnancy rate, medicine.anatomical_structure, reproductive techniques, Ovulation induction, Original Article, Female, pregnancy rate, Gonadotropin, assisted, Progestins, business, Progestin, in vitro fertilization, hormones, hormone substitutes, and hormone antagonists
Abstract: Objective To demonstrate the non-inferiority of Clinical Pregnancy Rates from Progestin-Primed Ovarian Stimulation compared to the GnRH Antagonist Protocol when the freeze-all and blastocyst transfer strategy is applied. Methods A retrospective study included all IVF cycles performed at Pro-Criar Reproductive Medicine Center, Belo Horizonte, Minas Gerais, Brazil, between May 2018 and May 2019 using a GnRH antagonist analogue or oral progestins to block the LH peak in IVF/intra-cytoplasmic sperm injection (ICSI) cycles for infertility treatment. Results The primary outcome of our study was Clinical Pregnancy Rate at the first ET (Blastocyst), which were 58.4% in the progestin group and 54.9% in the antagonist group (p=0.735), a finding consistent with most studies published to date using different progestins. The mean number of retrieved oocytes was 11 in the antagonist group and 9 oocytes in the progestin group (p=0.009). The fertilization rate was 80% for both groups (p=0.935). The rate of blastocyst formation per cycle was 50% in the antagonist group and 55.6% in the progestin group (p=0.106). The stimulation lasted a mean of 10 days in the two groups (p=0.403) and did not vary with patient age in either group. The gonadotropin dose used was higher in the antagonist group (2025 IU) than in the progestin group (1950 IU) (p=0.057). In addition, the blockade was effective: there was only one case of spontaneous ovulation, which corresponded to less than 1% of the cycles. Conclusions Progestin-Primed Ovarian Stimulation is a non-inferior alternative to the GnRH Antagonist Protocol in patients undergoing assisted reproductive techniques. An incidence compatible with the 0.34 to 8% risk described in the literature for failure to control the premature LH surge in antagonist protocol cycles.
Published: 2022

19. Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

Author: Stephen R Knight, Catherine A Shaw, Riinu Pius, Thomas M Drake, Lisa Norman, Adesoji O Ademuyiwa, Adewale O Adisa, Maria Lorena Aguilera, Sara W Al-Saqqa, Ibrahim Al-Slaibi, Aneel Bhangu, Bruce M Biccard, Peter Brocklehurst, Ainhoa Costas-Chavarri, Kathryn Chu, Anna Dare, Muhammed Elhadi, Cameron J Fairfield, J Edward Fitzgerald, Dhruv Ghosh, James Glasbey, Mark I. van Berge Henegouwen, J.C. Allen Ingabire, T Peter Kingham, Marie Carmela Lapitan, Ismaïl Lawani, Bettina Lieske, Richard Lilford, Janet Martin, Kenneth A McLean, Rachel Moore, Dion Morton, Dmitri Nepogodiev, Faustin Ntirenganya, Francesco Pata, Thomas Pinkney, Ahmad Uzair Qureshi, Antonio Ramos-De la Medina, Aya Riad, Hosni Khairy Salem, Joana Simões, Richard Spence, Neil Smart, Stephen Tabiri, Hannah Thomas, Thomas G Weiser, Malcolm West, John Whitaker, Ewen M Harrison, Arben Gjata, Maria Marta Modolo, Sebastian King, Erick Chan, Sayeda Nazmun Nahar, Ade Waterman, Dominique Vervoort, Alemayehu Ginbo Bedada, Bernardo De Azevedo, Ana Gabriela Figueiredo, Manol Sokolov, Venerand Barendegere, Gerald Ekwen, Arnav Agarwal, Qinyang Liu, Juan Camilo Correa, Kalisya Luc Malemo, Jacques Bake, Jakov Mihanovic, Kamila Kuncarová, Julius Orhalmi, Hosni Salem, Jyri Teras, Aristotelis Kechagias, Alexis P Arnaud, Judith Lindert, Vasileios Kalles, Maria-Lorena Aguilera-Arevalo, Gustavo Recinos, Zsolt Baranyai, Basant Kumar, Harish Neelamraju Lakshmi, Sanoop Koshy Zachariah, Philip Alexander, Sunil Kumar Venkatappa, C Pramesh, Radhian Amandito, Christina Fleming, Luca Ansaloni, Gianluca Pellino, Ahmed M. Altibi, Ibrahim Nour, Intisar Hamdun, Ali M. Ghellai, Donatas Venskutonis, Tomas Poskus, Justas Zilinskas, Precious Malemia, Yong Yong Tew, Elaine Borg, Sarah Ellul, fatima Zahraa Wafqui, David W Borowski, Anne Sophie van Dalen, Cameron Wells, Harissou Adamou, Adesoji Ademuyiwa, Adewale Adisa, Kjetil Søreide, Sara Al Saqqa, Osaid Alser, Haya Tahboub, Helmut Alfredo Segovia Lohse, Sebastian Shu Yip, Piotr Major, António Sampaio Soares, Matei Razvan Bratu, Andrey Litvin, Armen Vardanyan, JC Allen Ingabire, Ahmad Gudal, Naif Albati, Jovan Juloski, Miran Rems, Sarah Rayne, Stephanie Van Straten, Yoshan Moodley, Irene Ortega Vázquez, Jaime Ruiz-Tovar, Kithsiri Janakantha Senanayake, Sujeewa Priyantha Bandara Thalgaspitiya, Omer Abdelbagi Omer, Anmar Homeida, Yucel Cengiz, Daniel Clerc, Muhammad Alshaar, Hanen Bouaziz, Yuksel Altinel, Matthew Doe, Maryna Freigofer, Ella Teasdale, Rakan Kabariti, Joshua Michael Clements, Stephen Richard Knight, Ahsan Ashfaq, Ijeoma Azodo, Gabriela Wagner, Ivan Trostchansky, Mayaba Maimbo, David Linyama, Helidon Nina, Amanda Zeko, Claudio Gabriel Fermani, Santiago Villalobos, Federico Carballo, Pablo Farina, Sebastian Guckenheimer, Marilla Dickfos, Ankit Ajmera, Chester Chong, Ralph Gourlay, Sikandar Hussaini, Yi Jia Lee, Adeeb Majid, Peter Martin, Rebecca Miles, Owen James Morris, Jamie Phua, William Ridley, Tarunpreet Saluja, Ryan Renxin Tan, Jen Teh, Anna Wells, Bharti Arora, Qaasim Dollie, Debbie Ho, Yanru Ma, Omattage Mahasha Perera, Anthony Truong, Amanda Caroline Dawson, Bryan Lim, Upuli Pahalawatta, Jacqueline Phan, Xiao-Ming Sarah Woon-Shoo-Tong, Andrea Yeoh, Lillian Charman, Andrew Drane, Sharon Laura, Charmaine Chu Wen Lo, Amy Mozes, Rita Poon, Hao Han Tan, Ellen Wall, Prakshi Chopra, Jasmine De Giovanni, Bal Dhital, Brian Draganic, Alexander Duller, Jonathan Gani, Yao Kuan Goh, Jun Young Jeong, Brendan McManus, Prakash Nagappan, Peter Pockney, Anya Rugendyke, Mahsa Sarrami, Stephen Smith, Vanessa Wills, Hsu Ven Wong, Geoffrey Ye, Geoffrey Zhang, Ethan Brooker, Daniel Feng, Bonnie Lau, Carlin Ngai, Sarah Birks, David Gyorki, Jaime Otero de Pablos, Ali Abbosh, Chris Gillespie, Ahmed Mahmoud, Bianca Kwan, Joshua Lawson, Andrea Warwick, Janne Bingham, Andrew J Cockbain, Nagendra Naidu Dudi-Venkata, Jordan Ellaby-Hall, Ben Finlay, Emily Humphries, Jade Pisaniello, Monique Pisaniello, Salma Salih, Tarik Sammour, Haidar Hadri Abd Wahab, April De Silva, Nicola Hayward, Kartik Iyer, Guy Maddern, Gian Andrea Prevost, Naga Annapureddy, Krishna Pranathi Settipalli, Jeremy Yeo, Lucy Hempenstall, Lily Pham, Shaun Purcell, Cherry Talavera, Ashish I Vaska, Gurpreet Chaggar, Phillip Chrapko, Annelise Cocco, Sarah Michelle Crystal Jade Coulter-Nile, Grahame Ctercteko, James French, Houchen Gong, Martijn Gosselink, Thuvarahan Jegathees, Ivan Jin, Michelle Kalachov, Kathryn Kiefhaber, Katherine Lee, Jason Luong, Steven Phan, Henry Pleass, Kelly Veale, Zhi Zeng, Angela Au, Ashe DeBiasio, Idy Deng, Jananee Myooran, Amrita Nair, Peter Stewart, Anton Stift, Lukas Walter Unger, Kerstin Wimmer, Nabila Ahmed, Syed Hasan, Saber Rahman, Margaret O'Shea, Greg Padmore, Adrian Peters, Pietro Perduca, Guenda Pulcina, Nicolas Tinton, Frederic Buxant, Elsa Dabin, Giulia Garofalo, Francis Dossou, Freddy Houehanou Rodrigue Gnangnon, Yacoubou Imorou Souaibou, Pako Motlaleselelo, Omphile Tlhomelang, Igor Lima Buarque, Gustavo Mendonça Ataíde Gomes, Aldo Vieira Barros, Ilia Batashki, Nikolai Damianov, Vladislav Stoyanov, Dragomir Dardanov, Svilen Maslyankov, Plamen Petkov, George Todorov, Evgeni Zhivkov, Aygulya Akisheva, Miguel Angel Castilla Moreno, Geno Genov, Ivelina Ilieva, Tsvetomir Ivanov, Martin Karamanliev, Azhar Khan, Emil Mitkov, Tsanko Yotsov, Boyko Atanasov, Nikolay Belev, Mihail Slavchev, Carlos Nsengiyumva, Elgan Jones, Simon Stock, Steve Kyota, James Brown, Tresor Mabanza K., Lemery Nigo Samuel, Chidi Otuneme, Ngwang Prosper, Franklin Umenze, Marylise Boutros, Natasha Caminsky, Sinziana Dumitra, Richard Garfinkle, Dominique Morency, Ebram Salama, Alexander Banks, Lorenzo Ferri, Haitian He, Amit Katz, Alexander Sender Liberman, Sarkis Meterissian, Allison Pang, Elena Parvez, Usmaan Hameed, Fahima Osman, Sangita Sequeira, Natalie Coburn, Alisha Jaffer, Paul Karanicolas, Matthew Mosseler, Reilly Musselman, Xinyuan Liu, Ching Wan Yip, Juan Sebastian Garces-Otero, Carolina Guzman, Sebastian Sierra, Andres Uribe Valencia, Paulo Andrés Cabrera Rivera, Saul Camelo, Andrea Gonzalez, Alejandro González-Orozco, Manuel Santiago Mosquera Paz, Carlos J- Perez Rivera, Felipe Gonzalez, Andres Isaza-Restrepo, Laura Nino- Torres, Natalia Arias Madrid, Maria Clara Mendoza Arango, Justin Tsandiraki, Damir Jemendžic, Branislav Kocman, Oliver Šuman, Renata Canic, Darko Jurišic, Ivana Karakas, Ana Krizanovic Rupcic, Vlatka Pitlovic, Josip Samardžic, Mario Kopljar, Ivan Bacic, Edgar Domini, Robert Karlo, Danijela Miljanic, Andrea Simic, Mariam Ahmed, Majdi Al Nassrallah, Rabiya Altaf, Talal Amjad, Ruba Eltoum, Heba Haidar, Alhassan Hassan, Omar Khalil, Marwan Qasem, Rommel Ramesh, Gautham Sajith, Maham Wisal, Jan Žatecký, Michele Bujda, Katerina Jirankova, Ales Paclik, Aya Abdallah, Mariam Abdulgawad Almogy, Esraa Ayman El-sawy, Ahmed Moustafa ElFayoumy, Nourhan Elghareeb, Nourhan Ahmed Esmat, Ahmed Fadel, Abdullah Habater, Heba Hamdy, Amr Hefni, Marwa Kamal, Norhan Mohamed Abobakr, Ahmed Sayed, Nancy Shaker, Ehab Taha, Hoda Tharwat, Omar Zakaria, Ibrahem Abdelmotaleb, Ali Al-Dhufri, Hamza S. Al-Himyari, Enas El sheikh, Asmaa Eldmaty, Aya Elkhalawy, Ahmed M.Elkhashen, Kithara Magdy, Safa Mostafa, Habib Doutoum Sadia, Mohamed mahmoud Saleh, Dina Samir, Mohamed Yahia Mohamed Ali, Mahmoud A. Nassar, Samar Abdelhady, Aly Abdelrazek, Israa Abdelsalam, Aya El-Sawy, Eman Essam, Mohamed Gadelkarim, Khaled Ghaly, Mohamed Hassabalnaby, Rana Masarani, Nourhan Mohamed Shaaban, Ahmed Sabry, Menatalla Salem, Nourhan Akram Soliman, Diaaaldin Zahran, Moustafa Ramadan Abou El.soud, Esraa Tarek Badr, Hala Borham, Nehal Elmeslemany, Mohammad Elsayed, Fawzia Elsherif, Sara Eslam, Gehad Gaber, Sondos Ibrahim, Yara Kamh, Abdelrahman Mahmoud, Shimaa gamal Mohamed, Eman Morshedy, Cinderella Omar, Fatima Salem Soliman, Shaza Abdelkawy, Naglaa Abdelmohsen, Mahmoud Abdelshakour, Ahmed Dahy, Norhan Gamal, Mohammed Gamal, Ahmad Hasan, Helal Hetta, Nehad Mousa, Mohamed Omar, Somia Rabie, Mahmoud Saad, Bakeer Saleh, Marwa Sayed Mohamed, Muhammad Shawqi, Heba Abdelhady Mousa, Mostafa Alnoury, Mohamed Elbealawy, Ahmed Elshafey, Muhammad Essam Ibrahim El Desouki Muhammad Ahmed, Mennatullah Ghonaim, Fawzy Hgag, Mohamed Ibrahim, Mahmoud Morsy, Mohamed Reda Loaloa, Ahmed Refaat, Hadeer Samir, Fatma Shahien, Mohamed Sobhy, Fathy Sroor, Esraa Abdellatif, Marina Adel, Amr Abdelghani Afifi, Eman Afifi, Marco Antaky, Amr Dawoud, Naira El Zoghby, Amira El-remaily, Ali Abdelazez Elzanfaly, Ahmed Gadallah, Fatma Alzahraa Gamal, Omar Hashem, Shrouk Medhat Youssef, Aliaa Muhammad Attyah, Malak Munir, Omar Shazly, Esraa Taha, Karim Wilson, Sawsan Adel, Asmaa Ali, Esraa Eid, Esraa Elhelow, Marwa Elmahdy, Bassant Elshatby, Amany Hossam el-din Zakaria, Ahmad Hossny, Eman Ibrahim, Ahmed M.Yonis, Maram Metwalli, Basant Yousry, Esraa Zid, Mina A Yacoub, Ahmed Abdelhakim, Nervana Abouelsoad, Mo'min Alkhatib, Ahmed Ashraf, Alaa Ashraf, Yasmin Elazab, Mahmoud Elfanty, Osama Elkabir, Mai Elsayed, Ahmed Elshimy, Hager Elsobky, John Eskander, Ahmed Gad, Ward Hamsho, Noura Khaled Abdelwahed, Menna Magdy, Dalia Moharam, Abeer Osama, Shereen Ramadan, Radwa Roum, Taqwa Sayed, Tarneem Shehada, Ahmed Mohy Zidan, Khalid Abbas, Amr Ali, Mohamed Attia, Mohamed Balata, Ayman El Nakeeb, Mohamed Ibrahim Elsayed Elewaily, Ahmed Elfallal, Hossam Elfeki, Ahmed Elkhadragy, Sameh Emile, Helmy Ezzat, Hasnaa Hosni, Islam Mansour, Waleed Omar, Gehad Othman, Kareem Sadek, Mostafa Shalaby, Noura Shehab-Eldeen, Rawda Anas khalifa, Helmy Badr, Mostafa Eldeep, Ahmed Eldeep, Amany Eldoseuky mohammed, Salwa Khallaf, Eman Magdy Hegazy, Rokia Mahmoud, Pola Mikhail, Mahmoud Morsi, Sara Mowafy, Dina Raafat, Amina Safy, Marwa Sera, Ahmed shible Sera, Mostafa Salim Mohamed AbdAllah, Muhammad Abdelkader, Abdulrahman Osama Abdou, Ahmedgaber Ahmed, Shireen Gaafar, Fatma Ibrahim negm, Mina Lapic, Ahmed Maher, Hagar Mahmoud, Ahmed Mostafa, Mohamed Samir, Fatma Samy, Nourhan Semeda, Hind I. Shalaby, Alaa El-taweel, Ahmed Galal Elnagar, Ahmed Gamal Hemidan, Mohamed Hussein, Ahmed.A. Kandil, Mf Moawad, Ayat Allah Nasser Hamamah, Mostafa Soliman, Mohamed Abdelkhalek, Noura Abdelmaksoud Tawakel, Ahmed Mohamed Abdelwahed, Alrawy Abdou, Khalid Atallah, Mohammed Yasser Elsherbeny, Eman Emara, Mohamed Hamdy, Omar Hamdy, Amira Haron, Salma Ismail, Islam Hany Metwally, Nihal Mohamed Hamed Elgaml, Ahmed Nassar, Basel Refky, Mirna Sadek, Mahmoud Saleh, Asmaa Yunes, Mai Zakaria, Mohammed Zuhdy, Notila Fayed, Mohammed Mustafa Hassan Mohammed, Sander Kütner, Priit Melnik, Indrek Seire, Toomas Ümarik, Eppu Ainoa, Verner Eerola, Hanna Koppatz, Laura Koskenvuo, Ville Sallinen, Sini Takala, Jevgeni Katunin, Arto Turunen, Niki Christou, Muriel Mathonnet, Vincent Lavoue, Krystel Nyangoh Timoh, Lucie Soulabaille, Romain Lesourd, Aude Merdrignac, Laurent Sulpice, Benoît André, Elodie Chantalat, Charlotte Vaysse, Bertrand Dousset, Sebastien Gaujoux, Gregory Martin, Octavian Clonda, Domantas Juodis, Klaus Kienle, Andras Mravik, Samuel Palmer, Gabor Szabadhegyi, Anita Eseenam Agbeko, Solomon Gyabaah, Frank Enoch Gyamfi, Nuhu Naabo, Atta Owusu senior, Joseph Yorke, Frank Owusu, Francis Abantanga, Theophilus Teddy Kojo Anyomih, Abdul-Jalilu Mohammed Muntaka, Emmanuel Owusu Abem, Mohammed Sheriff, Paul M. Wondoh, Dimitrios Balalis, Dimitrios Korkolis, Georgios Gkiokas, Eirini Pantiora, Theodosios Theodosopoulos, Argyrios Ioannidis, Konstantinos Konstantinidis, Sofia Konstantinidou, Nikolaos Machairas, Anna Paspala, Anastasia Prodromidou, Christos Chouliaras, Konstantinos Papadopoulos, Ioannis Baloyiannis, Ioannis Mamaloudis, George Tzovaras, Ioanna Akrida, Maria-Ioanna Argentou, Stylianos Germanos, Evangelos Iliopoulos, Ioannis Maroulis, George Skroubis, George Theofanis, Christos Chatzakis, Orestis Ioannidis, Lydia Loutzidou, Panagiotis Karathanasis, Nikolaos Michalopoulos, Charalampos Theodoropoulos, Dimitrios Theodorou, Tania Triantafyllou, Zoe Garoufalia, Natasha Hasemaki, Michalis Kontos, Gregory Kouraklis, Stylianos Kykalos, Theodore Liakakos, Eustratia Mpaili, Alexandros Papalampros, Dimitrios Schizas, Athanasios Syllaios, Ekaterini Christina Tampaki, Antonios Tsimpoukelis, Maria Ioanna Antonopoulou, Eirini Deskou, Dimitrios K. Manatakis, Dimitrios Papageorgiou, Menelaos Zoulamoglou, Christos Anthoulakis, Michalis Margaritis, Nikolaos Nikoloudis, Veronica Campo, André Ceballos, Mario-Andrés Flores, Waleska Giron, Donghyun Ko, Gabriel Martinez, Verónica Rivera Lara, Nataly Rueda, Andres Sanchez, Jorge Carlos Guillermo Tejeda Garrido, Alvaro Eduardo Alvarez Rivera, Elvis Benjamin Bamaca Ixcajoc, Lilian Elizabeth Barreda Zelaya, Patricia Chacòn-Herrera, Ligia Margarita Corea Ruiz, Guillermo Echeverria-Davila, Mario Garcia, Danilo García, Edgar Fernando Gutiérrez Mayen, Noriega José, Nery Mazariegos, Diego Méndez, Michael Paniagua Espinoza, David Bardos, Marton Benke, Kristof Illes, Balint András Kokas, Réka Szabó, Akhila Appukuttan, Anjitha Asok, Vijaykumar D.k, Kapil Malik, Praveen Ravishankaran, Ritesh Tapkire, Guru Moorthy, Joyner Abraham, Ramesh Muthuvel, John Alapatt, Abhay Kattepur, Nizamudheen Pareekutty, Mebanshanbor Garod, Caleb Harris, Cliff Wanniang, Ashish Gupta, Deepak Nehra, Sanjeev Parshad, Rajgopal Acharya, Rajendra Badwe, Manish Bhandare, Urvashi Jain, Karishma Kirti, Nita Nair, Shailesh Shrikhande, Purvi Thakkar, Premkumar Anandan, Archana C S, Arun Holenarasipur Narasannaiah, Tejaswi Jagarlamudi, Rashmi M R, Mallikarjuna Manangi, Abhishek Raghavendra, K. Seshagiri Rao, Vinay S, Vinay Sajjan, Aneesh Shenoy, Santhosh Shivashankar Chikkanayakanahalli, Kavya Tharanath, Sushmita V, Peter Adidharma, Raksheeth Agarwal, Phebe Anggita Gultom, Ghafur Rasyid Arifin, Matthew Billy, Zatira Elfizri, Alessa Fahira, Devi Felicia, Triana Hardianti Gunardi, Nadya Johanna, Nadia Rahmadiani Nugrahadi, Sonar Soni Panigoro, Siti Rahmayanti, Retta Catherina Sihotang, Santi Yuanita Brata, Hadi Winoto, Nastaran Barati, Manoochehr Karami, Hamidreza Khorshidi, Homa Naderifar, Mazin A. Abdulla, Maggie Coleman, Ronan J Doherty, Rob Hannon, Brenda Murphy, Aine Stakelum, Des Winter, Lylas Aljohmani, Richard Farnan, Yeshey Seldon, Tanna Tan, Shriya Varghese, Mohammad Alherz, Muaaz Ather, Mohammad Bajilan, Vivien Graziadei, Isobel Pilkington, Omar Quidwai, Paul Ridgway, Haaris Shiwani, Abd al-Rahman Tahir, Eimear Blunnie, Daniel Burke, Niall Kennedy, Kate Macdonagh, Maeve O'Neill, Siobhan Rooney, Giuseppe Falco, Guglielmo Ferrari, Simone Mele, Gabriela Elisa Nita, Lara Ugoletti, Maurizio Zizzo, Gianmaria Confalonieri, Giovanni Pesenti, Fulvio Tagliabue, Gianluca Baronio, Deborah Ongaro, Giacomo Pata, Bruno Compagnoni, Renato Salvadori, Lucio Taglietti, Nicola D'Alessandro, Pierpaolo Di Lascio, Giovanni Pascale, Luca Bortolasi, Tommaso Campagnaro, Massimo Carlini, Giorgio Lisi, Davide Lombardi, Corrado Pedrazzani, Domenico Spoletini, Giulia Turri, Paola Violi, Donato Francesco Altomare, Fabrizio Aquilino, Nicola Musa, Vincenzo Papagni, Arcangelo Picciariello, Leonardo Vincenti, Dario Andreotti, Savino Occhionorelli, Matteo Tondo, Stefano Maria Massimiliano. Basso, Riccardo Cirelli, Marco Enrico Mario Maino, Guglielmo Niccolò Piozzi, Emanuele Picone, Rosa Scaramuzzo, Giovanni Sinibaldi, Alfonso Amendola, Lorenzo Anastasio, Luigi Bucci, Emanuele Caruso, Antonio Castaldi, Sara Di Maso, Vincenza Paola Dinuzzi, Giovanni Esposito, Maria Gaudiello, Mariano Cesare Giglio, Paola Antonella Greco, Gaetano Luglio, Andrea Manfreda, Ester Marra, Federica Mastella, Gianluca Pagano, Roberto Peltrini, Vincenzo Pepe, Michele Sacco, Viviana Sollazzo, Giovanni Spiezio, Ettore Cianchetti, Nunzia Menduni, Michele Maria Carvello, Francesca Di Candido, Antonino Spinelli, Fabio Corsi, Luca Sorrentino, Fabio Marino, Emanuele Luigi Giuseppe Asti, Luigi Bonavina, Emanuele Rausa, Martina Asta, Andrea Belli, Francesco Bianco, Carmela Cervone, Paolo Delrio, Armando Falato, Andrea Fares Bucci, Rita Guarino, Ugo Pace, Daniela Rega, Emilia De Luca, Gaetano Gallo, Giuseppe Sammarco, Giuseppe Sena, Giuseppina Vescio, Letizia Santandrea, Giampaolo Ugolini, Davide Zattoni, Nicola Chetta, Gaetano Logrieco, Serafino Vanella, Gianluca Garulli, Nicola Zanini, Andrea Bondurri, Francesco Cammarata, Francesco Colombo, Diego Foschi, Giulia Maria Beatrice Lamperti, Anna Maffioli, Gianluca Matteo Sampietro, Al'ona Yakushkina, Gloria Zaffaroni, Enrico Cicuttin, Maria Grazia Sibilla, Harmony Impellizzeri, Marco Inama, Gianluigi Moretto, Sylvie Mochet, Elisa Ponte, Antonella Usai, Stefano Mancini, Andrea Sagnotta, Luigi Solinas, Elisa Bolzonaro, Nicolò Tamini, Gianluca Curletti, Raffaele Galleano, Michele Malerba, Sofia Campanella, Gianfranco Cocorullo, Francesco Colli, Paolino De Marco, Nicolò Falco, Tommaso Fontana, Leonel jospin Kamdem Mambou, Antonella La Brocca, Leo Licari, Brenda Randisi, Giovanna Rizzo, Giulia Rotolo, Giuseppe Salamone, Roberta Tutino, Paolina Venturelli, Stefano Malabarba, Alessandro Sgrò, Ivan Vella, Bruno Cirillo, Daniele Crocetti, Giorgio De Toma, Pierfrancesco Lapolla, Andrea Mingoli, Paolo Sapienza, Angela Belvedere, Stefania Bianchini, Margherita Binetti, Arianna Birindelli, Valeria Tonini, Mauro Podda, Fabio Pulighe, Michele De Rosa, Lorenzo Bono, Felice Borghi, Paolo Geretto, Maria Carmela Giuffrida, Corrado Lauro, Alessandra Marano, Luca Pellegrino, Paola Salusso, Diego Sasia, Michela Campanelli, Alberto Realis Luc, Mario Trompetto, Roberto Cardia, Nicola Cillara, Antonio Nicola Giordano, Antonio Costanzo, Mario Alessandro Giovilli, Luca Turati, Silvestro Canonico, Guido Sciaudone, Francesco Selvaggi, Lucio Selvaggi, Nader Albsoul, Ahmad AlBsoul, Ala'a Aldeen Alkhatib, Osama Alsallaq, Justin Z. Amarin, Rami Ayoub, Isam Bsisu, M S El Muhtaseb, Mohammad Jabaiti, Jamal Melhem, Yasmeen Z. Qwaider, Mohammad Hasan Salameh, Ahmad Suleihat, Haya H. Suradi, Mohammad Alammarin, Almoutuz Aljaafreh, Mohammad Bani hani, Zeina Bani hani, Farah Bani Hani, Toqa Fahmawee, Shadi Hamouri, Cyrine Katanani, Ra'fat Tawalbeh, Tamara Tawalbeh, Hassan Zawahrah, Mohamad K. Abou Chaar, Lana Abusalem, Mahmoud Al-Masri, Hani Al-Najjar, Lutfi Barghuthi, Zahra Ahmed, Adnan Maulana, Omar Ngotho, Charbel Kamau, Aruyaru Stanley Mwenda, Fridah Bosire, Elizabeth Mwachiro, Robert Parker, Ian Simel, Kimutai Sylvester, Abdulmunem Ahmed Mustafa Althini, Sofian Elbarouni, Aya Elseed Elbeshina, Ahmed Gwea, Ans Malek, Wedad Albashir Masoud Farag, Abdulwahab Abdalei, Abu Baker Abdel Malik, Areej Abo-khammash, Ma'aly Abuhlaiga, Nour Adnan, Marwa Albaggar, Asma Alfitory, Asma Aljanfi, Fakhruddin Almuzghi, Zohoor Altumei, Fatima Alzabti, Hana Ashoushan, Mohamed Assalhi, Joma Azzubia, Sondos Bnhameida, Malik Delhen, Houssein Elshafei, Hana Elteir, Fatima Esbaga, Abdel Aziz Gobbi, Fatma Hamouda, Hamdan Hilan, Rania Ismail, Fieruz Jebran, Muataz Kasbour, Galia Maderi, Saja Mohammad, Burooj Mohammed, Habib Murtadi, Hamassat Mustafa, Mohamed Rajab, Sarah Trenba, Mariam Wafaa, Eman Al Sagheir, Alabas Almigheerbi, Ahmed Alzahaf, Sumayyah Ghayth Bahroun, Najah Ben Dallah, Mahmoud Elshaibani, Haitem Eswaye, Maha Karar, Samah Omar, Eman Younes, Maha Younes, Dafer Zreeg, Saleh Abujamra, Firas Ashour, Mala Elgammudi, Wesal Omar F. Aljadidi, Enas Saddouh, Randa Sharif, Aya Alabuzidi, AbdulMawlay Alwerfally, Sarra Aribi, Fatma Bibas, Taha Elfaituri, Yasmine Elhajjaji, Ala Khaled, Wegdan Khalil, Tesneem Layas, Enas Soula, Ahmed Tarek, Muad fathi khalleefah Abu hallalah, Hazem Abdelkarem Ahmed, Tagwa Alsharef, Abdulsalam Ali Ben Saoud, Tasnim El Gharmoul, Ahmed Elhadi, Safa Elrais, Abdulhalim Shebani, Heba Zarti, Asaid Zeiton, Marijus Ambrazevicius, Nerijus Kaselis, Migle Stakyte, Oleg Aliosin, Agne Cizauskaite, Sarunas Dailidenas, Vitalijus Eismontas, Migle Kybransiene, Vitalija Nutautiene, Narimantas Samalavicius, Dainius Simcikas, Algirdas Slepavicius, Albinas Tamosiunas, Nerijus Ubartas, Paulius Zeromskas, Saulius Bradulskis, Edvinas Dainius, Juozas Juocas, Egle Kubiliute, Juozas Kutkevicius, Aurimas Opolskis, Audrius Parseliunas, Andrejus Subocius, Egle Virbickaite, Diana Zuikyte, Algirdas Bogusevicius, Kristina Buzaite, Daiva Cepuliene, Ieva Cesleviciene, Vaidotas Cesna, Jolanta Gribauskaite, Povilas Ignatavicius, Mantas Jokubauskas, Monika Liugailaite, Ernest Margelis, Ruta Mazelyte, Lina Pankratjevaite, Matas Pažusis, Agne Rackeviciute, Justina Saladyte, Monika Škimelyte, Vygintas Šlenfuktas, Monika Sudeikyte, Algimantas Tamelis, Tomas Vanagas, Žygimantas Žumbakys, Aivaras Atkociunas, Audrius Dulskas, Justas Kuliavas, Justas Birutis, Sigitas Paškevicius, Mindaugas Šatkauskas, Donatas Danys, Matas Jakubauskas, Lina Jakubauskiene, Marius Kryzauskas, Vytautas Lipnickas, Gabija Makunaite, Fanjandrainy Rasoaherinomenjanahary, Herizo Rasolofonarivo, Luc Hervé Samison, Bitiel Banda, Vanessa Msosa, Ahmad Imran Ahmad Izzuddin, Andre Das, Ying Yee Gan, Tan Shong Sheng, Jia yng Siaw, Mohd Fadliyazid Ab Rahim, Dyg Zahratul Hamrak Abang Jamari, Nurfariza Che Husin, Muhd Yusairi Kamarulzaman, Yi Ping Lim, Nil Amri Mohamed Kamil, Mohd Razeen Mohd Hassan, Saidah Mohd Sahid, Johari Mustafa, Elaine Hui Been Ng, Wan Khamizar Wan Khazim, Ng Chang Ern, P.g. Lingeshan, Syariz Ezuan Sulaiman, Sue Ean Ang, Muhammad Navid Bin Mohamad Sithik, Yih Jeng Cheong, Mahadevan Deva Tata, Law Jia Xian, Aravinthan Kadravello, I-Ern Koh, Li-Yen Ng, Yuki Julius Ng We Yong, Kandasami Palayan, Chi Xuan Sam, Phuah Siow Jin, Jeremy Tan Ern Hwei, Yita Tang, Alvin Zubin Ter, Michael Pak-Kai Wong, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Fitjerald Henry, Thyivya Kalaiselvan, Muhammad Fairuz Shah Abd Karim, Mohamed Rezal Abdul Aziz, Nora Abdul Aziz, Tak Loon Khong, Peng Choong Lau, Hiong Chin Lim, April Camilla Roslani, Jonathan Chen Ken Seak, Sui-Weng Wong, Lai Fen Wong, Leow Yeen Chin, Mercy Chinemerem Anyanwu, Zachary Busuttil, Thomas Calleja, Kurt Lee Chircop, Ruth Cutajar, Andrew Michael Dimech, Joseph Galea, Kiara Gascon Perai, Ruth Gatt, Lisa Kelman, Elizabeth Micallef, Favour Nwolu, Kim Sammut, Joanna Thompson, Sean Warwicker, Matthew Zammit, Fernando Cordera, Efraín Cruz González, Jorge Sánchez-García, Francisco José Barbosa Camacho, Francisco Javier Barrera López, Carlos Jose Zuloaga Fernandez del Valle, Eric Acosta, Iván Romarico González Espinoza, Perla Moreno, Ana Olivia Cortes-Flores, Clotilde Fuentes Orozco, Alejandro Gonzalez Ojeda, Samantha Corro Díaz González, Laura Martinez, Bonifacio Mosqueda Amador, Armando Novoa, Dennet Arturo Olazo Espejo, Alejandro Jimenez, Federico Lopez Rosales, Elva Gabriela Vanoye, Luis Alberto Garcia Gonzalez, Roberto Carlos Miranda-Ackerman, Manuel Solano-Genesta, Alethia Alvarez-Cano, Hector Hugo Romero-Garza, Heriberto Medina-Franco, Lorelí Mejía-Fernández, Noel Salgado-Nesme, Omar Vergara-Fernandez, Guadalupe Montserrat Gutiérrez-Mota, Francisco Xavier Hernandez Vera, Anabella Llantada Lopez, Gilberto Morgan Villela, Felipe de Jesus Ramirez Padilla, Walezka Tapia Marin, Mónica Martínez Maldonado, Ramses Sánchez Suárez, José Manuel Troche, Chaymae Benyaiche, Oumaima Outani, Souadka Amine, Amine Benkabbou, Anass Mohammed Majbar, Raouf Mohsine, Ali Rafik, Thida Oung, Moe Moe Tin, Philipp Plarre, Anna Alberga, Nina Sluiter, Jurriaan Tuynman, Robin Blok, Didem Cömert, Roel Hompes, Marianne Kalff, Merel Elisabeth Stellingwerf, Pieter Tanis, Mark van Berge Henegouwen, Elise Maria van Praag, Daan Wisselink, Michael Gerhards, Josephine Lopes Cardozo, Emma Westerduin, Joske de Jonge, Aaw van Geloven, Kaz van Schilt, Frank den Boer, Simone Stoots, Stijn Vlek, Jamie Adams, Ibrahim S. Al-Busaidi, Gabrielle Budd, Seung il Choi, Michael Jen Jie Chu, Anurag Ganugapati, Lucy McKinstry, Rebecca Pascoe, Simon Richards, Kenrick Rosser, Annie Stevenson, Rebecca White, Shebani Farik, Jin Kwun, Ahmed Murad, Sarah Cowan, Timothy Hall, Michael Hayton, Laminou Malam Sani, Souleymane Oumarou Garba, Ibrahim Amadou Magagi, Oumarou Habou, Halima Aliyu, Muhammad Daniyan, Tunde T. Sholadoye, Lawal Abdullahi, Lofty-John Anyanwu, Aminu Mohammad Mohammad, Abubakar Bala Muhammad, Abdurrahman Abba Sheshe, Ibrahim Suleiman, Alaba Adesina, Ajibola Awolowo, Clement Onuoha, Omotayo Salami, Ogechukwu Taiwo, Agboola Taiwo, Stephen Kache, Jerry Godfrey Makama, Danjuma Sale, Olajide Abiola, Akinlabi Ajao, Anthony Ajiboye, Amarachukwu Etonyeaku, Julius Olaogun, Ademola Adebanjo, Opeoluwa Adesanya, Michael Olatunji Afolayan, Olanrewaju Balogun, Ayomide Makanjuola, Samuel Nwokocha, Rufus Wale Ojewola, Thomas Olagboyega Olajide, Adewale Aderounmu, Abdul-Rashid Adesunkanmi, Augustine Agbakwuru, Adeleke Akeem Aderogba, Olusegun Isaac Alatise, Olukayode Arowolo, Oladejo Lawal, Tajudeen Mohammed, Chinedu Ndegbu, Olalekan Olasehinde, Funmilola Wuraola, Akinbolaji Akinkuolie, Arinzechukwu Mosanya, Omobolaji Ayandipo, Peter Elemile, Taiwo Akeem Lawal, Samuel Ali SANI, Stephen Garba, Rebecca Hauwa SANI, Samson Olori, Henry Onyebuashi, Ifeanyi Umoke, Adedire Adenuga, Ademola Adeyeye, Olufemi Habeeb, Bashir Lawal, Abdulrasheed Nasir, Eirik Kjus Aahlin, Didrik Kjønås, Elisabeth Myrseth, Jibran Abbasy, Abdul Alvi, Omair Saleem, Asma Afzal, Anam Nazir, Muhammad Farooq, Ayesha Liaqat, Syed Asghar Naqi, Ali Raza, Muzna Sarfraz, Muhammad Sarwar, Muntaha Banglani, Ambreen Munir, Rahmat Sehrish, Bushra Ayub, Raza Sayyed, Amna Altaf, Saima Ayub, Komal Saeed, Bilal Syed, Sana Amir Akbar, Abdul Wahid Anwer, Ruqayya Naheed Khan, Amina Iqbal Khan, Shahid Khattak, Sameen Mohtasham, Muhammad Asad Parvaiz, Aamir Ali Syed, Abdul Basit Ansari, Noman Shahzad, Tanwir Khaliq, Isbah Rashid, Shahzad Hussain Waqar, Hasan Abu Al-saleem, Amjad Abu Alqumboz, Mohammad Alqadi, Adham Amro, Rawan Assa, Eman Awesat, Rawan Ayyad, Mohammed Hammad, Ayat Haymony, Bassel Hijazi, Bara Hmeidat, Rowaa Lahaseh, Aseel Qawasmi, Alaa Rajabi, Mohammed Shehada, Sundus Shkokani, Yasmine Yaghi, Nadine Yaghi, Mohammad AlZohour, Mohammad Farid, Yousef Mahmoud Habes, Wesam Juba, Yanal Nubani, Abdelrahman Rabee, Mohammad Sa'deh, Saeed Abed, Iyad Al basos, Mohammad Alswerki, Dina Ashour, Israa Awad, Samar Diab, Alaa El Jamassi, Sahar El-Kahlout, Somaya Elhout, Ahmed N K Hajjaj, Doaa Hasanain, Baraa Nabil hajjaj, Mohammed Obaid, Eman Saikaly, Ahmed Salhi, Hiba Al-Tammam, Murad Almasri, Muath Baniowda, Doha Beshtawi, Ali Horoub, Rami Misk, Bayan Mohammad, Rami Qasrawi, Tasnim Sholi, Samar Abu-Nimeh, Abrar Abu-srour, Sadi A. Abukhalaf, Samer Adawi, Barah Alsalameh, Kholoud Ayesh, Muawiyah Elqadi, Ahmad Hammouri, Fatima Karim Mustafa, Natalie Marzouqa, Shatha Melhem, Dima Miqdad, Balqees Mohamad, Mhammed Rawhi, Ayman B. Abu Ahammala, Ahmed Abu Ataya, Israa Abu Jayyab, Samar Al-Shwaikh, Othman Alagha, Mohammed Alasttal, Haneen Awadallah, Mahmood Elblbessy, Jehad Fares, Akram Jarbou, Ibtisam Mahfouz, Moath A. Albahnasawi, Asmaa' Abo mahadi, Hasan Abuelhatal, Ayham Abuelqomboz, Abdelrahman Almoqayyad, Abdallah Alwali, Reem Balaawi, Mahmoud Hamouda, Mohammed Humeid, Abdullah Jedyan, Tasneem Mahmoud Abu hamam, Ghadeer Matar, Ali Salem, Tahani Samra, Nureddin Shaheen, Karam Shihada, Ayoob A.Nemer, Mahmoud Abu Al Amrain, Abdulwhhab Abu Alamrain, Najlaa Abu Jamie, Mohammed R. Abu-Rous, Nada Alfarra, Mohammed AlTaweel, Noor Alwhaidi, Ramadan Hamed, Bader Saqqa, Ahmad Shaheen, Dana Aljaber, Loay Aljaberi, Malak Alwaheidi, Assef Jawaada, Hani Khaldi, Rami Qahoush, Jalil Qari, Rana Saadeh, Ahlam Salim, Aseel Yacoub, Abbas Abbas, Rana Abu shua`ib, Baraa Abu Zainah, Mahmoud AbuSirrees, Basheer Babaa, Ola Barhoush, Asef Belal qadomi, Laith Daraghmeh, Reema Haji, Alaa Khatatbeh, Lana Khatib, Salsabeel Qarariah, Yara Quzmar, Khalil Safadi, Roqaya Salameh, Mohammad Hassan, Shifaa Herzallah, Loai Massad, Ahmed Nazzal, Ranin Nazzal, Dennis Escobar, Gustavo Miguel Machain V, Agustin Rodriguez Gonzalez, Jorge Emerson Chachaima Mar, Nathaly Olga Chinchihualpa Paredes, Vicente Cuba, Walter Lopez, Maria Milagros Niquen Jimenez, Nestor Alberto Sanchez Bartra, Olenka Sapallanay Ojeda, Diego Sequeiros, Andrea Toscano Pacheco, María Vergara, Sol Abarca, Rodrigo Alcorta, Giuliano Borda-Luque, Ivan Edward Eusebio Zegarra, Claudia Luján López, Mirella Marrufo, Cinthya Mogrovejo, Andrea Nomura, Yamile Rodríguez Angeles, Maitza Rosario Vidal Meza, Gabriela Zavala, José Neiser Castillo Arrascue, Jomara Caroline Hidrogo Cabrera, José Julio Mariano Larrea vera, Miguel Osorio, Edgar Alcides Ylatoma Díaz, Mark Anthony Fontanilla, Joseph Roy Fuentes, Anna Leah Salazar, Genieve Dominguez, Marc Paul Lopez, Shiela Macalindong, Mark Augustine Onglao, Arjel Ramirez, Marie Dione Sacdalan, Mayou Martin Tampo, Gemma Leonora Uy, Jeremiah Mangahas, Kenneth Yabut, Joannes Paul Cañete, Bernalynn Eris Cansana, Ernes John Castro, Maria Kaiserin Lipana, Manuel Francisco Roxas, Vlu Jean Zara, Maciej Chrol, Paula Franczak, Michal Orlowski, Piotr Budzynski, Andrzej Budzynski, Pawel Bury, Agata Czerwinska, Jadwiga Dworak, Jacek Dziedzic, Michal Kisielewski, Jan Kulawik, Anna Lasek, Piotr Malczak, Marcin Migaczewski, Michal Pedziwiatr, Magdalena Pisarska, Dorota Radkowiak, Mateusz Rubinkiewicz, Anna Rzepa, Tomasz Skoczylas, Maciej Stanek, Katarzyna Truszkiewicz, Mateusz Wierdak, Marek Winiarski, Piotr Zarzycki, Anna Zub-Pokrowiecka, Piotr Kowalewski, Rafal Roszkowski, Maciej Waledziak, Miguel Tomé, Sara Patrocinio, Ines Guerreiro, Filipe Almeida, Xavier de Sousa, Nuno Monteiro, Maria Teresa Costa Santos, Daniela de Oliveira, Marta Lopes Serra, Daniela Morgado, Christian Neves, Ana Carolina Oliveira, Alice Pimentel, Sofia Silva, Márcia Carvalho, Lúcia Carvalho, Joana Magalhães, Leonor Matos, Tânia Monteiro, Carlota Ramos, Vanessa Santos, José Barbosa, Jose Costa-Maia, Vítor Devezas, Ana Fareleira, Cristina Fernandes, Diana Gonçalves, Henrique Mora, Marina Morais, Fabiana Silva de Sousa, Sara Catarino Santos, Ana Logrado, André Tojal, Edgar Amorim, Miguel F. Cunha, Ana Fazenda, João Pedro Melo Neves, Inês Isabel Sampaio da Nóvoa Gomes Miguel, Diogo Veiga, José Azevedo, Hugo Cardoso Louro, Mariana Leite, Maria Bairos Menezes, Bárbara Gama, Diana Brito, Marta Cristina Cruz Martins, André Graça e Magalhães, Ana Catarina Longras, Rita Lourenço, Diana Matos, Luis Castro, Filipa Policarpo, Joana Romano, Cristina Monteiro, Diogo Pinto, Marina Duarte, Sónia Fortuna Martins, Mariline Oliveira, Diogo Galvão, Lisandra Martins, Anaisa Silva, Viorel Taranu, Bárbara Vieira, Jessica Neves, Simone Oliveira, Hugo Ribeiro, Margarida Cinza, Rosa Felix, Arnaldo Machado, Joana Oliveira, Joana Patrício, Rita Pedroso de Lima, Mário Pereira, Miguel Rocha Melo, Cristina Velez, Alberto Abreu da Silva, Mariana Claro, Daniel Costa Santos, Andreia Ferreira, Hugo Capote, Daniela Rosado, Filipa Taré, Oriana Nogueira, Miguel Ângelo, José Miguel Baiao, Andreia Guimarães, João Marques, Miguel Nico Albano, Marta Silva, Ana Valente da Costa, Teresa Vieira Caroço, Sara Almeida Braga, Ines Capunge, Marta Fragoso, João Guimarães, Bruno Pinto, João Ribeiro, Miguel Angel, Guilherme Fialho, Monica Guerrero, Filipa Campos Costa, Diogo Cardoso, Vasco Cardoso, Magda Alves, Inês Estalagem, Tiago Louro, Cláudia Marques, Rita Martelo, Miguel Morgado, Rita Canotilho, Ana Margarida Correia, Pedro Martins, Mariana Peyroteo, João Gomes, Rita Monteiro, Manuela Romano, Daniela Macedo Alves, Rita Peixoto, Catarina Quintela, Maria João Jervis, Débora Melo, André Pacheco, Valter Paixão, Vera Pedro, Joana Pimenta, João Pimenta de Castro, Ana Rocha, Mircea Beuran, Cezar Ciubotaru, Bogdan Diaconescu, Sorin Hostiuc, Ionut Negoi, Bogdan Stoica, NA NA, Evgeny Anokhin, Georgy Kuznetsov, Giorgi Oganezov, Fedor Paramzin, Ekaterina Romanova, Valeryan Rutkovskii, Vasilii Rutkovskii, Mikhail Shushval, Mikhail Zabiyaka, Khasan Dzhumabaev, Valerii Ivanov, Zaman Mamedli, Sergey Achkasov, Artem Balkarov, Elnur Nabiev, Marat Nagudov, Evgeny Rybakov, Karina Saifutdinova, Oleg Sushkov, Lule Joseph, Isaac Ndayishimiye, Ntirenganya Faustin, Alphonse Zeta Mutabazi, Jean Paul Mvukiyehe, Vizir J.P Nsengimana, Carine Uwakunda, Mohammad Monir Abbas, Nouf Akeel, Murad Aljiffry, Kholoud Awaji, Ali Farsi, Ghader Jamjoum, Ahmad Khoja, Ashraf Maghrabi, Nadim Malibary, Mohammed Nassif, Abdulaziz Saleem, Abdullah Sultan, Wail Tashkandi, Hanaa Tashkandi, Nora Trabulsi, Mouhamadou Bachir Ba, Adja Coumba Diallo, Abdourahmane Ndong, Vladica Cuk, Uroš Jankovic, Sharon Zhiling Koh, Frederick Koh, Kuok Chung Lee, Kai Yin Lee, Sean Lee, Wei Qi Leong, Su Ann Lui, Prajwala Prakash, Jan Grosek, Gregor Norcic, Ales Tomazic, Nicolas Fitchat, Robert Jaich, Devorah Wineberg, Modise Zacharia Koto, Daniella Baiocchi, Damian Clarke, Christina Johanna Steenkamp, Sharon Bannister, Adam Boutall, Galya Chinnery, Anna Coccia, Angela Dell, Parveen Karjiker, Christo Kloppers, Nicholas Loxton, Tumi Mabogoane, Francois Malherbe, Eugenio Panieri, Shreya Rayamajhi, Tirsa van Wyngaard, Claire Warden, T E Madiba, Nivashen Pillay, Savannah Brooks, Charlise Kruger, Lisa Hannah Van Der Merwe, Ferhana Gool, Maahir Kariem, Heather Bougard, Nazmie Kariem, Fazlin Noor, Reantha Pillay, Leandi Steynfaardt, Lucía González González, José Miguel Marín Santos, Paula Martín-Borregón, Javier Martínez Caballero, Cristina Nevado García, Pastora Rodriguez Fraga, Gonzalo De Castro Parga, Maria Pilar Fernández Veiga, Lucía Garrido López, Hugo Infante Pino, Irene Lages Cal, Marta López Otero, Manuel Nogueira Sixto, Marta Paniagua García Señorans, Laura Rodríguez Fernández, Alejandro Ruano Poblador, Erika Rufo Crespo, Raquel Sanchez-Santos, Vincenzo Vigorita, Ester Alonso Batanero, Dorisme Asnel, Isabel Cifrian Canales, Elisa Contreras Saiz, Irene De Santiago Alvarez, Tamara Díaz Vico, Sebastian Fernandez Arias, Daniel Fernández Martínez, Carmen García Bernardo, Luis Joaquín García Flórez, Carmen Garcia Gutierrez, Manuel García Munar, Carlos Alberto Márquez Zorrilla Molina, Marta Merayo, José Luis Michi Campos, Maria Moreno Gijon, Jorge L. Otero-Diez, Jose Luis Rodicio Miravalles, Lorena Solar-Garcia, Aida Suárez Sánchez, Nuria Truan, Cristina Alejandre Villalobos, Yurena Caballero Díaz, Marta Jimenez, Dacil Montesdeoca, Antonio Navarro-Sánchez, Victor Vega, Juan Beltrán de Heredia, Zahira Gómez, Carlos Jezieniecki, Ana Patricia Legido Morán, Mario Montes-Manrique, Mario Rodriguez-Lopez, María Ruiz Soriano, Jeancarlos Trujillo Díaz, Andrea Vazquez Fernandez, Nuria Argudo, Miguel Pera, Laia Torrent Jansà, Melody García Domínguez, Ignacio Goded, Marta Roldón Golet, Issa Talal El-Abur, Alejandra Utrilla Fornals, Vanesa Zambrana Campos, Maria Del Mar Aguilar Martinez, Marina Bosch, Luis García-Catalá, Luis Sánchez-Guillén, Eva Artigau, Nuria Gomez Romeu, David Julià Bergkvist, Beatriz Espina Perez, Olga Morató, Carles Olona, Beatriz Diéguez, Alexander Forero-Torres, Manuel Losada, Segundo Gomez-Abril, Paula Gonzálvez, Rosario Martinez, Sergio Navarro Martínez, Carmen Payá-Llorente, Álvaro Pérez Rubio, Sandra Santarrufina Martinez, Juan Carlos Sebastián Tomás, Ramon Trullenque Juan, Alberto Gegúndez Simón, Paloma Maté, Maria Isabel Prieto-Nieto, Ines Rubio-Perez, Aitor Urbieta, Marina Vicario Bravo, David Abelló, Matteo Frasson, Alvaro Garcia-Granero, Alfredo Abad Gurumeta, Ane Abad-Motos, Elena Lucena-de Pablo, Beatriz Nozal, Javier Ripollés-Melchor, Rut Salvachúa, Esther Ferrero, Luis Garcia-Sancho Tellez, Antonio L. Picardo, Jose Alberto Rojo López, Laura Patricia Zorrilla Matilla, Carmen Cagigas Fernandez, Sonia Castanedo Bezanilla, José Estevez Tesouro, Maria Jose Fernandez-Diaz, Juan García Cardo, Marcos Gomez Ruiz, Erik Gonzalez-Tolaretxipi, Jaime Jimeno Fraile, Cristobal Poch, Montserrat Rodriguez-Aguirre, Noemí Troche Pesqueira, Maria Soledad Trugeda-Carrera, Javier de la Torre, Ruth Blanco-Colino, Eloy Espin-Basany, Martin Espinosa-Bravo, Clara Morales Comas, Eduardo Reyes Afonso, Joaquín Rivero Déniz, Christian Siso Raber, Mireia Verdaguer Tremolosa, Pramodh Chandrasinghe, Sumudu Kumarage, Nimeshi Wijekoon Arachchilage, Ahmed Abdalla Ahmed Elkamel, Mohammed A. Adam, Nina Blomme, Anders Thorell, Fredrik Wogensen, Andreas Älgå, Dhirar Ansarei, Fuat Celebioglu, Göran Heinius, Linda Nigard, Emil Pieniowski, Sandra Ahlqvist, Ida Björklund, Andreas Frånberg, Martina Håkansson, Karin Adamo, Oskar Franklin, Malin Sund, Rebecca Wiberg, Yvette Andersson, Abbas Chabok, Maziar Nikberg, Alexander Kugelberg, Claudia Canonica, Dimitrios Christoforidis, Fabrizio Fasolini, Paolo Gaffuri, Mauro Giuliani, Francesco Meani, Sotirios Georgios Popeskou, Silvia Pozza, Wiebke Wandschneider, Lorenz Peterer, Lukas Werner Widmer, Bernd Zimmermann, Panagiotis Bakoleas, Iris Chanousi, Lydia Charalampidou, Lukasz Filip Grochola, Franziska Heid, Sotirios Ntaoulas, Michail Outos, Georgios Peros, Hanna Podolska-Skoczek, Katharina Beate Reinisch, Christian Zielasek, Nicolas Demartines, Jérôme Gilgien, Amaniel Kefleyesus, Pénélope St-Amour, Arnaud Toussaint, Maryam Alhimyar, Bayan Alsaid, Amr Alyafi, Ahmad Alkhaledi, Basel Kouz, Ahmad Omarain, Yusra Al-Sabbagh, Haya Alkhatib, Samer Sara, Ahmad Alhaj, Aghyad Danial, Lama Kadoura, Sarah Maa Albared, Yamen Monawar, Louei Nahas, Barook Abd, Ahmad Saad, Habib Wakkaf, Hatem Bouzaiene, Montassar Ghalleb, Elif Akaydin, Ata Cem Akbaba, Onur Atakul, Ege Baltaci, Sevval Besli, Gökçen Burgu, Ulukan Cenal, Cansu de Muijnck, Hasan Can Demirkaya, Alper Dogruoz, Zeynep Ipek Gezer, Yasemin Gündogdu, Merve Kara, Hasan Kürsad Korkmaz, Gökalp Kagan Kurtoglu, Volkan Ozben, Berk Baris Ozmen, Ahmet Murat Pektas, Eda Kübra Sel, Nilüfer Yenidünya, Fuat Baris Bengur, Berke Mustafa Oral, Tahir Koray Yozgatli, Seymur Abdullayev, Mehmet Emin Gunes, Nuri Alper Sahbaz, Tuba Banaz, Kübra Kargici, Omer Faruk Kuyumcu, Erkan Yanikoglu, Merve Yesilsancak, Duygu Yilmaz, Melik Kagan Aktas, Ahmet Rencuzogullari, Arda Isik, Sezai Leventoglu, Ali Yalçinkaya, Osman Yüksel, Mustafa U Kalayci, Yasin Kara, Inanc Samil Sarici, Alp Akin, Gökçe nur Alemdag, Ekin Arslan, Bahadir Emre Baki, Muhammed Selim Bodur, Adnan Calik, Bahar Candas Altinbas, Irem Cihanyurdu, Oguz Erkul, Burak Gül, Ali Guner, Beyza Köse, Anil Semiz, Sule Sevim, Serkan Tayar, Kadir Tomas, Ozan yavuz Tüfek, Serdar Türkyilmaz, Mehmet Ulusahin, Arif Usta, Reyyan Yildirim, Sertaç Ata Güler, Ozan Can Tatar, Ecenur Varol, Busenur Kirimtay, Muhammed Uysal, Alp Yildiz, Emin Kose, Ahmet Burak Ciftci, Elif Çolak, Huseyin Eraslan, Gultekin Ozan Kucuk, Kürsat Yemez, Herman Lule, Mumbere Bienfait, Emmanuel Bua, Noella Okalany, Maksym Basarab, Oleksii Bielosludtsev, Kateryna Kolhanova, Kateryna Perepelytsia, Kateryna Romanukha, Dmytro Savenkov, Stanislav Siryi, Maksym Tereshchenko, Nezamai Viacheslav, Anton Volovetskyi, Andrey Kebkalo, Yegor Tryliskyy, Volodimir Tyselskiy, Eilidh Bruce, Bing Lun Chow, Emma Iddles, Sarah McGuckin, Nicola Newall, George Ramsay, Parivrudh Sharma, Caitlin Stewart, Jeremy Wong, Abdul Badran, Michael Bath, Fanny Belais, Eman Butt, Kaustuv Joshi, Milan Kapur, Mike Shaw, Adam Townson, Christopher Yee Khang Williams, Timothy Gray, Robert Greig, Mansoor Husain, Elspeth Murray, Ahmed Mustafa, Ashar Asif, Arya Gokul, Max Shah, Mabel Temisanren Akitikori, Alexandros Charalabopoulos, Sophie Davidson, Sinead McNally, Shamil Rupani, Fatema Juma, Sarah Catherine Mills, Laura Muirhead, Kate Sellars, Una Walsh, Oliver Warren, Alice Chambers, Richard Hunt, Stephen Boyce, Hannah Cornwall, Isabel Tol, Eleftherios Orestis Argyriou, Nicola Eardley, Meical Povey, Joanna M S Aithie, Ahmer Irfan, Mari-Claire McGuigan, Robert Starr, Craig Russell Warren, Jess Archibald, Georgia Kirby, Ivan Kisyov, Chun Kheng Khoo, Rachel Lee, Dana Photiou, Rowan Davis, Uday Prasad, P Zichu Yang, Jonathan Bird, Edmund Leung, Virginia Summerour, Chelise Currow, Jianshen Kiam, Gerald Jack Soon Tan, Anitha Muthusami, Ibifunke Pegba-Otemolu, Tomas Urbonas, Joseph Nunoo-Mensah, Edgaras Smolskas, Alex Boddy, Gianpiero Gravante, David Hunter, David Andrew, Amanda Koh, Amari Thompson, Lawrence Adams, Hollie A Clements, Kasun De Silva, Ogbonnia Ekpete, Seraj Haque, Scott Henderson, Bilal Ibrahim, Thummini Jayasinghe, Jennifer Livie, Keir Mailley, Gopikrishnan Nair, Daniel Tan, Caitlin Baggaley, Aleksander Dawidziuk, Bartosz Szyszka, Charlotte Barter, Nirav Gandhi, Karen Hassell, Samantha Hitchin, Jennett Kelsall, Eva Nagy, Ashrafun Nessa, Lisa Whisker, Fady Yanni, Mahmoud Ali, Deeksha Arora, Sunanda Hediwattege, Navam Kumarasinghe, Munir Rathore, Athula Tennakoon, Syed Mustafa Ali Ahmad, Oreoluwa Bajomo, Fahema Nadira, Valerio Celentano, Ewen Griffiths, Rama Santhosh Karri, Jason Kei Chak Mak, Michelle Pipe, Muhammad Iqbal Bhatti, Mohamed Rabie, Connor Boyle, David Hamilton, Aishath Mihuna, James Chean Khun Ng, Gary Nicholson, Agata Oliwa, Robert Pearson, Anna Rose, Shun Qi Yong, Catherine Boereboom, Michael Hanna, Catherine Walter, Thomas Samuel Greensmith, Rachel Mitchell, Eimear Monaghan, James Crawford, Susan Moug, James Blackwell, Hannah Boyd-Carson, Philip Herrod, Omar Al-Allaf, Miriam Beattie, Cameron Bullock, Shivang Burman, Gemma Clark, Nicolas Flamey, Oliver Flannery, Alexander Harding, Ben Kodiatt, Samuel Lawday, Shivani Mahapatra, Navin Mukundu Nagesh, Michael Ng, Dupinderjit Rye, Andrel Yoong, Laura Clark, Chris Deans, Monisha Edirisooriya, Emma Victoria Carrington, Tsz Lun Ernest Wong, Baasil Yusuf, Carla Chamberlain, Kathryn Duke, Elizabeth Kmiotek, Azel Botes, Natalie Condie, Timothy Schrire, Reena Shah, Iolo Thomas-Jones, Charlotte Yates, Natasha Anthony, Edward Matthews, Kapil Sahnan, James Tankel, Sally Tucker, Jasmine Winter Beatty, Paul Ziprin, William Duggan, Anastasia Kantartzi, Shruthi Sridhar, Rachel Alys Khaw, Prakhar Srivastava, Charlotte Underwood, Homero Alves do Canto Brum, Sharat Chopra, Laura Davis, Rebecca Hughes, Joshua Tulley, Justin Alberts, Thomas Athisayaraj, Mojolaoluwa Olugbemi, Kasim Ahmad, Claudia Chan, Gavin Chapman, Hannah Fleming, Benjamin Fox, Julia Grewar, Kate Hulse, Duncan Rutherford, Mackay Sinead, Scott Smith, Doug Speake, Peter G Vaughan-Shaw, Natasha Christodoulides, Simrit Kudhail, Matthew Welch, Syed Muhibullah Husaini, Simon Lambracos, Chikamuche Anyanwu, Rishi Suresh, Jimmy Scott Thomas, Elizabeth Gleeson, Rebecca Platoff, Areeba Saif, Zachary Enumah, Eric Etchill, Alodia Gabre-Kidan, Mitchell Bernstein, Francesco Maria Carrano, Joseph Connors, Patricio Lynn, Marcovalerio Melis, Elliot Newman, Deshka S Foster, Kenneth Perrone, Ashley Titan, Sarwat Ahmad, Andrea Chao M.D. Bafford, Marco Dal Molin, Nader Hanna, Syed Nabeel Zafar, Mark Hemmila, Lena Napolitano, Jane J Wong, Julia Chandler, Lauren Wood, Sherry Wren, Taylor Ottesen, Lucia You, Kristin Yu, María del pilar Arciénega Yañez, Martin Ferreira Fernandes, Daniel González, Santiago Cubas, María Catalina González, Vanessa Zubiaurre, Rodrigo Demolin, Nicolas Giroff, Pablo Sciuto, Maite Campos, Gabriela Rodríguez Cantera, Garg Deepika, Elliot Simuchimba, Anadi Bulaya, Chali Chibuye, Bright Chirengendure, Mary-Rose Kabale, Kizito Kabongo, James Munthali, Oliver Mweso, Francis Pikiti, James Otieno, Log Tung Lai, Brighid Blackman, Sophie Richards, Suren Subramaniam, Rafid Karim, Nathan Kok, Yanni Dion Lee, Shabina Ali, Aanjaneya Sinha, Robert Corrigan, Nicole Barnes, Florence Wong, Grace Dennis, Julia Jedamzik, Emil Phillips, Wivine Piette, Marie Van hentenryck, Houenoukpo Koco, Souliath Lawani, Mamo Woldu Kassa, Tainá Santos Bezerra, Petar Gribnev, Dobromir Dimitrov, Panche Krastev, Sovannarith Oum, Divine Tim Bonghaseh, Maryam Al Farsi, Nourah Alsharqawi, Veronica Acevedo, Andrea Carolina Castillo Barbosa, Felipe Giron, Jimmy Paul Leon Rodriguez, Darko Kucan, Damir Rosko, Neven Barsic, Domagoj Župan, Amgad Hegazi, Vendula Truncíková, Vladimir Fryba, Mostafa Mohamed, Ahmed Sultan, Ahmed Nagi, Abdallah Rashad Temerik, Mohamed Elemam Elshawy, Moustafa Ibrahim Mahmoud, Shrouk Omar, Mohamed Anwar, Tarek Rageh, Aya Elmokadem, Khaled Gaballa, Sandra Teppo, Antti Turunen, Pasi Pengermä, Quentin Ballouhey, Damien Bergeat, Ariane Weyl, Elisabeth Hain, Adam Gyedu, Edwin Yenli, Dorcas 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Castilla Moreno M.A., Genov G., Ilieva I., Ivanov T., Karamanliev M., Khan A., Mitkov E., Yotsov T., Atanasov B., Belev N., Slavchev M., Nsengiyumva C., Jones E., Stock S., Kyota S., Brown J., Mabanza K. T., Nigo Samuel L., Otuneme C., Prosper N., Umenze F., Boutros M., Caminsky N., Dumitra S., Garfinkle R., Morency D., Salama E., Banks A., Ferri L., He H., Katz A., Liberman A.S., Meterissian S., Pang A., Parvez E., Hameed U., Osman F., Sequeira S., Coburn N., Jaffer A., Karanicolas P., Mosseler M., Musselman R., Liu X., Yip C.W., Garces-Otero J.S., Guzman C., Sierra S., Uribe Valencia A., Cabrera Rivera P.A., Camelo S., Gonzalez A., Gonzalez-Orozco A., Mosquera Paz M.S., Perez Rivera C.J., Gonzalez F., Isaza-Restrepo A., Nino- Torres L., Arias Madrid N., Mendoza Arango M.C., Tsandiraki J., Jemendzic D., Kocman B., Suman O., Canic R., Jurisic D., Karakas I., Krizanovic Rupcic A., Pitlovic V., Samardzic J., Kopljar M., Bacic I., Domini E., Karlo R., Miljanic D., Simic A., Ahmed M., Al Nassrallah M., Altaf R., Amjad T., Eltoum R., Haidar H., Hassan A., Khalil O., Qasem M., Ramesh R., Sajith G., Wisal M., Zatecky J., Bujda M., Jirankova K., Paclik A., Abdallah A., Abdulgawad Almogy M., Ayman El-sawy E., ElFayoumy A.M., Elghareeb N., Esmat N.A., Fadel A., Habater A., Hamdy H., Hefni A., Kamal M., Mohamed Abobakr N., Sayed A., Shaker N., Taha E., Tharwat H., Zakaria O., Abdelmotaleb I., Al-Dhufri A., Al-Himyari H.S., El sheikh E., Eldmaty A., Elkhalawy A., M.Elkhashen A., Magdy K., Mostafa S., Sadia H.D., Saleh M.M., Samir D., Yahia Mohamed Ali M., A. Nassar M., Abdelhady S., Abdelrazek A., Abdelsalam I., El-Sawy A., Essam E., Gadelkarim M., Ghaly K., Hassabalnaby M., Masarani R., Mohamed Shaaban N., Sabry A., Salem M., Soliman N.A., Zahran D., Abou El.soud M.R., Badr E.T., Borham H., Elmeslemany N., Elsayed M., Elsherif F., Eslam S., Gaber G., Ibrahim S., Kamh Y., Mohamed S.G., Morshedy E., Omar C., Salem Soliman F., Abdelkawy S., Abdelmohsen N., Abdelshakour M., Dahy A., Gamal N., Gamal M., Hasan A., Hetta H., Mousa N., Omar M., Rabie S., Saad M., Saleh B., Sayed Mohamed M., Shawqi M., Abdelhady Mousa H., Alnoury M., Elbealawy M., Elshafey A., Essam Ibrahim El Desouki Muhammad Ahmed M., Ghonaim M., Hgag F., Ibrahim M., Morsy M., Reda Loaloa M., Refaat A., Samir H., Shahien F., Sobhy M., Sroor F., Abdellatif E., Adel M., Afifi A.A., Afifi E., Antaky M., Dawoud A., El Zoghby N., El-remaily A., Elzanfaly A.A., Gadallah A., Gamal F.A., Hashem O., Medhat Youssef S., Muhammad Attyah A., Munir M., Shazly O., Wilson K., Adel S., Ali A., 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S., Alherz M., Ather M., Bajilan M., Graziadei V., Pilkington I., Quidwai O., Ridgway P., Shiwani H., Tahir A.A.-R., Blunnie E., Burke D., Kennedy N., Macdonagh K., O'Neill M., Rooney S., Falco G., Ferrari G., Mele S., Nita G.E., Ugoletti L., Zizzo M., Confalonieri G., Pesenti G., Tagliabue F., Baronio G., Ongaro D., Pata G., Compagnoni B., Salvadori R., Taglietti L., D'Alessandro N., Di Lascio P., Pascale G., Bortolasi L., Campagnaro T., Carlini M., Lisi G., Lombardi D., Pedrazzani C., Spoletini D., Turri G., Violi P., Altomare D.F., Aquilino F., Musa N., Papagni V., Picciariello A., Vincenti L., Andreotti D., Occhionorelli S., Tondo M., Basso S.M.M., Cirelli R., Maino M.E.M., Piozzi G.N., Picone E., Scaramuzzo R., Sinibaldi G., Amendola A., Anastasio L., Bucci L., Caruso E., Castaldi A., Di Maso S., Dinuzzi V.P., Esposito G., Gaudiello M., Giglio M.C., Greco P.A., Luglio G., Manfreda A., Marra E., Mastella F., Pagano G., Peltrini R., Pepe V., Sacco M., Sollazzo V., Spiezio G., 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G., Morshedy, E., Omar, C., Salem Soliman, F., Abdelkawy, S., Abdelmohsen, N., Abdelshakour, M., Dahy, A., Gamal, N., Gamal, M., Hasan, A., Hetta, H., Mousa, N., Omar, M., Rabie, S., Saad, M., Saleh, B., Sayed Mohamed, M., Shawqi, M., Abdelhady Mousa, H., Alnoury, M., Elbealawy, M., Elshafey, A., Essam Ibrahim El Desouki Muhammad Ahmed, M., Ghonaim, M., Hgag, F., Ibrahim, M., Morsy, M., Reda Loaloa, M., Refaat, A., Samir, H., Shahien, F., Sobhy, M., Sroor, F., Abdellatif, E., Adel, M., Afifi, A. A., Afifi, E., Antaky, M., Dawoud, A., El Zoghby, N., El-remaily, A., Elzanfaly, A. A., Gadallah, A., Gamal, F. A., Hashem, O., Medhat Youssef, S., Muhammad Attyah, A., Munir, M., Shazly, O., Wilson, K., Adel, S., Ali, A., Eid, E., Elhelow, E., Elmahdy, M., Elshatby, B., Hossam el-din Zakaria, A., Hossny, A., Ibrahim, E., M. 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G., Hussein, M., Kandil, A. A., Moawad, M., Nasser Hamamah, A. A., Soliman, M., Abdelkhalek, M., Abdelmaksoud Tawakel, N., Abdelwahed, A. M., Abdou, A., Atallah, K., Elsherbeny, M. Y., Emara, E., Hamdy, M., Hamdy, O., Haron, A., Ismail, S., Metwally, I. H., Mohamed Hamed Elgaml, N., Nassar, A., Refky, B., Sadek, M., Saleh, M., Yunes, A., Zakaria, M., Zuhdy, M., Fayed, N., Mohammed, M. M. H., Kutner, S., Melnik, P., Seire, I., Umarik, T., Ainoa, E., Eerola, V., Koppatz, H., Koskenvuo, L., Sallinen, V., Takala, S., Katunin, J., Turunen, A., Christou, N., Mathonnet, M., Lavoue, V., Nyangoh Timoh, K., Soulabaille, L., Lesourd, R., Merdrignac, A., Sulpice, L., Andre, B., Chantalat, E., Vaysse, C., Dousset, B., Gaujoux, S., Martin, G., Clonda, O., Juodis, D., Kienle, K., Mravik, A., Palmer, S., Szabadhegyi, G., Agbeko, A. E., Gyabaah, S., Gyamfi, F. E., Naabo, N., Owusu senior, A., Yorke, J., Owusu, F., Abantanga, F., Anyomih, T. T. K., Muntaka, A. -J. M., Owusu Abem, E., Sheriff, M., Wondoh, P. M., Balalis, D., Korkolis, D., Gkiokas, G., Pantiora, E., Theodosopoulos, T., Ioannidis, A., Konstantinidis, K., Konstantinidou, S., Machairas, N., Paspala, A., Prodromidou, A., Chouliaras, C., Papadopoulos, K., Baloyiannis, I., Mamaloudis, I., Tzovaras, G., Akrida, I., Argentou, M. -I., Germanos, S., Iliopoulos, E., Maroulis, I., Skroubis, G., Theofanis, G., Chatzakis, C., Ioannidis, O., Loutzidou, L., Karathanasis, P., Michalopoulos, N., Theodoropoulos, C., Theodorou, D., Triantafyllou, T., Garoufalia, Z., Hasemaki, N., Kontos, M., Kouraklis, G., Kykalos, S., Liakakos, T., Mpaili, E., Papalampros, A., Schizas, D., Syllaios, A., Tampaki, E. C., Tsimpoukelis, A., Antonopoulou, M. I., Deskou, E., Manatakis, D. K., Papageorgiou, D., Zoulamoglou, M., Anthoulakis, C., Margaritis, M., Nikoloudis, N., Campo, V., Ceballos, A., Flores, M. -A., Giron, W., Ko, D., Martinez, G., Rivera Lara, V., Rueda, N., Sanchez, A., Tejeda Garrido, J. C. 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M., Rodriguez Gonzalez, A., Chachaima Mar, J. E., Chinchihualpa Paredes, N. O., Cuba, V., Lopez, W., Niquen Jimenez, M. M., Sanchez Bartra, N. A., Sapallanay Ojeda, O., Sequeiros, D., Toscano Pacheco, A., Vergara, M., Abarca, S., Alcorta, R., Borda-Luque, G., Eusebio Zegarra, I. E., Lujan Lopez, C., Marrufo, M., Mogrovejo, C., Nomura, A., Rodriguez Angeles, Y., Vidal Meza, M. R., Zavala, G., Castillo Arrascue, J. N., Hidrogo Cabrera, J. C., Larrea vera, J. J. M., Osorio, M., Ylatoma Diaz, E. A., Fontanilla, M. A., Fuentes, J. R., Salazar, A. L., Dominguez, G., Lopez, M. P., Macalindong, S., Onglao, M. A., Ramirez, A., Sacdalan, M. D., Tampo, M. M., Uy, G. L., Mangahas, J., Yabut, K., Canete, J. P., Cansana, B. E., Castro, E. J., Lipana, M. K., Roxas, M. F., Zara, V. 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P., Cagigas Fernandez, C., Castanedo Bezanilla, S., Estevez Tesouro, J., Fernandez-Diaz, M. J., Garcia Cardo, J., Gomez Ruiz, M., Gonzalez-Tolaretxipi, E., Jimeno Fraile, J., Poch, C., Rodriguez-Aguirre, M., Troche Pesqueira, N., Trugeda-Carrera, M. S., de la Torre, J., Blanco-Colino, R., Espin-Basany, E., Espinosa-Bravo, M., Morales Comas, C., Reyes Afonso, E., Rivero Deniz, J., Siso Raber, C., Verdaguer Tremolosa, M., Chandrasinghe, P., Kumarage, S., Wijekoon Arachchilage, N., Abdalla Ahmed Elkamel, A., A. Adam, M., Blomme, N., Thorell, A., Wogensen, F., Alga, A., Ansarei, D., Celebioglu, F., Heinius, G., Nigard, L., Pieniowski, E., Ahlqvist, S., Bjorklund, I., Franberg, A., Hakansson, M., Adamo, K., Franklin, O., Sund, M., Wiberg, R., Andersson, Y., Chabok, A., Nikberg, M., Kugelberg, A., Canonica, C., Christoforidis, D., Fasolini, F., Gaffuri, P., Giuliani, M., Meani, F., Popeskou, S. G., Pozza, S., Wandschneider, W., Peterer, L., Widmer, L. 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Akram, Zahran, Diaaaldin, Abou El Soud, Moustafa Ramadan, Badr, Esraa Tarek, Borham, Hala, Elmeslemany, Nehal, Elsayed, Mohammad, Elsherif, Fawzia, Eslam, Sara, Gaber, Gehad, Ibrahim, Sondos, Kamh, Yara, Mahmoud, Abdelrahman, Mohamed, Shimaa Gamal, Morshedy, Eman, Omar, Cinderella, Salem Soliman, Fatima, Abdelkawy, Shaza, Abdelmohsen, Naglaa, Abdelshakour, Mahmoud, Dahy, Ahmed, Gamal, Norhan, Gamal, Mohammed, Hasan, Ahmad, Hetta, Helal, Mousa, Nehad, Omar, Mohamed, Rabie, Somia, Saad, Mahmoud, Saleh, Bakeer, Sayed Mohamed, Marwa, Shawqi, Muhammad, Abdelhady Mousa, Heba, Alnoury, Mostafa, Elbealawy, Mohamed, Elshafey, Ahmed, Essam Ibrahim El Desouki Muhammad Ahmed, Muhammad, Ghonaim, Mennatullah, Hgag, Fawzy, Ibrahim, Mohamed, Morsy, Mahmoud, Reda Loaloa, Mohamed, Refaat, Ahmed, Samir, Hadeer, Shahien, Fatma, Sobhy, Mohamed, Sroor, Fathy, Abdellatif, Esraa, Adel, Marina, Afifi, Amr Abdelghani, Afifi, Eman, Antaky, Marco, Dawoud, Amr, El Zoghby, Naira, El-Remaily, Amira, Elzanfaly, Ali Abdelazez, Gadallah, Ahmed, Gamal, Fatma Alzahraa, Hashem, Omar, Medhat Youssef, Shrouk, Muhammad Attyah, Aliaa, Munir, Malak, Shazly, Omar, Taha, Esraa, Wilson, Karim, Adel, Sawsan, Ali, Asmaa, Eid, Esraa, Elhelow, Esraa, Elmahdy, Marwa, Elshatby, Bassant, Hossam El-Din Zakaria, Amany, Hossny, Ahmad, Ibrahim, Eman, M Yonis, Ahmed, Metwalli, Maram, Yousry, Basant, Zid, Esraa, A Yacoub, Mina, Abdelhakim, Ahmed, Abouelsoad, Nervana, Alkhatib, Mo'min, Ashraf, Ahmed, Ashraf, Alaa, Elazab, Yasmin, Elfanty, Mahmoud, Elkabir, Osama, Elsayed, Mai, Elshimy, Ahmed, Elsobky, Hager, Eskander, John, Gad, Ahmed, Hamsho, Ward, Khaled Abdelwahed, Noura, Magdy, Menna, Moharam, Dalia, Osama, Abeer, Ramadan, Shereen, Roum, Radwa, Sayed, Taqwa, Shehada, Tarneem, Zidan, Ahmed Mohy, Abbas, Khalid, Ali, Amr, Attia, Mohamed, Balata, Mohamed, El Nakeeb, Ayman, Elewaily, Mohamed Ibrahim Elsayed, Elfallal, Ahmed, Elfeki, Hossam, Elkhadragy, Ahmed, Emile, Sameh, Ezzat, Helmy, Hosni, Hasnaa, Mansour, Islam, Omar, 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Athisayaraj, Thomas, Olugbemi, Mojolaoluwa, Ahmad, Kasim, Chan, Claudia, Chapman, Gavin, Fleming, Hannah, Fox, Benjamin, Grewar, Julia, Hulse, Kate, Rutherford, Duncan, Sinead, Mackay, Smith, Scott, Speake, Doug, Vaughan-Shaw, Peter G, Christodoulides, Natasha, Kudhail, Simrit, Welch, Matthew, Husaini, Syed Muhibullah, Lambracos, Simon, Anyanwu, Chikamuche, Suresh, Rishi, Thomas, Jimmy Scott, Gleeson, Elizabeth, Platoff, Rebecca, Saif, Areeba, Enumah, Zachary, Etchill, Eric, Gabre-Kidan, Alodia, Bernstein, Mitchell, Carrano, Francesco Maria, Connors, Joseph, Lynn, Patricio, Melis, Marcovalerio, Newman, Elliot, Foster, Deshka S, Perrone, Kenneth, Titan, Ashley, Ahmad, Sarwat, Bafford, Andrea Chao M D, Dal Molin, Marco, Hanna, Nader, Zafar, Syed Nabeel, Hemmila, Mark, Napolitano, Lena, Wong, Jane J, Chandler, Julia, Wood, Lauren, Wren, Sherry, Ottesen, Taylor, You, Lucia, Yu, Kristin, Arciénega Yañez, María Del Pilar, Ferreira Fernandes, Martin, González, Daniel, Cubas, Santiago, González, María Catalina, Zubiaurre, Vanessa, Demolin, Rodrigo, Giroff, Nicolas, Sciuto, Pablo, Campos, Maite, Rodríguez Cantera, Gabriela, Deepika, Garg, Simuchimba, Elliot, Bulaya, Anadi, Chibuye, Chali, Chirengendure, Bright, Kabale, Mary-Rose, Kabongo, Kizito, Munthali, James, Mweso, Oliver, Pikiti, Francis, Otieno, James, Lai, Log Tung, Blackman, Brighid, Richards, Sophie, Subramaniam, Suren, Karim, Rafid, Kok, Nathan, Lee, Yanni Dion, Ali, Shabina, Sinha, Aanjaneya, Corrigan, Robert, Barnes, Nicole, Wong, Florence, Dennis, Grace, Jedamzik, Julia, Phillips, Emil, Piette, Wivine, Van Hentenryck, Marie, Koco, Houenoukpo, Lawani, Souliath, Kassa, Mamo Woldu, Santos Bezerra, Tainá, Gribnev, Petar, Dimitrov, Dobromir, Krastev, Panche, Oum, Sovannarith, Bonghaseh, Divine Tim, Al Farsi, Maryam, Alsharqawi, Nourah, Acevedo, Veronica, Castillo Barbosa, Andrea Carolina, Giron, Felipe, Leon Rodriguez, Jimmy Paul, Kucan, Darko, Rosko, Damir, Barsic, Neven, Župan, Domagoj, Hegazi, Amgad, Truncíková, Vendula, Fryba, Vladimir, Mohamed, Mostafa, Sultan, Ahmed, Nagi, Ahmed, Rashad Temerik, Abdallah, Elshawy, Mohamed Elemam, Mahmoud, Moustafa Ibrahim, Omar, Shrouk, Anwar, Mohamed, Rageh, Tarek, Elmokadem, Aya, Gaballa, Khaled, Teppo, Sandra, Turunen, Antti, Pengermä, Pasi, Ballouhey, Quentin, Bergeat, Damien, Weyl, Ariane, Hain, Elisabeth, Gyedu, Adam, Yenli, Edwin, Osei-Poku, Dorcas, Rompou, Vaia-Aliki, Zoikas, Athanasios, Gaitanidis, Apostolos, Koukis, Georgios, Perivoliotis, Konstantinos, Tavlas, Panagiotis, Galanos-Demiris, Konstantinos, Zografos, George, Karavokyros, Ioannis, Xanthopoulou, Georgia, Iordanidou, Eirini, Ayau, Fernanda, Garcia, Allan, Damján, Pekli, Wason, Deepender, B L, Ashika, Rangganata, Ervandy, Kamath, Prerna, O'Connor, Donal B, Pinto, Margherita, Perrone, Fabrizio, Tropeano, Francesca Paola, Troilo, Francesca, Bossi, Daniela, Scala, Dario, Pulitanò, Lucrezia, Carella, Marcella, Pietrabissa, Andrea, Gori, Alice, Giraudo, Giorgio, De Simone, Veronica, Russo, Alfio Alessandro, Braccio, Bartolomeo, Al-Taher, Raed, Athamneh, Sarah, Parker, Andrea, Sawiee, Adnan, Kattia, Amina, Salem, Malik, Tababa, Osama, Shaeeb, Zuhour, Syminas, Vilius, Jurgaitis, Jonas, Damuleviciene, Gyte, Svagzdys, Saulius, Poskus, Tomas, Razafimanjato, Narindra Njarasoa Mihaja, Chieng Loo, Ling, Tiong, Ing Ching, Wan Muhmad, Wan Farahiyah, Vijeyan, Harinthiran, Li Ying, Teoh, Grech, Gabriella, Arrangoiz, Rodrigo, Jimenez Ley, Vania Brickelia, Arizpe, Daniel, Lagunes Lara, Elizabeth, Castro López, Elizabeth Victoria, Eaazim, Jose, Gordinou de Gouberville, Marije, Bastiaenen, Vivian, Rottier, Simone, Nahab, Fouad, Ji, Maria Yeonhee, Seyoji, Mohammed, Nwachukwu, Callistus, Emeghara, Okechukwu, Muhammed, Sayyid Egbunu, Idowu, Ayodeji, Sowemimo, Olamiposi, Ogundoyin, Olakayode, Akande, Oluwatosin, Lott, Alexander, Nadeem, Maliha, Laghari, Ahsan Ali, Loya, Asif, Mushtaq, Hassan, Abdullah, Muhammad Tariq, Abuhilal, Baseel, Atawneh, Mohammad, Hamdan, Hamdan, Alhabil, Belal, Srour, Abedelrahman, Mousa, Ibrahim, Da Silva Medina, Luis, Bartosiak, Katarzyna, Ferreira, Pedro, Francisco, Vítor, Lemos, Ricardo, Frutuoso, Luísa, Fernandes, Sara, Fonseca, Telma, Pereira, Jorge, Rachadell, Juan, Torre, Ana, Madeira Martins, Filipe, Carvalho, Ana Cristina, Rodrigues Ferreira, Joana, Ribeiro da Silva, Bruno, Devesa, Helena, Vieira, Ana, Mónica, Inês, Amaro, Margarida, Sousa, Diogo, Reia, Marta, Louro, João, Martins, Ana, Dominguez, Joaquina, Santos, Inês, Freitas Oliveira, Nuno Miguel, Pereira, José Carlos, Silva-Vaz, Pedro, Freire, Ligia, Escrevente, Ricardo, Negoita, Valentina Madalina, Shakhmatov, Dmitry, Nezerwa, Yves, Radulovic, Radosav, Obery, Gareth, Viljoen, Francois, Mendes, Tome, Suarez, Antonio, Moncada, Enrique, Fernandez-Hevia, Maria, Curtis Martínez, Carolina, Gil Garcia, Julia Maria, González Zunzarren, Mariana, Idris, Tarig, Eklöv, Karolina, Grahn, Oskar, Amin, Leila, Blomqvist, Malin, Ajani, Costanza, Kraus, Rebecca, Seeger, Nico, Willemin, Melissa, Rayya, Fadi, Ayash, Mohammad, Msouti, Raneem, Kannas, Israa, Abazid, Eias, Esper, Asil, Slim, Skander, Kavcar, Akil Serdar, Aytac, Erman, Dural, Ahmet Cem, Ilker, Ayse, Eray, Ismail Cem, Kurnaz, Eray, Altiner, Saygin, Tepe, Mustafa Deniz, Sahin, Can, Savli, Evrim, Innocent, Aryon, Babirye, Lilian, Diachenko, Andrii, Hordoskiy, Vladislav, Curry, Heather, Chau, Charlene Yat Che, Robertson, Harry, Mahmoud, Arin, Lennon, Hannah, Loi, Lynette, Kirkham, Emily, McCann, Cameron, Watts, Daniel, Gurung, Binay, Wilson, Michael, Tribedi, Thomas, Garofalo, Eleonora, Zahra, Baryab, MacDonald, Scott, Daniels, Ian, Ng, Nathan, Khosla, Shivun, Olivier, James, Yue, Sum Yu Pansy, Suresh, Gayathri, Wellington, Jack, Lorejo, Emmanuel, Mossaad, Mafdi, Crutcher, Madison, Alimi, Marjan, Baiu, Ioana, Abdou, Hossam, Conway, Alison, Peck, Connor, Perdomo Perez, Mauro Andres, Zulu, Stanley, Nakazwe, Mildred, Burger, Sule, Davies, Justine, Donaldson, Rachel, Ede, Chikwendu, Garden, O James, Lesetedi, Chiapo, Mabedi, Charles, Magill, Laura, Makinde Alakaloko, Felix, Makupe, Alex, Monahan, Mark, Mulira, Soloman, Muller, Elmi, Musowoyo, Jospeh, Olory-Togbe, Jean Léon, Roberts, Tracey, Smith, Martin, Tayler, Viki, Windsor, John, Yepez, Raul, Sundar, Sudha, Runigamugabo, Emmy, Verjee, Azmina, Chen, José, Daya, Leonid, El Aroussi, Nouhaila, Farina, Valeria, Gnintedeme Olivier, Tchianze, Gonzales Nacarino, Mauricio, Hammani, Aamr, Honjo, Sarah, Jacobs, Rebecca, Kimura, Hitomi, Nkoronko, Mugisha, Oscullo Yepez, Jasson Javier, Pin Hung, Wei, Raj, Ankit, Romani Pozo, Alina, Rommaneh, Muna, Sassamela Fabiano, Samuel Chimbioputo, Shiroma Gago, Camila Milagros, Srinivas, Abhishekh, Sung, Chia-Yen, Tai, Aswan, Valle Aranda, Yener Cristyell, Venturini, Sara, and Wilguens Lartigue, Jean
Subjects: Pediatrics, Colorectal cancer, IMPACT, Disease, Colorectal Neoplasm, 030204 cardiovascular system & hematology, Cancer, surgery, postoperative mortality, 0302 clinical medicine, Postoperative Complications, Global health, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, General Medicine, DISEASES, Income, cancer surgery, Colorectal Neoplasms, Breast Neoplasm, Cohort study, Human, Adult, Developed Countrie, medicine.medical_specialty, Global surgery, General surgery, International multicentre study, Cancer surgery, Breast Neoplasms, Department of Error, NO, Developing Countrie, 03 medical and health sciences, Breast cancer, Stomach Neoplasms, medicine, Humans, Developing Countries, Neoplasm Staging, business.industry, Developed Countries, Odds ratio, CARE, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, Prospective Studie, Postoperative Complication, business
Abstract: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Background: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit.
Published: 2021

20. Relationship between Pulse Wave Velocity and Cardiovascular Biomarkers in Patients with Risk Factors

Author: Thiago Veiga Jardim, Paulo César Brandão Veiga Jardim, Ellen de Souza Lelis, Rayne Ramos Fagundes, Weimar Kunz Sebba Barroso, Ana Luiza Lima Souza, Priscila Valverde de Oliveira Vitorino, and Pedro Cunha
Subjects: Fatores de Risco, medicine.medical_specialty, Carotid arteries, Blood Pressure, Left Ventricle Dysfunction, Pulse Wave Analysis, 030204 cardiovascular system & hematology, Doenças Cardiovasculares/mortalidade, Disfunção Ventricular Esquerda, 03 medical and health sciences, 0302 clinical medicine, Central blood pressure, Risk Factors, Diabetes mellitus, Internal medicine, medicine, Diabetes Mellitus, Humans, Diseases of the circulatory (Cardiovascular) system, Statistical analysis, cardiovascular diseases, Pulse wave velocity, business.industry, Artigo Original, Hemodynamics, Cardiovasclar Diseases/mortality, medicine.disease, medicine.anatomical_structure, Cardiovascular Diseases, Heart Disease Risk Factors, Ventricle, RC666-701, Hypertension, cardiovascular system, Cardiology, Original Article, Pressão Arterial, Cardiology and Cardiovascular Medicine, business, Biomarkers, Dyslipidemia, Hipertensão
Abstract: Resumo Fundamento A relação entre velocidade de onda de pulso (VOP) e biomarcadores de mudanças estruturais do ventrículo esquerdo e artérias carótidas ainda é pouco elucidada. Objetivo Investigar a relação entre VOP e esses biomarcadores. Métodos Estudo transversal, retrospectivo e analítico. Revisamos prontuários médicos de pacientes com diabetes mellitus, dislipidemia, e pré-hipertensão ou hipertensão, que realizaram medida de pressão arterial central (PAC) utilizando o Mobil-O-Graph®, e doppler de carótida ou ecocardiografia três meses antes ou após a medida da PAC. Análise estatística realizada por correlação de Pearson ou de Spearman, análise de regressão múltipla e de regressão bivariada, e teste t (independente) ou de Mann-Whitney. Um p 1 mm (p=0,006), placa de carótida (p=0,0001), estenose ≥ 50% (p=0,003), e lesões de órgãos-alvo (p=0,0001). Conclusões A VOP correlacionou-se com a EIM e com parâmetros ecocardiográficos, e se associou independentemente com EIM. Essa associação foi mais forte em pacientes com hipertrofia do ventrículo esquerdo, EIM aumentada, placa de carótida, estenose ≥ 50%, e lesões de órgãos-alvo. (Arq Bras Cardiol. 2020; 115(6):1125-1132) Abstract Background The relationship between pulse wave velocity (PWV) and biomarkers of structural changes of the left ventricle and carotid arteries remains poorly understood. Objective To investigate the relationship between PWV and these biomarkers. Methods This was an analytical, retrospective, cross-sectional study. Medical records of patients with diabetes mellitus, dyslipidemia, and pre-hypertension or hypertension, who underwent central blood pressure (CBP) measurement using Mobil-O-Graph®, and carotid doppler or echocardiography three months before and after the CBPM were analyzed. Statistical analysis was performed using Pearson or Spearman correlation, linear bivariate and multiple regression analysis, and the t test (independent) or Mann-Whitney test. A p 1 mm (p=0.006), carotid plaque (p=0.0001), stenosis ≥ 50% (p=0.003), and target-organ damage (p=0.0001). Conclusion PWV was correlated with IMT and echocardiographic parameters, and independently associated with IMT. This association was stronger in individuals with left ventricular hypertrophy, increased IMT, carotid plaque, stenosis ≥ 50%, and target organ damage. (Arq Bras Cardiol. 2020; 115(6):1125-1132)
Published: 2021

21. Alterações no Perfil dos Pacientes atendidos no Pronto Socorro durante o Surto de COVID-19 em um Hospital Geral Especializado em Tratamento Cardiovascular no Brasil

Author: Luciana Muniz Veiga Jardim, Thiago Veiga Jardim, Juliana Tranjan Coragem, Paulo César Brandão Veiga Jardim, Guilherme Moreira Firmino, Flavio Veiga Jardim, and Cristovão Fernandes Castro
Subjects: SciELO, 2019-20 coronavirus outbreak, Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Doenças Cardiovasculares, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Cardiovascular care, Hospital Público, medicine.disease_cause, Diseases of the circulatory (Cardiovascular) system, Medicine, General hospital, Epidemiologia, Síndrome Respiratória Aguda, Coronavirus, Hospitalização, Pandemia, SARS-CoV-2, business.industry, COVID-19, Outbreak, Coronavírus, RC666-701, Cardiology and Cardiovascular Medicine, business
Abstract: Introducao A doenca do novo coronavirus (COVID-19) e causada pelo virus da sindrome respiratoria aguda grave coronavirus 2 (severe acute respiratory syndrome-coronavirus-2, SARS-CoV-2). Em 11 de marco de 2020, a COVID-19 foi declarada uma pandemia pela Organizacao Mundial de Saude, e o primeiro caso no Brasil foi relatado no final de fevereiro. Dada a ausencia de tratamento especifico e os altos indices de morbimortalidade da COVID-19, especialmente nos grupos de risco, medidas extraordinarias de saude publica vem sendo implementadas em [...]
Published: 2021

22. The Effect of Aging on Body Temperature: A Systematic Review and Meta- Analysis

Author: Amanda Veiga Sardeli and Paulo Roberto Hernandes Júnior
Subjects: Pulmonary and Respiratory Medicine, Gerontology, business.industry, Meta-analysis, Pediatrics, Perinatology and Child Health, Medicine, Temperature a, business
Abstract: Background: Since age is the major risk factor for chronic diseases and mortality, it seems mistaken that older adults have lower basal temperature than young individuals. Many confounding factors could hinder the achievement of a consensus, such as the different sites of measurement, control of basal conditions, health conditions, age difference compared, sex, and others. Objective: The aim was to meta-analyze previous studies in order to find a consensus regarding the effects of aging on body temperature in humans, considering different types of temperature assessments, age difference and sex. Methods: A systematic search was performed in PubMed and 16 studies comparing basal temperature between older and young adults were meta-analyzed. Results: Older adults have significantly lower body temperature than young adults (-0.17 °C (-0.30; -0.03), p=0.04). Considering the different sites of measure, while core temperature tended to be lower in older adults (-0.13 °C (-0.27; 0.01), p=0.07), and skin temperature was not different (-0.21 °C (-0.5; 0.08), p=0.15). The aging effects were more prominent in men when assessed by oral temperature and when compared between higher age difference. Conclusion: Indeed, there is a small reduction in overall temperature with aging, drove by the reduction in core temperature rather than skin temperature. The confirmation of these findings by this meta-analysis, now provide the base for the development of strategies to face the impairment in thermoregulation and metabolic efficiency with aging.
Published: 2021

23. Thromboembolic and bleeding events in intensive care unit patients with COVID-19: results from a Brazilian tertiary hospital

Author: Victoria Masi Queiroz, Phillip Scheinberg, Viviane Cordeiro Veiga, Cleyton Zanardo de Oliveira, Salomón Soriano Ordinola Rojas, Amanda Ayako Minemura Ordinola, Danielle Leão Cordeiro de Farias, and Antonio Adolfo Guerra Soares Brandão
Subjects: Microbiology (medical), medicine.medical_specialty, Deep vein, Context (language use), Infectious and parasitic diseases, RC109-216, intensive care unit, survival, law.invention, law, medicine, Risk factor, Stroke, thrombosis, business.industry, COVID-19, Retrospective cohort study, General Medicine, medicine.disease, Intensive care unit, Thrombosis, Pulmonary embolism, Infectious Diseases, medicine.anatomical_structure, D-dimer, Emergency medicine, business
Abstract: Objectives: To describe the incidence of thromboembolic events in adult patients with severe COVID-19 and identify clinical and laboratory factors associated with these events. Design: Observational retrospective cohort study of 243 adult patients with severe COVID-19 admitted to an intensive care unit (ICU) at a Brazilian tertiary hospital. Results: The incidence of all thromboembolic events was 14.8%, in which 3.8% developed deep vein thrombosis, 7.8% pulmonary embolism, 2.5% acute myocardial infarction, 1.2% stroke, and 1.2% peripheral artery occlusion. Risk factors identified were D-dimer at admission >3000 ng/mL (P=
Published: 2021

24. The epidemiology of sepsis in paediatric intensive care units in Brazil (the Sepsis PREvalence Assessment Database in Pediatric population, SPREAD PED): an observational study

Author: Daniela Carla de Souza, Joelma Gonçalves Martin, Vanessa Soares Lanziotti, Cláudio Flauzino de Oliveira, Cristian Tonial, Werther Brunow de Carvalho, José Roberto Fioretto, Jefferson Pedro Piva, Eduardo Juan Troster, Aline Siqueira Bossa, Flávia Gregorini, Josiane Ferreira, Juliana Lubarino, Alexandre Biasi Cavalcanti, Flávia Ribeiro Machado, SC Silva, J Giacomazzi, Domingos A. Boldrini, FH Gilli, LC de Castro, ML de Albuquerque, VCTG Osorio, MLC Elias, AA da Câmara, M Maia, PB de Carvalho, FM Augusto, RCCM de Figueiredo, EL Ikino, FAS Nogueres, RJ de Almeida, L Torreão, J Ramalho, MMS Camões, CS de Oliveira, VIIS Serafim, J Colleti Junior, CG de Almeida, MHM da Costa, JF Valerio, ME Navajas, PM Riveiro, A Lubiana, ACLC Brito, V Moretto, LMMD Rachid, M Valle, PP de Souza, RPL Victor, NR Castro, T Sakomura, M Molon, AR Ferreira, JG da Fonseca, VCA Cunali, VCA Chagas, G Belek, TS da Rocha, LCFF de Mello, LM Machado, NV Moliterno, C Duran, CLEB Sanos, GT Ribeiro, PSL da Silva, R Lipinski, A Soledade, KC Branco, ACO Teles, GF da Cruz, MR de Mendonça, E Malheiros, J Vicari, PNT Izidro, NMP Campos, TC Pontes, CRF Carneiro, AH Imamura, FM Yoshioka, MCMB Duarte, T Menezes, C Falconiere, F Matos, RS Zeitel, CC Nogueras, ML da Silva, M Aprille, TYM Pires, AF Portella, PVG Flores, PP Alfradique, RC Nascimento, MO Saldanha, AT Alves, WJ de Almeida, M Rodrigues, E Lopes Júnior, MRP Komka, MAR Nascimento, CRC Lopes, TMC Bernardi, RV Falcão, AR Fraga, AA Machado, JEF Godoy, J Barcellos, RLS Queiroz, VVS de Almeida, JZG Lira, M Alvo, TCP Peçanha, AM de Sousa, CS Sanches, AR Wendhausen, SR Pinheiro, MA Orione, AM Minossi, NL Bresolin, CDF Martins, VF Cury, RPB Quinet, AL Netto, R Limonge, SST Tamari, SER de Souza, R Veiga, NGCB Couto, MFP Ribeiro, AK de Aguiar, M Evangelista, JR Krauzer, H Muller, DHS Genu, PA Alvares, KL Maciel, FT Valente, M Centeville, GJ Espinheira, A da Silva, PL Vasconcelos, AZ Hädrich, ALDGC Sousa, GA Gandra, ACA Souto, L Sabatini, PRD João, ABMP Machado, FR Fonseca, APA Resende, RV da Silva, TP da Silva, LLT Barros, CSV de Souza, KO Harada, D Calçado, LSB Pinheiro, MCM Frota, LB Pulcheri, LM e Silva, KJ dos Santos, FH de Nuncio, IO Gomes Júnior, ACC Gomes, MA Klitzke, FR de Souza, FSC Carvalho, FP de Lima, LR Braun Filho, MAG de Oliveira, T Castilho, IP Pistelli, JD Paccez, C Cendon, R Sapolnick, D Fronza, C Toscan, RM Pinelli, JV Alencar, HL di Pace, AD Ramos, AC Molinari, JF Assis, APCR Chavarri, RC Pereira, CL Freitas, ICDM Salmen, RCM Guerini, J Asakura, ACR Pires, G Benvenuti, LM Fernandes, NF Oliveira, HJB Barros, LCE Nascimento, MB Machado, AOR dos Santos, AC da Silva, ACE de Oliveira, SKY Reinheimer, PCS Mello, IO Araújo, KLC Rodrigues, MN Amari, M Andersson, LMCM Petrini, AKSF Luz, ESS Serafim, RF Barbosa, D Souza, AF Delgado, ALP Guerra, JY Afiune, J Huber, S Casonato, DCB da Silva, OR de Araujo, FMD Fialho, LFR Soares, AA de Queiroz Júnior, A Sartorelli, ACP Zuccoli, M Castelani, LAA da Silva, SRA Lima, MJSL de Araújo, ACS da Cruz, PM Sillero, G Sgorlon, TRS Alves, MMB Muniz, RHP Pereira, NR Gonçalves, RPV Teixeira, IA Vasconcelos, CT Rossetti, RG Cesar, MAJ Alves, MK Martins, JAR Rocha, L Arruda, ALY Grillo, and G Barros
Subjects: Male, medicine.medical_specialty, Adolescent, Databases, Factual, Prevalence, Intensive Care Units, Pediatric, Sepsis, symbols.namesake, Epidemiology, Developmental and Educational Psychology, medicine, Humans, Hospital Mortality, Poisson regression, Child, business.industry, Septic shock, Mortality rate, Infant, Newborn, Infant, medicine.disease, Hospitalization, Child, Preschool, Relative risk, Pediatrics, Perinatology and Child Health, Emergency medicine, symbols, Female, Observational study, business, Brazil
Abstract: Data on the prevalence and mortality of paediatric sepsis in resource-poor settings are scarce. We aimed to assess the prevalence and in-hospital mortality of severe sepsis and septic shock treated in paediatric intensive care units (PICUs) in Brazil, and risk factors for mortality.We performed a nationwide, 1-day, prospective point prevalence study with follow-up of patients with severe sepsis and septic shock, using a stratified random sample of all PICUs in Brazil. Patients were enrolled at each participating PICU on a single day between March 25 and 29, 2019. All patients occupying a bed at the PICU on the study day (either admitted previously or on that day) were included if they were aged 28 days to 18 years and met the criteria for severe sepsis or septic shock at any time during hospitalisation. Patients were followed up until hospital discharge or death, censored at 60 days. Risk factors for mortality were assessed using a Poisson regression model. We used prevalence to generate national estimates.Of 241 PICUs invited to participate, 144 PICUs (capacity of 1242 beds) included patients in the study. On the day of the study, 1122 children were admitted to the participating PICUs, of whom 280 met the criteria for severe sepsis or septic shock during hospitalisation, resulting in a prevalence of 25·0% (95% CI 21·6-28·8), with a mortality rate of 19·8% (15·4-25·2; 50 of 252 patients with complete clinical data). Increased risk of mortality was associated with higher Pediatric Sequential Organ Failure Assessment score (relative risk per point increase 1·21, 95% CI 1·14-1·29, p0·0001), unknown vaccination status (2·57, 1·26-5·24; p=0·011), incomplete vaccination status (2·16, 1·19-3·92; p=0·012), health care-associated infection (2·12, 1·23-3·64, p=0·0073), and compliance with antibiotics (2·38, 1·46-3·86, p=0·0007). The estimated incidence of PICU-treated sepsis was 74·6 cases per 100 000 paediatric population (95% CI 61·5-90·5), which translates to 42 374 cases per year (34 940-51 443) in Brazil, with an estimated mortality of 8305 (6848-10 083).In this representative sample of PICUs in a middle-income country, the prevalences of severe sepsis or septic shock and in-hospital mortality were high. Modifiable factors, such as incomplete vaccination and health care-associated infections, were associated with greater risk of in-hospital mortality.Fundação de Amparo à Pesquisa do Estado de São Paulo and Conselho Nacional de Desenvolvimento Científico e Tecnológico.For the Portuguese translation of the abstract see Supplementary Materials section.
Published: 2021

25. Accuracy of Doppler assessment of the uterine arteries in healthy girls for the diagnosis of pubertal onset

Author: Iara Regina Siqueira Lucena, Leila Cristina Pedroso de Paula, Marcia Puñales, Fabiola Costenaro, Amanda Veiga Cheuiche, Sandra Pinho Silveiro, Letícia Guimarães da Silveira, Cristiane Kopacek, and Gustavo Monteiro Escott
Subjects: medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Youden's J statistic, Urology, Pulsatility index, Doppler imaging, Endocrinology, medicine.artery, Humans, Medicine, Child, Uterine artery, Ultrasonography, Breast development, Receiver operating characteristic, business.industry, Uterus, Ultrasound, Ultrasonography, Doppler, Uterine Artery, Cross-Sectional Studies, Child, Preschool, Female, business, Puberty onset
Abstract: Purpose: To evaluate the accuracy of the uterine artery pulsatility index (PI) for the diagnosis of pubertal onset in girls. Methods: Cross-sectional study of girls with normal pubertal development. Puberty was diagnosed by the presence of Tanner breast development score ≥2. All girls underwent pelvic ultrasound and Doppler imaging of the uterine arteries. We evaluated the uterine artery PI and uterine, endometrial, and ovarian measurements. We used ROC curves with cutoffs determined by Youden index for data analysis. Results: We included 169 girls aged 5-16 years who underwent 202 pelvic ultrasound examinations. Prepubertal girls had a significantly higher mean PI (mean, 6.70; SD, 2.15) than girls in initial puberty (mean, 4.14; SD, 1.55) and in late puberty (mean, 2.81; SD, 1.05) (P3.75 cm³ had a sensitivity of 73%, specificity of 95%, PPV of 97%, and accuracy of 79% to detect initial puberty. Conclusions: The significant reduction in the PI during pubertal development combined with increasing uterine volume can be a valuable, highly specific, noninvasive tool to confirm the onset of puberty.
Published: 2021

26. Homeopathy in parasitic diseases

Author: Denise Lessa Aleixo, Franciele Karina da Veiga, Fabiana Nabarro Ferraz, Silvana Marques de Araújo, and Leoni Villano Bonamin
Subjects: medicine.medical_specialty, Complementary and alternative medicine, business.industry, Actual practice, medicine, Homeopathy, Homeopathic medicine, Intensive care medicine, Biological effect, business, Critical discussion
Abstract: Background: The use of homeopathic medicines has increased, partly because conventional drugs do not always elicit the desired effects, and partly because their side effects might compromise the patientâ€™sâ€™ adherence to treatment. Several studies showed benefits in the use of highly diluted medicines for the treatment of infectious diseases. Aim: The aim of the present review was to perform a critical discussion about aspects of homeopathy and the current status of veterinary experimentation, as well as of the use of highly diluted drugs in infectious and parasitic diseases. The main aspects of effects, therapeutic regimens and / or dynamizations used in various models are discussed. Methods: Articles published since 2000 in journals included in databases PubMed and SciELO and specialized journals sought for and reviewed using keywords â€œparasitic diseases/homeopathyâ€ and â€œparasitic diseases/ ultra-dilutionsâ€. Results: Several recent experimental studies demonstrated the biological effect of highly diluted medications on parasitic infections, with reduction of the number of parasites and improvement of the clinical condition of the affected animals. Several articles exhibit problems in the description of methods, which threaten the reproducibility of experiments. Conclusion: The acknowledgment of homeopathy depends on the credibility of investigators. Although research on homeopathy has clearly increased in recent years, relative to both implementation of more consistent methods and description of data and methods, improvement is still required. Precise and detailed descriptions will contribute to advance the use of homeopathy, so that society at large might benefit in actual practice.
Published: 2021

27. Discordancia del tratamiento de la enfermedad pulmonar obstructiva crónica según la guía GesEPOC vs. GOLD

Author: Rafael Golpe, I. Guzmán-Peralta, I. Veiga, M. Acosta-Sorensen, J.M. Figueira Gonçalves, and Cristóbal Esteban
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, Medicine, 030212 general & internal medicine, General Medicine, business, Humanities
Abstract: Resumen Introduccion En Espana, el tratamiento farmacologico de la enfermedad pulmonar obstructiva cronica se basa en la Global Initiative for Chronic Obstructive Lung Disease (GOLD) y la Guia espanola de la enfermedad pulmonar obstructiva cronica (GesEPOC). El objetivo principal de este estudio fue evaluar la concordancia entre los tratamientos de inicio asignados por GOLD y GesEPOC. Material y metodos Estudio de simulacion. Se emplearon las siguientes variables: FEV1%, exacerbaciones, disnea inicial, eosinofilia en sangre, antecedente de asma y grado de reversibilidad en la prueba broncodilatadora. Cuatro neumologos clasificaron/asignaron un tratamiento a cada paciente (2 de ellos segun GOLD y 2 segun GesEPOC). Se calculo el coeficiente Kappa de Cohen global. Resultados Se incluyeron 467 pacientes. La concordancia entre el tratamiento recomendado por GOLD y GesEPOC fue pobre (Kappa: 0,17, IC 95%: 0,12-0,23). Conclusion Existe una pobre concordancia entre GOLD y GesEPOC a la hora de iniciar tratamiento en los pacientes con enfermedad pulmonar obstructiva cronica.
Published: 2021

28. Discordance in treatment of chronic obstructive pulmonary disease following GesEPOC guideline vs. GOLD

Author: I. Veiga, M. Acosta-Sorensen, J.M. Figueira Gonçalves, Rafael Golpe, I. Guzmán-Peralta, and Cristóbal Esteban
Subjects: medicine.medical_specialty, medicine.drug_class, business.industry, Concordance, Pulmonary disease, General Medicine, Guideline, medicine.disease, Obstructive lung disease, Bronchodilator, Internal medicine, medicine, Eosinophilia, medicine.symptom, business, Kappa, Asthma
Abstract: Introduction Pharmacological treatment of chronic obstructive pulmonary disease in Spain is usually chosen according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) or Spanish guidelines for chronic obstructive pulmonary disease (GesEPOC). The main objective of this study was to evaluate the degree of concordance between treatment for newly diagnosed chronic obstructive pulmonary disease patients according to GOLD and GesEPOC. Material and methods Simulation study. The following variables were used: FEV1%, exacerbations, dyspnoea at first evaluation, blood eosinophilia, personal history of asthma, and degree of bronchodilator reversibility. Four investigators classified and assigned a treatment to each patient (2 using GOLD criteria and the other 2 using GesEPOC). Global Kappa index was calculated. Results The database included 467 patients. Agreement between treatment decided using GOLD and GesEPOC was poor (Kappa: 0.17, 95% CI: 0.12–0.23). Conclusion There is a poor agreement between GOLD and GesEPOC recommendations for initial chronic obstructive pulmonary disease treatment.
Published: 2021

29. Effects of the exercise training on skeletal muscle oxygen consumption in heart failure patients with reduced ejection fraction

Author: Jean Marcelo Roque, Silvia Moreira Ayub Ferreira, Guilherme Veiga Guimarães, Rafael E. Castro, Fernando Ribeiro, Ligia M. Antunes-Correa, Alexander Douglas Teixeira Machado, and Edimar Alcides Bocchi
Subjects: Male, Muscle tissue, medicine.medical_specialty, Oxygen Consumption, Internal medicine, Heart rate, medicine, Humans, Plethysmograph, Muscle, Skeletal, Exercise, Heart Failure, Ejection fraction, business.industry, Skeletal muscle, Stroke Volume, Microneurography, Oxygenation, medicine.disease, medicine.anatomical_structure, Heart failure, Exercise Test, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Aims Skeletal muscle dysfunction is a systemic consequence of heart failure (HF) that correlates with functional capacity. However, the impairment within the skeletal muscle is not well established. We investigated the effect of exercise training on peripheral muscular performance and oxygenation in HF patients. Methods and results HF patients with ejection fraction ≤40% were randomized 2:1 to exercise training or control for 12 weeks. Muscle tissue oxygen was measured noninvasively by near-infrared spectroscopy (NIRS) during rest and a symptom-limited cardiopulmonary exercise test (CPET) before and after intervention. Measurements included skeletal muscle oxygenated hemoglobin concentration, deoxygenated hemoglobin concentration, total hemoglobin concentration, VO2 peak, VE/VCO2 slope, and heart rate. Muscle sympathetic nerve activity by microneurography, and muscle blood flow by plethysmography were also assessed at rest pre and post 12 weeks. Twenty-four participants (47.5 ± 7.4 years, 58% men, 75% no ischemic) were allocated to exercise training (ET, n = 16) or control (CG, n = 8). At baseline, no differences between groups were found. Exercise improved VO2 peak, slope VE/VCO2, and heart rate. After the intervention, significant improvements at rest were seen in the ET group in muscle sympathetic nerve activity and muscle blood flow. Concomitantly, a significant decreased in Oxy-Hb (from 29.4 ± 20.4 to 15.7 ± 9.0 μmol, p = 0.01), Deoxi-Hb (from 16.3 ± 8.2 to 12.2 ± 6.0 μmol, p = 0.003) and HbT (from 45.7 ± 27.6 to 27.7 ± 13.4 μmol, p = 0.008) was detected at peak exercise after training. No changes were observed in the control group. Conclusion Exercise training improves skeletal muscle function and functional capacity in HF patients with reduced ejection fraction. This improvement was associated with increased oxygenation of the peripheral muscles, increased muscle blood flow, and decreased sympathetic nerve activity.
Published: 2021

30. Physical Activity is Associated With Lower Arterial Stiffness in Patients With Resistant Hypertension

Author: Cátia Leitão, Jorge Polónia, Alberto Jorge Alves, Guilherme Veiga Guimarães, Fernando Ribeiro, José Carlos Oliveira, José Mesquita-Bastos, João L. Viana, Verónica Ribau, Susana Lopes, Daniela Figueiredo, Pedro Carvalho, Catarina Garcia, and Susana Bertoquini
Subjects: Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Resistant hypertension, Physical activity, Blood Pressure, Pulse Wave Analysis, Overweight, Vascular Stiffness, Internal medicine, medicine, Humans, In patient, Exercise, Pulse wave velocity, business.industry, medicine.disease, Blood pressure, Hypertension, Cardiology, Arterial stiffness, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Body mass index
Abstract: Background Physical activity is associated with reduced arterial stiffness, although such a relationship has not been reported in those with resistant hypertension. Therefore, this study aimed to determine the association between daily physical activity and arterial stiffness in patients with resistant hypertension. Methods Fifty-seven (57) patients with resistant hypertension (50.9% men), aged 58.8±9.4 years, were consecutively recruited. Arterial stiffness was evaluated using carotid-femoral pulse wave velocity (cf-PWV). Daily physical activity was objectively assessed with accelerometers during 7 consecutive days. Results Patients had a body mass index of 29.0±4.0 kg/m2 (84.3% overweight/obese) and were taking an average 4.5 antihypertensive medications. Overall, the cf-PWV was 9.2±2.4 m/s and the majority of participants (n=41, 71.9%) presented a cf-PWV Conclusions Higher daily levels of light-intensity and total physical activity were associated with lower arterial stiffness. Nonetheless, this association is weak and attenuated or abolished when adjusted for blood pressure and age. These results suggest that physical activity may play an important role as a lifestyle intervention for patients with resistant hypertension. Future studies with larger samples sizes are necessary to confirm this preliminary data.
Published: 2021

31. Does law as resource bring a competitive advantage to companies?

Author: Pedro Veiga, Fernando Teixeira, and João J. Ferreira
Subjects: Resource (biology), Strategy and Management, Business, Business and International Management, Competitive advantage, Industrial organization
Abstract: Purpose Resources and their analysis are essential to understand better companies’ internal and external dynamics and the weight each has in obtaining competitive advantages over the competition. This study aims to address the law and legal knowledge as a fundamental resource for companies to succeed in the markets to obtain a sustainable competitive advantage. Design/methodology/approach Based upon a sample of 200 managers, a structural equation model was used to validate the hypotheses under study. Findings Results show awareness and managers’ perception of the importance of law as a resource and its advantages for companies and the dichotomy between recognising this importance and not using it consistently. Originality/value Knowing the scope of business law and its growing importance for companies and being academically aware of the inexistence of studies that analyse the law as an individualised resource for companies, this study has a crucial contribution to the interconnection of these two fields – business and law.
Published: 2021

32. Research productivity of management faculty: job demands-resources approach

Author: Brent B. Clark, Chet E. Barney, and Serge P. da Motta Veiga
Subjects: Service (business), Organizational Behavior and Human Resource Management, Business, Environmental economics, Productivity, Social Sciences (miscellaneous)
Abstract: PurposeThe main purpose of this study was to examine which job resources are most valuable for research productivity, depending on varying teaching demands.Design/methodology/approachData was collected from 324 management faculty at research, balanced and teaching (i.e. respectively low-, moderate- and high-teaching demands) public universities in the United States.FindingsResults showed that no single job resource predicted research productivity across all three types of schools. At research schools (i.e. low-teaching demands), productivity was positively associated with job resources including summer compensation, level of protection for untenured faculty and number of research assistant hours, while negatively associated with travel funding. At balanced schools (i.e. moderate-teaching demands), research output was positively associated with time allocated to research, grant money, travel funding and conference attendance, while negatively associated with amount of consulting hours. At teaching schools (i.e. high-teaching demands), the only significant resource was time allocated to research.Practical implicationsThis paper can help management faculty and business school leaders understand what resources are most appropriate given the teaching demands associated with the specific institution, and by further helping these institutions attract and retain the best possible faculty.Originality/valueThis study extends prior work on academic research performance by identifying resources that can help faculty publish given different levels of teaching demands. This is important as teaching demands tend to be relatively stable within an institution, while they can vary greatly across types of institutions.
Published: 2021

33. Time-dependent evolution of IgG antibody levels after first and second dose of mRNA-based SARS-CoV-2 vaccination in haemodialysis patients: a multicentre study

Author: Mónica A. Silva, Michael Haase, Pedro Veiga, Carla Santos-Araújo, Mary Luz Duarte, Catarina Romãozinho, Fernando Macário, Carlos Lucas, Mário João Santos, Lídia Santos, Mathias Haarhaus, and Faculdade de Medicina
Subjects: medicine.medical_specialty, COVID-19 Vaccines, medicine.medical_treatment, Antibodies, Viral, Immunogenicity, Vaccine, Immune system, Renal Dialysis, Internal medicine, medicine, Humans, Seroconversion, AcademicSubjects/MED00340, Beta (finance), Adverse effect, BNT162 Vaccine, Vaccines, Synthetic, Transplantation, hemodialysis, biology, SARS-CoV-2, business.industry, SARS-Cov-2 vaccination, Vaccination, COVID-19, Nephrology, Immunoglobulin G, Spike Glycoprotein, Coronavirus, Cohort, biology.protein, Original Article, mRNA Vaccines, Hemodialysis, Antibody, business
Abstract: Background Vaccination programs are essential for the containment of the COVID-19 pandemic, which has affected hemodialysis populations especially hard. Early reports suggest a reduced immunologic response to SARS-Cov-2 vaccines in dialysis patients, in spite of a high degree of seroconversion. We aimed to identify risk factors for a reduced efficacy of an mRNA vaccine in a cohort of hemodialysis patients. Method In a multicenter study, including 294 Portuguese hemodialysis patients who had received 2 doses of BNT162b2 with a three week interval, IgG-class antibodies against the SARS-CoV-2 spike protein were determined 3 weeks after the first dose (M1) and 6 weeks after the second dose (M2). The threshold for seroconversion was 10UR/mL. Demographic and clinical data was retrieved from a quality registry. Adverse events were registered using a questionnaire. Results At M2, seroconversion was 93.1% with a median antibody level of 197.5U/mL (1.2–3237.0) and a median increase of 180.0U/mL (-82.9–2244.6) from M1. Age (beta -8.9; 95%CI: -12.88 to -4.91; P 600ng/mL (beta 183.93; 95%CI: 74.75 to 293.10; P = 0.001) and physical activity (beta 265.79; 95%CI: 30.7 to 500.88; P = 0.03) were independent predictors of SARS-Cov-2 antibody levels after two vaccine doses. Plasma albumin > 3.5g/dL independently predicted the increase of antibody levels between both doses (OR 14.72; 95%CI: 1.38 to 157.45; P = 0.03). Only mild adverse reactions were observed in 10.9% of patients. Conclusions The SARS-Cov-2 vaccine BNT162b2 is safe and effective in hemodialysis patients. Besides age, iron status and nutrition are possible modifiable modulators of the immunologic response to SARS-Cov-2 mRNA vaccines. This data suggests the need for an early identification of populations at higher risk for diminished antibody production and the potential advantage of the implementation of oriented strategies to maximize the immune response to vaccination in these patients., Graphical Abstract Graphical Abstract
Published: 2021

34. Infecciones mamarias por Corynebacterium kroppenstedtii: comunicación de 4 casos

Author: María Florencia Veiga, Nahuel Sanchez Eluchans, Marisa Almuzara, Carlos Vay, Rosana Cittadini, Ana María Ozuna Villca, Viviana Vilches, and Claudia Barberis
Subjects: Microbiology (medical), 0303 health sciences, 030306 microbiology, medicine.drug_class, business.industry, Sulfamethoxazole, Antibiotics, Clindamycin, General Medicine, Granulomatous mastitis, medicine.disease, Microbiology, Trimethoprim, Ciprofloxacin, 03 medical and health sciences, medicine, Ceftriaxone, Vancomycin, business, medicine.drug
Abstract: Corynebacterium kroppenstedtii is an immobile, non-sporulated, glucose-fermenting and lipophilic gram-positive rod of the skin microbiota. In recent years, numerous isolates of this species have been reported mainly in breast infections, such as abscesses and granulomatous mastitis. We present here four cases of C. kroppenstedtii infections isolated from breast aspiration samples in women. C. kroppenstedtii was identified by conventional methodology and mass spectrometry (MALDI-TOF MS). Using the epsilometric method, these isolates showed susceptibility to penicillin, ceftriaxone, minocycline, ciprofloxacin, and vancomycin, and variable susceptibility to clindamycin and trimethoprim sulfamethoxazole. Due to the association of C. kroppenstedtii with mammary infections, the identification at the species level of those corynebacteria isolated from this location is highly advisable in order to reach the final diagnosis and to test the antimicrobial susceptibility in order to apply the appropriate antibiotic treatment.
Published: 2021

35. Agreement between two diagnostic methods for COVID-19: preliminary data from a Brazilian clinical laboratory

Author: Joyce Regina Santos Raimundo, Glaucia Luciano Veiga, Beatriz Costa Aguiar Alves, Jéssica Freitas Araújo Encinas, Marina Cristina Peres, Matheus Moreira Perez, Claudia Giorgia Bronzatti de Oliveira Rodrigues, Aleksandra Vanessa Lambiasi Sant’Anna, Flavia Gehrke, and Fernando Luiz Affonso Fonseca
Subjects: medicine.medical_specialty, Diagnostic methods, biology, Coronavirus disease 2019 (COVID-19), business.industry, diagnostic, Gastroenterology, Asymptomatic, Immune system, covid-19, Antigen, Internal medicine, symptomatic, medicine, biology.protein, asymptomatic, Medicine, medicine.symptom, Antibody, business, Kappa, Antibody detection
Abstract: Objective: To investigate possible differences between laboratory profiles of symptomatic and asymptomatic patients. There are different of them available for COVID-19 diagnoses and surveillance, so this research was to evaluate the positive agreement the diagnostic methods. Methods: For symptomatic patients swab samples from nasal and oral mucosal were collected between first and second week after symptoms onset, to perform RT-PCR, blood samples were collected 7 days after to perform antibody detection test. For asymptomatic patients, only antibody detection was performed to confirm the infection. We investigated specific humoral immune response for symptomatic and asymptomatic patients and also analyzed the positivity index and kappa agreement between immunochromatographic and ELISA assays. Results: Most symptomatic patients presented negative RT-PCR with IgM and IgA detection. Symptomatic and asymptomatic patients have presented elevated IgM and IgA immunoglobulins, being this detection higher in symptomatic patients. The positivity index for immunochromatographic was higher than ELISA and there was no kappa agreement between IgM and IgA detection between these two methods. Conclusion: Symptomatic patients presented higher amounts of IgM and IgA than asymptomatic, suggesting a relation between antibody quantity and severity of disease. We verified no agreement between IgM and IgA detection, and observed higher positivity index for IMMUNO when compared to ELISA. The different kinetics may cause a variation in their detection. Also, many different virus proteins can be used as antigens in these methods, being able of altering their sensibility and specificity.
Published: 2021

36. Lupus cutáneo discoide inducido por capecitabina

Author: M.E. Rosón López, H.A. Vázquez Veiga, N. Moreiras Arias, and J.M. Suárez Peñaranda
Subjects: business.industry, RL1-803, Medicine, Dermatology, General Medicine, business, Internal medicine, RC31-1245
Published: 2021

37. Fiscal forecast manipulations and electoral results: evidence from Portuguese municipalities

Author: Mamadou Boukari and Francisco Veiga
Subjects: Public Administration, business.industry, Political science, language, Foundation (evidence), Accounting, Portuguese, business, General Economics, Econometrics and Finance, language.human_language
Abstract: This article aims to evaluate the impact of budget forecast manipulations on election results using a sample that covers all 308 Portuguese municipalities over the period running from 1998 to 2017. The results reveal that incumbent mayors overestimate revenues and expenditures. Overstating the budget more on the revenue side, they end up with a deficit. We check if this opportunistic behaviour is electorally beneficial. The results provide little or no evidence that election-year manipulations of revenue forecasts affect the vote shares of the party of the incumbent mayor. On the other hand, the opportunistic management of total and capital expenditure forecasts pays off, which is consistent with previous results for Portugal indicating that increased total and, mainly, capital expenditures lead to higher vote shares.
Published: 2021

38. Tratamiento con oxígeno hiperbárico en el fenómeno de Raynaud y las úlceras digitales asociadas a esclerosis sistémicas

Author: Elia Baragaño-Ordóñez, Patricia E Carreira, María Ahijón-Lana, Raúl Veiga-Cabello, and Carmen de la Cruz-Tapidor
Subjects: Raynaud phenomenon, Hyperbaric oxygen, integumentary system, Rheumatology, Refractory, business.industry, Anesthesia, Conventional treatment, Medicine, In patient, business
Abstract: We describe 4patients with Raynaud's phenomenon associated with systemic sclerosis, 3with ischaemic ulcers, successfully treated with hyperbaric oxygen. This therapy has been useful in the treatment of chronic wounds due to its anti-inflammatory, antimicrobial and angiogenic effects. Hyperbaric oxygen treatment could be a therapeutic option in patients with Raynaud's phenomenon refractory to conventional treatment.
Published: 2022

39. Characterisation of old azulejos setting mortars: A contribution to the conservation of this type of coatings

Author: Damas, Ana Leonor, Veiga, Maria do Rosario, Faria, Paulina, and Silva, Antonio Santos
Subjects: Portuguese culture -- History, Coatings -- Usage -- Mechanical properties, Building materials -- Usage, Business, Construction and materials industries
Abstract: ABSTRACT One of the most typical Portuguese facades' coatings is the glazed tile (azulejo) wall coating. Azulejos are in Portuguese history for six centuries, being considered a historical heritage and [...]
Published: 2018
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40. Variability of in-situ testing on rendered walls in natural ageing conditions--Rebound hammer and ultrasound techniques

Author: Galvao, J., Flores-Colen, I., de Brito, J., and Veiga, M.R.
Subjects: Concretes -- Analysis -- Chemical properties -- Mechanical properties, Pendulums -- Usage, Business, Construction and materials industries
Abstract: ABSTRACT External renders are the first barrier against degradation agents and their performance affects directly that of building facades. During the life cycle of renders there is a progressive reduction [...]
Published: 2018
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41. Air lime mortars: What else do we need to know to apply them in conservation and rehabilitation interventions? A review

Author: Veiga, Rosario
Subjects: Mortar -- Usage, Decomposition (Chemistry) -- Analysis, Business, Construction and materials industries
Abstract: ABSTRACT Air lime mortars were used in construction since immemorial times until at least the beginning of the 20th century. This material may tell the history of construction, in large [...]
Published: 2017
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42. The calm after the storm: re-starting ART treatments safely in the wake of the COVID-19 pandemic

Author: Gianaroli, Luca, Ata, Baris, Lundin, Kersti, Rautakallio-Hokkanen, Satu, Tapanainen, Juha S., Vermeulen, Nathalie, Veiga, Anna, Mocanu, Edgar, ESHRE COVID-19 Working Group, Ata, Mustafa Barış (ORCID 0000-0003-1106-3747 & YÖK ID 182910), ESHRE COVID-19 Working Group, Gianaroli, Luca, Lundin, Kersti, Rautakallio-Hokkanen, Satu, Tapanainen, Juha S., Vermeulen, Nathalie, Veiga, Anna, Mocanu, Edgar, School of Medicine, HUS Gynecology and Obstetrics, Reproductive Disease Modeling, Department of Obstetrics and Gynecology, and Clinicum
Subjects: medically assisted reproduction, Code of conduct, Opinion, Reproductive Techniques, Assisted, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019, 03 medical and health sciences, 0302 clinical medicine, 3123 Gynaecology and paediatrics, Pregnancy, Informed consent, Obstetrics and Gynaecology, Pandemic, medicine, Humans, 030212 general & internal medicine, Adaptation (computer science), Pandemics, Dissemination, 030219 obstetrics & reproductive medicine, SARS-CoV-2, pandemic, Rehabilitation, COVID-19, Obstetrics and Gynecology, Medically assisted reproduction, IVF, Triage, Testing, ART services, Coronavirus disease 2019, Severe acute respiratory syndrome coronavirus 2, medicine.disease, AcademicSubjects/MED00905, testing, 3. Good health, Reproducció humana assistida, Reproductive Medicine, Medicine, Reproductive physiological process, Reproductive techniques, Female, Reproductive Health Services, Medical emergency, Business, Human reproductive technology, triage, severe acute respiratory syndrome coronavirus 2
Abstract: The coronavirus disease 2019 (COVID-19) pandemic created a significant impact on medically assisted reproduction (MAR) services. ESHRE decided to mobilize resources in order to collect, analyse, monitor, prepare and disseminate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) knowledge specifically related to ART and early pregnancy. This article presents the impact of the SARS-CoV-2 pandemic focusing on reproductive healthcare. It details the rationale behind the guidance prepared to support MAR services in organizing and managing the re-start of treatments or in case of any future wave of COVID-19 disease. The guidance includes information on patient selection and informed consent, staff and patient triage and testing, adaptation of ART services, treatment planning and code of conduct. The initiatives detailed in this article are not necessarily COVID-specific and such action plans could be applied effectively to manage similar emergency situations in different areas of medicine, in the future., NA
Published: 2020

43. Slip Clip after successful microsurgery of a blister aneurysm: Should bypass always be the first option?

Author: Guilherme Brasileiro de Aguiar, José Carlos Esteves Veiga, Aline Lariessy Campos Paiva, and Juan Antonio Castro Flores
Subjects: Brain aneurysm, Microsurgery, medicine.medical_specialty, Subarachnoid hemorrhage, medicine.medical_treatment, education, Cerebral revascularization, Case Report, Cerebral Revascularization, Aneurysm, medicine.artery, medicine, cardiovascular diseases, medicine.diagnostic_test, business.industry, Clipping (medicine), medicine.disease, nervous system diseases, Surgery, cardiovascular system, Internal carotid artery, business, Cerebral angiography
Abstract: Blood Blister-like aneurysms are intracranial non-saccular aneurysms with higher rupture risk due to its fragile wall. Diagnosis is performed in the acute phase of a subarachnoid hemorrhage. There are several treatment options based on reconstructive or deconstructive techniques. This paper aims to discuss the limitations of microsurgery clipping for a ruptured blister aneurysm. We report on a case of a female patient presented with a Fisher III subarachnoid hemorrhage. Cerebral angiography revealed an internal carotid artery blister aneurysm. Initially microsurgery clipping was successfully performed. However, after a few days the patient presented new subarachnoid hemorrhage. The new cerebral angiography showed growth of the previously clipped aneurysm, with displacement of the clip from the position adjacent to the artery. High-flow bypass was performed obtaining definitive treatment. This is a definitive approach for blister aneurysms. If microsurgery clipping is chosen, a strict follow-up is required due to the dynamic nature of this lesion and the chance of re-bleeding even after successfully clipping.
Published: 2021

44. Câncer de boca: conhecimento e atitudes de acadêmicos de odontologia e cirurgiões-dentistas da atenção primária à saúde / Mouth cancer: knowledge and attitudes of dental students and dental surgeons of primary health care

Author: Daniela Mendes da Veiga Pessoa, Luanna Mayrany Alves Costa Silva, Gilmara Celli Maia de Almeida, Jamile Marinho Bezerra de Oliveira Moura, and Maria Helaynne Faria Diniz
Subjects: Marketing, Pharmacology, Organizational Behavior and Human Resource Management, Mouth cancer, Nursing, business.industry, Strategy and Management, Drug Discovery, Primary health care, Pharmaceutical Science, Medicine, business, medicine.disease
Published: 2021

45. Ué, um Petrônio caipira? 'O causo da muié de Éfis'

Author: Paulo Eduardo de Barros Veiga
Subjects: LITERATURA LATINA, business.industry, General Medicine, Sociology, Comics, business, Latin text, Linguistics, Prejudice (legal term)
Abstract: Apresentam-se duas traduções variacionais do episódio da matrona de Éfeso, extraído do livro Satíricon, de Petrônio (século I d.C.). Ambas as traduções, que partem do texto original latino, expressam-se mediante variantes linguísticas brasileiras e propõem equivalentes cômicos da obra romana. Especificamente, a primeira tradução procura representar uma variante da região do interior paulista como expressão materna. A segunda, de teor mais experimental, vale-se da imitatio do falar interiorano para provocar efeito de caipira, a partir dos descritores linguísticos que demarcam a variante. Dessa forma, procura-se demonstrar ser possível verter um texto antigo para uma variante sem incidir em possíveis preconceitos. Mais importante, deseja-se reavivar, em português caipira, a maestria cômica do arbiter elegantiae.
Published: 2021

46. MR Denoising Increases Radiomic Biomarker Precision and Reproducibility in Oncologic Imaging

Author: Blanca Martínez de las Heras, Cinta Sangüesa Nebot, Adela Cañete Nieto, Leonor Cerdá Alberich, Diana Veiga Canuto, Matías Fernández Patón, and Luis Martí-Bonmatí
Subjects: Diagnostic Imaging, Image quality, Computer science, Noise reduction, Image processing, 02 engineering and technology, Signal-To-Noise Ratio, Article, Standard deviation, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, 0202 electrical engineering, electronic engineering, information engineering, Humans, Radiology, Nuclear Medicine and imaging, Reproducibility, Radiological and Ultrasound Technology, business.industry, Noise (signal processing), Reproducibility of Results, Pattern recognition, Filter (signal processing), Computer Science Applications, Gaussian filter, symbols, 020201 artificial intelligence & image processing, Artificial intelligence, business, Algorithms, Biomarkers
Abstract: Several noise sources, such as the Johnson–Nyquist noise, affect MR images disturbing the visualization of structures and affecting the subsequent extraction of radiomic data. We evaluate the performance of 5 denoising filters (anisotropic diffusion filter (ADF), curvature flow filter (CFF), Gaussian filter (GF), non-local means filter (NLMF), and unbiased non-local means (UNLMF)), with 33 different settings, in T2-weighted MR images of phantoms (N = 112) and neuroblastoma patients (N = 25). Filters were discarded until the most optimal solutions were obtained according to 3 image quality metrics: peak signal-to-noise ratio (PSNR), edge-strength similarity–based image quality metric (ESSIM), and noise (standard deviation of the signal intensity of a region in the background area). The selected filters were ADFs and UNLMs. From them, 107 radiomics features preservation at 4 progressively added noise levels were studied. The ADF with a conductance of 1 and 2 iterations standardized the radiomic features, improving reproducibility and quality metrics.
Published: 2021

47. Traumatic injury of dural venous sinus as cause of epidural hematoma: importance of recognition and adequate surgical planning

Author: Guilherme Brasileiro de Aguiar, Leonardo Henrique da Silva Rodrigues, Paulo Adolfo Wessel Xander, Tiago Marques Avelar, Guilherme Henrique Ferreira da Costa, Andrew Vinícius De Souza Batista, and José Carlos Esteves Veiga
Subjects: medicine.medical_specialty, business.industry, medicine.medical_treatment, Middle meningeal artery, Intracranial hematoma, Glasgow Coma Scale, General Medicine, medicine.disease, Surgery, Epidural hematoma, medicine.anatomical_structure, Hematoma, medicine.artery, Dural venous sinuses, medicine, business, Craniotomy, Sinus (anatomy)
Abstract: Background: Although most traumatic epidural hematomas are secondary to arterial injuries, particularly rupture of the middle meningeal artery, around 9.7% of cases are associated with dural venous sinus injury, leading to poorer prognosis and greater complications. We report a case of a patient presenting cranial trauma with bone fracture and laceration of the transverse sinus producing epidural hematoma, and discuss the main aspects of this condition. Case description: A 47-year-old man struck by a motorcycle was admitted to the Emergency Room with a score of 15 on the Glasgow Coma Scale, evolving over 5 hours with reduced level of consciousness. A cranial CT scan was performed disclosing right parieto- occipital hyperdensity, consistent with acute epidural hematoma, and a parieto-occipital fracture line crossing the path of the ipsilateral transverse sinus. Parietal craniotomy was performed to drain the hematoma, revealing a venous sinus injury requiring immediate repair. Conclusions: This case and discussion highlight the many details and technical specificities to be taken into account by neurosurgeons when encountering intracranial hematoma caused by traumatic injury of the dural venous sinus, and which are pivotal in determining the efficacy of the treatment approach and prognosis of the patient.
Published: 2021

48. The role of probiotics as gastrointestinal infections treatment and prophylaxis: A review

Author: Carlos Américo Veiga Damasceno and Gabriel Gomes Vieira Ribeiro Leite
Subjects: Helicobacter pylori infection, medicine.medical_specialty, business.industry, Pseudomembranous colitis, Oral cavity, Gastrointestinal infections, law.invention, Clinical trial, Diarrhea, Probiotic, law, medicine, medicine.symptom, Intensive care medicine, business
Abstract: Objective: Probiotics are products that contain microorganisms capable of supporting symbiotic relations with native microbiota of many environments. They are widely used and studied due to their capacity to improve biological systems’ overall health. Many hypothesis exist surrounding the mechanisms by which every microbe labelled as probiotic is the cause by which system health is enhanced by its presence. The aim of this review was to compile article’s data concerning the role of different combinations of probiotics used to treat and prevent gastrointestinal conditions, such as antibiotic-associated diarrhea, pseudomembranous colitis, Helicobacter pylori infections, oral, pharyngeal and Salmonella infections. In general, other than presenting excellent safety records, several probiotic combinations registered in clinical trials could prove themselves capable of significantly preventing those infections and some proved to be capable to also treat them once established. The main challenge among the infections studies seems to be oral cavity infections, probably due to microbiota complexity. Nevertheless, probiotics seem to have good prospect for playing a major preventive and protective role in gastrointestinal infections with further investigation to gather sufficient evidence to base treatment protocols.
Published: 2021

49. A kinesthetic teaching approach for automating micropipetting repetitive tasks

Author: Joana N R Dias, Cláudia Rocha, Pedro Costa, Germano Veiga, and António Paulo Moreira
Subjects: Flexibility (engineering), Panorama, business.industry, Computer science, Mechanical Engineering, Interface (computing), Kinesthetic learning, Usability, Industrial and Manufacturing Engineering, Computer Science Applications, Operator (computer programming), Control and Systems Engineering, Human–computer interaction, Workbench, business, Robotic arm, Software
Abstract: Nowadays, a laboratory operator in the areas of chemistry, biology or medicine spends considerable time performing micropipetting procedures, a common, monotonous and repetitive task which compromises the ergonomics of individuals, namely related to wrist musculoskeletal disorders. In this work, the design of a kinesthetic teaching approach for automating the micropipetting technique is presented, allowing to redirect the operator to other non-repetitive tasks, aiming to reduce the exposure to ergonomic risks. The proposed robotic solution has an innovative gripping system capable of supporting, actuating and regulating the volume of a manual micropipette. The system is able to configure the position of diverse laboratory materials, such as lab containers and plates, on the workbench through a collaborative robotic arm, providing flexibility to adapt to different procedures. A projected human-machine interface, which combines the display of information on the workbench with an infrared based interaction device was developed, providing a more intuitive interaction between the operator and the system during the configuration and operation phases. In contrast to the majority of the existing liquid handling systems, the proposed system allows the operator to place the materials freely on the workbench and the usage of different materials’ variants, facilitating the implementation of the system in any laboratory. The attained performance and ease of use of the system were very encouraging since all the defined tasks in the conducted experiments were successfully performed by users with minimum training, highlighting its potential inclusion in the laboratory routine panorama.
Published: 2021

50. Determination of pharmaceuticals and heavy metals in groundwater for human and animal consumption and crop irrigation in Galicia

Author: Carlos Manuel Franco, María Veiga-Gómez, Alberto Cepeda, Elena Falqué, Benita Perez, and Carolina Nebot
Subjects: Irrigation, Agricultural Irrigation, Antifungal Agents, Health, Toxicology and Mutagenesis, Water supply, Toxicology, Crop, Metals, Heavy, Groundwater pollution, Animals, Humans, Groundwater, Health risk assessment, business.industry, Public Health, Environmental and Occupational Health, Heavy metals, General Chemistry, General Medicine, Contamination, Anti-Bacterial Agents, Spain, Environmental chemistry, Coccidiostats, Environmental science, business, Water Pollutants, Chemical, Environmental Monitoring, Food Science
Abstract: Pharmaceuticals and heavy metals are contaminants present in groundwaters, which are the main source of drinking water in most parts of the world. In the northwest region of Spain, Galicia, groundwater harvesting is a common practice for drinking water supply, crop irrigation, cattle watering, as well as recreational use such as filling pools. In order to assess the quality of Galician groundwaters, the presence of 21 pharmaceuticals and 10 heavy metals was analysed by UPLC-MS/MS and ICP/MS methods, respectively, in a total of 118 groundwater samples from private wells. Seventeen of the 21 compounds studied were detected in 28% of the samples, with the highest presence of pharmaceuticals belonging to the antimicrobial group (52%), specifically the sulphonamides group in a range of concentration between 21 and 14.9 ng/L. In addition, 30% of the samples contained at least one heavy metal (Mn, As and Fe) above the legally permitted levels. Evaluation of the risk associated with the consumption of the analysed groundwater indicated no human risk for any of the detected pharmaceuticals but high cancer risk for children due to Cd, Cr and As concentrations was observe.
Published: 2021

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