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We studied 100 patients who had coronary implantation of Palmaz-Schatz stents in our institution from November 1989 until March 1991. A total of 126 standard and 6 short stents were implanted. The patients' mean age was 58 ± 5 years, and 97 were males. The indications were lesions with high risk of restenosis (29 patients), restenosis (27 patients), suboptimal result of angioplasty (24 patients), dissection (16 patients), and recanalized chronic total occlusion (6 patients). In 17 patients a brachial cut-down approach was used. Stents were correctly placed in 98 patients. Stent related complications occurred in 9 patients: major ischemic complications in 7 patients (acute myocardial infarction in 2 patients, emergency bypass surgery in 3 patients and emergency angio-plasty in 2 patients); in 3 of these patients there was a subacute closure of the stent and in 2 patients there were delivery problems. Vascular complications at the site of arterial puncture occured in 3 patients (some patients had more than one complication). A learning curve was observed. There was a decrease in the complication rate with the higher number of patients treated: 28% for the first 50 patients and 6% for the last 50 patients. Clinical follow-up was available in all patients. Of the 92 patients eligible for follow-up (7 ± 2 months), 69 patients were asymptomatic and 23 had recurrence of angina: 19 patients for stent restenosis and 4 patients for coronary artery disease progression. Follow-up angiogram was done in 79/92 (86%) patients: 21 had restenosis (27%). Restenosis rate was higher in patients with multiple stents 40% (6/15) than with the single stent 23% (15/64), and when the indications were for dissection 35% (6/17). These differences did not reach statistical significance. The global incidence of restenosis appears to be lower when compared to balloon coronary angloplasty, although there is no garantee these populations are comparable. Stenting seems to be a good alternative to coronary angioplasty in lesions which are not considered ideal for the balloon dilatation and to treat occlusive dissections. The use of multiple and partial overlapping stents is associated with a high restenosis rate. These impressions need to be tested in a large, randomized, multicenter study. © 1992 Wiley-Liss, Inc.

BACKGROUND: Current recommendations for prophylaxis of Pneumocystis carinii pneumonia (PCP) are based on data from patients who have had at least one episode of PCP (secondary prevention). We designed a study to determine the efficacy and side effects of inhaled pentamidine in the primary prevention of PCP. METHODS: Two hundred twenty-three patients sero-positive for human immunodeficiency virus (HIV) who had the acquired immunodeficiency syndrome (AIDS) but not PCP, who had advanced AIDS-related complex, or who had less than 0.2 x 10(9) CD4-positive lymphocytes per liter received either 300 mg of pentamidine isethionate or 300 mg of sodium isethionate every 28 days by inhaler. The proportion of patients surviving without PCP was analyzed with the log-rank test as a function of time spent in the trial, according to the intention to treat with either placebo or pentamidine. RESULTS: The third of five planned interim analyses showed a significant difference in the occurrence of PCP, with 8 cases in pentamidine group and 23 in the placebo group (nominal P value = 0.0021). There were no deaths within 60 days of the diagnosis of PCP and no significant differences in survival between groups. Approximately 53 inhalations were needed to prevent one episode of pneumonia. Thirty-eight of 114 patients given pentamidine (33 percent) and 7 of 109 given placebo (6 percent) had moderate-to-severe coughing during inhalations (two-tailed P less than 0.00001), which caused 4 patients given pentamidine (3.5 percent) to discontinue taking it. CONCLUSIONS: A dose of 300 mg of aerosolized pentamidine given every four weeks was well tolerated and 60 to 70 percent effective in preventing a first episode of PCP in patients with HIV infection.

Background: Several lines of evidence indicate a potential association between oral lichen-reactions and the presence of dental amalgam fillings. Aim: We examined the relation between oral lichen reaction cases and the site of amalgam fillings in the oral cavity. Methods: We conducted an observational study in 5 consecutive patients who had OLR and underwent to dental amalgam replacement. The number of total amalgam surfaces and OLR sites were charted. Saliva samples were taken and levels of total mercury were measured by CV-AAS method. Also we did patch-testing with dental series in all patients. Results: Our observational study revealed that oral lichen reactions may not have an association with the physical proximity the mercury tooth fillings. Unexpectedly, we noted a complete remission in patients with OLR (n = 5). The patients with OLR presented allergies to mercury (n = 4) or gold (n = 1). All patients were negative for HCV/HBV and they had not been taking any drug-induced lichenoid mucositis. Findings: In this case report series no topographical association was found between OLR and the dental amalgam fillings. All OLR cases were in full recovery after total amalgam removal within three months. Saliva mercury concentrations were significantly elevated in all subjects. After amalgam removal the mercury levels were undetectable. We suggest that dental amalgam removal is important therapeutic option in OLR cases even if the lichenoid lesions are not adjacent to dental amalgam restorations.

Background: Burning mouth syndrome (BMS) is a burning and painful sensation of the mouth and perioral tissues. Despite several research its causes remain unknown. The treatment of BMS continues to be a challenge. This study investigated the relation between allergy to metals and long-term outcomes in 5 patients with BMS. Methods: We studied 12 consecutive patients who had received a diagnosis of the BMS (ranging in age from 35 to 71). Mean duration of BMS symptoms was 10 months. We did patch-testing in all patients with dental series. We measured the saliva metal concentrations in each subjects. Of the 12 patients studied, 5 had symptoms which appeared to be related to type 3 BMS. Thus, they were assigned to total metals alloy removal procedures because allergic to at least one metal and had high levels of metals in saliva. No subjects had been receiving drug therapy. The primary outcome was the relief of BMS symptoms. Patients were followed for an average of 1.6 years. Findings: Of the 5 patients who underwent to total metal alloy removal, 4 had a complete remission and one had showed notable improvement of his symptoms. Three patients were allergic to mercury. Two patients showed an allergy to gold. The saliva mercury and gold levels were significantly over the threshold limit. We also noted in three patients a full recovery of systemic dermatologic manifestations associated with BMS. Conclusions: We believe that our exploratory investigation adds evidence that allergy to dental metals are involved in BMS.

Context. —Apparent second episodes of varicella are reported in immunocompetent hosts, but laboratory confirmation of prior immune status has rarely been possible. Objective. —To evaluate adult patients with varicella who claimed to have had previous varicella to determine whether they had true second episodes or primary cases with inaccurate clinical histories. Design. —Adult subjects with varicella who enrolled in an antiviral treatment trial were interviewed about a history of varicella. The clinical course of varicella was documented prospectively in all subjects. Serum samples that predated the acute illness were obtained from the US Navy's central serum storage facility for subjects who reported a previous episode of varicella. These stored samples were tested in parallel by enzyme-linked immunosorbent assay, latex agglutination, and Western blot for IgG antibodies to varicella-zoster virus (VZV). Paeticipants. —Twenty military personnel with varicella and a history of the disease. Setting. —A military hospital in San Diego, Calif. Main Outcome Measure. —Presence or absence of antibodies to VZV. Results. —Twenty (10.8%) of 184 adults with serologically confirmed acute varicella reported a prior history of varicella. The clinical course of these 20 patients did not differ from those with no history of varicella. Serum samples that had been collected a mean of 12.4 months (median, 12 months; range, 3 days to 34 months) before the incident episode were available for 19 subjects. All 19 serum samples lacked IgG antibodies to VZV. Conclusion. —A history of previous varicella infection in adults with varicella may not be reliable. True second episodes of varicella are probably rare in immunocompetent adults.

A population of 105 patients (pts) with recent onset (l 72 hours) atrial fibrillation (AF) without clinical signs of heart failure were randomly treated with a single loading oral dose of propafenone (PFN) (600 mg) or digoxin (DIG) (1 mg) or with placebo (PLA). A 24-hour holter monitoring was performed and conversion to sinus rhythm (SR) after 2, 4 and 24 hours was considered as criterion of efficacy. We also evaluated the effect on mean ventricular rate (MVR) in those pts with still lasting AF four hours after drug administration. The 3 groups were comparable as to gender, age, etiology, duration of AF, mean ventricular rate at baseline and left atrial dimension. Conversion to SR PFN (n = 36) DIG (n = 34) PLA (n = 35) p value after 2 hours 16 (44%) 5 (15%) 7 (20%) 0.011 after 4 hours 25 (69%) 11 (32%) 12 (34%) 0.002 after 24 hours 30 (83%) 24 (71%) 25 (71%) ns Mean conversion time within 4 hours was 139 ± 117’ for PFN, 123 ± 66’ for DIG and 116 ± 78’ for PLA (p = ns). Reduction MVR PFN (n = 11) DIG (n = 23) PLA (n = 23) p value baseline (bpm) 134 ± 20 133 ± 29 136 ± 28 †;‡l 0.001 after 2 hours 106 ± 22† 113 ± 32‡ 124 ± 29 vsbaseline (-21%)** (1-15%) (-9%)** * = 0.002 after 4 hours 92 ± 15† 104 ± 29‡ 121 ± 27 °°l 0.01 (-31%)°/* (-22%)°/°° (-11%)*/°° °;**l 0.05 No serious adverse effects were noted in either group. Phases of regular tachycardia were observed in 3 pts of each group, but only in 2 cases, both receiving placebo, 1: 1 AV conduction ensued. 1) Oral loading dose of PFN is safely and promptly efficacious in converting recent onset AF to SR. 2) The efficacy of oral PFN is significantly superior in comparison to oral DIG while oral loading dose of DIG is no better than placebo. 3) PFN and DIG are both effective in reducing MVR in pts with recentonset AF who did not revert to SR or who reverted late after drug administration.

To study incidence and risk factors of heterosexually transmitted HIV infection, we followed a cohort of 343 seronegative women, stable, monogamous partners of infected men whose only risk of acquiring HIV was sexual exposure to the infected partner. Nineteen seroconversions occurred in 529.6 person years (py) of observation, yielding an incidence rate of 3.6 per 100 py. The incidence rate was 7.2 per 100 py among women who did not always use or never used condoms and 1.1 among those who always used them [relative risk (RR) 6.6, 95% confidence interval (CI) 1.9-21.9]. Anal sex was associated with a risk increase in only those women not always using condoms (RR 1.4, 95% CI 0.4-4.8). No seroconversions were observed among 22 women using oral contraceptives. One of the women using intrauterine devices seroconverted. In couples who did not always use condoms, seroconversions occurred more frequently in partners of men with symptomatic diseases, with a low CD4+ cell number ( or = 1 year) showed a lower risk of seroconversion (RR 0.3, CI 0.1-0.8), and those partners of men positive for p24 antigen in serum had an increased risk of seroconversion (RR = 4.0, CI 0.1-0.8).

The mucocutaneous manifestations observed in 516 patients infected with human immunodeficiency virus attending an outpatient clinic for acquired immunodeficiency syndrome in Milan, Italy, from July 1985 to March 1987 are listed, and the clinicopathologic aspects of these disorders are reported. The prognostic significance of some human immunodeficiency virus-associated dermatoses is also discussed.

A homosexual male, seropositive to HIV and with previously documented syphilitic infections, developed a slowly growing nodule on his left wrist (possibly a chancre) followed, after 2 months, by a few scattered, large papular lesions. Serological evidence of active syphilis was obtained and treponema were identified in the initial lesion by means of immunofluorescent staining. Treatment with both aqueous crystalline penicillin G and benzathine penicillin G healed the lesions. This represents a further case of an atypical presentation of early syphilis in an immunocompromised host.

Background: Herpes simplex virus type 2 (HSV-2) infections may be a risk factor for the transmission of HIV. Data on the prevalence of HSV-2 infection among HIV-positive individuals are scarce. Goal: The goal was to study the seroprevalence of and risk factors for HSV-2 infection among a cohort of Italian HIV-positive individuals. Study Design: This was a cross-sectional study. HSV-2 serologic testing was performed for individuals with known date of HIV seroconversion, on the serum specimen obtained on the date closest to the estimated date of seroconversion. Antibodies to HSV-2 (anti-HSV-2) were detected by a gG2-specific ELISA. Results: A total of 380 HIV-positive individuals were tested for anti-HSV-2; 126 (33.2%) of them were positive. Older age at HIV seroconversion and homosexuality were significantly associated with HSV-2 infection in the multivariate analysis. Conclusions: These data stress the need for including anti-HSV-2 testing and therapy in the management of HIV positivity, especially for reducing the risk of transmission of HIV through herpetic lesions.

To the Editor.— In patients with the acquired immunodeficiency syndrome (AIDS)- or human immunodeficiency virus (HIV)-related disorders, mucocutaneous manifestations caused by herpesvirus are frequent,1and may present with unusual clinical features.2Chronic anogenital ulcers due to herpes simplex virus (HSV), severe dermatomal herpes zoster (HZ), and protracted forms of varicella and vesiculobullous eruptions due to cytomegalovirus have all been described.3-5The purpose of this article is to illustrate a peculiar form of disseminated ecthymatous varicella zoster virus (VZV) infection in two patients with AIDS, which was characterized by necrotic cutaneous lesions and a prolonged course. Report of Cases.—Case 1. —A 35-year-old bisexual man with a history of varicella during childhood and condylomata acuminata for one year was found to be seropositive to HIV in May 1986, when he was hospitalized forPneumocystis cariniipneumonia and oral candidiasis. He developed cerebral toxoplasmosis in June 1986, and noted

Community-acquired methicillin-resistant Staphylococcus aureus is the first causeof skin and soft tissue infections, but can also produce severe diseases such as bacteremia,osteomyelitis and necrotizing pneumonia. Some S. aureus lineages have been described in casesof necrotizing pneumonia worldwide, usually in young, previously healthy patients. In this work,we describe a fatal case of necrotizing pneumonia due to community-acquired methicillin-resistant S. aureus clone ST30-SCCmecIVc-spat019-PVL positive in an immunocompetent adultpatient Fil: Fernández, Silvina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Murzicato, Sofía. Hospital Municipal Emilio Zerboni; Argentina Fil: Sandoval, Orlando. Hospital Municipal Emilio Zerboni; Argentina Fil: Fernández Canigia, Liliana. Hospital Aleman; Argentina Fil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

MADERNA'S REQUIEM RECOVERED Bruno Maderna. Requiem per soli, cori e orchestra (1946). A cura di Veniero Rizzardi. (Riedizione critica delle opere di Bruno Maderna.) Milan: Edizioni Suvini Zerboni, [2012], c2006. [Introd. in Ital., Eng., p. v-xii; desc. of sources in Ital., Eng., p. xiii-xvi; editing criteria in Ital., Eng., p. xvii-xxiv; apparatus criticus in Ital., Eng., p. xxv-xxxiv; note on the completion of the "parte prima" by Giorgio Colombo Taccani, in Ital., Eng., p. xxxv; text of the requiem, p. xxxvi-xxxviii; complete or- chestration, p. xxxix-xlii; score, p. 1-155. Pub. no. S. 13075 Z. i 200.]"I have resumed work on the Requiem, in- terrupted for many months for obvious rea- sons, and I hope to bring it to a satisfactory end. This work will be a real landmark for me," Bruno Maderna wrote in a letter to his teacher and mentor Gian Francesco Malipiero on 31 August 1945 (p. vi). Maderna had been called to the Italian army of Benito Mussolini during World War II, but during the last months of the war he entered the Italian Resistance. For a short time in February 1945, the German SS detained him under arrest.Presumably composed between 1944 and 1946, the Requiem for soloists, choirs, and orchestra by Maderna, one of Italy's most eminent composers and conductors of the post-World War II avant-garde, has come to light only after sixty years. For a long time it was believed lost. The discovery of the au- tograph score in a United States library oc- curred thanks to the perseverance and ex- pertise of Veniero Rizzardi, who was supported by the Istituto per la Musica of the G. Cini Foundation in Venice. Following the publication of a facsimile (Esumazione di un Requiem: Edizione anastat- ica della partitura e note informative sul ritrova- mento del giovanile Requiem di Bruno Maderna, ed. Veniero Rizzardi, Studi di musica veneta, Archivio G. F. Malipiero, 3 [Florence: Leo Olschki, 2007]) and first performed on 19 November 2009 at the Gran Teatro La Fenice in Venice (Andrea Molino conducting the Orchestra and Choir of the Teatro La Fenice and soloists Carmela Remigio, Veronica Simeoni, Simone Alberghini, and Mario Zeffiri), the score of Maderna's Requiem is now avail- able in a critical re-edition of Maderna's works compiled by Mario Baroni and Rossana Dalmonte, a collection of Maderna's early and some of his mature compositions "in a form best suited to study and performance" (p. iii; with the prefix "re," Baroni and Dalmonte intend to dis- tance themselves from the idea of a "Complete Works"). An additional goal of the collection is to promote research into Maderna sources, in the hope of discover- ing further materials concealed in archives or in private possession. A starting point for work in this direction was the volume Bruno Maderna: Documenti (ed. Mario Baroni, Rossana Dalmonte, and Francesca Magnani [Milan: Suvini Zerboni, 1985]).In the introduction to the critical re- edition, Rizzardi describes the context of the Requiem's genesis and destiny. While he was completing his Requiem (the date appearing in the autograph score is September 1946), Maderna had the oppor- tunity to conduct for the first time at the Biennale di Venezia in a concert dedicated to the "giovane scuola italiana" (Young Italian School), presented by Malipiero, a member of the "generazione dell'Ottanta" (generation of the Eighties). The concert included his piece Serenata, which is now lost. Around the same time, Maderna met the American composer and critic Virgil Thomson, to whom he was introduced in July 1946 by Malipiero. Having scrutinized the Requiem still to be finished, Thomson praised it enthusiastically in an article he wrote for the European edition of the New York Herald Tribune, "Venice and Its Musical Life" (Paris, 10 August 1946), and called for a performance in the United States. A letter from Maderna to Thomson dated 3 March 1947 (published in Esumazione di un Requiem, p. xvii) reveals that Maderna sent him a cyanotype copy of the manu- script, which became the motivation for Rizzardi's search for the lost work. …

THE FIRST VOLUME IN THE COMPLETE WORKS OF ERCOLE PASQUINI Ercole Pasquini. Toccate, canzoni, ricercari. Edizione critica a cura di Paul Kenyon. (Monumenti musicali italiani, 30.) (Ercole Pasquini Opere complete, 1.) Milan: Edizioni Suvini Zerboni, 2015. [2 bound parts within slipcase: Part 1: Intavolature / Tablatures: Score, p. 1-64. Part 2: Testi e apparato / Texts and apparatus, p. i-xxx (Italian), p. xxxi-lix (English). ISMN 9790215617193. Pl. no. S. 14907 Z. euro92.60.]This is the first of two publications that will comprise the collected keyboard works of Ercole Pasquini. Born in Ferrara in the mid-sixteenth century and active in Rome until at least 1608, Ercole is not to be confused with Bernardo Pasquini, who lived a century later. Although a prolific composer of keyboard and other music, Bernardo appears to have been less innovative than was Ercole in his thirty or so extant works. Ercole was one of the very first composers of keyboard music that can be described as "baroque," and he seems to have provided models without which Frescobaldi, his successor as organist at Rome's Cappella Giulia, might not have written what he did.Unlike Frescobaldi, whose toccatas, canzonas, and other compositions appeared in sumptuous engraved editions, Ercole published none of his keyboard music, which remains obscure even though nearly the complete corpus has already appeared in two previous editions. On the one hand, the pioneering transcription into modern notation by W. Richard Shindle no longer reflects current understanding of the sources or the repertory (Ercole Pasquini: Collected Keyboard Works, Corpus of Early Keyboard Music, 12 [Neuhausen-Stuttgart: American Institute of Musicology, 1966]), while on the other hand, a facsimile edition of the principal manuscripts by Alexander Silbiger is impractical for everyday use (Ravenna, Biblioteca comunale Classense, MS Classense 545, 17th Century Keyboard Music: Sources Central to the Keyboard Art of the Baroque, 12 [New York: Garland, 1987]; Rome, Biblioteca del Conservatorio di Musica Santa Cecilia, MS A/400, 17th Century Keyboard Music, 13 [New York: Garland, 1987]; and Trent, Museo provinciale d'arte, Biblioteca musicale L. Feininger, n.s., 17th Century Keyboard Music, 16 [New York: Garland, 1987]).Anyone attempting to play from or study these previous editions is likely to be baffled by seemingly faulty if not incomprehensible musical texts. A reliable modern edition with up-to-date textual commentary would therefore be welcome. But although the present publication makes the music accessible to nonspecialists, it falls short of what is expected in a modern critical edition, and it does not always succeed in finding satisfactory readings for scores that the composer, or at least the copyists, often seem to have left not quite finished. Moreover, a serious production error makes it desirable that the edition be withdrawn and reprinted. Collections that seek comprehensive holdings of keyboard music will need to acquire this edition, but others may wish to wait to see whether the publisher will rectify the problem described below.Although the series title describes it as containing Ercole's "complete works," it is unclear whether the new edition will extend beyond the keyboard music (a handful of vocal works are also known). The present volume 1 contains twenty-five short preludial and contrapuntal compositions (toccatas, canzonas, and ricercars). A few brief dances and several lengthy variation sets (partite) will presumably follow in a second volume. This first volume actually comprises two separate items in distinct formats, held in a paper slipcase: a bilingual Italian-English textual apparatus in upright format, and a score volume in organ (landscape) orientation. Pages in the "apparatus" volume bear roman numeration; arabic pagination is used for the scores. I have not read Fabiana Ciampi's Italian translation of the verbal matter word-for-word, but spot-checking revealed no inaccuracies. …

Fil: Lopardo, Gustavo. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Lopardo, Gustavo. Fundación del Centro de Estudios Infectológicos; Argentina Fil: Belloso, Waldo H. Hospital Italiano de Buenos Aires. Department of Research; Argentina Fil: Nannini, Esteban. Sanatorio Británico. Departamento de Enfermedades Infecciosas; Argentina Fil: Nannini, Esteban. Consejo Nacional de Investigaciones Científicas y Tecnicas; Argentina Fil: Colonna, Mariana. Inmunova S.A; Argentina Fil: Sanguineti, Santiago. Inmunova S.A; Argentina Fil: Zylberman, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Zylberman, Vanesa. Inmunova S.A; Argentina Fil: Munoz, Luciana. Inmunova S.A; Argentina Fil: Dobarro, Martín. Sanatorio Sagrado Corazón; Argentina Fil: Lebersztein, Gabriel. Sanatorio Sagrado Corazón; Argentina Fil: Farina, Javier. Hospital de Alta Complejidad Cuenca Alta Néstor Kirchner; Argentina Fil: Vidiella, Gabriela. Sanatorio Agote; Argentina Fil: Bertetti, Anselmo. Sanatorio Güemes; Argentina Fil: Crudo, Favio. Hospital Municipal Emilio Zerboni; Argentina Fil: Crudo, Favio. Universidad Nacional de San Antonio de Areco; Argentina Fil: Alzogaray, María Fernanda. Instituto Medico Platense; Argentina Fil: Barcelona, Laura. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Teijeiro, Ricardo. Hospital General de Agudos Dr. Ignacio Pirovano; Argentina Fil: Lambert, Sandra. Hospital de Alta Complejidad El Cruce Néstor Kirchner; Argentina Fil: Scublinsky, Darío. Clínica Zabala; Argentina Fil: Iacono, Marisa. Hospital Provincial Neuquén Dr. Castro Rendón; Argentina Fil: Stanek, Vanina. Hospital Italiano de Buenos Aires. Servicio de Medicina Interna. Sección de Infectología; Argentina Fil: Solari, Ruben. Hospital de Infecciosas Francisco Javier Muñiz; Argentina Fil: Cruz, Pablo. Centro Gallego de Buenos Aires; Argentina Fil: Casas, Marcelo Martín. Clínica Adventista Belgrano; Argentina Fil: Abusamra, Lorena. Hospital Municipal Dr. Diego Thompson; Argentina Fil: Luciardi, Hector Lucas. Hospital Centro de Salud Zenón J. Santillán; Argentina Fil: Cremona, Alberto. Hospital Italiano La Plata; Argentina Fil: Caruso, Diego. Hospital Español; Argentina Fil: Miguel, Bernardo de. mAbxience; España Fil: Millan, Susana. mAbxience; España Fil: Kilstein, Yael. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Kilstein, Yael. Hospital Italiano de Buenos Aires. Department of Research; Argentina Fil: Pereiro, Ana. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Pereiro, Ana. Sanatorio Británico. Departamento de Enfermedades Infecciosas; Argentina Fil: Sued, Omar. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Sued, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cahn, Pedro. Hospital Municipal Dr. Bernardo Houssay; Argentina Fil: Cahn, Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Spatz, Linus. Inmunova S.A.; Argentina Fil: Goldbaum, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Goldbaum, Fernando. Inmunova S.A.; Argentina Fil: Goldbaum, Fernando. Fundación Instituto Leloir; Argentina Fil: Goldbaum, Fernando. Universidad Nacional de San Martín Campus Miguelete. Centro de Rediseño e Ingeniería en Proteínas; Argentina Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Tecnicas; Argentina Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina Fil: Pérez Lloret, Santiago. Universidad Abierta Interamericana. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina Abstract: Background: passive immunotherapy is a therapeutic alternative for patients with COVID-19. Equine polyclonal antibodies (EpAbs) could represent a source of scalable neutralizing antibodies against SARS-CoV-2. Methods: we conducted a double-blind, randomized, placebo-controlled trial to assess efficacy and safety of EpAbs (INM005) in hospitalized adult patients with moderate and severe COVID-19 pneumonia in 19 hospitals of Argentina. Primary endpoint was improvement in at least two categories in WHO ordinal clinical scale at day 28 or hospital discharge (ClinicalTrials.gov number NCT04494984). Findings: between August 1st and October 26th, 2020, a total of 245 patients were enrolled. Enrolled patients were assigned to receive two blinded doses of INM005 (n = 118) or placebo (n = 123). Median age was 54 years old, 65 1% were male and 61% had moderate disease at baseline. Median time from symptoms onset to study treatment was 6 days (interquartile range 5 to 8). No statistically significant difference was noted between study groups on primary endpoint (risk difference [95% IC]: 5 28% [-3 95; 14 50]; p = 0 15). Rate of improvement in at least two categories was statistically significantly higher for INM005 at days 14 and 21 of follow-up. Time to improvement in two ordinal categories or hospital discharge was 14 2 (§ 0 7) days in the INM005 group and 16 3 (§ 0 7) days in the placebo group, hazard ratio 1 31 (95% CI 1 0 to 1 74). Subgroup analyses showed a beneficial effect of INM005 over severe patients and in those with negative baseline antibodies. Overall mortality was 6 9% the INM005 group and 11 4% in the placebo group (risk difference [95% IC]: 0 57 [0 24 to 1 37]). Adverse events of special interest were mild or moderate; no anaphylaxis was reported. Interpretation: Albeit not having reached the primary endpoint, we found clinical improvement of hospitalized patients with SARS-CoV-2 pneumonia, particularly those with severe disease.

The Music of Luigi Dallapiccola. By Raymond Fearn. (Eastman Studies in Music.) Rochester, NY: University of Rochester Press, 2003. [xviii, 303 p. ISBN 1-58046-OV8-X. $90.] Music examples, list of compositions, bibliography, index. English readers have long awaited a definitive book on the life and works of Luigi Dallapiccola. While American and British writers have produced a number of important articles and essays and a handful of unpublished doctoral dissertations on specific works from Dallapiccola's oeuvre, there is to date neither a full-scale biographical study nor a critical examination of his compositional output. Raymond Fearn seeks to fill this serious gap for English readers of Iwenticth-century music history by providing a study of the complete works of Dallapiccola documented with information about their historical context. The book complements Dietrich Kamper's study of twenty years ago (Gefangenschaft und Freiheil: Leben und Werk des Komponisten Luigi Dallapiccola [Koln: Gitarre + Laute Verlag, 1984]) and Mario Ruffini's recent sourcebook (L'opera di Luigi Dallapiccola: Catalogo Ragionato [Milan: Edizioni Suvini Zerboni, 2002]). The real strength of Fearn's book is found in its historical and biographical side, providing the reader with much information and detail that has never been made available in print. Especially in the first chapter, the author provides a wealth of information about Dallapiccola's musical training and background and aspects of his musical life and literary activity in Italy prior to the Second World War. The book also includes very full discussions of Dallapiccola's literary sources and the role that Laura Dallapiccola played in helping him to make judicious textual choices. Fearn has consulted a wide range of both primary and secondary source materials: sketches, letters, notebooks, and diaries from the archival collection in Florence, Italy; writings of and consultation with specialists; and interviews with members of the Dallapiccola family. Included is an accurate listing of the composer's published compositions and writings on music, a good selective list of secondary literature on Dallapiccola, and a substantial listing of current secondary literature on twelve-tone music in general. The book is organized under six chronologically ordered headings: "The Beginnings (1904-1938)"; "Self-Exile and Discovery (1939-1945)"; "Towards the Light of Freedom (1945-1948)"; "The Serial Idea (1948-1953)"; "Text and Symbol (1954-1964)"; and "Ulysses, Wanderer and Discoverer (1965-1975)." Whereas these titles are useful in identifying thematic elements that Fearn wishes to explore in the book, the chronological divisions thus established separate compositional groups that were conceived together. In particular, the constellation of works that include the piano set Quaderno musicale di Annalibera (1951-52), the Vanazioni per Orchestra (1954), and the symphonic choral work Canti di liberazione (1951-55), all based upon the same tone row, are discussed in separate chapters without reference to mutual influences between them and the place that such mutual influence played in Dallapiccola's development as a composer of large-scale serial works. There is also an inconsistency in the purpose of the individual chapter titles when they also serve as guides to the composer's chronology. Is the reader to infer that Dallapiccola's compositional procedure varied between nonreferential structuralism ("The Serial Idea") and poetic conception ("Towards the Light of Freedom") in different periods of his life? The chronological approach followed in this text would be better served with chapter divisions and titles that reflect musical stylistic changes, probably with a break before Liriche greche (begun in 1942), the first completely serial work; a second break after Canti di liberazione (1955), when the Quaderno/Variazioni/Canti group was completed; while retaining the final break in 1964. …

1. Zerboni L, 2. Nader S, 3. Aoki K, 4. Arvin AM (1998) J Infect Dis. 177:1701–1704. [OpenUrl][1][Abstract/FREE Full Text][2] #### Purpose of the Study To evaluate the persistence of humoral and cellular immunity to varicella-zoster virus (VZV) in children and adults immunized with live attenuated VZV vaccine. ##### Study Population Two hundred healthy children (ages 2–12 years) and forty healthy adults (ages 13–45 years) were vaccinated and identified as seroconverters who did not develop breakthrough varicella. Of these individuals, 60 children and 18 adults agreed to be reevaluated. … [1]: {openurl}?query=rft.jtitle%253DJ%2BInfect%2BDis.%26rft_id%253Dinfo%253Adoi%252F10.1086%252F517426%26rft_id%253Dinfo%253Apmid%252F9607852%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=jinfdis&resid=177/6/1701&atom=%2Fpediatrics%2F104%2FSupplement_2%2F402.2.atom