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Abstract: This paper presents a new approach to constrain paleoburial and subsequent uplift by folding in fold–thrust belts, combining differential stress estimates from mechanically-induced calcite twins with the assumption that stress in the upper crust is in frictional equilibrium. Calcite twin data were collected from pre-folding veins in late Cretaceous limestones from the Ionian zone in Albania in order to (1) determine Paleogene–Neogene stresses associated with the development of the major vein sets in the frontal anticlines of the Outer Albanides and (2) estimate paleoburial of the Cretaceous reservoir rocks during pre-folding flexural subsidence of the foreland. The first vein set (set I) trends N140 (±20) and the second set (set II) is oriented N060 (±20). Calcite twinning analysis from set I veins reveals a pre-folding N030° extension likely related to foreland flexure; a later pre-folding, NE-directed compression (LPS) is identified either from one or from both vein sets in the samples from the Saranda anticline; this NE compression is instead recorded by twinning in set II veins from the Kremenara anticline during late stage fold tightening. This NE compression well agrees with independent microtectonic data, regional transport direction and contemporary stress. The differential stress values related to this NE compression are combined with the hypothesis of crustal frictional stress equilibrium to derive first-order estimates of paleoburial of the Cretaceous limestones just before they were uplifted by folding. The ~4 km paleoburial of these limestones estimated in the Saranda anticline is consistent with independent paleoburial estimates from stratigraphy, maturity rank of organic matter, paleotemperature/paleogeothermal gradients from fluid inclusions and predictions of kinematic modelling of the Albanian foreland. Our results therefore place reliable constraints on the amount and rate of vertical uplift of these Cretaceous limestones and yield a promising methodology for better constraining paleoburial and therefore erosion and uplift in fold–thrust belts. [Copyright &y& Elsevier]