1. No Causal Relation Between Bupropion in Therapeutic Dose and Serotonin Toxicity.
- Author
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Borgsteede, Sander D., Birkenhager, Tom K., Zaal, Rianne J., and Alsma, Jelmer
- Subjects
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BUPROPION , *MEDICAL personnel , *MEDICAL personnel as patients - Abstract
They described 266 single-agent bupropion intoxications, with 13 patients diagnosed with serotonin toxicity (ST), and conclude that bupropion overdose may be associated with ST. As the risk profile of bupropion in the therapeutic range has proven to be acceptable without any proven risks for ST [[5]], it is remarkable that Murray advises to avoid the combination of bupropion with serotonergic medication. With a number of prescriptions of bupropion of about 25 million prescriptions in the USA in 2017 [[10]], it can be expected that a substantial number of patients combine bupropion with serotonergic medication. [Extracted from the article]
- Published
- 2020
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