1. Isolated Tramadol Overdose Associated with Brugada ECG Pattern.
- Author
-
COLE, JON B., SATTIRAJU, SRINIVASAN, BILDEN, ELISABETH F., ASINGER, RICHARD W., and BERTOG, STEFAN C.
- Subjects
DRUG overdose ,ELECTROCARDIOGRAPHY ,ARTIFICIAL respiration ,MENTAL depression ,DRUG toxicity ,ECHOCARDIOGRAPHY ,HIGH performance liquid chromatography ,NALOXONE ,SUICIDE ,BRUGADA syndrome ,TRAMADOL ,CORONARY angiography ,DIAGNOSIS - Abstract
Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication. (PACE 2012; 35:e219-e221) [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF