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23 results on '"Herzig, Stephan"'

4. Endocrine and autocrine/paracrine modulators of brown adipose tissue mass and activity as novel therapeutic strategies against obesity and type 2 diabetes.

Author

Scheideler, Marcel, Herzig, Stephan, and Georgiadi, Anastasia

Subjects
*OBESITY treatment, *BROWN adipose tissue, *TYPE 2 diabetes, *WHITE adipose tissue, *THERAPEUTICS
Abstract

The dramatically increasing world-wide prevalence of obesity is recognized as a risk factor for the development of various diseases. The growing research on the role of adipose tissue in controlling energy homeostasis and insulin sensitivity has revealed that the promotion of brown adipose tissue (BAT) activity and the browning of white adipose tissue (WAT) leads to multiple health benefits and prevents obesity and type 2 diabetes (T2D). Inducible thermogenic adipocytes do exist in adult humans and are linked with increased energy combustion and lower body fat mass. Thus brown adipocytes are currently placed at the center of attention for novel therapeutic strategies against metabolic diseases such as obesity and diabetes. Besides the classical, norepinephrinemediated sympathetic recruitment and activation of thermogenic adipocytes, a number of novel circulating factors have been recently identified to have a positive or negative impact on thermogenic adipocyte formation and activity. In this review their mechanism of action and the plausible therapeutic applications will be summarized and discussed. [ABSTRACT FROM AUTHOR]

Published
2017
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5. In vivo assessment of cold stimulation effects on the fat fraction of brown adipose tissue using DIXON MRI.

Author

Stahl, Vanessa, Maier, Florian, Freitag, Martin T., Floca, Ralf O., Berger, Moritz C., Umathum, Reiner, Berriel Diaz, Mauricio, Herzig, Stephan, Weber, Marc‐André, Dimitrakopoulou‐Strauss, Antonia, Rink, Kristian, Bachert, Peter, Ladd, Mark E., Nagel, Armin M., Weber, Marc-André, and Dimitrakopoulou-Strauss, Antonia

Subjects
ADIPOSE tissue physiology, ADIPOSE tissues, ALGORITHMS, ANTHROPOMETRY, BODY temperature, COLD (Temperature), DIAGNOSTIC imaging, MAGNETIC resonance imaging, COMPUTERS in medicine, RESEARCH evaluation, PHYSIOLOGICAL stress, ANATOMY
Abstract

Purpose: To evaluate the volume and changes of human brown adipose tissue (BAT) in vivo following exposure to cold using magnetic resonance imaging (MRI).Materials and Methods: The clavicular region of 10 healthy volunteers was examined with a 3T MRI system. One volunteer participated twice. A cooling vest that was circulated with temperature-controlled water was used to expose each volunteer to a cold environment. Three different water temperature phases were employed: baseline (23°C, 20 min), cooling (12°C, 90 min), and a final warming phase (37°C, 30 min). Temperatures of the water in the circuit, of the body, and at the back skin of the volunteers were monitored with fiberoptic temperature probes. Applying the 2-point DIXON pulse sequence every 5 minutes, fat fraction (FF) maps were determined and evaluated over time to distinguish between brown and white adipose tissue.Results: Temperature measurements showed a decrease of 3.8 ± 1.0°C of the back skin temperature, while the body temperature stayed constant at 37.2 ± 0.9°C. Focusing on the two interscapular BAT depots, a mean FF decrease of -2.9 ± 2.0%/h (P < 0.001) was detected during cold stimulation in a mean absolute volume of 1.31 ± 1.43 ml. Also, a correlation of FF decrease to back skin temperature decrease was observed in all volunteers (correlation coefficients: |r| = [0.51; 0.99]).Conclusion: We found that FF decreases in BAT begin immediately with mild cooling of the body and continue during long-time cooling.Level Of Evidence: 2 J. Magn. Reson. Imaging 2017;45:369-380. [ABSTRACT FROM AUTHOR]

Published
2017
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6. Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells.

Author

Medrikova, Dasa, Sijmonsma, Tjeerd P., Sowodniok, Katharina, Richards, David M., Delacher, Michael, Sticht, Carsten, Gretz, Norbert, Schafmeier, Tobias, Feuerer, Markus, and Herzig, Stephan

Subjects
BROWN adipose tissue, T cells, CELLULAR control mechanisms, IMMUNE response, METABOLIC regulation, GENE expression
Abstract

Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature. As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress. [ABSTRACT FROM AUTHOR]

Published
2015
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7. Thermogenic adipocytes: From cells to physiology and medicine.

Author

Diaz, Mauricio Berriel, Herzig, Stephan, and Vegiopoulos, Alexandros

Subjects
BODY temperature regulation, FAT cells, CLINICAL trials, METABOLIC disorders, BODY mass index, POSITRON emission tomography, PLATELET-derived growth factor
Abstract

The identification of active brown fat in humans has evoked widespread interest in the biology of non-shivering thermogenesis among basic and clinical researchers. As a consequence we have experienced a plethora of contributions related to cellular and molecular processes in thermogenic adipocytes as well as their function in the organismal context and their relevance to human physiology. In this review we focus on the cellular basis of non-shivering thermogenesis, particularly in relation to human health and metabolic disease. We provide an overview of the cellular function and distribution of thermogenic adipocytes in mouse and humans, and how this can be affected by environmental factors, such as prolonged cold exposure. We elaborate on recent evidence and open questions on the distinction of classical brown versus beige/brite adipocytes. Further, the origin of thermogenic adipocytes as well as current models for the recruitment of beige/brite adipocytes is discussed with an emphasis on the role of progenitor cells. Focusing on humans, we describe the expanding evidence for the activity, function and physiological relevance of thermogenic adipocytes. Finally, as the potential of thermogenic adipocyte activation as a therapeutic approach for the treatment of obesity and associated metabolic diseases becomes evident, we highlight goals and challenges for current research on the road to clinical translation. [ABSTRACT FROM AUTHOR]

Published
2014
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8. Browning of White Adipose Tissue Uncouples Glucose Uptake from Insulin Signaling.

Author

Mössenböck, Karin, Vegiopoulos, Alexandros, Rose, Adam J., Sijmonsma, Tjeerd P., Herzig, Stephan, and Schafmeier, Tobias

Subjects
WHITE adipose tissue, BROWN adipose tissue, MAMMAL body composition, OVERWEIGHT persons, PEOPLE with diabetes
Abstract

Presence of thermogenically active adipose tissue in adult humans has been inversely associated with obesity and type 2 diabetes. While it had been shown that insulin is crucial for the development of classical brown fat, its role in development and function of inducible brown-in-white (brite) adipose tissue is less clear. Here we show that insulin deficiency impaired differentiation of brite adipocytes. However, adrenergic stimulation almost fully induced the thermogenic program under these settings. Although brite differentiation of adipocytes as well as browning of white adipose tissue entailed substantially elevated glucose uptake by adipose tissue, the capacity of insulin to stimulate glucose uptake surprisingly was not higher in the brite state. Notably, in line with the insulin-independent stimulation of glucose uptake, our data revealed that brite recruitment results in induction of solute carrier family 2 (GLUT-1) expression in adipocytes and inguinal WAT. These results for the first time demonstrate that insulin signaling is neither essential for brite recruitment, nor is it improved in cells or tissues upon browning. [ABSTRACT FROM AUTHOR]

Published
2014
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9. Techniques and Applications of Magnetic Resonance Imaging for Studying Brown Adipose Tissue Morphometry and Function

Author

Karampinos, Dimitrios C., Weidlich, Dominik, Wu, Mingming, Hu, Houchun H., Franz, Daniela, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor

Published
2019
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10. Brown Adipose Tissue Development and Metabolism

Author

Jung, Su Myung, Sanchez-Gurmaches, Joan, Guertin, David A., Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor

Published
2019
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11. Translational Aspects of Brown Fat Activation by Food-Derived Stimulants

Author

Yoneshiro, Takeshi, Matsushita, Mami, Saito, Masayuki, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor

Published
2019
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12. Aging of Brown and Beige/Brite Adipose Tissue

Author

Graja, Antonia, Gohlke, Sabrina, Schulz, Tim J., Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor

Published
2019
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13. Multispectral Optoacoustic Tomography of Brown Adipose Tissue

Author

Karlas, Angelos, Reber, Josefine, Liapis, Evangelos, Paul-Yuan, Korbinian, Ntziachristos, Vasilis, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor

Published
2019
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14. Regulatory Small and Long Noncoding RNAs in Brite/Brown Adipose Tissue

Author

Scheideler, Marcel, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor

Published
2019
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15. Infrared Thermography

Author

Law, James, Morris, David E., Budge, Helen, Symonds, Michael E., Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor

Published
2019
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16. In Vivo Detection of Human Brown Adipose Tissue During Cold and Exercise by PET/CT

Author

Nascimento, Emmani B. M., van Marken Lichtenbelt, Wouter D., Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor

Published
2019
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17. Brown Adipose Tissue in Human Infants

Author

Lidell, Martin E., Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor

Published
2019
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18. Brown Adipokines

Author

Villarroya, Francesc, Gavaldà-Navarro, Aleix, Peyrou, Marion, Villarroya, Joan, Giralt, Marta, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor

Published
2019
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19. Role of cAMP and cGMP Signaling in Brown Fat

Author

Reverte-Salisa, Laia, Sanyal, Abhishek, Pfeifer, Alexander, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor

Published
2019
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20. Evolution of UCP1

Author

Gaudry, Michael J., Campbell, Kevin L., Jastroch, Martin, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor

Published
2019
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21. BAT Exosomes: Metabolic Crosstalk with Other Organs and Biomarkers for BAT Activity

Author

Goody, Deborah, Pfeifer, Alexander, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, Pfeifer, Alexander, editor, Klingenspor, Martin, editor, and Herzig, Stephan, editor

Published
2019
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22. cGMP and Brown Adipose Tissue

Author

Hoffmann, Linda S., Larson, Christopher J., Pfeifer, Alexander, Rosenthal, Walter, Editor-in-chief, Barrett, James E., Series editor, Flockerzi, Veit, Series editor, Frohman, Michael A., Series editor, Geppetti, Pierangelo, Series editor, Hofmann, Franz B., Series editor, Michel, Martin C., Series editor, Page, Clive P., Series editor, Thorburn, Andrew M., Series editor, Wang, KeWei, Series editor, and Herzig, Stephan, editor

Published
2016
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23. The role of brown and beige adipose tissue in glycaemic control.

Author

Klepac, Katarina, Georgiadi, Anastasia, Tschöp, Matthias, and Herzig, Stephan

Subjects
*BROWN adipose tissue, *ADIPOSE tissues, *GLUCOSE metabolism, *METABOLIC disorders
Abstract

For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting the so-called batokines to communicate with other metabolic tissues and regulate systemic energy homeostasis. However, despite numerous studies showing the benefits of BAT in rodents, it is still not clear whether recruitment of BAT can be utilized to treat human patients. Here, we review the advances on understanding the role of BAT in metabolism and its benefits on glucose and lipid homeostasis in both humans and rodents. Moreover, we discuss the latest methodological approaches to assess the contribution of BAT to human metabolism as well as the possibility to target BAT, pharmacologically or by lifestyle adaptations, to treat metabolic disorders. [ABSTRACT FROM AUTHOR]

Published
2019
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