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Your search keyword '"Zingaretti, M. C."' showing total 2 results
Start Over Author "Zingaretti, M. C." Topic brown adipocyte
2 results on '"Zingaretti, M. C."'

1. The Adipose Organ Is a Unitary Structure in Mice and Humans.

Author

Giordano, A., Cinti, F., Canese, R., Carpinelli, G., Colleluori, G., Di Vincenzo, A., Palombelli, G., Severi, I., Moretti, M., Redaelli, C., Partridge, J., Zingaretti, M. C., Agostini, A., Sternardi, F., Giovagnoni, A., Castorina, S., and Cinti, S.

Subjects
ADIPOSE tissues, ORGANS (Anatomy), MAGNETIC resonance imaging, MICE, OBESITY
Abstract

Obesity is the fifth leading cause of death worldwide. In mice and humans with obesity, the adipose organ undergoes remarkable morpho-functional alterations. The comprehension of the adipose organ function and organization is of paramount importance to understand its pathology and formulate future therapeutic strategies. In the present study, we performed anatomical dissections, magnetic resonance imaging, computed axial tomography and histological and immunohistochemical assessments of humans and mouse adipose tissues. We demonstrate that most of the two types of adipose tissues (white, WAT and brown, BAT) form a large unitary structure fulfilling all the requirements necessary to be considered as a true organ in both species. A detailed analysis of the gross anatomy of mouse adipose organs in different pathophysiological conditions (normal, cold, pregnancy, obesity) shows that the organ consists of a unitary structure composed of different tissues: WAT, BAT, and glands (pregnancy). Data from autoptic dissection of 8 cadavers, 2 females and 6 males (Age: 37.5 ± 9.7, BMI: 23 ± 2.7 kg/m2) and from detailed digital dissection of 4 digitalized cadavers, 2 females and 2 males (Age: 39 ± 14.2 years, BMI: 22.8 ± 4.3 kg/m2) confirmed the mixed (WAT and BAT) composition and the unitary structure of the adipose organ also in humans. Considering the remarkable endocrine roles of WAT and BAT, the definition of the endocrine adipose organ would be even more appropriate in mice and humans. [ABSTRACT FROM AUTHOR]

Published
2022
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2. Adipocyte metabolism and cellularity are related to differences in adipose tissue maturity between Holstein and Charolais or Blond d'Aquitaine fetuses

Author

Taga, Hajer, Bonnet, Muriel, Picard, Brigitte, Zingaretti, M. C., Cassar-Malek, Isabelle, Cinti, S., Chilliard, Yves, Unité de Recherches sur les Herbivores (URH), Institut National de la Recherche Agronomique (INRA), Università Politecnica delle Marche, and Partenaires INRAE

Subjects
breed, white adipocyte, [SDV]Life Sciences [q-bio], ENERGY-METABOLISM, SERUM LEPTIN CONCENTRATIONS, [SHS]Humanities and Social Sciences, NEWBORN CALF, bovine fetus, lipid metabolism, morphology, BROWN ADIPOCYTES, UNCOUPLING PROTEIN, DEVELOPMENTAL-CHANGES, [INFO]Computer Science [cs], ENZYME-ACTIVITIES, FATTY-ACIDS, WHITE FAT, MESSENGER-RNA, brown adipocyte
Abstract

International audience; This paper reports the metabolic and morphological characteristics of bovine adipose tissue (AT) at end of fetal life and its variability with breed and anatomical site of AT. Our hypothesis was that, in cattle, end-of-fetal-life differences in adipocyte number, size, and histology may account for differences in AT maturity. To address this question, perirenal and intermuscular AT were sampled from Charolais, Blond d'Aquitaine, and Holstein fetuses at 260 d postconception. Holstein fetuses showed greater leptin mRNA abundance, which is consistent with the greater perirenal AT weight (P = 0.03) than Blond d'Aquitaine fetuses. Compared with Blond d'Aquitaine or Charolais fetuses, Holstein fetuses had larger (P < 0.001) adipocytes, greater (P < 0.05) activities of enzymes involved in de novo fatty acid (FA) synthesis (FA synthase, glucose- 6- phosphate dehydrogenase, malic enzyme) and FA esterification (glycerol- 3- phosphate dehydrogenase), and greater (P = 0.06, P = 0.10, P < 0.001) mRNA abundance for lipolytic enzymes (hormone- sensitive li- pase and adipose triglyceride lipase) and uncoupling protein 1 in both perirenal and intermuscular AT. This indicates increased FA turnover in Holstein adipocytes through FA storage, mobilization, and oxidation pathways. Whatever the breed, adipocytes were smaller in perirenal AT than intermuscular AT. Whatever the breed or anatomical site, bovine AT at 260 d postconception contained predominantly unilocular adipocytes believed to be white adipocytes together with a few multilocular brown adipocytes. We conclude that the greater metabolic and morphologic maturity of adipocytes from Holstein than Blond d'Aquitaine and Charolais fetuses may contribute to the greater thermogenic aptitude of Holstein newborns. Moreover, the presence of both white and brown adipocytes at the end of fetal life highlights the complexity of AT structure and may indicate that the cellular and functional heterogeneity of AT repeatedly observed postnatally has a developmental origin.

Published
2011
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