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Your search keyword '"Bonikos D"' showing total 2 results
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2 results on '"Bonikos D"'

1. Endocrine cells of bronchial and bronchiolar epithelium.

Author

Bonikos DS and Benson KG

Subjects
APUD Cells physiology, Bronchi metabolism, Bronchi pathology, Carcinoma, Small Cell metabolism, Enterochromaffin Cells metabolism, Enterochromaffin Cells pathology, Epithelial Cells, Epithelium metabolism, Epithelium pathology, Humans, Bronchi cytology
Abstract

Among the epithelial elements of the pulmonary airways are cells with features suggestive of endocrine function. Although these cells share a number of properties with the intestinal endocrine (argentaffine) cells, peptide hormones analogous to the multitude of those present in the gastrointestinal tract have yet to be identified in the lung. The oat cell carcinoma, which arises from this cell type, is of importance clinically, yet investigations into the basic properties and functions of this cell have been difficult and sparse, in part due to a lack of appreciation of the problem.

Published
1977
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2. Oxygen toxicity in the newborn. The effect of chronic continuous 100 percent oxygen exposure on the lungs of newborn mice

Author

Bonikos, D. S., Bensch, K. G., and Northway, W. H.

Subjects
Pulmonary Fibrosis, Bronchi, Epithelial Cells, Organ Size, Epithelium, Mice, Inbred C57BL, Oxygen, Pulmonary Alveoli, Mice, Necrosis, Animals, Newborn, Animals, Mortality, Lung, Cell Division, Research Article
Abstract

Continuous exposure of newborn mice of a single, highly inbred strain to 100% oxygen at normal atmospheric pressure for up to 6 weeks resulted in a progressive evolution of pulmonary changes which consisted of dense fibrous tissue deposition, chronic bronchitis and bronchiolitis, and emphysema. Survival of the experimental animals decreased with the duration of exposure, and it was 18% after the sixth week. While the pulmonary changes were evolving, lung growth was markedly inhibited in the experimental animals, whereas lung weight increased significantly. The present study indicates that in contrast to the adult mouse, survival of a substantial percentage of newborn mice for at least 6 weeks is possible, but it is associated with severe changes in pulmonary structure that doubtlessly lead to serious derangement of cardiopulmonary functions.

Published
1976

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