1. Diffusely Metastasized Adenocarcinoma Arising in a Mucinous Carcinoid of the Ovary: A Case Report.
- Author
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Van Rompuy AS, Vanderstichele A, Vergote I, and Moerman P
- Subjects
- Adenocarcinoma, Mucinous pathology, Adenocarcinoma, Mucinous secondary, Breast Neoplasms pathology, Breast Neoplasms secondary, Carcinoid Tumor metabolism, Carcinoid Tumor pathology, Diagnosis, Differential, Female, Humans, Immunohistochemistry, Keratin-7 metabolism, Middle Aged, Neoplasm Metastasis, Ovarian Neoplasms metabolism, Ovarian Neoplasms pathology, Ovary metabolism, Ovary pathology, Adenocarcinoma, Mucinous diagnosis, Biomarkers, Tumor metabolism, Breast Neoplasms diagnosis, Carcinoid Tumor diagnosis, Ovarian Neoplasms diagnosis, PAX8 Transcription Factor metabolism
- Abstract
Mucinous (goblet cell) carcinoids are a rare type of ovarian carcinoid tumors. Only a limited number of primary mucinous carcinoids of the ovary have been reported in the literature. We describe the case of a 55-year-old woman with a diffusely metastasized adenocarcinoma arising in a primary ovarian mucinous carcinoid. The differential diagnosis with a metastatic goblet cell carcinoid from the appendix or elsewhere can be very challenging. In our case, especially the immunohistochemical profile of the tumor with diffuse positivity for cytokeratin 7 and PAX8, and no expression of cytokeratin 20 and CDX2, directed us toward a primary ovarian origin. Expression of PAX8 in ovarian mucinous carcinoid has never been reported before.
- Published
- 2018
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