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Start Over Author "Atiba JO" Topic breast neoplasms
2 results on '"Atiba JO"'

1. Phase II evaluation of mitoxantrone plus cis-platinum in patients with advanced breast cancer. A Southwest Oncology Group study.

Author

Atiba JO, Green SJ, Hynes HE, Osborne CK, Miller TP, and Davidner M

Subjects
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Cisplatin administration & dosage, Female, Humans, Middle Aged, Mitoxantrone administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms drug therapy
Abstract

The Southwest Oncology Group studied the response rate and toxicity of mitoxantrone (7.5 or 10 mg/m2 to 12.0 mg/m2) and cis-platinum (100 mg/m2) in 30 patients with advanced breast cancer as second-line therapy. There were 2 partial responses in 29 eligible patients. Toxicity was considerable, with 27 patients having grade 3 or 4 toxicity. Grade 3-4 toxicity included vomiting, thrombocytopenia, granulocytopenia, leukopenia and anemia. The combination of mitoxantrone plus cis-platinum has minimal activity as second-line therapy in metastatic breast cancer.

Published
1994
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2. Chemoprevention of breast cancer.

Author

Atiba JO and Meyskens FL Jr

Subjects
Animals, Diet, Female, Humans, Antineoplastic Agents therapeutic use, Breast Neoplasms prevention & control
Published
1992

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