1. Hysteroscopic Endometrial Resection in Women Treated With Tamoxifen for Breast Cancer Provides Definitive Diagnosis and Effective Long-Term Therapy.
- Author
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Vilos GA, Alzawawi N, Oraif A, Lam JS, Badeghiesh A, Abu-Rafea B, and Vilos AG
- Subjects
- Antineoplastic Agents, Hormonal therapeutic use, Endometrium pathology, Endometrium surgery, Female, Humans, Hysterectomy, Hysteroscopy, Pregnancy, Tamoxifen therapeutic use, Breast Neoplasms drug therapy, Breast Neoplasms surgery, Endometrial Neoplasms diagnosis, Endometrial Neoplasms pathology, Endometrial Neoplasms surgery, Polyps diagnosis, Polyps pathology, Polyps surgery
- Abstract
We evaluated resectoscopic surgery for definitive diagnosis and long-term therapy in 16 symptomatic tamoxifen-treated women with breast cancer who presented with abnormal uterine bleeding and/or intrauterine anomalies. Seven pre-menopausal women had benign pre- and post-operative endometrial biopsy, and 4 had benign polyps. At a median of 7 years of follow-up (range 2-8 y), all remained amenorrheic. Of 9 post-menopausal women, pre-operative biopsy was inadequate in 4, benign endometrium was found in 4, and non-atypical endometrial hyperplasia was found in 1. Post-operatively, all had benign pathology, 8 having polyp and 1 leiomyoma. At a median follow-up of 7 years (range 2-13 y), all were amenorrheic, with no recurrence of breast cancer or uterine pathology., (Copyright © 2021 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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