1. Sonoelastography in the diagnosis of malignant and benign breast lesions: initial clinical experiences.
- Author
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Hatzung G, Grunwald S, Zygmunt M, Geaid AA, Behrndt PO, Isermann R, Kohlmann T, and Ohlinger R
- Subjects
- Adenocarcinoma, Mucinous diagnostic imaging, Adenocarcinoma, Mucinous pathology, Adult, Aged, Biopsy methods, Breast pathology, Breast Diseases pathology, Breast Neoplasms pathology, Carcinoma, Ductal diagnostic imaging, Carcinoma, Intraductal, Noninfiltrating diagnostic imaging, Carcinoma, Intraductal, Noninfiltrating pathology, Carcinoma, Lobular diagnostic imaging, Carcinoma, Lobular pathology, Female, Fibroadenoma diagnostic imaging, Fibroadenoma pathology, Humans, Middle Aged, Papilloma diagnostic imaging, Papilloma pathology, Prospective Studies, Sensitivity and Specificity, Breast Diseases diagnostic imaging, Breast Neoplasms diagnostic imaging, Elasticity Imaging Techniques methods, Ultrasonography, Mammary methods
- Abstract
Purpose: This prospective study aimed to compare sonoelastography, B-mode ultrasonography, and mammography in terms of their ability to distinguish benign from malignant breast lesions. We also assessed how the diagnostic value of sonoelastography differs between palpable and clinically occult lesions., Materials and Methods: Evaluation revealed a total of 97 lesions (66 benign; 31 malignant) without histological confirmation at the time of the initial examination. The sensitivity, specificity, positive (PPV) and negative predictive value (NPV) as well as efficiency were calculated. These parameters were separately assessed for palpable lesions and for non-palpable lesions. We subsequently compared these results., Results: Sonography had a sensitivity of 97% and a specificity of 82% (PPV: 71 %, NPV: 98%, efficiency: 87%). For mammography, the respective figures were 84% and 89% (PPV: 79%, NPV: 92%, efficiency: 88%). Sonoelastography had a sensitivity of 71% and a specificity of 48% (PPV: 39%, NPV: 78%, efficiency: 56%). The combination of sonography and sonoelastography yielded a sensitivity of 100% and a specificity of 38% (PPV: 43%, NPV: 100%, efficiency: 58%). The sensitivity and specificity were not statistically different between the groups of palpable and non-palpable lesions., Conclusion: Sonoelastography is easily performed and not very time-consuming. Used by itself, the method is not more efficacious than alternative techniques. When used in conjunction with B-mode ultrasonography, the latter's sensitivity was increased, albeit at the expense of specificity., (© Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2010
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