1. The impact of G protein-coupled oestrogen receptor 1 on male breast cancer: a retrospective analysis.
- Author
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Maiwald, Jan-Hendrik, Sprung, Susanne, Czapiewski, Piotr, Lessel, Wiebke, Scherping, Anna, Schomburg, Dirk, Plaumann, Markus, Tomasik, Bartłomiej, Behre, Gerhard, Haybaeck, Johannes, Ignatov, Atanas, Eggemann, Holm, and Nass, Norbert
- Subjects
G protein coupled receptors ,BREAST cancer diagnosis ,BREAST cancer prognosis ,IMMUNOHISTOCHEMISTRY ,KAPLAN-Meier estimator - Abstract
Introduction: The G protein-coupled oestrogen receptor 1 (GPER-1) is a potential prognostic marker in breast cancer. However, its role in male breast cancer (MBC) is still unknown. This study evaluates the expression of GPER-1 in MBC samples and correlates these data with clinical and pathological parameters including patients' survival. Material and methods: For this retrospective analysis of a prospectively maintained cohort of patients with MBC, we examined 161 specimens for GPER-1 expression using immunohistochemistry. An immunoreactive score (IRS) was calculated based on staining intensity and the percentage of positive tumour cells. Then, we correlated GPER-1 IRS with clinical and pathological parameters, and overall and relapse-free survival. Results: About 40% of MBC samples were positive for GPER-1 expression (IRS ≥ 4). There was no significant correlation with clinicopathological parameters, such as hormone receptor status or grading. However, a statistical trend was observed for tumour size (≥ 2 cm, p = 0.093). Kaplan-Meier survival analysis revealed no significant correlation with relapse-free survival. However, there was a significant correlation with overall survival, but when we adjusted the log-rank p-value to compensate for the cut-off point optimization method, it rose above 0.1. Additionally, GPER-1-positive patients were older at diagnosis. When adjusted for age by multivariable Cox regression analysis, the significance of GPER-1 status for survival was further reduced. Conclusions: We found no significant prognostic value of GPER-1 in this MBC cohort as anticipated from studies on female BC. Future studies with higher sample size are needed to further verify a potential sex-specific role of GPER-1. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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