1. The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer.
- Author
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Wu, Hua-Tao, Chen, Wen-Jia, Xu, Ya, Shen, Jia-Xin, Chen, Wen-Tian, and Liu, Jing
- Subjects
BREAST cancer prognosis ,BREAST tumor risk factors ,MORTALITY risk factors ,ANTIGENS ,APOPTOSIS ,CELLULAR signal transduction ,GENE expression ,IRON ,MEMBRANE proteins ,RISK assessment ,SURVIVAL analysis (Biometry) ,KAPLAN-Meier estimator - Abstract
Objective. To investigate the expression patterns and prognostic values of STEAP family members in the occurrence and development of breast cancer. Materials and Methods. The Human Protein Atlas was used to analyze the expression level of STEAPs in human normal tissues and malignant tumors. ONCOMINE datasets were analyzed for the comparison of the STEAPs levels between malignant cancers and corresponding normal tissues. Kaplan-Meier plotter was used to analyze the prognostic value of STEAPs in breast cancer patients. Results. STEAPs were widely distributed in human normal tissues with diverse levels. Normally, it is predicted that STEAP1 and STEAP2 were involved in the mineral absorption process, while STEAP3 participated in the TP53 signaling pathway and iron apoptosis. The results from ONCOMINE showed downregulation of STEAP1, STEAP2, and STEAP4 in breast cancers. Survival analysis revealed that breast cancer patients with high levels of STEAP1, STEAP2, and STEAP4 had a good prognosis, while those with low expression had high overall mortality. Conclusion. STEAP1, STEAP2, and STEAP4 are predicted to be the potential prognostic biomarkers for breast cancer patients, providing novel therapeutic strategies for them. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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