Search

Breast cancer (BC) is the most common cancer among women, making it essential to have an accurate and dependable system for diagnosing benign or malignant tumors. It is essential to detect this cancer early in order to inform subsequent treatments. Currently, fine needle aspiration (FNA) cytology and machine learning (ML) models can be used to detect and diagnose this cancer more accurately. Consequently, an effective and dependable approach needs to be developed to enhance the clinical capacity to diagnose this illness. This study aims to detect and divide BC into two categories using the Wisconsin Diagnostic Breast Cancer (WDBC) benchmark feature set and to select the fewest features to attain the highest accuracy. To this end, this study explores automated BC prediction using multi-model features and ensemble machine learning (EML) techniques. To achieve this, we propose an advanced ensemble technique, which incorporates voting, bagging, stacking, and boosting as combination techniques for the classifier in the proposed EML methods to distinguish benign breast tumors from malignant cancers. In the feature extraction process, we suggest a recursive feature elimination technique to find the most important features of the WDBC that are pertinent to BC detection and classification. Furthermore, we conducted cross-validation experiments, and the comparative results demonstrated that our method can effectively enhance classification performance and attain the highest value in six evaluation metrics, including precision, sensitivity, area under the curve (AUC), specificity, accuracy, and F1-score. Overall, the stacking model achieved the best average accuracy, at 99.89%, and its sensitivity, specificity, F1-score, precision, and AUC/ROC were 1.00%, 0.999%, 1.00%, 1.00%, and 1.00%, respectively, thus generating excellent results. The findings of this study can be used to establish a reliable clinical detection system, enabling experts to make more precise and operative decisions in the future. Additionally, the proposed technology might be used to detect a variety of cancers. [ABSTRACT FROM AUTHOR]

Dysregulation of epigenetic mechanisms have been depicted in several pathological consequence such as cancer. Different modes of epigenetic regulation (DNA methylation (hypomethylation or hypermethylation of promotor), histone modifications, abnormal expression of microRNAs (miRNAs), long non-coding RNAs, and small nucleolar RNAs), are discovered. Particularly, lncRNAs are known to exert pivot roles in different types of cancer including breast cancer. LncRNAs with oncogenic and tumour suppressive potential are reported. Differentially expressed lncRNAs contribute a remarkable role in the development of primary and acquired resistance for radiotherapy, endocrine therapy, immunotherapy, and targeted therapy. A wide range of molecular subtype specific lncRNAs have been assessed in breast cancer research. A number of studies have also shown that lncRNAs may be clinically used as non-invasive diagnostic biomarkers for early detection of breast cancer. Such molecular biomarkers have also been found in cancer stem cells of breast tumours. The objectives of the present review are to summarize the important roles of oncogenic and tumour suppressive lncRNAs for the early diagnosis of breast cancer, metastatic potential, and chemotherapy resistance across the molecular subtypes. [ABSTRACT FROM AUTHOR]

Breast cancer is the most frequent disease in women, with one in every 19 women at risk. Breast cancer is the fifth leading cause of cancer death in women around the world. The most effective and efficient technique of controlling cancer development is early identification. Mammography helps in the early detection of cancer, which saves lives. Many studies conducted various tests to categorize the tumor and obtained positive findings. However, there are certain limits. Mass categorization in mammography is still a problem, although it is critical in aiding radiologists in establishing correct diagnoses. The purpose of this study is to develop a unique hybrid technique to identify breast cancer mass pictures as benign or malignant. The combination of two networks helps accelerate the categorization process. This study proposes a novel-based hybrid approach, CNN-Inception-V4, based on the fusing of these two networks. Mass images are used in this research from the CBIS-DDSM dataset. 450 images are taken for benign, and 450 images are used for malignant. The images are first cleaned by removing pectoral muscles, labels, and white borders. Then, CLAHE is used to these images to improve their quality in order to produce promising classification results. Following preprocessing, our model classifies cancer in mammography pictures as benign or malignant abnormalities. Our proposed model's accuracy is 99.2%, with sensitivity of 99.8%, specificity of 96.3%, and F1-score of 97%. We also compared our proposed model to CNN, Inception-V4, and ResNet-50. Our proposed model outperforms existing classification models, according to the results. [ABSTRACT FROM AUTHOR]