1. Breast cancer grade and stage do not affect fertility preservation outcomes
- Author
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Wald, Kaitlyn, Wang, Ange, Abel, Mary Kathryn, Morris, Jerrine, Letourneau, Joseph M, Mok-Lin, Evelyn, Cedars, Marcelle I, and Rosen, Mitchell P
- Subjects
Reproductive Medicine ,Biomedical and Clinical Sciences ,Clinical Research ,Contraception/Reproduction ,Breast Cancer ,Cancer ,Reproductive health and childbirth ,Breast Neoplasms ,Cryopreservation ,Female ,Fertility Preservation ,Humans ,Oocyte Retrieval ,Oocytes ,Ovulation Induction ,Retrospective Studies ,Fertility preservation ,Breast cancer ,Cancer grade ,Cancer stage ,Genetics ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Reproductive medicine - Abstract
PurposeTo investigate if breast cancer stage and grade affect fertility preservation outcomes.MethodsWe performed a retrospective cohort study that included premenopausal women with breast cancer undergoing fertility preservation diagnosed between January 2011 and January 2019. The primary outcome measure was the number of mature oocytes (MII) per antral follicle count (AFC). Secondary outcome measures included total oocytes retrieved, total mature oocytes retrieved, and greater than 10 mature oocytes preserved. Univariate and multivariate models were used to assess the association of low vs. high stage (low stage I-II and high stage III-IV) and grade I vs. grade II/III with each outcome, with adjustment for confounders.ResultsA total of 267 premenopausal breast cancer patients undergoing fertility preservation were included in our study, with the majority presenting with low stage (N = 215, 80.5%), grade II/III (N = 235, 88.1%) disease. Baseline AFC, total gonadotropin dose, days of stimulation, and follicles [Formula: see text] 13 mm on the day of trigger did not differ by stage or grade. After adjusting for age, BMI, and baseline AFC, we found that the mean MII per AFC did not differ by stage (1.0 vs. 1.1, P = 0.3) or grade (1.0 vs. 1.0, P = 0.92). Similarly, total oocytes retrieved, total MII retrieved, and percentage of patients who were able to preserve greater than 10 MII did not differ by breast cancer stage or grade (all P > 0.2).ConclusionBreast cancer grade and stage do not impact ovarian stimulation or fertility preservation outcome.
- Published
- 2022