Search

Your search keyword '"Andrac-Meyer, L."' showing total 2 results
Start Over Author "Andrac-Meyer, L." Topic breast cancer
2 results on '"Andrac-Meyer, L."'

1. c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays

Author

Charpin-Taranger C, Claude Allasia, Charafe-Jauffret E, David Jérémie Birnbaum, Séverine Carpentier-Meunier, Jean-Philippe Dales, Pascal Bonnier, Lavaut Mn, Stéphane Garcia, Andrac-Meyer L, and Jocelyne Jacquemier

Subjects
Cancer Research, medicine.medical_specialty, Pathology, C-Met, Immunocytochemistry, Breast Neoplasms, Biology, chemistry.chemical_compound, Automation, Phosphatidylinositol 3-Kinases, Breast cancer, immunocytochemistry, image analysis, medicine, skin and connective tissue diseases, Molecular Diagnostics, c-Met, Tissue microarray, tissue microarray, Anatomical pathology, Proto-Oncogene Proteins c-met, medicine.disease, Cadherins, Immunohistochemistry, Oncology, chemistry, Tissue Array Analysis, Cancer research, Breast carcinoma, Inflammatory Breast Carcinoma
Abstract

Inflammatory breast carcinoma (IBC) is a rare but aggressive tumour associated with poor outcome owing to early metastases. Increased expression of c-Met protein correlates with reduced survival and high metastatic risk in human cancers including breast carcinomas and is targetable by specific drugs, that could potentially improve the prognosis. In the present study, we compared c-Met expression in IBC (n=41) and non-IBC (n=480) immunohistochemically (Ventana Benchmark autostainer) in two tissue microarrays (TMA) along with PI3K and E-cadherin. The results were quantified through an automated image analysis device (SAMBA Technologies). We observed that (i) c-Met was significantly overexpressed in IBC as compared with non-IBC (P

Published
2007

2. c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays.

Author

Garcia, S., Dalès, J.-P., Jacquemier, J., Charafe-Jauffret, E., Birnbaum, D., Andrac-Meyer, L., Lavaut, M.-N., Allasia, C., Carpentier-Meunier, S., Bonnier, P., and Charpin-Taranger, C.

Subjects
BREAST cancer, CANCER invasiveness, IMMUNOCYTOCHEMISTRY, METASTASIS, CANCER prognosis, CELL motility
Abstract

Inflammatory breast carcinoma (IBC) is a rare but aggressive tumour associated with poor outcome owing to early metastases. Increased expression of c-Met protein correlates with reduced survival and high metastatic risk in human cancers including breast carcinomas and is targetable by specific drugs, that could potentially improve the prognosis. In the present study, we compared c-Met expression in IBC (n=41) and non-IBC (n=480) immunohistochemically (Ventana Benchmark autostainer) in two tissue microarrays (TMA) along with PI3K and E-cadherin. The results were quantified through an automated image analysis device (SAMBA Technologies). We observed that (i) c-Met was significantly overexpressed in IBC as compared with non-IBC (P<0.001), (ii) PI3K was overexpressed (P<0.001) in IBC, suggesting that the overexpressed c-Met is functionally active at least through the PI3K signal transduction pathway; and (iii) E-cadherin was paradoxically also overexpressed in IBC. We concluded that overexpressed c-Met in IBC constitutes a potential target for specific therapy for the management of patients with poor-outcome tumours such as IBC. Automated image analysis of TMA proved to be a valuable tool for high-throughput immunohistochemical quantification of the expression of intratumorous protein markers.British Journal of Cancer (2007) 96, 329–335. doi:10.1038/sj.bjc.6603569 www.bjcancer.com [ABSTRACT FROM AUTHOR]

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results