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The article discusses a research study which examined the association between survival and occult metastases detected by immunochemical staining of sentinel lymph nodes and bone marrow specimens from female patients with early-stage invasive breast cancer. Results of immunochemical staining showed that 76.3 percent of the SLN specimens were tumor-negative and 10.5 percent were tumor-positive, while 3.0 percent of bone marrow specimens were positive for tumors. Data reveals that 435 patients had died and 376 had disease recurrence. Evidence showed the insignificant association of SLN metastases with overall survival, while bone marrow metastases were found to be associated with decreased overall survival.

The article discusses application of fine-needle aspiration (FNA) to reverse-phase protein microarray (RPPM) technology. It is suggested that this study can help the development of rational drug targets. It also offers that data on protein-DNA interactions during tumorigensis may help in the development of therapeutic strategies for a patient's molecular profile. Also discussed are breast cancer, proteomics, and RPPM's sensitivity and precision.