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LDL-C level can be measured by direct methods (LDL-C M) or calculated by Friedewald formula (LDL-C C). The aim of this study was to investigate the difference between LDL-C M and LDL-C C after a daily breakfast in Chinese patients with coronary heart disease (CHD). Three hundred and three inpatients, including 203 CHD patients (CHD group) and 100 non-CHD controls (CON group), were enrolled in this study. Serum levels of blood lipid parameters, including LDL-C C and LDL-C M , at 0, 2 and 4 h (h) were monitored after a daily breakfast in all subjects. LDL-C M was significantly higher than LDL-C C in fasting state in each group and at 4 h postprandially in CHD group (P <.05). Postprandial LDL-C M and LDL-C C significantly decreased in each group (P <.05). Postprandial decline in LDL-C M was significantly greater than that of LDL-C C (P <.05). For CHD patients taking statins for ≥1 month before admission, non-fasting percent attainment of LDL-C M or LDL-C C was significantly higher than its fasting value, especially at 4 h (P <.05). The percent deviation of LDL-C M from 1.8 mmol/L at 4 h was significantly different from its fasting value. However, there was no significant difference in percent deviation of LDL-C C from 1.8 mmol/L between fasting and non-fasting states. It indicated that the clinical monitoring of non-fasting LDL-C level in CHD patients could be relatively complex, and the judgement may depend not only on the method to acquire LDL-C level, but also on the evaluation method. • A significant difference between LDL-C C and LDL-C M in Chinese patients with CHD. • The decrement in LDL-C M was lager than that in LDL-C C in non-fasting state. • Percent attainment of LDL-C C and LDL-CM <1.8 mmol/L was higher in non-fasting state. • No significant difference between fasting and non-fasting percent deviation of LDL-C C from 1.8 mmol/L. [ABSTRACT FROM AUTHOR]

Abstract Background Overweight is always accompanied by hypertriglyceridemia (HTG), but the change in non-fasting triglyceride (TG) concentration in overweight subjects without postprandial hypertriglyceridemia was unknown. Methods Concentrations of serum lipids were measured at 2 and 4 h in matched overweight (OW group, n = 54) and control subjects (CON group, n = 55) after a daily meal. Concentrations of remnant cholesterol and non-HDL cholesterol were calculated according to the formulas. The diagnostic criteria for non-fasting HTG were based on 2 different consensus statement. ROC curve was used to determine the pointcut of postprandial HTG. Results OW group had higher fasting concentrations of RC and non-HDL-C than CON group. Non-fasting concentrations of triglyceride and RC significantly increased in 2 groups while were higher in OW group (p <.05). The proportion of non-fasting HTG increased after a daily meal in OW group was significantly higher than the percentage of fasting HTG (p <.05). There was a significant correlation between the postprandial concentrations of TG and RC. Conclusions Overweight subjects were more likely to develop non-fasting hypertriglyceridemia and higher concentrations of RC and non-HDL-C. Additionally, 2.0 mmol/l at 4 h after breakfast could be a pointcut value to detect changes in lipid profile of Chinese overweight people. Highlights • Overweight subjects were more likely to develop HTG after a Chinese daily diet. • The non-fasting diagnostic accuracy of HTG was compared by different standards. • 2.0 mmol/L could be a better cut-point to diagnose non-fasting TG elevation. • The correlation between levels of TG and RC was highest at 4 h after breakfast. • 4 h after a diet could be an ideal time to detect the levels of non-fasting lipids. [ABSTRACT FROM AUTHOR]