1. Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study.
- Author
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Angelo, H. D., Gomes Silva, I. I. F., Oliveira, R. D. R., Louzada‐Júnior, P., Donadi, E. A., Crovella, S., Maia, M. M. D., de Souza, P. R. E., and Sandrin‐Garcia, P.
- Subjects
INTERLEUKINS ,INTERFERONS ,GENETIC polymorphisms ,BRAZILIANS ,GENETICS of rheumatoid arthritis ,CYTOKINE genetics ,GENE expression ,DISEASES - Abstract
Polymorphisms in interleukin (IL)-18, IL-12 and interferon (IFN)-γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis ( RA). IL-18 +105 A/C, IL-12B +1188 A/C and IFN-γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism-polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL-18 +105 A/C polymorphism between the RA and control groups (odds ratio = 3.77; P < 0.0001). Individual carriers of the variant allele C had a 3.77-fold increased risk of for RA ( P = 0.0032). No association was observed for IL-12B and IFN-γ polymorphisms. Our finds suggest a possible role for IL-18 polymorphism in the RA susceptibility in studied population. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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