1. Insulin resistance influences central opioid activity in polycystic ovary syndrome
- Author
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Berent-Spillson, Alison, Love, Tiffany, Pop-Busui, Rodica, Sowers, MaryFran, Persad, Carol C., Pennington, Kathryn P., Eyvazaddeh, Aimee D., Padmanabhan, Vasantha, Zubieta, Jon-Kar, and Smith, Yolanda R.
- Subjects
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INSULIN resistance , *OPIOID receptors , *NEURAL transmission , *POLYCYSTIC ovary syndrome , *POSITRON emission tomography , *ENDORPHINS , *WOMEN'S health , *BRAIN tomography , *HUMAN reproduction , *HYPOGLYCEMIC agents , *METFORMIN , *BINDING sites , *BRAIN , *CELL receptors , *FENTANYL , *GLUCOSE tolerance tests , *MAGNETIC resonance imaging , *RADIOISOTOPES , *RESEARCH funding , *TIME , *PILOT projects , *TREATMENT effectiveness , *CASE-control method ,BRAIN metabolism - Abstract
This pilot study describes a relationship between insulin resistance and μ-opioid neurotransmission in limbic appetite and mood-regulating regions in women with polycystic ovary syndrome (PCOS), suggesting that insulin–opioid interactions may contribute to behavioral and reproductive pathologies of PCOS. We found that [1] patients with PCOS who are insulin-resistant (n = 7) had greater limbic μ-opioid receptor availability (nondisplaceable binding potential) than controls (n = 5); [2] receptor availability was correlated with severity of insulin resistance; and [3] receptor availability normalized after insulin-regulating treatment. [Copyright &y& Elsevier]
- Published
- 2011
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