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Modalities like MRI give information about organs and highlight diseases. Organ information is visualized in intensities. The segmentation method plays an important role in the identification of the region of interest (ROI). The ROI can be segmented from the image using clustering, features, and region extraction. Segmentation can be performed in steps; firstly, the region is extracted from the image. Secondly, feature extraction performed, and better features are selected. They can be shape, texture, or intensity. Thirdly, clustering segments the shape of tumor, tumor has specified shape, and shape is detected by feature. Clustering consists of FCM, K-means, FKM, and their hybrid. To support the segmentation, we conducted three studies (region extraction, feature, and clustering) which are discussed in the first line of this review paper. All these studies are targeting MRI as a modality. MRI visualization proved to be more accurate for the identification of diseases compared with other modalities. Information of the modality is compromised due to low pass image. In MRI Images, the tumor intensities are variable in tumor areas as well as in tumor boundaries., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2022 Khurram Ejaz et al.)