1. Cerebral circulation time derived from fMRI signals in large blood vessels
- Author
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Yunjie Tong, James H Wang, Jinxia Fiona Yao, Aaron A. Cohen-Gadol, Zhenhu Liang, Ho-Ching Shawn Yang, and Vitaliy L. Rayz
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Article ,030218 nuclear medicine & medical imaging ,Young Adult ,03 medical and health sciences ,Cerebral circulation ,Sex Factors ,0302 clinical medicine ,Oscillometry ,Internal medicine ,medicine.artery ,Statistical significance ,Image Processing, Computer-Assisted ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Brain Mapping ,Human Connectome Project ,Resting state fMRI ,Echo-Planar Imaging ,business.industry ,Brain ,Middle Aged ,Magnetic Resonance Imaging ,Oxygen ,SSS ,Cerebrovascular Circulation ,Cardiology ,Female ,Internal carotid artery ,Superior Sagittal Sinus ,business ,Perfusion ,Carotid Artery, Internal ,Superior sagittal sinus - Abstract
Background The systemic low-frequency oscillation (sLFO) functional (f)MRI signals extracted from the internal carotid artery (ICA) and the superior sagittal sinus (SSS) are found to have valuable physiological information. Purpose 1) To further develop and validate a method utilizing these signals to measure the delay times from the ICAs and the SSS. 2) To establish the delay time as an effective perfusion biomarker that associates with cerebral circulation time (CCT). 3) To explore within subject variations, and the effects of gender and age on the delay times. Study type Prospective. Subjects In all, 100 healthy adults (Human Connectome Project [HCP], age range 22-36 years, 54 females and 46 males), 56 healthy children (Adolescent Brain Cognitive Development project) were included. Field strength/sequence Echo planar imaging (EPI) sequence at 3T. Assessment The sLFO fMRI signals from the ICAs and the SSSs were extracted from the resting state fMRI data. The maximum cross-correlation coefficients and their corresponding delay times were calculated. The gender and age differences of delay times were assessed statistically. Statistical tests T-tests were conducted to measure the gender differences. The Kruskal-Wallis test was used to detect age differences. Results Consistent and robust results were found from 80% of the 400 HCP scans included. Negative correlations (-0.67) between the ICA and the SSS signals were found with the ICA signal leading the SSS signal by ∼5 sec. Within subject variation was 2.23 sec at the 5% significance level. The delay times were not significantly different between genders (P = 0.9846, P = 0.2288 for the left and right ICA, respectively). Significantly shorter delay times (4.3 sec) were found in the children than in the adults (P Data conclusion We have shown that meaningful perfusion information (ie, CCT) can be derived from the sLFO fMRI signals of the large blood vessels. Level of evidence 1 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:1504-1513.
- Published
- 2019