1. Expression of c-myc and c-fos oncogenes in different rat brain regions during postnatal development.
- Author
-
Parma DL, Benasayag SJ, and Szijan I
- Subjects
- Animals, Cell Division physiology, Cytoplasm metabolism, Nucleic Acid Hybridization, RNA, Messenger metabolism, Rats, Rats, Inbred Strains, Brain growth & development, Brain Chemistry physiology, Gene Expression Regulation, Neoplastic physiology, Genes, fos physiology, Genes, myc physiology
- Abstract
We have studied the expression of c-myc and c-fos proto-oncogenes in various areas of the central nervous system during postnatal development. c-myc mRNA levels increased during the first 5 days and then decreased over the next 15 days in all nervous regions studied. c-fos mRNA levels changed in a different way in four brain areas. While in cerebral cortex and cerebellum there was a sharp decrease during the first 10 days, in white matter and hypothalamus c-fos transcript levels remained high during the same period, decreasing at a later stage. Changes in oncogenes mRNA levels are related to various developmental events, such as neurite growth, myelination and cell proliferation. The dissimilar patterns of c-myc and c-fos expression suggests that they play different functions in CNS maturation. c-myc mRNA levels are temporally related to active neurite growth and to cell proliferation. Changes in c-fos mRNA correlate in time with early developmental processes and also with those occurring at later stages, such as myelination.
- Published
- 1991
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