1. Hematopoietic progenitors express myelin basic protein and ensheath axons in Shiverer brain.
- Author
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Goolsby J, Makar T, Dhib-Jalbut S, Bever CT Jr, Pessac B, and Trisler D
- Subjects
- Animals, Axons pathology, Brain pathology, Brain surgery, Cells, Cultured, Hematopoietic Stem Cells pathology, Mice, Mice, Inbred C3H, Mice, Neurologic Mutants, Myelin Sheath pathology, Axons metabolism, Brain metabolism, Hematopoietic Stem Cell Transplantation methods, Hematopoietic Stem Cells metabolism, Myelin Basic Protein biosynthesis, Myelin Sheath metabolism
- Abstract
Oligodendroglia are cells of the central nervous system (CNS) that form myelin sheath, which insulates neuronal axons. Neuropathologies of the CNS include dysmyelination of axons in multiple sclerosis and CNS trauma. Cell replacement is a promising but largely untested therapy for dysmyelination. Shiverer mouse, a genetic mutant that does not synthesize full-length myelin basic protein (MBP), a critical prerequisite protein in CNS myelin sheath formation, provides an unequivocal model for determining the potential of stem cells to become oligodendroglia. We demonstrate that adult wild-type mouse bone marrow stem cells can express MBP and ensheath axons when transplanted into Shiverer brain., (Published by Elsevier B.V.)
- Published
- 2013
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