1. Role of immune-derived diffusible mediators in AIDS-associated neurological disorders.
- Author
-
Ensoli F, Fiorelli V, De Cristofaro M, Muratori DS, Novi A, Isgrò A, and Aiuti F
- Subjects
- Acquired Immunodeficiency Syndrome complications, Diffusion, Humans, Nervous System Diseases complications, Neuroglia immunology, Neurons immunology, Acquired Immunodeficiency Syndrome immunology, Brain immunology, HIV-1 immunology, Nervous System Diseases immunology, Neurotoxins biosynthesis
- Abstract
Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.
- Published
- 2000