1. PET Imaging with S-[ 11 C]Methyl-L-Cysteine and L-[Methyl- 11 C]Methionine in Rat Models of Glioma, Glioma Radiotherapy, and Neuroinflammation.
- Author
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Parente A, van Waarde A, Shoji A, de Paula Faria D, Maas B, Zijlma R, Dierckx RAJO, Langendijk JA, de Vries EFJ, and Doorduin J
- Subjects
- Animals, Cysteine chemistry, Cysteine pharmacokinetics, Disease Models, Animal, Inflammation pathology, Kinetics, Male, Methionine chemistry, Methionine pharmacokinetics, Rats, Wistar, Tumor Burden, Brain diagnostic imaging, Brain pathology, Cysteine analogs & derivatives, Glioma diagnostic imaging, Glioma radiotherapy, Inflammation diagnostic imaging, Methionine analogs & derivatives, Positron-Emission Tomography
- Abstract
Purpose: S-[
11 C]-methyl-L-cysteine ([11 C]MCYS) has been claimed to offer higher tumor selectivity than L-[methyl-11 C]methionine ([11 C]MET). We examined this claim in animal models., Procedures: Rats with implanted untreated (n = 10) or irradiated (n = 7, 1 × 25 Gy, on day 8) orthotopic gliomas were scanned after 6, 9, and 12 days, using positron emission tomography. Rats with striatal injections of saline (n = 9) or bacterial lipopolysaccharide (n = 9) were scanned after 3 days., Results: Uptake of the two tracers in untreated gliomas was similar. [11 C]MCYS was not accumulated in salivary glands, nasal epithelium, and healing wounds, in contrast to [11 C]MET, but showed 40 % higher accumulation in the healthy brain. Both tracers showed a reduced tumor uptake 4 days after irradiation and minor accumulation in inflamed striatum. [11 C]MCYS indicated higher lesion volumes than [11 C]MET (untreated tumor + 47 %; irradiated tumor up to + 500 %; LPS-inflamed striatum + 240 %)., Conclusions: [11 C]MCYS was less accumulated in some non-tumor tissues than [11 C]MET, but showed lower tumor-to-brain contrast.- Published
- 2018
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