1. [Study of the neuroprotective action of hybrid structures based on fullerene C60].
- Author
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Grigor'ev VV, Petrova LN, Ivanova TA, Kotel'nikova RA, Bogdanov GN, Poletaeva DA, Faĭngol'd II, Mishchenko DV, Romanova VS, Kotel'nikov AI, and Bachurin SO
- Subjects
- Animals, Antioxidants chemistry, Brain cytology, Brain enzymology, Brain metabolism, Calcium metabolism, Fullerenes chemistry, In Vitro Techniques, Lipid Peroxidation drug effects, Malondialdehyde metabolism, Mitochondria drug effects, Mitochondria enzymology, Molecular Structure, Monoamine Oxidase metabolism, Neuroprotective Agents chemistry, Rats, Receptors, AMPA metabolism, Synaptosomes drug effects, Synaptosomes metabolism, Antioxidants pharmacology, Brain drug effects, Fullerenes pharmacology, Neuroprotective Agents pharmacology
- Abstract
The neuroprotective action of hybrid structures based on fullerene C60 with attached proline amino acid has been studied. Hybrid structures contained natural antioxidant carnosine or addends with one or two nitrate groups. It has been shown that all studied compounds had antioxidant activity and decreased the concentration of malondialdehyde in homogenates of the rat brain. Compound 1, which contained the antioxidant carnosine, has been found to be the most effective antioxidant. All compounds except IV and V inhibited the activity of monoamine oxidase B, while compounds I-IV increased the activity of monoamine oxidase A. All investigated compounds inhibited glutamate-induced Ca2+ uptake into synaptosomes of the rat brain cortex. Compound III, containing two nitrate groups, has been found to be the most effective inhibitor. This compound caused a significant increase of the currents of AMPA receptors (AMPA, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid).
- Published
- 2011