1. Bayesian analysis of fMRI data with ICA based spatial prior.
- Author
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Bathula DR, Tagare HD, Staib LH, Papademetris X, Schultz RT, and Duncan JS
- Subjects
- Bayes Theorem, Data Interpretation, Statistical, Humans, Image Enhancement methods, Principal Component Analysis, Reproducibility of Results, Sensitivity and Specificity, Algorithms, Brain physiology, Brain Mapping methods, Evoked Potentials physiology, Image Interpretation, Computer-Assisted methods, Magnetic Resonance Imaging methods
- Abstract
Spatial modeling is essential for fMRI analysis due to relatively high noise in the data. Earlier approaches have been primarily concerned with the spatial coherence of the BOLD response in local neighborhoods. In addition to a smoothness constraint, we propose to incorporate prior knowledge of brain activation patterns learned from training samples. This spatially informed prior can significantly enhance the estimation process by inducing sensitivity to task related regions of the brain. As fMRI data exhibits intersubject variability in functional anatomy, we design the prior using Independent Component Analysis (ICA). Due to the non-Gaussian assumption, ICA does not regress to the mean activation pattern and thus avoids suppressing intersubject differences. Results from a real fMRI experiment indicate that our approach provides statistically significant improvement in estimating activation compared to the standard general linear model (GLM) based methods.
- Published
- 2008
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