1. Renin-angiotensin system modulation through enalapril and/or exercise training improves visceral adiposity in obese mice.
- Author
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Alexandre-Santos, Beatriz, Magliano, D'Angelo Carlo, Giori, Isabele Gomes, Medeiros, Gabriela Rodrigues de Oliveira, Vieira, Carla P., Conte-Junior, Carlos Adam, Nobrega, Antonio Claudio Lucas da, and Frantz, Eliete Dalla Corte
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RENIN-angiotensin system , *EXERCISE therapy , *OBESITY , *BRADYKININ receptors , *WHITE adipose tissue , *INSULIN receptors , *HIGH-fat diet - Abstract
Obesity-related metabolic diseases occur as a result of disruptions in white adipose tissue (WAT) plasticity, especially through visceral fat accumulation and adipocyte hypertrophy. This study aimed to evaluate the impact of renin–angiotensin system (RAS) and bradykinin receptors modulation by enalapril treatment and/or exercise training on WAT morphology and related deleterious outcomes. Male C57BL/6 mice were fed either a standard chow or a high-fat (HF) diet for 16 weeks. At the 8th week, HF-fed animals were divided into sedentary (HF), enalapril treatment (HF-E), exercise training (HF-T), and enalapril treatment plus exercise training (HF-ET) groups. Following the experimental protocol, body mass gain, adiposity index, insulin resistance, visceral WAT morphometry, renin-angiotensin system, and bradykinin receptors were evaluated. The HF group displayed increased adiposity, larger visceral fat mass, and adipocyte hypertrophy, which was accompanied by insulin resistance, overactivation of Ang II/AT1R arm, and favoring of B1R in bradykinin receptors profile. All interventions ameliorated visceral adiposity and related outcomes by favoring the Ang 1–7/MasR arm and the B2R expression in B1R/B2R ratio. However, combined therapy additively reduced Ang II/Ang 1–7 ratio. Our results suggest that Ang 1–7/MasR arm and B2R activation might be relevant targets in the treatment of visceral obesity. • Enalapril treatment and exercise training ameliorates visceral adiposity. • Visceral adiposity is related to Ang II/AT1R and B1R overexpression in vWAT. • The interventions favor the counterregulatory arm of visceral adipose RAS. • Combined therapy additively reduces Ang II/Ang 1–7 ratio in vWAT. • The interventions shift the bradykinin receptor profile towards B2R in vWAT. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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