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The main aims of the present research were to: (1) describe the scientific outputs indexed in the Scopus and Web of Science databases, from now on WoS, regarding the use of comic books as didactic resources in the teaching-learning of the sciences, and; (2) establish the conceptual structure of scientific output regarding the use of comic books as didactic resources in the teaching-learning of science. A quantitative-bibliometric methodology was followed on a sample of 60 scientific documents recovered using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses strategy, from now on PRISMA. Findings suggest that the topic is still emerging given the novelty of the discipline and that published studies tend to be low impact in terms of the number of citations they receive. With regards to the conceptual structure, the most relevant themes and trends to emerge pertained to medical education, comic books and illustrations, and the use of mobile devices. Finally, analysis of the keywords used by the top 20 most relevant authors, it was possible to infer a degree of correspondence between sources, keywords and the continents responsible for the greatest scientific output on the topic.